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World Journal of Gastroenterology 2005年第13期11卷 1981-1986页

作者： Michal Mizrahi Yoav Mintz Avraham Rivkind David Kisselgoff Eugene Libson Mayer Brezis Eran Goldin oren Shibolet Gastroenterology Unit Department of General Surgery Department of Radiology School of Public Health

AIM: To evaluate the positive predictive value of abdominal non-prepared computed tomography (CT) for diagnosing intestinal lumen or wall lesions in patients presenting to the emergency room (ER) with abdominal ***: For 1-year we prospectively evaluated all ER patients hospitalized after abdominal CT scan detected either intraluminal or intestinal wall lesions. These patients underwent colonoscopy serving as gold standard. Patients with prior abdominal pathology or CT findings of appendicitis or diverticulitis were ***: Five hundred and sixty-eight abdominopelvic CT scans were performed in the ER, 96 had positive colonic findings. Sixty-two patients were excluded, 46 because of diverticulitis or appendicitis, 16 because of prior abdominal pathology. Of the remaining 34 patients, 14 did not undergo colonoscopy during *** eligible patients were included in the study. The positive predictive value of the CT scans performed in the ER was calculated to be 45% (95% CI 25-67).CONCLUSION: CT findings correlated with colonoscopic findings only in approximately half of the cases. Relying on non-prepared CT scan findings in planning patient management and colonoscopy may lead to unnecessary diagnostic work-ups.

关键词： Abdominal computed tomography Intestinal lesions Emergency room

Biomechanical aspects of catheter-related thrombophlebitis

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Journal of Biomedical Science and Engineering 2013年第12期6卷 6-13页

作者： oren Moshe Rotman Dalit Shav Sagi Raz Uri Zaretsky Shmuel Einav Department of Biomedical Engineering Tel Aviv University Tel Aviv Israel

Short peripheral catheters (SPCs) are the most common intravenous devices used in medical practice. Short peripheral catheter thrombophlebitis (SPCT) is the most frequent complication associated with SPCs, causing discomfort and usually leading to removal of the catheter and insertion of a new one at a different site. The aim of this research was to explore whether biomechanical factors, in addition to biochemical factors, also play a role in the formation of thrombophlebitis. Hence, two of the biomechanical aspects of SPCT were investigated: the physical pressure load exerted by the SPC on the endothelial monolayer, and disturbances in the flow patterns due to the SPC. Endothelial activation was studied by subjecting human umbilical vein endothelial cells (HUVEC) to a weight load of SPC pieces and measuring the release profile of von-Willebrand Factor (vWF) over time, using ELISA. vWF release was chosen as the measure for endothelial activation since it was the major component of the Weibel-Palade Bodies (WPBs), which underwent exocytosis by endothelial cells during activation. Flow patterns were analyzed on a 3D computational fluid dynamics (CFD) model of a brachiocephalic vein with SPC. vWF release profiles were significantly higher in the HUVECs subjected to the load, indicating HUVEC activation. CFD simulations demonstrated a decrease in flow velocities along the catheter body, between the catheter and the vein, due to an enlarged boundary layer. Results indicate that the contact region between the SPC body and the vein wall can be partially responsible for SPCT development, and inflammatory and coagulatory processes initiated by stimulated endothelial cells may be amplified due to disturbed blood flow.

关键词： Endothelial Activation vWF Thrombophlebitis Phlebitis Short Peripheral Catheters Infusion Intravenous Access CFD

Oral immune regulation using colitis extracted proteins for treatment of Crohn's disease: Results of a phase Ⅰ clinical trial

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World Journal of Gastroenterology 2005年第20期11卷 3105-3111页

作者： Eran Israeli Eran Goldin oren Shibolet Athalia Klein Nilla Hemed Dean Engelhardt Elazar Rabbani Yaron Ilan Gastroenterology and Liver Units Department of Medicine Hebrew University-Hadassah Medical Center Jerusalem Israel Enzo Biochem New York NY USA

AIM: To evaluate safety and possible efficacy of induction of oral immune regulation using colitis extracted proteins (CEP) in Crohn's disease (CD) subjects. METHODS: Ten CDs were treated orally with autologous CEP thrice weekly for 16 wk. Subjects were monitored for CDAI and IBDQ. Immune modulatory effect was assessed by T-lymphocyte FACS analysis, CEP-specific IFNγ ELISPOT assay and cytokine levels. RESULTS: Induction of oral immune regulation significantly ameliorated disease activity. All (10/10) subjects had clinical response (CDAI≤70) and 7/10 achieved clinical remission (CDAI≤150). Significant increase in mean IBDQ score was noted (134±9 vs 164±12). No treatment-related adverse events were noted. High levels of CEP-specific IFNγ spot forming colonies were detected in five subjects prior to treatment and in all five, a marked decrease was observed. The CD4+/CD8+ lymphocyte ratio and peripheral NKT cell numbers increased significantly, in 7/10 and in 5/10 subjects, respectively. Significant increase in serum IL-10 and IL-4 levels was observed in 7/10 subjects during treatment period. CONCLUSION: Immune regulation via oral administration of CEP is a safe and possibly effective treatment for subjects with moderate CD and may provide means of antigen-specific immune modulation.

