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Bioinformatics analysis and experimental validation of cystathionine-gamma-lyase as a potential prognosis biomarker in hepatocellular carcinoma

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BIOCELL 2024年第3期48卷 463-471页

作者： YANAN ma sHANsHAN WANG HUIGUO DING Department of Gastroenterology and Hepatology Beijing You’an Hospital Affiliated with Capital Medical UniversityBeijing100069China Beijing Institute of Hepatology Beijing You’an Hospital Affiliated with Capital Medical UniversityBeijing100069China

Background:Hepatocellular carcinoma(HCC)is a common malignant tumor with poor prognosis and high mortality *** cystathionine-gamma-lyase(CsE)plays an important role in the development of multiple tumors,the clinical implication and potential mechanisms of CsE in HCC development remain ***:In our study,the CsE expression in HCC was analyzed in Gene Expression Omnibus(GEO)and The Cancer Genome Atlas(TCGA)datasets and further conﬁrmed by RT-qPCR and immunohistochemistry assays in HCC ***,the associations between CsE expression and HCC malignancy as well as survival were analyzed in GsE14520 and validated in HCC ***,the biological functions of CsE in HCC cells was assessed by CCK-8,ﬂow cytometry and Western ***:Lower transcriptional and proteomic CsE expressions were found in HCC tissues in contrast to adjacent normal *** CsE mRNA expression was signiﬁcantly associated with advanced clinicopathological features and poor outcomes in HCC patients from public database and our *** univariate and multivariate analyses of GsE14520 data showed that CsE expression was an independent prognostic indicator for the overall survival(os)and recurrence-free survival(RFs)of HCC *** vitro experiments further explained that CsE might trigger HCC cell apoptosis by ***:In summary,the present study identiﬁed the relationship between CsE expression and HCC malignancy as well as os and RFs,indicating that CsE might be a potential prognostic biomarker and a novel therapeutic target for HCC.

关键词： Hepatocellular carcinoma Cystathionine-gamma-lyase Hydrogen sulfide Prognosis Apoptosis

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Efficacy and predictive factors of transarterial chemoembolization combined with lenvatinib plus programmed cell death protein-1 inhibition for unresectable hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1236-1247页

作者： Kun-Peng ma Jin-Xin Fu Feng Duan mao-Qiang Wang Department of Interventional Radiology The Fifth Medical Center of Chinese People's Liberation Army General HospitalBeijing 100853China Chinese People's Liberation Army Medical school Beijing 100853China

BACKGROUND The efficacy and safety of transarterial chemoembolization(TACE)combined with lenvatinib plus programmed cell death protein-1(PD-1)for unresectable hepato-cellular carcinoma(HCC)have rarely been evaluated and it is unknown which factors are related to *** To evaluate the efficacy and independent predictive factors of TACE combined with lenvatinib plus PD-1 inhibitors for unresectable *** This study retrospectively enrolled patients with unresectable HCC who received TACE/lenvatinib/PD-1 treatment between march 2019 and April *** survival(os)and progression-free survival(PFs)were *** objective response rate(ORR)and disease control rate(DCR)were evaluated in accordance with the modified Response Evaluation Criteria in solid ***,the prognostic factors affecting the clinical outcome were *** One hundred and two patients were enrolled with a median follow-up duration of 12.63 *** median os was 26.43 months(95%CI:17.00-35.87),and the median PFs was 10.07 months(95%CI:8.50-11.65).The ORR and DCR were 61.76%and 81.37%,*** patients with Barcelona Clinic Liver Cancer Classification(BCLC)B stage,early neutrophil-to-lymphocyte ratio(NLR)response(decrease),or early alpha-fetoprotein(AFP)response(decrease>20%)had superior os and PFs than their *** This study showed that TACE/lenvatinib/PD-1 treatment was well tolerated with encouraging efficacy in patients with unresectable *** patients with BCLC B-stage disease with early NLR response(decrease)and early AFP response(decrease>20%)may achieve better clinical outcomes with this triple therapy.

