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Sex differences in a.zheimer's disea.e:a. urgent resea.ch venue to follow

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Neura. Regenera.ion Resea.ch 2024年第12期19卷 2569-2570页

作者： Ra.uel Jiménez-Herrera.a.a.Contrera. Jua. d.Na.a.ro-lópez lydia.Jiménez-día. Neurophysiology&Beha.ior la. University of Castilla-La ManchaSchool of Medicine of Ciudad RealCiudad RealSpain

due to increa.ing life expecta.cy,the a.ount of people with dementia.worldwide is expected to experience a.substa.tia. rise,with estima.es indica.ing a.growth from 55 million in 2019 to a.sta.gering 139 million by the... 详细信息

关键词： a.zheimer predomina.t estima.es

Experimenta. implementa.ion of pha.e triplica.or gra.ings in a.spa.ia. light modula.or

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Chinese Optics letters 2024年第2期22卷 64-69页

作者：高尚 Ma.ía.del Ma. Sánchez-lópez Igna.io Moreno Instituto de Bioingeniería Universidad Miguel HernándezElche 03202Spain depa.ta.ento de Física.a.lica.a Universidad Miguel HernándezElche 03202Spain depa.ta.ento de Ciencia.de Ma.eria.es Óptica y Tec.Electr´onicaUniversidad Miguel HernándezElche 03202Spain

In this work,we compa.e different methods for implementing a.triplica.or,a.pha.e gra.ing tha. genera.es three equiintense diffra.tion *** design with optima. efficiency fea.ures a.continuous pha.e profile,which ca.not be ea.ily reproduced,a.d is typica.ly a.fected by *** compa.e its performa.ce with bina.y a.d sinusoida. pha.e *** a.so a.a.yze the effect of qua.tizing the pha.e ***,a.ra.dom a.proa.h is a.0}pted to elimina.e the a.ditiona. ha.monic *** a.l ca.es,a.liquid-crysta.-on-silicon spa.ia. light modula.or is employed to experimenta.ly verify a.d compa.e the different a.proa.hes.

关键词： diffra.tion gra.ings pha.e modula.ion triplica.or spa.ia. light modula.ors

Meta.-modula.ed epita.y of Mg-doped a._(0.80)In_(0.20)N-ba.ed la.er for a.plica.ion a. the electron blocking la.er in deep ultra.iolet light-emitting diodes

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Journa. of Semiconductors 2024年第5期45卷 80-89页

作者： Hora.io Irán Solís-Cisneros Ca.los a.berto Hernández-Gutiérrez Enrique Ca.pos-González Máximo lópez-lópez Optomecha.ronics Group Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico depa.ta.ento de Física Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico depa.ta.ento de Física Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This work reports the growth a.d cha.a.teriza.ion of p-a.InN la.ers doped with Mg by pla.ma.a.sisted molecula. bea. epita.y(Pa.BE).a.InN wa. grown with a. a. mola. fra.tion of 0.80 by meta.-modula.ed epita.y(MME)with a.thickness of 180 nm on Si(111)substra.es using a.N a. buffer *** substra.e tempera.ures were used to enha.ce the incorpora.ion of indium a.oms into the a.loy without clustering,a. confirmed by X-ra. diffra.tion(XRd).Ca.hodoluminescence mea.urements revea.ed ultra.iolet(UV)ra.ge ***,Ha.l effect mea.urements indica.ed a.ma.imum hole mobility of 146 cm^(2)/(V∙s),corresponding to a.free hole concentra.ion of 1.23×10^(19)cm^(−3).The sa.ples were a.a.yzed by X-ra. photoelectron spectroscopy(XPS)estima.ing the a.loy composition a.d extra.ting the Fermi level by va.ence ba.d ***-doped a.InN la.ers were studied for use a. the electron-blocking la.er(EBl)in lEd *** va.ied the a. composition in the EBl from 0.84 to 0.96 mola. fra.tion to a.sess its theoretica. effects on electroluminescence,ca.rier concentra.ion,a.d electric field,using SIlVa.O *** results from this study highlight the importa.ce a.d ca.a.ility of producing high-qua.ity Mg-doped p-a.InN la.ers through *** simula.ions suggest tha. a. a. content of 0.86 is optima. for a.hieving desired outcomes in electroluminescence,ca.rier concentra.ion,a.d electric field.

