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What factors explain anger and mental health during the COVID-19 pandemic? The case of Israeli society

World Journal of Psychiatry 2021年第10期11卷 864-875页

作者： orna braun-lewensohn Sarah Abu-Kaf Tehila Kalagy Department of Interdisciplinary Studies Conflict Management&Resolution ProgramBen-Gurion University of the NegevBeer Sheva 8410501IsraelIsrael Department of Public Policy and Management Ben-Gurion University of the NegevBeer Sheva 8410501IsraelIsrael

BACKGROUND What factors affected the levels of anger and emotional distress experienced during the coronavirus disease 2019(COVID-19)pandemic?We hypothesized that(1)sociodemographic factors and resiliency factors would partially explain psychological distress and anger,with stronger resiliency associated with lower levels of distress and anger;(2)women would report more trust in national leadership,as well as more psychological problems;(3)individuals of low socioeconomic status would report less resiliency,less trust in national leadership,and greater distress than individuals of higher socioeconomic status;and(4)hope would mediate the relationships between the other resiliency factors and both anger and *** To explore whether community resilience,hope,and trust in leaders were associated with lower levels of anger and emotional distress during the COVID-19 *** For this observational study,data were gathered in Israel during the second wave of the COVID-19 pandemic,just before the Jewish New Year(mid-September 2020),as a second lockdown was *** were gathered from 636 Israeli adults,who were recruited by the Midgam research *** participants filled out self-reported questionnaires including one on state anger,the Brief Symptom Inventory as a measure of mental-health problems(i.e.,somatization,depression,and anxiety),and questionnaires about trust in the state’s leaders,community resilience(CCRAM),and hope as measures of coping resources and resiliency.t-tests were used to explore differences between men and women and between those of lower and higher socioeconomic status.A hierarchical multiple regression analysis was then used to examine whether and how the sociodemographic and resiliency variables explained state anger and psychological distress.A Sobel test was used to evaluate the possible effects of hope on community resilience and trust in leadership in the context of both distress and *** Our results revealed di

关键词： Community resilience Hope Trust in government Anger Mental health Pandemic

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Effective extraction of polyribosomes from astrocytes enables future discoveries on translation regulation

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Neural Regeneration Research 2025年第4期20卷 1083-1084页

作者： orna Elroy-Stein Sagol School of Neuroscience Tel Aviv UniversityTel AvivIsrael Shmunis School of Biomedicine and Cancer Research George S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael

Translation regulation is an important layer of gene expression:Generation of genome-wide expression datasets at multi-omics levels in spatial,temporal,and cell-type resolution is essential for deciphering brain *** of gene expression is a highly dynamic process aiming at the production of precise levels of gene products to guarantee optimal cellular function,in response to physiological *** advances in next-generation sequencing enabled the understanding of epigenomic and transcriptomic dynamic landscapes of different brain regions along development,aging,and disease ***,the correlation of the“transcriptome”with protein levels is poor because numerous mRNAs are subjected to manipulation of their translation efficiency,to warrant a favorable result under certain ***,it is widely accepted that regulation at the translation level is a vital layer of gene *** of actively translated mRNA populations(i.e.,“translatome”)is a more reliable predictor of the“proteome”(Wang et al.,2020).

关键词： translation enable landscape

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Mitochondrial malfunction in vanishing white matter disease： a disease of the cytosolic translation machinery

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Neural Regeneration Research 2017年第10期12卷 1610-1612页

作者： orna Elroy-Stein Dept of Cell Research and Immunology George S.Wise Faculty of Life Sciences Sagol School of NeuroscienceTel Aviv UniversityIsrael

Vanishing white matter （VWM） disease - a disease of the cytosolic translation machinery： VWM is a recessive genet- ic neurodegenerative disease caused by mutations in any of the five genes encoding the subunits of ... 详细信息

关键词： Mitochondrial malfunction in vanishing white matter disease:a disease of the cytosolic translation machinery ETC

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Gender medicine:Lessons from COVID-19 and other medical conditions for designing health policy

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World Journal of Clinical Cases 2020年第17期8卷 3645-3668页