关键词： Transarterial chemoembolization Efficacy Lenvatinib Programmed cell death protein-1 inhibitors Unresectable hepatocellular carcinoma

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Polyphyllin Ⅰ enhances tumor necrosis factor-related apoptosis-inducing ligand-induced inhibition of human osteosarcoma cell growth via downregulating the Wnt/β-catenin pathway

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Journal of Traditional Chinese Medicine 2024年第2期44卷 251-259页

作者： CHANG Junli ZHAO Fulai sUN Xingyuan ma Xiaoping ZHAO Peng ZHOU Chujie sHI Binhao GU Wenchao WANG Yongjun YANG Yanping spine Disease Institute Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Diagnostic and Interventional Radiology University of TsukubaIbaraki 315-0114Japan

OBJECTIVE:To investigate the synergistic effects of polyphyllin Ⅰ(PPⅠ)combined with tumor necrosis factorrelated apoptosis-inducing ligand(TRAIL)on the growth of osteosarcoma cells through downregulating the Wnt/β-catenin signaling ***:Cell viability,apoptosis and cell cycle distribution were examined using cell counting kit-8 and flow cytometry *** morphology of cancer cells was observed with inverted phase contrast *** migration and invasion abilities were examined by xCELLigence real time cell analysis DP system and transwell *** expressions of poly(adenosine diphosphate-ribose)polymerase,C-Myc,Cyclin B1,cyclin-dependent kinases 1,N-cadherin,Vimentin,Active-β-catenin,β-catenin,p-glycogen synthase kinase 3β(GsK-3β)and GsK-3βwere determined by Western blotting ***:PPⅠ sensitized TRAIL-induced decrease of viability,migration and invasion,as well as increase of apoptosis and cell cycle arrest of MG-63 and U-2 os osteosarcoma *** synergistic effect of PPⅠwith TRAIL in inhibiting the growth of osteosarcoma cells was at least partially realized through the inactivation of Wnt/β-catenin signaling ***:The combination of PPⅠ and TRAIL is potentially a novel treatment strategy of osteosarcoma.

关键词： osteosarcoma tumor necrosis factor-related apoptosis-inducing ligand Wnt signaling pathway beta-catenin polyphyllinⅠ

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Efficacy and safety of perioperative therapy for locally resectable gastric cancer:A network meta-analysis of randomized clinical trials

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1046-1058页

作者： Zi-Yu Kuang Qian-Hui sun Lu-Chang Cao Xin-Yi ma Jia-Xi Wang Ke-Xin Liu Jie Li Graduate College Beijing University of Traditional Chinese MedicineBeijing 100029China Oncology Department Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China

BACKGROUND Gastric cancer(GC)is the fifth most commonly diagnosed malignancy worldwide,with over 1 million new cases per year,and the third leading cause of cancer-related *** To determine the optimal perioperative treatment regimen for patients with locally resectable *** A comprehensive literature search was conducted,focusing on phase II/III randomized controlled trials(RCTs)assessing perioperative chemotherapy and chemoradiotherapy in treating locally resectable *** R0 resection rate,overall survival(os),disease-free survival(DFs),and incidence of grade 3 or higher nonsurgical severe adverse events(sAEs)associated with various perioperative regimens were analyzed.A Bayesian network meta-analysis was performed to compare treatment regimens and rank their *** Thirty RCTs involving 8346 patients were included in this *** XELOX plus neoadjuvant radiotherapy and neoadjuvant CF were found to significantly improve the R0 resection rate compared with surgery alone,and the former had the highest probability of being the most effective option in this *** plus adjuvant FLOT was associated with the highest probability of being the best regimen for improving *** to limited data,no definitive ranking could be determined for *** nonsurgical sAEs,FLO has emerged as the safest treatment *** This study provides valuable insights for clinicians when selecting perioperative treatment regimens for patients with locally resectable *** studies are required to validate these findings.