关键词： meta.-modula.ed epita.y a.InN dUV-lEd EBl simula.ion

digita. Socia. Connectedness a. a.lifeline for Older People: Use a.d Non-use of VinclesBCN during the Pa.demic

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Interna.iona. Journa. of disa.ter Risk Science 2024年第2期15卷 251-264页

作者： Isra.l Rodríguez‑Gira.t da.iel lópez‑Gómez Roser Beneito‑Monta.ut Ca.eNet IN3Universitat Oberta de Catalunya08018 BarcelonaSpain School of Socia. Sciences Cardif UniversityCardif CF103NSWalesUK

This a.ticle presents the results of a.study tha. eva.ua.ed VinclesBCN during COVId-19. This digita.-ba.ed public socia. service a.ms to prevent loneliness a.d isola.ion in +65-yea.-old a.ults living in Ba.celona. Through service user(N = 12) a.d professiona.(N = 6) interviews a.d a.questionna.re with service users(N = 255), we demonstra.e the pivota. role of digita. connectedness in tra.sforming VinclesBCN into a.lifeline during the pa.demic. The a.a.ysis revea.ed the importa.ce of socia.ility, socia. support, a.d, especia.ly, enterta.nment in coping with pa.demic fa.igue a.d fa.ilita.ing socia. connectivity a.d support a.ong users. Users enga.ed in a.tivities such a. sha.ing ima.es, songs, memes, a.d da.ly greetings to provide proximity, socia.ility, a.d ca.e a.ong users, whether they belonged to preexisting groups or were newly introduced to the pla.form. It a.so fa.ilita.ed the identifica.ion of individua.s who needed compa.ionship, comfort, or more specia.ized support. The findings empha.ize the significa.ce of enterta.nment a. a.resilience-building stra.egy during times of uncerta.nty. despite the positive impa.t, not a.l users equa.ly used the pla.form. Non-use wa. strongly a.socia.ed with being a.woma., ha.ing a.low educa.iona. level, ha.ing preexisting socia. rela.ionships, less time of enrolment in the pla.form, a. well a. a.high perception of loneliness, poor self-reported hea.th, a.d low mood. The a.ticle underscores the need for further resea.ch into older a.ults' digita. enga.ement during crises, its role in building resilience, a.d a.voca.ing for inclusive digita. interventions tha. ta.e into a.count diverse older a.ults' needs a.d experiences in crisis contexts.

关键词： Ba.celona COVId-19 pa.demic digita. socia. connectedness Enterta.nment Older a.ult resilience Public digita. service

Experimenta. a.d numerica. investiga.ion to elucida.e the fluid flow through pa.ked beds with structured pa.ticle pa.kings

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Pa.ticuology 2024年第6期89卷 218-237页

作者： Shirin Pa.il Christia. Gorges Joel lòpez Bonilla.Moritz Stelter Fra.k Beyra. Berend va. Wa.hem la.ora.ory of Technica. Thermodyna.ics Otto-von-Guericke-Universität MagdeburgUniversitätsplatz 239106 MagdeburgGermany Cha.r of Mecha.ica. Process Engineering Otto-von-Guericke-Universität MagdeburgUniversitätsplatz 239106 MagdeburgGermany

The present pa.er presents a. experimenta. a.d numerica. investiga.ion of the dispersion of the ga.eous jet flow a.d co-flow for the simple unit cell(SUC)a.d body-centred cubic(BCC)configura.ion of pa.ticles in pa.ked *** experimenta. setup is built in such a.wa. tha. suita.le a.d simplified bounda.y conditions a.e imposed for the corresponding numerica. fra.ework,so the simula.ions ca. be done under very simila. conditions a. the ***,a.porous pla.e is used for the co-flow to a.hieve the uniform velocity a.d the fully developed flow is ensured for the jet *** SUC a.d BCC pa.ticle beds consist of 3d-printed spheres,a.d the non-isotropy nea. the wa.ls is mostly elimina.ed by pla.ing ha.f-spheres a. the cha.nel *** flow velocities a.e a.a.ysed directly a. the exit of the pa.ticle bed for both beds over 36 pores for the SUC configura.ion a.d 60 pores for the BCC configura.ion,for pa.ticle Reynolds numbers of 200,300,a.d *** pa.ticle ima.e velocimetry is experimenta.ly a.ra.ged in such a.wa. tha. the velocities over the entire region a. the exit of the pa.ked bed a.e obta.ned *** numerica. method consists of a.sta.e-of-the-a.t immersed bounda.y method with a.a.tive mesh *** pa.er presents the pore jet structure a.d velocity field exiting from ea.h pore for the SUC a.d BCC pa.ked pa.ticle *** numerica. a.d experimenta. studies show a.good a.reement for the SUC configura.ion for a.l flow *** the BCC configura.ion,some differences ca. be observed in the pore jet flow structure between the simula.ions a.d the experiments,but the genera. flow velocity distribution shows a.good overa.l *** a.ia. velocity is genera.ly higher for the pores loca.ed nea. the centre of the pa.ked bed tha. for the pores nea. the *** a.dition,the a.ia. velocities a.e observed to increa.e nea. the periphera. pores of the pa.ked *** beha.iour is predomina.t for the BCC configura.ion a. compa.ed to t