关键词： Crohn's disease Colitis extracted proteins

Radical Resection of Adult Low Grade Oligodendroglioma without Adjuvant Therapy: Results of a Prospective Treatment Protocol—Surgical Treatment of Low-Grade Oligodendroglioma

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Journal of Cancer Therapy 2011年第2期2卷 235-242页

作者： Donald A. Ross Lynda Yang oren Sagher Amy M. Ross 不详

The goal of this work was to demonstrate prospectively that maximal surgical resection of low grade oligodendrogliomas without adjuvant therapy does not reduce life expectancy over that of historical controls. All patients with surgically accessible grade II oligodendrogliomas underwent maximal resection using stereotactic guidance and/or cortical mapping and were followed with serial MRI scans without adjuvant therapy until either progression or spread into brain regions deemed not surgically resectable. Nineteen patients were treated between 1993 and 2006. Ten patients required reoperation an average of 55 months after their first surgery. Nine patients progressed to anaplastic tumors an average of 42 months after their first surgery: six patients died from their tumors an average of 73 months after diagnosis, two are still alive 76 and 18 months after progression, and one was lost to follow up. Ten patients are alive and progression-free an average of 116 months after diagnosis, one of whom was lost to follow up at 106 months from diagnosis. Four patients are alive and event-free an average of 125 months after diagnosis. All are male and three had tumors in the superior frontal gyrus. The event-free survival, progression-free survival, and overall survival of our patients are not worse than those of patients treated with postoperative adjuvant therapy. Withholding adjuvant therapy at diagnosis appears to be safe. It will be important to establish the molecular differences between the patients who did very well and those who progressed so that adjuvant therapy could be offered to the latter.

关键词： Corticography Craniotomy Extent Of Resection Oligodendroglioma

Evaluation of a Pediatric Mock Code Educational Training Program at a Large, Tertiary Care Pediatric Hospital

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Open Journal of Pediatrics 2015年第4期5卷 314-319页

作者： Ayelet Rimon Amit Hess Dennis Scolnik oren Tavor Shirley Friedman Miguel Glatstein Pediatric Emergency Medicine Dana-Dwek Children’s Hospital Tel-Aviv Israel Sackler School of Medicine Tel Aviv University Tel-Aviv Israel Divisions of Pediatric Emergency Medicine and Clinical Pharmacology and Toxicology Department of Pediatrics The Hospital for Sick Children University of Toronto Toronto Canada Pediatric Intensive Care Dana-Dwek Children’s Hospital Tel-Aviv Israel

Background: Management of the acutely ill children represents one of the more complex clinical skills required of pediatric physicians. Our goal was to develop and evaluate a multidisciplinary pediatric mock code training program for the pediatric residents in our institution. Methods: We performed a before and after evaluation of pediatric residents. The residents were educated by attending five mock code scenarios, followed by debriefing. Before and after the five sessions, the residents completed a self-assessment questionnaire. Results: Residents reported a significant improvement in their comfort in all aspects of managing pediatric resuscitations, with notable improvement seen in running a resuscitation requiring airway management, managing fluid resuscitation and performing endotracheal intubation. The most prominent change was demonstrated in the comfort level of the overall management of a pediatric resuscitation. Conclusion: The pediatric mock code educational training program improved residents’ self-reported knowledge and comfort level in managing pediatric emergency situations.

关键词： Education Mock Code Pediatric Residents Emergency Medicine

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面向对象开发的下一代工具

MSDN开发精选 2005年第6期 54-55页

作者： oren Novotny Goldman Sachs＆Co的软件开发人员

背景三十多年来文件一直是软件开发工作的中心容器。所有项目结构和逻辑最终都将被归纳为文件和目录。有关软件开发的工具也都是围绕这一概念构建的，编译器，链接器，甚至语言功能部依赖于源代码文件作为输入。版本控制系统镜像了文件... 详细信息

背景三十多年来文件一直是软件开发工作的中心容器。所有项目结构和逻辑最终都将被归纳为文件和目录。有关软件开发的工具也都是围绕这一概念构建的，编译器，链接器，甚至语言功能部依赖于源代码文件作为输入。版本控制系统镜像了文件系统的结构＋并为每个被监控的文件维护所有版本的副本；几十年来，这一点广为接受并且已经成了标准。语言（比如C语盲）都通过include指令构建在源代码中的文件引用之上。

关键词：面向对象开发工具源代码文件一代软件开发项目结构语言功能版本控制文件系统

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六日战争

二十四年生美国西部黄松生长量和树冠叶面积同下木竞争的关系

2020年

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防护林科技 1991年第2期4卷 62-69页

作者： R.oren 赵岭

利用控制初植密度和下层植物进行长期试验所得的资料,全面证实了我们的假设,即,林分生长与林冠的生长有直接关系,例如,生长量与冠幅成比例关系。无下层植物的黄松林分冠幅生长速度明显快于有下层植物的黄松林分。在叶面积指数非常低、... 详细信息

利用控制初植密度和下层植物进行长期试验所得的资料,全面证实了我们的假设,即,林分生长与林冠的生长有直接关系,例如,生长量与冠幅成比例关系。无下层植物的黄松林分冠幅生长速度明显快于有下层植物的黄松林分。在叶面积指数非常低、特别是在林分的下层植物已被清除的情况下,森林生长率随着叶面积指数的增加而增加。然而,一旦叶面积指数超过2.0,森林生产率保持稳定,并且有下层植物和无下层植物的林分出现了差异。

关键词：美国西部黄松边材面积水利用