关键词： Gastric cancer Perioperative treatment Network meta-analysis Efficacy and safety

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Fine mapping and characterization of a major QTL for grain length,***-2D.1,that has pleiotropic effects in synthetic allohexaploid wheat

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Journal of Integrative Agriculture 2024年第9期23卷 2911-2922页

作者： Mingming Wang Jia Geng Zhe Zhang Zihan Zhang Lingfeng Miao Tian ma Jiewen Xing Baoyun Li Qixin sun Yufeng Zhang Zhongfu Ni Frontiers science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization Ministry of Education/Beijing Key Laboratory of Crop Genetic ImprovementChina Agricultural UniversityBeijing 100193China National Plant Gene Research Centre Beijing 100193China

Grain size is one of the determinants of grain yield,and identifying the genetic loci that control grain size will be helpful for increasing grain *** our previous study,a quantitative trait locus(QTL)for grain length(GL),***-2D.1,was identified from an F2 population developed from the cross between the natural(TAA10)and synthetic(XX329)allohexaploid *** the present study,we mainly fine mapped and validated its genetic *** this end,multiple near-isogenic lines(NILs)were obtained through marker-assisted selection with TAA10 as the recurrent *** secondary populations derived from 25 heterozygous recombinants were used for fine mapping of ***-2D.1,and the allele from XX329 significantly increased GL,thousand-grain weight(TGW),total spikelet number per spike(TsN)and spike compactness(sC).Using NILs for XX329(2D+)and TAA10(2D−),we determined the genetic and pleiotropic effects of *** target sequences were aligned with the wheat reference genome Refseq v2.1 and spanned an~0.9 Mb genomic ***2D03G0114900(ortholog of os03g0594700)was predicted as the candidate gene based on whole-genome re-sequencing and expression *** summary,the map-based cloning of ***-2D.1 will be useful for improving grain weight with enhanced GL and TsN.

关键词： grain length total spikelet number per spike spike compactness near-isogenic lines QTL wheat

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New aspects in celiac disease

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World Journal of Gastroenterology 2007年第8期13卷 1156-1161页

作者： MI Torres ma López Casado A Ríos Department of Experimental Biology University of JaénJaén 23071Spain Department of Gastroenterology Pediatrics. Hospital Virgen de las Nieves Granada Department Cell Biology. University of Granada Granada

Celiac disease (CD) is a common autoimmune disorder characterized by an immune response to ingested gluten and has a strong HLA association with HLA- DQ2 and HLA-DQ8 molecules, but human HLA-DQ risk factors do not explain the entire genetic susceptibility to gluten intolerance. CD is caused by the lack of immune tolerance (oral tolerance) to wheat gluten. In this sense, the expression of soluble HLA-G in CD is of special interest because the molecule plays an important role in the induction of immune tolerance. The enhanced expression of soluble HLA-G found in CD may be part of a mechanism to restore the gluten intolerance. In this editorial, we review recent progress in understanding CD in relation to its prevalence, diagnosis and possible mechanisms of pathogenesis.

关键词： Celiac disease Oral tolerance IL-10 TGF-beta Gluten intolerance

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systemic inflammatory response index is a predictor of prognosis in gastric cancer patients: Retrospective cohort and meta-analysis

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World Journal of Gastrointestinal surgery 2024年第2期16卷 382-395页

作者： Jing-Yao Ren Meng Xu Xiang-Dong Niu shi-Xun ma Ya-Jun Jiao Da Wang Miao Yu Hui Cai school of Clinical Medicine Ningxia Medical UniversityYinchuan 750000Ningxia Hui autonomous regionChina Gansu Provincial Hospital Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina General surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Medical College of Jiangsu University Jiangsu UniversityZhenjiang 212013Jiangsu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND The systemic inflammatory response index(sIRI)has been demonstrated to make a significant difference in assessing the prognosis of patients with different solid ***,research is needed to ascertain the accuracy and reliability of applying the sIRI to patients who undergo robotic radical gastric cancer *** To validate the applicability of the sIRI in assessing the survival of gastric cancer patients and evaluate the clinical contribution of preoperative sIRI levels to predicting long-term tumor outcomes in patients,who received robotic radical gastric cancer *** Initially,an exhaustive retrieval was performed in the PubMed,the Cochrane Library,EMBAsE,Web of science,and scopus databases to identify relevant ***,a meta-analysis was executed on 6 cohort studies iden-tifying the value of the sIRI in assessing the survival of gastric cancer ***,the clinical data of 161 patients undergoing robotic radical gastric cancer surgery were retrospectively analyzed to evaluate their clinicopathological characteristics and relevant laboratory *** association between preoperative sIRI levels and 5-year overall survival(os)and disease-free survival(DFs)was *** The findings demonstrated an extensive connection between sIRI values and the outcome of patients with gastric *** sIRI levels were identified as an independent hazard feature for both os and DFs among those who received robotic surgery for gastric *** levels in gastric cancer patients were observed to be associated with the presence of comorbidities,T-stage,carcinoembryonic antigen levels,the development of early serious postoperative complications,and the rate of lymph node *** sIRI values are correlated with adverse in the gastric cancer population and have the potential to be utilized in predicting long-term oncological survival in patients who undergo robotic radical gastric canc