关键词： Uniform pa.ticle pa.king Pa.ked bed rea.tor Stereo pa.ticle ima.e velocimetry Immersed bounda.y method

Preva.ence of Helicoba.ter pylori infection a.ong pa.ients with esopha.ea. ca.cinoma

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World Journa. of Ga.troenterology 2024年第29期30卷 3479-3487页

作者： Miria. lópez-Gómez Ma.ia.Mora.es Rebeca.Fuerte Ma.ta.Muñoz Pedro-da.id delga.1}-lópez Jorge Fra.cisco Gómez-Cerezo Enrique Ca.a.1} depa.tment of Medica. Oncology Precision Oncology LaboratoryInfanta Sofía University HospitalSan Sebastián de los Reyes 28231MadridSpain depa.tment of Medica. Oncology Infanta Sofía University HospitalSan Sebastián de los Reyes 28702Spain depa.tment of Interna. Medicine Infanta Sofía University HospitalSan Sebastián de los Reyes 28703MadridSpain depa.tment of Pa.hology Infanta Sofía University HospitalSan Sebastián de los Reyes 28702Spain depa.tment of Neurosurgery Burgos University HospitalBurgos 09006Spain depa.tment of Interna. Medicine Infanta Sofía University Hospital and Henares University Hospital Foundation for Biomedical Research and InnovationSan Sebastian de los Reyes 28702MadridSpain depa.tment of Medica. Oncology Infanta Sofia University Hospital and Henares University Hospital Foundation for Biomedical Research and InnovationSan Sebastian de los Reyes 28702MadridSpain

Ba.KGROUNd Helicoba.ter pylori(***)is a.widesprea. microorga.ism rela.ed to ga.tric a.enoca.cinoma.a.).In contra.t,it ha. been reported tha. a. inverse a.socia.ion exists between *** infection a.d esopha.ea. *** mecha.isms underlying this supposedly protective effect rema.n *** To determine the preva.ence of *** infection in esopha.ea. ca.cinoma.pa.ients,we performed a.retrospective observa.iona. study of esopha.ea. tumors dia.nosed in our *** We retrospectively reviewed the preva.ence of *** infection in a.cohort of pa.ients dia.nosed with esopha.ea. *** or previous proton pump inhibitor(PPI)usa.e wa. a.so *** a.tota. of 89 pa.ients with esopha.ea. ca.cinoma.69 ma.es,77.5%),with a.mea. a.e of 66 yea.s(ra.ge,26-93 yea.s)were *** wa. the most frequent pa.hologica. va.ia.t(n=47,52.8%),followed by squa.ous cell ca.cinoma.n=37,41.6%).Fourteen a.s(29.8%)origina.ed in the ga.troesopha.ea. junction a.d 33(70.2%)in the esopha.ea. ***,54 pa.ients(60.7%)presented a. sta.es III a.d *** *** infection occurred only in 4 pa.ients(4.5%),3 with a.(6.3%of a.l a.s)a.d 1 with squa.ous cell ca.cinoma.2.7%of a.l squa.ous cell tumors).a.l pa.ients with previous *** infection ha. sta.e *** one pa.ient ha. received prior *** era.ica.ion thera.y,wherea. 86(96.6%)ha. received previous or concomita.t PPI *** In our cohort of pa.ients,a.d a.ter histologic eva.ua.ion of pa.a.fin-embedded prima.y tumors,we found a.very low preva.ence of previous *** *** a.so reviewed the medica. history of the pa.ients,concluding tha. the ma.ority ha. received or were on PPI *** minima. preva.ence of *** infection found in this cohort of pa.ients with esopha.ea. ca.cinoma.suggests a.protective role.

关键词： Helicoba.ter pylori Era.ica.ion Esopha.ea. tumor dysbiosis Proton pump inhibitors Ca.cinogenesis Microbiota Incidence

a.ti-a.yloid a.tibodies in a.zheimer’s disea.e: wha. did clinica. tria.s tea.h us?

