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Nutrition and physical activity in NAFLD:An overview of the epidemiological evidence

World Journal of Gastroenterology 2011年第29期17卷 3377-3389页

作者： Shira Zelber-Sagi ran oren Zelber-Sagi Vlad Ratziu The Liver Unit Department of GastroenterologyTel Aviv Sourasky Medical Center64239 Tel-AvivIsrael School of Public Health Faculty of Social Welfare and Health SciencesUniversity of Haifa31905 HaifaIsrael Université Pierre et Marie Curie Hpital Pitié Salpêtrière75013 ParisFrance The Sackler Faculty of Medicine Tel-Aviv University 64239 Tel-AvivIsrael

Nonalcoholic fatty liver disease(NAFLD)has been recognized as a major health *** high prevalence of NAFLD is probably due to the contemporary epidemics of obesity,unhealthy dietary pattern,and sedentary *** efficacy and safety profile of pharmacotherapy in the treatment of NAFLD remains uncertain and obesity is strongly associated with hepatic steatosis;therefore,the first line of treatment is lifestyle *** usual management of NAFLD includes gradual weight reduction and increased physical activity(PA)leading to an improvement in serum liver enzymes,reduced hepatic fatty infiltration,and,in some cases,a reduced degree of hepatic inflammation and *** has been demonstrated to be associated with NAFLD and Non-alcoholic steatohepatitis(NASH)in both animals and humans,and thus serves as a major route of prevention and ***,most human studies are observational and retrospective,allowing limited inference about causal *** prospective studies and clinical trials are now needed to establish a causal *** on available data,patients should optimally achieve a 5%-10%weight *** realistic goals is essential for long-term successful lifestyle modification and more effort must be devoted to informing NAFLD patients of the health benefits of even a modest weight ***,all NAFLD patients,whether obese or of normal weight,should be informed that a healthy diet has benefits beyond weight *** should be advised to reduce saturated/trans fat and increase polyunsaturated fat,with special emphasize on omega-3 fatty *** should reduce added sugar to its minimum,try to avoid soft drinks containing sugar,including fruit juices that contain a lot of fructose,and increase their fiber *** the heavy meat eaters,especially those of red and processed meats,less meat and increased fish intake should be *** fast food intake will also help mainta

关键词： Nonalcoholic fatty liver disease Nutrition Physical activity Weight reduction Fat Carbohydrates Soft drinks Nutrients

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Isolation, characterization and culture of Thy1-positive cells from fetal rat livers

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World Journal of Gastroenterology 2006年第24期12卷 3841-3847页

作者： Zvibel Isabel Bronstein Miri Hubel Einav Bar-Lev Ella Halpern Zamir oren ran Liver Unit Gastroenterology Institute Tel Aviv Sourasky Medical CenterWeizmann 6Tel Aviv 64239Israel Internal Medicine Ⅰ Tel Aviv Sourasky Medical Center Weizmann 6Tel Aviv 64239Israel

AIM： To investigate whether Thyl recognizes oval cells in the fetal liver and to characterize the cultured Thy1 selected cells from E14 rat livers. METHODS： Thyl populations were analyzed by fluorescence activated cell sorter analysis. Thyl positive cells were isolated using magnetic beads. Hepatic markers were detected by Western blotting, immunocytochemistry and RT-PCR. RESULTS： The percentage of Thyl-positive cells decreased during early development of fetal rat liver （E13-E16）. E14 fetal livers contained 7.8% Thy1 positive cells, of which 61% were positive for α-fetoprotein （AFP） and 25% expressed albumin. The Thy1＋ population expressed oval cell markers c-Kit and CXCR4, liver enriched-transcription factors HNF1α and HNF6, hepatocytic markers albumin, AFP and cytokeratin 18, and biliary marker cytokeratin 19. Thy1- selected cells formed only mesenchymal colonies when plated on collagen and in serum-containing media. Thyl selected cells were able to form hepatic colonies positive for HNF1α, HNF6, albumin, AFP, cytokeratin 18, cytokeratin 19 and glycogen, when grown on STO feeder layers in serum free-media. CONCLUSION： Oval cells positive for Thyl are present in early liver embryonic stages.