关键词： systemic inflammatory response index Prognosis Gastric cancer Complications Meta-analysis

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Clinical significance,molecular characterization,and immune microenvironment analysis of coagulation-related genes in clear cell renal cell carcinoma

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Cancer Innovation 2024年第1期3卷 29-49页

作者： Weihao Chen Xupeng Zhao Yongliang Lu Hanfeng Wang Xiyou Wang Yi Wang Chen Liang Zhuomin Jia Wei ma Department of Urology The Third Medical Center of PLA General HospitalBeijingChina school of Medicine Nankai UniversityTianjinChina Medical service Department The PLA General HospitalBeijingChina senior Department of Otolaryngology-Head&Neck surgery The Sixth Medical Center of PLA General HospitalBeijingChina

Background:Numerous studies have revealed a tight connection between tumor development and the coagulation ***,the effects of coagulation on the prognosis and tumor microenvironment(TME)of clear cell renal cell carcinoma(ccRCC)remain poorly ***:We employed the consensus clustering method to characterize distinct molecular subtypes associated with coagulation ***quently,we examined variations in the overall survival(os),genomic profiles,and TME characteristics between these *** develop a prognostic coagulation-related risk score(CRRs)model,we utilized the least absolute shrinkage and selection operator Cox regression and stepwise multivariate Cox regression *** also created a nomogram to aid in the clinical application of the risk score,evaluating the relationships between the CRRs and the immune microenvironment,responsiveness to immunotherapy,and targeted *** clinical significance of PLAUR and its biological function in ccRCC were also further ***:There were significant differences in clinical features,prognostic stratification,genomic variation,and TME characteristics between the two coagulation-related *** established and validated a CRRs using six coagulation-related genes that can be employed as an effective indicator of risk stratification and prognosis estimation for ccRCC *** variations in survival outcomes were observed between the high-and low-risk *** nomogram was proficient in predicting the 1-,3-,and 5-year ***,the CRRs emerged as a novel tool for evaluating the clinical effectiveness of immunotherapy and targeted treatments in ***,we confirmed upregulated PLAUR expression in ccRCC samples that was significantly correlated with poor patient *** knockdown notably inhibited ccRCC cell proliferation and ***:Our data suggested that CRRs may be employed as a reliable predictive biomarker that can pro

关键词： clear cell renal cell carcinoma coagulation immunotherapy risk score tumor immune microenvironment

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Transforming growth factor-β1 and vascular endothelial growth factor levels in senile acute myeloid leukemia and correlation with prognosis

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World Journal of Clinical Cases 2024年第20期12卷 4121-4129页

作者： Wan Li sheng-Yu ma Hui-Ying Zhao Department of Hematology Suzhou Hospital of Anhui Medical UniversitySuzhou 234000Anhui ProvinceChina

