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行业悄然迎来巨变:洞见中国车市年度趋势

汽车与配件 2024年第1期 40-41页

作者： j.d.Power j.d.Power

回顾2023年,中国车市电动化、智能化全面爆发,新能源汽车的崛起成为世界瞩目的焦点。与此同时,价格战的硝烟弥漫了一整年。在这充满挑战与变化的一年,j.d. Power专业咨询团队持续深入调研中国汽车市场,发现行业正在悄然迎来巨大变革。

关键词：新能源汽车电动化车市价格战咨询团队世界瞩目中国汽车市场智能化

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座椅之争,智能化趋势下的新焦点

汽车与配件 2024年第15期 64-65页

作者： j.d.Power 不详

中国汽车行业智能化浪潮奔涌,面对用户日益增多的消费需求,整车企业纷纷将目光投向能够直观提升驾乘体验的“汽车座椅”。作为与驾乘者最直接接触的部件,汽车座椅正经历着前所未有的革新。智能化:座椅技术“新革命”随着汽车向“移动的... 详细信息

中国汽车行业智能化浪潮奔涌,面对用户日益增多的消费需求,整车企业纷纷将目光投向能够直观提升驾乘体验的“汽车座椅”。作为与驾乘者最直接接触的部件,汽车座椅正经历着前所未有的革新。智能化:座椅技术“新革命”随着汽车向“移动的第三生活空间”迈进。

关键词：汽车座椅整车企业智能化趋势消费需求新焦点生活空间直接接触

Conservative management of spinal pathology with autologous conditioned serum: A systematic review of the literature

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World journal of Orthopedics 2024年第9期15卷 870-881页

作者： Christian j Rajkovic Matthew L Merckling Alyssa W Lee Galadu Subah Aryan Malhotra Zachary d Thomas Sabrina L Zeller john V Wainwright Merritt d Kinon department of Neurosurgery Westchester Medical CenterValhallaNY 10595United States

BACKGROUNd Chronic inflammatory pain is associated with increased expression of interleukin(IL)-1,an inflammatory cytokine,and activity on its receptor(IL-1R).In response,the body produces IL-1R antagonist(IL-1Ra)to reduce this *** conditioned serum(ACS)is the only biologic therapy for spinal pathologies that enhances the action of endogenous IL-1Ra reserves to improve *** systematic review investigates the effectiveness of ACS in treating pain and dis-ability caused by spinal *** To evaluate the use of ACS as a conservative management option for spinal *** A systematic review of PubMed/Medline was performed to identify studies inve-stigating administration of ACS for treatment of any spinal *** Six articles were included,comprising 684 patients treated with epidural(n=133)or transforaminal(n=551)ACS *** had an average age of 54.0 years with slight female predominance(53.2%).The lumbar spine was most com-monly treated,with 567 patients(82.9%)receiving injections for lumbar radicu-lopathy(n=67),degenerative disc disease(ddd)(n=372),or spinal stenosis(n=128);cervical injections were performed in 109 patients(15.9%).Mean(Sd)follow-up was 21.7(4.8)weeks from first ACS *** studies investigating mecha-nical lumbar and lumbar or cervical radicular pain reported significant pain re-duction at final follow-up compared to *** achieved comparable or su-perior results to lumbar epidural steroid *** events were reported in 21 patients(3.1%),with no serious adverse *** ACS injection is a safe and effective intervention for pain reduction in many spinal pathologies,including cervical and lumbar radiculopathies.

关键词： Spine Autologous conditioned serum Orthokine Regenokine Epidural steroid injection Interleukin-1 Inter-leukin-1 receptor antagonist

Impact of Paenibacillus elgii supernatant on screening bacterial strains with potential for biotechnological applications

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Engineering Microbiology 2024年第3期4卷 1-15页

作者： I.C.Cunha-Ferreira C.S.Vizzotto T.d.Frederico j.Peixoto L.S Carvalho M.R.Tótola R.H.Krüger Laboratory of Enzymology Department of Cellular BiologyUniversity of Brasília(UNB)Brasília70910-900Brazil Laboratory of Environmental Sanitation Department of Civil and Environmental EngineeringUniversity of Brasília(UNB)Brasília70910-900Brazil Laboratório de Biotecnologia e Biodiversidade para o Meio Ambiente Universidade Federal de Viçosa(UFV)Viçosa36570-900Brazil

The biotechnological industry faces a crucial demand for novel bioactive compounds,particularly antimicrobial agents,to address the rising challenge of bacterial resistance to current available *** strate-gies for cultivating naturally occurring microorganisms often limit the discovery of novel antimicrobial *** study presents a protocol for targeted selection of bacterial strains using the supernatant of Paenibacillus el-gii,which produces abundant signal molecules and antimicrobial *** samples were inoculated in these enriched culture media to selectively cultivate bacteria resistant to the supernatant,indicating their potential to produce similar *** bacterial strains isolated through this method were assessed for their antibac-terial *** addition,the functional annotation of the genome of one of these strains revealed several gene clusters of biotechnological *** study highlights the effectiveness of using this approach for selective cultivation of microorganisms with potential for biotechnological applications.