作者： Yossy Machluf Yoram Chaiter orna Tal Shamir Research Institute University of HaifaKazerin 1290000Israel The Israeli Center for Emerging Technologies in Hospitals and Hospital-based Health Technology Assessment Shamir(Assaf Harofeh)Medical CenterZerifin 7030100Israel Shamir(Assaf Harofeh)Medical Center Affiliated to the Sackler Faculty of MedicineTel Aviv UniversityZerifin 7030100Israel Department of Management Program of Public Health and Health System AdministrationBar Ilan UniversityRamat Gan 5290002Israel

Gender-specific differences in the prevalence,incidence,comorbidities,prognosis,severity,risk factors,drug-related aspects and outcomes of various medical conditions are well *** present a literature review on the extent to which research in this field has developed over the years,and reveal gaps in gender-sensitive awareness between the clinical portrayal and the translation into gender-specific treatment regimens,guidelines and into gender-oriented preventive strategies and health ***,through the lens of gender,we describe these domains in detail for four selected medical conditions:Asthma,obesity and overweight,chronic kidney disease and coronavirus disease *** some of the key gender differences become more apparent during adolescence,we focus on this developmental ***,we propose a model which is based on three influential issues:(1)Investigating gender-specific medical profiles of related health conditions,rather than a single disease;(2)The dynamics of gender disparities across developmental stages;and(3)An integrative approach which takes into account additional risk factors(ethnicity,socio-demographic variables,minorities,lifestyle habits etc.).Increasing the awareness of gender-specific medicine in daily practice and in tailored guidelines,already among adolescents,may reduce inequities,facilitate the prediction of future trends and properly address the characteristics and needs of certain subpopulations within each gender.

关键词： Gender medicine Adolescent health Model Risk factors Guidelines and policy Asthma COVID-19 Obesity Chronic kidney disease

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Role of antibiotics for treatment of inflammatory boweldisease

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World Journal of Gastroenterology 2016年第3期22卷 1078-1087页

作者： orna Nitzan Mazen Elias Avi Peretz Walid Saliba Infectious Disease Unit Baruch-Padeh Medical CenterPoriya 15208Israel Department of Internal Medicine C Ha’Emek Medical CenterAfula 18101Israel Walid Saliba Bruce Rappaport Faculty of MedicineTechnion-Israel Institute of TechnologyHaifa 31096Israel Clinical Microbiology Laboratory Baruch-Padeh Medical CenterPoriya 15208Israel Department of Community Medicine and Epidemiology Carmel Medical CenterHaifa 34362Israel

Inflammatory bowel disease is thought to be caused by an aberrant immune response to gut bacteria in a genetically susceptible host. The gut microbiota plays an important role in the pathogenesis and complications of the two main inflammatory bowel diseases: Crohn's disease(CD) and ulcerative colitis. Alterations in gut microbiota, and specifically reduced intestinal microbial diversity, have been found to be associated with chronic gut inflammation in these disorders. Specific bacterial pathogens, such as virulent Escherichia coli strains, Bacteroides spp, and Mycobacterium avium subspecies paratuberculosis, have been linked to the pathogenesis of inflammatory bowel disease. Antibiotics may influence the course of these diseases by decreasing concentrations of bacteria in the gut lumen and altering the composition of intestinal microbiota. Different antibiotics, including ciprofloxacin, metronidazole, the combination of both, rifaximin, and anti-tuberculous regimens have been evaluated in clinical trials for the treatment of inflammatory bowel disease. For the treatment of active luminal CD, antibiotics may have a modest effect in decreasing disease activity and achieving remission, and are more effective in patients with disease involving the colon. Rifamixin, a non absorbable rifamycin has shown promising results. Treatment of suppurative complications of CD such as abscesses and fistulas, includes drainage and antibiotic therapy, most often ciprofloxacin, metronidazole, or a combination of both. Antibiotics might also play a role in maintenance of remission and prevention of post operative recurrence of CD. Data is more sparse for ulcerative colitis, and mostly consists of small trials evaluating ciprofloxacin, metronidazole and rifaximin. Most trials did not show a benefit for the treatment of active ulcerative colitis with antibiotics, though 2 meta-analyses concluded that antibiotic therapy is associated with a modest improvement in clinical symptoms. Antibio