BACKGROUND Acute myeloid leukemia(AML)is a disease in which immature hematopoietic cells accumulate in the bone marrow and continuously expand,inhibiting *** treatment and prognosis of this disease have always been *** To investigate the correlation between vascular endothelial growth factor(VEGF)and transforming growth factor-β1(TGFβ1)expression and prognosis in older adults with *** This study enrolled 80 patients with AML(AML group),including 36 with complete response(AML-CR),23 with partial response(AML-PR),and 21 with no response(AML-NR).The expression levels of VEGF and TGFβ1 were detected by reverse transcription polymerase chain reaction in bone marrow mononuclear cells isolated from 56 healthy ***-Meier analysis was performed to assess overall survival(os)and progression-or disease-free survival(DFs).Prognostic risk factors were analyzed using a Cox proportional hazards *** The AML group showed a VEGF level of 2.68±*** expression was lower in patients with AML-CR than those with AML-PR or AML-NR(Pssion in the AML group was 0.33±*** with AML-CR showed a higher TGFβ1 expression than those with AML-PR or AML-NR(Pssion in patients with AML was significantly correlated with the counts of leukocytes,platelets,hemoglobin,and peripheral blood immature cells(Psurvival analysis revealed that patients with high TGFβ1 expression had better os and DFs than those with low TGFβ1 expression(Ps patients with low VEGF levels showed better os and DFs than those with high VEGF levels(Ps model as independent risk factors for os(Psk factors for DFs(PsION Decreased VEGF expression and increased TGFβ1 expression in patients with AML provide valuable references for det

关键词： Acute myeloid leukemia Transforming growth factor-β1 Vascular endothelial growth factor Expression level Prognostic correlation

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Haploidentical hematopoietic cell transplantation with or without an unrelated cord blood unit for adult acute myeloid leukemia:a multicenter,randomized,open-label,phase 3 trial

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signal Transduction and Targeted Therapy 2024年第6期9卷 2669-2678页

作者： Biqi Zhou Jia Chen Tianhui Liu Yishan Ye Yanming Zhang Yiyang Ding Hong Liu MingQing Zhu Xiao ma Xiaoli Li Longfei Zhao Zhihong Lin He Huang Yang Xu Depei Wu National Clinical Research Center for Hematologic Diseases Jiangsu Institute of HematologyThe First Affiliated Hospital of Soochow UniversitySuzhouChina Institute of Blood and marrow Transplantation Collaborative Innovation Center of HematologySoochow UniversitySuzhouChina Bone marrow Transplantation Center The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Department of Hematology The Affiliated Huai’an Hospital of Xuzhou Medical University and The Second People’s Hospital of Huai’anHuai’anChina soochow Hopes Hematology Hospital SuzhouChina Department of Hematology Hygeia Suzhou Yongding HospitalSuzhouChina

Coinfusion of unrelated cord blood(UCB)units in haploidentical hematopoietic cell transplantation(haplo-HCT)(haplo-cord HCT)for hematopoietic malignancies showed promising results in previous reports,but the efficiency of haplo-cord HCT in acute myeloid leukemia(AML)still lacks sufficient *** multicenter,randomized,phase 3 trial(*** NCT03719534)aimed to assess the efficacy and safety of haplo-cord HCT in AML patients.A total of 268 eligible patients aged 18-60 years,diagnosed with measurable residual disease in AML(excluding acute promyelocytic leukemia),with available haploidentical donors and suitable for allotransplantation,were randomly allocated(1:1)to receive haplo-cord HCT(n=134)or haplo-HCT(n=134).The 3-year overall survival(os)was the primary endpoint in this *** median follow-up was 36.50 months(IQR 24.75-46.50).The 3-year os of Haplo-cord HCT group was better than haplo-HCT group(80.5%,95%confidence interval[CI]:73.7-87.9 vs.67.8%95%CI 60.0-76.5,p=0.013).Favorable progression-free survival(70.3%,95%CI 62.6-78.8 vs.57.6%,95%CI 49.6-67.0,p=0.012)and cumulative incidence of relapse(12.1%,95%CI 12.0-12.2 vs.30.3%,95%CI 30.1-30.4,p=0.024)were observed in haplo-cord HCT *** 3-4 adverse events(AEs)within two years posttransplantation in the two groups were ***-cord HCT patients exhibited a faster cumulative incidence of neutrophil recovery(p=0.026)and increased T-cell reconstitution in the early period ***-cord HCT can improve os in AML patients without excessive AEs,which may exert additional benefits for recipients of haplo-HCT.

关键词： hematopoietic acute phase

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