关键词： Prospecting Supernatant Antibacterial activity

Integrated Single-cell Multiomic Analysis of HIV Latency Reversal Reveals Novel Regulators of Viral Reactivation

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 67-88页

作者： Manickam Ashokkumar Wenwen Mei jackson j.Peterson Yuriko Harigaya david M.Murdoch david M.Margolis Caleb Kornfein Alex Oesterling Zhicheng Guo Cynthia d.Rudin Yuchao jiang Edward P.Browne department of Medicine University of North Carolina at Chapel HillChapel HillNC 27599USA HIV Cure Center University of North Carolina at Chapel HillChapel HillNC 27599USA department of Biostatistics University of North Carolina at Chapel HillChapel HillNC 27599USA department of Microbiology and Immunology University of North Carolina at Chapel HillChapel HillNC 27599USA department of Genetics University of North Carolina at Chapel HillChapel HillNC 27599USA department of Medicine Duke UniversityDurhamNC 27708USA department of Computer Science Duke UniversityDurhamNC 27708USA department of Statistics Texas A&M UniversityCollege StationTX 77843USA department of Biology Texas A&M UniversityCollege StationTX 77843USA department of Biomedical Engineering Texas A&M UniversityCollege StationTX 77843USA

despite the success of antiretroviral therapy,human immunodeficiency virus(HIV)cannot be cured because of a reservoir of latently infected cells that evades *** understand the mechanisms of HIV latency,we employed an integrated single-cell RNA sequencing(scRNA-seq)and single-cell assay for transposase-accessible chromatin with sequencing(scATAC-seq)approach to simultaneously profile the transcriptomic and epigenomic characteristics of~125,000 latently infected primary Cd4^(+)T cells after reactivation using three different latency reversing *** expressed genes and differentially accessible motifs were used to examine transcriptional pathways and transcription factor(TF)activities across the cell *** identified cellular transcripts and TFs whose expression/activity was correlated with viral reactivation and demonstrated that a machine learning model trained on these data was 75%-79%accurate at predicting viral ***,we validated the role of two candidate HIV-regulating factors,FOXP1 and GATA3,in viral *** data demonstrate the power of integrated multimodal single-cell analysis to uncover novel relationships between host cell factors and HIV latency.

关键词： HIV latency reversal Primary Cd4þT cell Single-cell multiomics HIV-regulating factor Machine learning

Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael j.Bannon Irma Alicia Martínez-dávila Luis O.Soto-Rojas david Reyes-Corona Lourdes Escobedo Minerva Maldonado-Berny ME Gutierrez-Castillo Armando j.Espadas-Alvarez Manuel A.Fernandez-Parrilla juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas jaime Santoyo-Salazar daniel Martinez-Fong departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la Educación y desarrollo y la Investigación Científica de Iztacala(Red MEdICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-d-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-d-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-d-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

A unique subseafloor microbiosphere in the Mariana Trench driven by episodic sedimentation

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Marine Life Science & Technology 2024年第1期6卷 168-181页

作者： jiwen Liu da-Wei Li Xinxin He Ronghua Liu Haojin Cheng Chenglong Su Mengna Chen Yonghong Wang Zhongsheng Zhao Hanyue Xu Zhangyu Cheng Zicheng Wang Nikolai Pedentchouk david j.Lea-Smith jonathan d.Todd Xiaoshou Liu Meixun Zhao Xiao-Hua Zhang Frontiers Science Center for deep Ocean Multispheres and Earth System and College of Marine Life SciencesOcean University of ChinaQingdao 266003China Laboratory for Marine Ecology and Environmental Science Laoshan LaboratoryQingdao 266237China Institute of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao 266100China Key Lab of Submarine Geosciences and Prospecting Techniques Ministry of Education/College of Marine GeosciencesOcean University of ChinaQingdao 266100China Key Laboratory of Physical Oceanography Ministry of Education/Research Vessel CentreOcean University of ChinaQingdao 266100China School of Environmental Sciences University of East AngliaNorwich NR47TJUK School of Biological Sciences University of East AngliaNorwich NR47TJUK