关键词： Antibiotic treatment Inflammatory boweldisease Ulcerative colitis Crohn's disease

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Clostridium difficile and inflammatory bowel disease: Role in pathogenesis and implications in treatment

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World Journal of Gastroenterology 2013年第43期19卷 7577-7585页

作者： orna Nitzan Mazen Elias Bibiana Chazan Raul Raz Walid Saliba Infectious Disease Unit Ha’emek Medical CenterAfula 18101Israel Bruce Rappaport Faculty of Medicine Technion-Israel Institute of TechnologyHaifa 31096Israel Department of Internal Medicine C Ha’emek Medical CenterAfula 18101Israel

Clostridium difficile(***)is the leading cause of antibiotic associated colitis and nosocomial *** with inflammatory bowel disease(IBD)are at increased risk of developing *** infection(CDI),have worse outcomes of CDI-including higher rates of colectomy and death,and experience higher rates of ***,it is still not clear whether *** is a cause of IBD or a consequence of the inflammatory state in the intestinal *** burden of CDI has increased dramatically over the past decade,with severe outbreaks described in many countries,which have been attributed to a new and more virulent strain.A parallel rise in the incidence of CDI has been noted in patients with *** patients with CDI tend be younger,have less prior antibiotic exposure,and most cases of CDI in these patients represent outpatient acquired *** clinical presentation of CDI in these patients can be unique-including diversion colitis,enteritis and pouchitis,and typical findings on colonoscopy are often *** to the high prevalence of CDI in patients hospitalized with an IBD exacerbation,and the prognostic implications of CDI in these patients,it is recommended to test all IBD patients hospitalized with a disease flare for *** includes general measures such as supportive care and infection control *** therapy with either oral metronidazole,vancomycin,or the novel antibiotic-fidaxomicin,should be initiated as soon as *** macrobiota transplantation constitutes another optional treatment for severe/recurrent *** aim of this paper is to review recent data on CDI in IBD:role in pathogenesis,diagnostic methods,optional treatments,and outcomes of these patients.

关键词： Clostridium difficile Diarrhea Inflammatory bowel disease Pathogenesis Treatment

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Encephalitis associated with autoantibodies binding toγ-aminobutyric acid-A,γ-aminobutyric acid-B and glycine receptors:immunopathogenic mechanisms and clinical characteristics

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Neuroimmunology and Neuroinflammation 2016年第1期3卷 86-92页

作者： Amy May Lin Quek orna O’Toole Department of Medicine National University HospitalNational University Health SystemSingapore 119228Singapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119228Singapore Department of Neurology Mercy University HospitalGrenville PlaceCorkIreland

Recent,discoveries of neural antibodies have facilitated the diagnosis of immune-mediated,immunotherapy-responsive neurologic *** that target inhibitory central nervous system receptors,such asγ-aminobutyric acid-B,γ-aminobutyric acid-A,and glycine receptors,disrupt inhibitory regulatory synaptic functions,and lead to neuronal *** myriad of neurologic,manifestations associated with these antibodies includes seizures,encephalopathy,muscle rigidity and *** article provides a review of the immunopathogenic mechanisms and the clinical and therapeutic implications of autoimmune encephalitis associated with these antibodies that target inhibitory receptors.

关键词： Autoimmune encephalitis autoimmune epilepsy limbic encephalitis neural antibodies

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Perspective on the q-bio Summer School anc Conference： 2007- 2014 and beyond

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Frontiers of Electrical and Electronic Engineering in China 2014年第1期9卷 54-58页

作者： orna Resnekov Brian Munsky William S. Hlavacek Molecular Sciences Institute Berkeley CA 94704 USA Department of Chemical and Biological Engineering Colorado State University Fort Collins CO 80523 USA New Mexico consortium Los Alamos NM87544 US-A Theoretical Division and Center for Nonlinear Studies Los Alamos National Laboratory Los Alamos NM 87545 USA

INTRODUCTIONThe q-bio Conference and the associated q-bio Summer School were started in 2007 by a prescient group of researchers based at Los Alamos National Laboratory （LANL） and the University of New Mexico （J. Edwards, J. Faeder, W. Hlavacek, Y. Jiang, I. Nemenman and M. Wall） who envisioned a systems biology community focused on modeling,