关键词： Fetal liver Oval cells Thy1

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Factors associated with surgery in patients with intra-abdominal fistulizing Crohn's disease

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World Journal of Gastroenterology 2016年第47期22卷 10380-10387页

作者： Shaul Yaari Ariel Benson Eyal Aviran Naama Lev Cohain ran oren Jacob Sosna Eran Israeli IBD Unit Institute of Gastroenterology and Liver Diseases Hadassah-Hebrew University Medical Center Department of Radiology and Medical Imaging Hadassah-Hebrew University Medical Center

AIM To characterize radiological and clinical factors associated with subsequent surgical intervention in Crohn's disease(CD) patients with intra-abdominal *** From a cohort of 1244 CD patients seen over an eight year period(2006 to 2014), 126 patients were identified as having intra-abdominal fistulae, and included in the study. Baseline patient information was collected from the medical records. Imaging studies were assessed for: anatomic type and number of fistulae; diameter of the inflammatory conglomerate; length of diseased bowel; presence of a stricture with pre-stenotic dilatation; presence of an abscess; lymphadenopathy; and the degree of bowel enhancement. Multivariate analysis for the prediction of abdominal surgery was calculated via Generalized Linear *** In total, there were 193 fistulae in 132 patients, the majority(52%) being entero-enteric. Fifty-nine(47%) patients underwent surgery within one year of the imaging study, of which 36(29%) underwent surgery within one month. Radiologic features that were associated with subsequent surgery included: multiple fistulae(P = 0.009), presence of stricture(P = 0.02), and an entero-vesical fistula(P = 0.01). Evidence of an abscess, lymphadenopathy, or intense bowel enhancement as well as C-reactive protein levels was not associated with an increased rate of surgery. Patients who were treated after the imaging study with combination immunomodulatory and anti-TNF therapy had significantly lower rates of surgery(P = 0.01). In the multivariate analysis, presence of a stricture [RR 4.5(1.23-16.3), P = 0.02] was the only factor that increased surgery *** A bowel stricture is the only factor predicting an increased rate of surgery. Radiological parameters may guide in selecting treatment options in patients with fistulizing CD.

关键词： Crohn’s disease Fistula Cross-sectional imaging Intra-abdominal surgery Magnetic resonance imaging Computed tomography-scan

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Increased fibrosis progression rates in hepatitis C patients carrying the prothrombin G20210A mutation

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World Journal of Gastroenterology 2011年第45期17卷 5007-5013页

作者： Nitsan Maharshak Philippe Halfon Varda Deutsch Hava Peretz Shlomo Berliner Sigal Fishman Shira Zelber-Sagi Uri Rozovski Moshe Leshno ran oren Department of Gastroenterology and Liver diseases Tel Aviv Sourasky Medical Center aff iliated to the Sackler School of Medicine Tel Aviv University Department of Virology Laboratoire Alphabio 23 Rue de Friedland Hpital Ambroise Paré The Hematology Institute Tel Aviv Sourasky Medical Center affi liated to the Sackler School of Medicine Tel Aviv University Clinical Biochemistry Laboratory Tel Aviv Sourasky Medical Center affiliated to the Sackler School of Medicine Tel Aviv University Internal Medicine "E" Tel Aviv Sourasky Medical Center affi liated to the Sackler School of Medicine Tel Aviv University

AIM: To examine whether hepatitis C virus (HCV)-infected patients who carry hypercoagulable mutationssuffer from increased rates of liver fi brosis. METHODS: We analyzed DNA samples of 168 HCV patients for three common hypercoagulable gene mutations: prothrombin 20210 (PT20210), factor V Leiden (FV Leiden) and methylene tetrahydrofolate reductase (MTHFR). The patients were consecutively recruited as part of the prospective "Fibroscore Study" in France. The effect of the various mutations on the rate of fi-brosis was analyzed statistically and was correlated with epidemiological, clinical and biochemical data such as grade and stage of liver biopsies, patients' risk factors for liver cirrhosis, and timing of infection. RESULTS: Fifty two of the patients were categorized as "fast fi brosers" and 116 as "slow fi brosers"; 13% of the "fast fi brosers" carried the PT20210 mutation as compared with 5.5% of the "slow fi brosers", with an odds ratio of 4.76 (P = 0.033; 95% CI: 1.13-19.99) for "fast" liver fibrosis. Carriage of MTHFR or FV Leiden mutations was not associated with enhanced liver fi brosis. CONCLUSION: Carriage of the PT20210 mutation is related to an increased rate of liver fi brosis in HCV patients.

