检索结果-南通市图书馆

Whole exome sequencing and single nucleotide polymorphism array analyses to identify germline alterations in genes associated with testosterone metabolism in a patient with androgen insensitivity syndrome and early-onset colorectal cancer

引用

Chinese Journal of Cancer 2016年第10期35卷 546-559页

作者： Vittoria Disciglio Andrea Devecchi orazio palumbo Massimo Carella Donata Penso Massimo Milione Giorgio Valle Marco Alessandro Pierotti Marco Vitellaro Lucio Bertario Silvana Canevari Stefano Signoroni Loris De Cecco Department of Experimental Oncology and Molecular Medicine Func-tional Genomics and BioinformaticsFondazione IRCCS Istituto Nazionale dei Tumori20133 MilanItaly. Medical Genetics Unit IRCCS Casa Sollievo della Soferenza71013 San Giovanni Rotondo FGItaly. Department of Pathol-ogy and Laboratory Medicine Fondazione IRCCS Istituto Nazionale Tumori20133 MilanItaly. Department of Biology University of Padova35131 PaduaItaly. Fondazione IRCCS Istituto Nazionale dei Tumori 20133 MilanItaly. Hereditary Digestive Tract Tumors Unit Department of Preventive and Pre-dictive MedicineFondazione IRCCS Istituto Nazionale dei Tumori20133 MilanItaly. Colorectal Surgery Unit Department of SurgeryFondazione IRCCS Istituto Nazionale dei Tumori20133 MilanItaly.

Background: Androgen insensitivity syndrome(AIS), a disorder of sexual development in 46, XY individuals, is caused by loss-of-function mutations in the androgen receptor(AR) gene. A variety of tumors have been reported in association with AIS, but no cases with colorectal cancer(CRC) have been *** presentation: Here, we present a male patient with AIS who developed multiple early-onset CRCs and his pedigree. His first cousin was diagnosed with AIS and harbored the same AR gene mutation, but with no signs of CRC. The difference in clinical management for the two patients was that testosterone treatment was given to the proband for a much longer time compared with the cousin. The CRC family history was negative, and no germline mutations in well-known CRC-related genes were identified. A single nucleotide polymorphism array revealed a microduplication on chromosome 22q11.22 that encompassed a micro RNA potentially related to CRC pathogenesis. In the proband, whole exome sequencing identified a polymorphism in an oncogene and 13 rare loss-of-function variants, of which two were in CRC-related genes and four were in genes associated with other human ***: By pathway analysis, all inherited germline genetic events were connected in a unique network whose alteration in the proband, together with continuous testosterone stimulation, may have played a role in CRC pathogenesis.

关键词： Androgen insensitivity syndrome Androgen receptor Colorectal cancer Single nucleotide polymorphism array Testosterone Whole exome sequencing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Best management practices to reduce soil erosion and change water balance components in watersheds under grain and dairy production

引用

International Soil and Water Conservation Research 2024年第1期12卷 121-136页

作者： Thais palumbo Silva Danielle Bressiani Éderson Diniz Ebling JoséMiguel Reichert Soil Science of Federal University of Santa Maria Roraima Avenuenumber 1000CEP:97.105-900Santa MariaRio Grande do SulBrazil Technological Development Center Federal University of PelotasGomes Carneiro Streetnumber 1CEP:96010-610PelotasRio Grande do SulBrazil Department of Soil Federal University of Santa MariaCampus Universitário s/nCEP 97.105-900Santa MariaRio Grande do SulBrazil

Soil erosion and sedimentation are among the most serious global environmental *** and water conservation measures have been proven effective ways to reduce soil *** objective of this study was to evaluate the impact of three approaches of soil and water conservation measures(soil management,vegetative measures,and structural practices)on soil erosion and water balance of two paired agricultural watersheds located in Southern *** and sediment monitoring was carried out from 2016 to 2019 in the two small paired agricultural watersheds;called North watershed(NW)and South watershed(SW).Modeling using Soil&Water Assessment Tool(SWAT)was performed to simulate individual(nine scenarios)and combined(four scenarios)best management practices(BMPs),by including the three *** the nine individual BMP scenarios,the most effective in reducing soil erosion was crop rotation and cover crop(sediment yield,SY,reduction of 38.4 for NW,and 28.8%for SW).Among the four combined scenarios,the association of all conservation approaches was the most effective in reducing soil erosion(SY reduction of 46 for NW,and 41.5%for SW),followed by the vegetative measures scenario(SY reduction of 43.5 and 34.1%for NW and SW).All combined scenarios increased infiltration and subsurface water components,and decreased surface *** findings of this study can help farmers and policymakers choosing appropriate BMPs to reduce current soil erosion problems and promote water and soil conservation.