关键词： Advisory Committee Member Program Committee Member Quantitative Biology Summer School Synthetic Circuit

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Humus-Rich Compost Increases Lettuce Growth, Nutrient Uptake, Mycorrhizal Colonisation, and Soil Fertility

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Pedosphere 2019年第2期29卷 170-179页

作者： Zakaria M.SOLAIMAN Hongjun YANG Deb ARCHDEACON orna TIPPETT Michaela TIBI Andrew S.WHITELEY SoilsWest UWA School of Agriculture and Environment and the UWA Institute of Agriculture Faculty of Science The University of Western Australia College of Resources and Environment Southwest University C-Wise

Sandy soils, typical of Australia's west, either have little or no habitat protection for microbes including arbuscular mycorrhizal(AM) fungi, which are essential for nutrient cycling. To minimize this problem, the application of organic matter, such as humus-rich composts, is necessary during vegetable crop production. This study aimed at determining the effects of humus-rich composts on either indigenous or inoculated AM fungal colonisation in roots, lettuce(Lactuca sativa L. var. Quechua) growth, and soil fertility improvement. Four different humus-rich composts with varying humus contents were applied at the same standard rate to lettuce grown under glasshouse conditions for 10 weeks after sowing and compared with two low-humus composts and non-amended soil(control). Humus-rich composts significantly increased lettuce shoot growth, root growth, and AM fungal colonisation in roots. Humus contents in the composts were also correlated with lettuce shoot and root growth. Soil dissolved organic carbon, microbial biomass carbon, and fertility were increased with the application of humus-rich composts. These humus-rich composts, especially the compost of higher humic acid with and without AM inoculation, might have a significant role in sustainable vegetable production, for example lettuce growth. Overall, the results indicate that supplementation with humus-rich compost is highly beneficial to enhance soil fertility and potentially maintain the sustainability of vegetable production.

关键词： arbuscular mycorrhizal fungi humus nitrogen phosphorus vegetable production

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Higher Cell Viability and Enhanced Sample Quality Following Laser-Assisted Liposuction versus Mechanical Liposuction

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Journal of Cosmetics, Dermatological Sciences and Applications 2015年第3期5卷 238-245页

作者： Alexander Levenberg Mickey Scheinowitz orna Sharabani-Yosef Department of Plastic Surgery Tel Aviv Sourasky Medical Center Tel Aviv Israel Department of Biomedical Engineering Faculty of Engineering Tel Aviv University Tel Aviv Israel

Background: Despite the popularity of autologous fat transfer applications, high resorption rates, and consequential volume loss, have been reported. Viable adipocyte content has been defined as a key determinant of fat transfer longevity. Moreover, traces of blood, free oil fat and fibrotic tissue accelerate adipocyte degradation. Objective: To compare the effectiveness of a 1470 nm, radial emitting laser-assisted liposection device to a mechanical liposection device in maintaining adipocyte viability in fat tissue harvests. Methods: Bilateral subcutaneous adipose tissue samples were harvested from ten female patients. Fat was harvested from one side using the LipoLife laser-assisted liposuction device and from the other side with a Byron mechanical aspirator. Samples were visually analyzed and blood:fat ratios and cell viability were determined. Results: Laser-harvested samples separated into two distinct phases, with a negligible blood phase at the bottom (1.1%) and a significant adipose phase at the top (98.9%), containing small, uniform-sized cells, of which 95.7% ± 2.7% proved viable. Mechanically harvested samples separated into blood (18%), adipose (60%) and lipid (22%) phases. The adipose phase contained significant amounts of connective tissue, large adipose tissue fragments, large oil droplets and a mean 79.7% ± 18.3% viable adipocytes. Conclusions: Laser liposuctioning was superior to mechanical liposuctioning, providing both higher cell viability and enhanced sample quality. The 1470 nm diode laser bears the potential of improving long-term clinical outcomes of fat transfer procedures. Improved purity of the harvested sample and heightened preadipocyte content are projected to provide for extended graft longevity.

关键词： Laser Liposuction Cell Viability Fat Transfer Preadipocyte

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