关键词： Hepatitis C virus Liver fi brosis Hyperco-agulation Prothrombin 20210

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Effect of resistance training on non-alcoholic fatty-liver disease a randomized-clinical trial

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World Journal of Gastroenterology 2014年第15期20卷 4382-4392页

作者： Shira Zelber-Sagi Assaf Buch Hanny Yeshua Nahum Vaisman Muriel Webb Gil Harari Ofer Kis Naomi Fliss-Isakov Elena Izkhakov Zamir Halpern Erwin Santo ran oren oren Shibolet Department of Gastroenterology Tel Aviv Medical Center6423906 Tel-AvivIsrael School of Public Health University of Haifa3498838 HaifaIsrael The Sackler Faculty of Medicine Tel-Aviv University6997801 Tel AvivIsrael Wingate Institute for Physical Education and Sport 4290200 NetanyaIsrael

AIM: To evaluate the effect of resistance training (RT) on non alcoholic liver disease (NAFLD) patients.

关键词： Resistance exercise Obesity Nutrition Physical activity Abdominal fat

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Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification

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World Journal of Gastroenterology 2013年第1期19卷 57-64页

作者： Shira Zelber-Sagi Muriel Webb Nimer Assy Laurie Blendis Hanny Yeshua Moshe Leshno Vlad Ratziu Zamir Halpern ran oren Erwin Santo Department of Gastroenterology Tel Aviv Sourasky Medical Center64239 Tel-AvivIsrael School of Public Health Faculty of Social Welfare and Health SciencesUniversity of Haifa31905 HaifaIsrael Liver Unit Ziv Medical CenterIsrael and Bar Ilan University13100 SafedIsrael The Sackler Faculty of Medicine Tel-Aviv University69978 Ramat AvivIsrael Université Pierre et Marie Curie H pital Pitié Salpêtrière75013 ParisFrance

AIM:To compare noninvasive methods presently used for steatosis detection and quantification in nonalcoholic fatty liver disease(NAFLD).METHODS:Cross-sectional study of subjects from the general population,a subgroup from the First Israeli National Health Survey,without excessive alcohol consumption or viral *** subjects underwent anthropometric measurements and fasting blood *** of liver fat was performed using four noninvasive methods:the SteatoTest;the fatty liver index(FLI);regular abdominal ultrasound(AUS);and the hepatorenal ultrasound index(HRI).Two of the noninvasive methods have been validated vs liver biopsy and were considered as the reference methods:the HRI,the ratio between the median brightness level of the liver and right kidney cortex;and the SteatoTest,a biochemical surrogate marker of liver *** FLI is calculated by an algorithm based on triglycerides,body mass index,γ-glutamyl-transpeptidase and waist circumference,that has been validated only vs *** < 30 rules out and FLI ≥ 60 rules in fatty ***:Three hundred and thirty-eight volunteers met the inclusion and exclusion criteria and had valid *** prevalence rate of NAFLD was 31.1% according to *** FLI was very strongly correlated with SteatoTest(r = 0.91,P < 0.001) and to a lesser but significant degree with HRI(r = 0.55,P < 0.001).HRI and SteatoTest were significantly correlated(r = 0.52,P < 0.001).The κ between diagnosis of fatty liver by SteatoTest(≥ S2) and by FLI(≥ 60) was 0.74,which represented good *** sensitivity of FLI vs SteatoTest was 85.5%,specificity 92.6%,positive predictive value(PPV) 74.7%,and negative predictive value(NPV) 96.1%.Most subjects(84.2%) with FLI < 60 had S0 and none had *** κ between diagnosis of fatty liver by HRI(≥ 1.5) and by FLI(≥ 60) was 0.43,which represented only moderate *** sensitivity of FLI vs HRI was 56.3%,specificity 86.5%,PPV 57.0%,and NPV 86.1%.The diagnostic accuracy of F

关键词： Steatosis Hepatorenal ultrasound index SteatoTest Fatty liver index Screening Agreement Sensitivity Specificity

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p53:not just a tumor suppressor

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Journal of Molecular Cell Biology 2019年第7期11卷 539-543页

作者： Moshe oren Department of Molecular Cell Biology Weizmann Institute of ScienceRehovot 76100Israel

Nowadays,p53 is like a Dreamliner airplane,riding the high skies of cancer research with dignity and *** do not have to be a card-bearing p53 researcher to know about p53,care about it,and respect ***,this was not always *** a matter of fact,in the first years of p53 research,from its discovery in the late 1970's to about the end of the 1980's,p53 was more like a kite:one moment high up in the air,the next moment being dragged on the ground.