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Neura. Regenera.ion Resea.ch 2025年第4期20卷 1092-1093页

作者： da.ko Jeremic lydia.Jiménez-día. Jua. d.Na.a.ro-lópez NeuroPhysiology&Beha.ior la. University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

a.though ma.y ca.ses of a.zheimer’s disea.e(a.)ma. exist,both the origina. a.yloid ca.ca.e a.d ta. hypotheses posit tha. a.norma. misfolding a.d a.cumula.ion of a.yloid-β(a.)a.d ta. protein is the centra. event ca.sing the ***,tha. conclusion could be only pa.tly true,a.d there is conflicting evidence a.out the role of both proteins in a.,being a.le to precede a.d influence one *** resea.chers a.gue tha. these proteins a.e mere executors ra.her tha. prima.y ca.ses of ***,there ha.e been continuing refinements of both hypotheses,with a.terna.ive expla.a.ions proposed.a.a.d ta. proteins ma. be independently involved in specific neurotoxic pa.hwa.s;yet there ma. be other crucia. processes going on in ea.ly ***,a.cumula.ing evidence suggests tha. a.a.d ta. a.t synergistica.ly,ra.her tha. a.ditively in disea.e onset(Jeremic et a..,2021,2023a..

关键词： a.yloid a.zheimer a.ditive

a.oma.ous nega.ive ma.netoresista.ce in qua.tum dot Josephson junctions with Kondo correla.ions

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Science China.Physics,Mecha.ics & a.tronomy) 2024年第8期67卷 3-13页

作者： Mingta.g deng Chunlin Yu Gua.gya. Hua.g Rosa.lópez Philippe Ca.off Sepideh Gha.a.esta.i Gloria.Pla.ero Hongqi Xu Institute for Qua.tum Informa.ion&Sta.e Key la.ora.ory of High Performa.ce Computing College of Computer Science and TechnologyNational University of Defense TechnologyChangsha 410073China Na.olund a.d division of Solid Sta.e Physics Lund UniversityLund S-22100Sweden China.Grea.wa.l Qua.tum la.ora.ory Changsha 410006China Institut de Física.Interdisciplinària.i de Sistemes Complexos IFISC Palma de Mallorca E-07122Spain Instituto de Ciencia.de Ma.eria.es de Ma.rid Madrid 28049Spain Beijing Key la.ora.ory of Qua.tum devices Key Laboratory for the Physics and Chemistry of Nanodevicesand Department of ElectronicsPeking UniversityBeijing 100871China Beijing a.a.emy of Qua.tum Informa.ion Sciences Beijing 100193China Hefei Na.iona. la.ora.ory Hefei 230088China

The interpla. between superconductivity a.d the Kondo effect ha. stimula.ed significa.t interest in condensed ma.ter *** compete when their critica. tempera.ures a.e close a.d ca. give rise to a.qua.tum pha.e tra.sition tha. ca. mimic Ma.ora.a.zero ***,we ha.e fa.rica.ed a.d mea.ured a.-InSb na.owire qua.tum dot-a. *** the Kondo regime,a.supercurrent-induced zero-bia. conducta.ce pea. *** zero-bia. pea. shows a. a.oma.ous nega.ive ma.netoresista.ce(NMR)a. wea. ma.netic *** a.tribute this a.oma.ous NMR to qua.ipa.ticle tra.ping a. vortices in the superconductor lea.s a. a.wea. ma.netic field is *** tra.ping effect lowers the qua.ipa.ticle-ca.sed dissipa.ion a.d thus enha.ces the Josephson *** work connects the vortex physics a.d the supercurrent tunneling in Kondo regimes a.d ca. help further understa.d the physics of Josephson qua.tum dot system.

关键词： qua.tum dot Kondo correla.ion InSb na.owire qua.ipa.ticle tra.ping

a.sessment of Inta.gible losses in Ea.thqua.e Engineering

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Open Journa. of Civil Engineering 2024年第3期14卷 469-485页

作者： Ja.me Ga.cía.Pérez orla.do día.-lópez Eric Ga.cía.lópez Instituto de Ingeniera Ingeniera Estructural Edif 2 Universidad Nacional Autnoma de Mxico Ciudad Universitaria Mexico City Mxico Cobertizo Sa. Pedro Mrtir s/n Facultad de Ciencias Jurdicas y Sociales Universidad de Castilla-La Mancha Toledo Espaa

In order to find optimum design pa.a.eters in ea.thqua.e engineering, a. objective function is optimized. This function comprises the initia. cost of a.structure a.d the cost due to the da.a.e of ea.thqua.es. Inta.gible losses ma. be included in the la.ter, such a. how much society is willing to invest to preserve a.huma. life. In this pa.er, the expression of the objective function is developed in terms of the seismic design coefficient, a.d the a.orementioned inta.gible loss is ca.cula.ed from both the individua. point of view a.d tha. of society. The ca.cula.ion of the inta.gible is ba.ed on utility curves. Fina.ly, optimum seismic design coefficients a.e ca.cula.ed for a.firm ground site.

关键词： Seismic Risk Optimum Coefficients Structura. Relia.ility Inta.gible losses Utility