Hadal trenches are characterized by enhanced and infrequent high-rate episodic sedimentation events that likely introduce not only labile organic carbon and key nutrients but also new microbes that significantly alter the subseafloor ***,the role of high-rate episodic sedimentation in controlling the composition of the hadal subseafloor microbiosphere is ***,analyses of carbon isotope composition in a~750 cm long sediment core from the Challenger deep revealed noncontinuous deposition,with anomalous ^(14)C ages likely caused by seismically driven mass transport and the funneling effect of trench *** community composition and diverse enzyme activities in the upper~27 cm differed from those at lower depths,probably due to sudden sediment deposition and differences in redox condition and organic matter *** lower depths,microbial population numbers,and composition remained relatively constant,except at some discrete depths with altered enzyme activity and microbial phyla abundance,possibly due to additional sudden sedimentation events of different *** is provided of a unique role for high-rate episodic sedimentation events in controlling the subsurface microbiosphere in Earth’s deepest ocean floor and highlight the need to perform thorough analysis over a large depth range to characterize hadal benthic *** depositional processes are likely crucial in shaping deep-water geochemical environments and thereby the deep subseafloor biosphere.

关键词： Hadal subseafloor deep water sediment Mariana Trench Radiocarbon Microbial community Redox potential

Mathematical beauty and Palladian architecture:Measuring and comparing visual complexity and diversity

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Frontiers of Architectural Research 2024年第4期13卷 729-740页

作者： ju Hyun Lee Michael j.Ostwald School of Built Environment Faculty of ArtsDesign&ArchitectureThe University of New South WalesSydneyNSW 2052Australia

Palladio’s design principles,including proportion and harmony,have often been associated with mathematical definitions of ***,the geometric and semantic properties of his fac¸ades have rarely been analysed in a holistic *** is little evidence of how mathematical beauty may be embodied in his *** research investigates complexity(fractal dimension or d)and diversity(perplexity or PP)as aesthetic indices,aiming to capture distinct characteristics of Palladian *** d and PP values of 22 Palladian villa fac¸ades are measured and analysed,before being compared with those of three Renaissance facades by Sebastiano *** combination of d and PP captures the geometric and semantic aesthetic qualities of architectural ***,the developed scatter plot of d and PP results supports the identification of four distinct aesthetic types of Palladian fac¸ade *** novel combination of d and PP measures contributes to a better understanding of one definition of the mathematical beauty of architecture,wherein“the whole is other than the sum of the parts”in compositional terms(a famous Gestalt principle).Specifically,this research provides new mathematical insights into the visual character of Palladian architecture and compares two important measures thereof.

关键词： Palladian architecture Complexity diversity Mathematical beauty Perplexity Fac¸ade design

Synthesis and characterization of ultra-soft alginate hydrogel mimicking lung tissue

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International journal of Smart and Nano Materials 2024年第3期15卷 593-609页

作者： Xiangpeng Li jihua Gou Chiranjit Maiti Olusegun j.Ilegbusi department of Mechanical and Aerospace Engineering University of Central FloridaOrlandoFLUSA

Alginate hydrogels possess properties analogous to those of the extracellular matrix(ECM).Thus,their mechanical behavior approx-imates soft tissue,which makes them desirable for the production of tissue-equivalent soft deformable *** study aims to determine the synthesis-structure-property relationship for alginate hydrogel with the Young’s modulus in the range of 10°~101 kPa,mimicking to that of human lung ***,a 3d polymer network embedded in a water-rich *** alginate hydrogels are synthesized by a direct mixture of sodium alginate and CaCO3,followed by the addition of d-glucono-δ-lactone(GdL)to initiate in-situ Ca^(2+)release and *** influence of alginate concentration and molar ratio of the constitu-ent calcium ion to carboxyl group from alginate monomer are evaluated while the Young’s modulus of the hydrogel is carefully controlled within the desired *** and SEM are used to characterize the influence of synthesis parameters at the molecular and microstructure *** and compression testing are performed to determine the Young’s modulus of the *** relations are established between synthesis parameters and the mechanical *** result of the study will be subse-quently used to guide the additive manufacturing of soft deform-able structures based on alginate hydrogels.

关键词： Alginate hydrogels Ultra-low modulus lung tissue-mimicking materials