关键词： Dreamliner dignity ground

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Limnological instrumentation in the middle of the 19^(th) century:the first temperature and density profiles measured in the Dead Sea

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Chinese Journal of Oceanology and Limnology 2015年第6期33卷 1496-1504页

作者： Aharon oren Department of Plant and Environmental Sciences Alexander Silberman Institute of Life SciencesHebrew University of Jerusalem

The first modem survey of the Dead Sea was performed by the Geological Survey of Israel in 1959-1960, and the report published remains the baseline study for our understanding of the physical and chemical properties of the lake. At the time the Dead Sea was a meromictic lake with a strong salinity gradient separating the deep waters （〉40 m depth） from the less saline surface waters. A few results of analyses of deeper water samples collected in the 1930s were reported, but overall we have very little information about the structure of the lake＇s water column before the 1959-1960 survey. However, it is little known that data on the physical and the chemical structure of the Dead Sea water column were obtained already in the middle of the 19~ century, and the information collected then is highly relevant for the reconstruction of the limnological properties of the lake in earlier times. The expedition of Lieutenant William Lynch （U.S. Navy） in 1848 reported the presence of a temperature minimum at a depth of-18 m, and also retrieved a water sample collected close to the bottom for chemical analysis. In 1864, the French Dead Sea exploration by the Duc de Luynes and his crew yielded detailed density and salinity profiles for a number of sampling stations. The results of these pioneering studies are discussed here, as well as the sampling equipment and measuring instruments used by the 1848 and the 1864 expeditions.

关键词： Dead Sea stratification research history sampling equipment self-registering thermometer

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Motion of charged particles in bright squeezed vacuum

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Light(Science & Applications) 2024年第2期13卷 347-353页

作者： Matan Even Tzur oren Cohen Solid State Institute and Physics Department Technion-Israel Institute of TechnologyHaifa3200003Israel

The motion of laser-driven electrons quivers with an average energy termed pondermotive *** explore electron dynamics driven by bright squeezed vacuum(BSV),finding that BSV induces width oscillations,akin to electron quivering in laser light,with an equivalent ponderomotive *** identify closed and open trajectories of the electronic width that are associated with high harmonic generation and above-threshold ionization,respectively,similarly to trajectories of the electron position when its motion is driven by coherent *** the case of bound electrons,the width oscillations may lead to ionization with noisy sub-cycle *** results are foundational for strong-field and free-electron quantum optics,as they shed light on ionization,high harmonic generation,and nonlinear Compton scattering in BSV.

关键词： structure vacuum ionization

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Coupling concepts for simulation:A systematic and comprehensive view and advantages with declarative models

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International Journal of Modeling, Simulation, and Scientific Computing 2014年第2期5卷 158-174页

作者： Tuncer oren School of Electrical Engineering and Computer Science University of Ottawa Ottawa OntarioCanada

A brief review of the importance of simulation-based engineering and science(including social sciences)is followed by a historic perspective of model-based *** 2 is on declarative modeling of component systems as well as its advantages for self-documentation and for computer-aided checks and *** an example for declarative modeling,General System Theory(GEST)implementor is *** Sec.3,basic concepts for coupling of component models,and rules for computer-assisted coupling specification are *** 4 is devoted to possible computerized checks in couplings of declarative models such as:(1)automatic unit checking to avoid meaning-less input/output matching at the time of coupling specification,(2)automatic threshold checking to provide warnings and/or to avoid disasters,and(3)automatic unit conversion for convenience of using library *** 5 is about several layers of nested couplings for modeling systems of *** Sec.6,two types of variable couplings are discussed:(1)couplings with variable connections(to allow input/output relations of models to depend on time or state conditions)and(2)coupling with variable component models(to allow component(or coupled)models to be switched based on time or state conditions).Section 7 is on the use of multimodels as component models in *** 8 is on types of inputs and their use in couplings as well as on exter-nal inputs to simulation *** Sec.9,conclusions and future work for complex systems are ***,the values of simulation systems engineering as well as understanding and avoidance of misunderstanding in cognitive and emotive simulations are *** A is a list of almost 50 types of couplings and Appendix B lists over 50 terms related with couplings in modeling and *** show the richness of“input”concept which is important in specification of input/output relations of component models,Appendix C lists almost 150 types of inputs.I

关键词： Declarative modeling coupling nested coupling variable coupling time-varying coupling types of model couplings multi-models in coupling endogenous inputs types of inputs

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