关键词： Agricultural hydrology Conservation measures SWAT Subtropical watersheds

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sailboats

引用

小学生时代（大嘴英语） 2024年第7期 28-33页

作者： Edward palumbo Ag Jatkowska(图) 不详

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Approaches to quantify axonal morphology for the analysis of axonal degeneration

引用

Neural Regeneration Research 2023年第2期18卷 309-310页

作者： Alex palumbo Marietta Zille Department of Neurobiology Harvard Medical School Department of Cancer Biology Dana-Farber Cancer InstituteBostonMAUSA Department of Pharmaceutical Sciences Division of Pharmacology and ToxicologyUniversity of ViennaViennaAustria

Morphological hallmarks of axonal degeneration(AxD):Axons transmit signals from one neuron to another and a re crucial for the proper communication in the nervous ***,the disintegration of axons,a process named AxD,ha... 详细信息

关键词： degeneration axonal Morphological

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The coexistence of fast and slow diffusion processes in the life cycle of Aedes aegypti mosquitoes

引用

International Journal of Biomathematics 2021年第1期14卷 73-103页

作者： Antonella Lupica Annunziata palumbo Engineering School DEIm DepartmentUniversity of TusciaLargo dell’Università01100 ViterboItaly

A new model that describes the life cycle of mosquitoes of the species Aedes aegypti,main carriers of vector-borne diseases,is *** novelty is to include in the model the coexistence of two independent diffusion processes,one fast which obeys the constitutive Fick’s law,the other slow which satisfies the Cattaneo evolution *** analysis of the corresponding ODE model shows the overall stability of the Mosquitoes-Free Equilibrium(MFE),together with the local stability of the other equilibrium point admitted by the *** wave type solutions have been investigated,providing an estimate of the minimal speed for which there are monotone waves that connect the homogeneous equilibria allowed by the system.A special section is dedicated to the analysis of the hyperbolic model obtained neglecting the fast diffusive *** particular case is suitable to describe the biological process as it overcomes the paradox of infinite speed propagation,typical of parabolic *** numerical simulations compare the existing models in the literature with those presented in this discussion,showing that although the generalized model is parabolic,the associated wave velocity admits upper bound represented by the speed of the waves linked to the classic parabolic model present in the published literature,so the presence of a slow flux together with a fast one slows down the speed with which a population spreads.

关键词： Population growth reaction-diffusion equation stability traveling wave

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lyapunov stability of competitive cells dynamics in tumor mechanobiology

引用

Acta Mechanica Sinica 2021年第2期37卷 244-263页

作者： Angelo Rosario Carotenuto Arsenio Cutolo Stefania palumbo Massimiliano Fraldi Department of Structures for Engineering and Architecture University of Napoli Federico IINapoliItaly

Poromechanics plays a key role in modelling hard and soft tissue behaviours,by providing a thermodynamic framework in which chemo-mechanical mutual interactions among fluid and solid constituents can be consistently rooted,at different scale *** this context,how different biological species(including cells,extra-cellular components and chemical metabolites)interplay within complex environments is studied for characterizing the mechanobiology of tumor growth,governed by intra-tumoral residual stresses that initiate mechanotransductive processes deregulating normal tissue homeostasis and leading to tissue *** the coupling between tumor poroelasticity and interspecific competitive dynamics has recently highlighted how microscopic cells and environment interactions influence growth-associated stresses and tumor pathophysiology,the nonlinear interlacing among biochemical factors and mechanics somehow hindered the possibility of gaining qualitative insights into cells *** by this,in the present work we recover the linear poroelasticity in order to benefit of a reduced complexity,so first deriving the well-known Lyapunov stability criterion from the thermodynamic dissipation principle and then analysing the stability of the mechanical competition among cells fighting for common space and resources during cancer growth and *** the end,the linear poroelastic model enriched by interspecific dynamics is also exploited to show how growth anisotropy can alter the stress field in spherical tumor masses,by thus indirectly affecting cell mechano-sensing.

关键词： Tumor growth Poroelasticity Cells competition Volterra-Lotka dynamics Stability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improving the Hydromechanical Deep-Drawing Process Using Aluminum Tailored Heat Treated Blanks

引用

Acta Metallurgica Sinica(English Letters) 2015年第12期28卷 1482-1489页

作者： Antonio Piccininni Gabriella Di Michele Gianfranco palumbo Donato Sorgente Luigi Tricarico Dipartimento di Meccanica Matematica e Management Politecnico di Bari

The present work demonstrates the effectiveness of combining the hydromechanical deep-drawing process with the Tailored Heat Treated Blank（THTB） technique. In the hydromechanical deep-drawing process, the fluid pressure is used for postponing the fracture occurrence in the blank, while the THTB technique allows to create a material property gradient through a suitable artificial aging treatment carried out prior to the forming process. Since the number of process variables is large, in the present work the authors propose an optimization loop for the determination of the parameters controlling the extension of the blank regions to be subjected to the aging treatment and the temperature levels to be set during the heat treatment. The proposed methodology couples a simple finite element model（Abaqus） with a multiobjective optimization platform（mode FRONTIER）. A preliminary experimental campaign was carried out for determining the effect of the aging treatment on the mechanical（through tensile tests） and deformative（through formability tests）behavior of the AC170 PX aluminum alloy. Optimization results prove the effectiveness of the adopted methodology and put in evidence that the adoption of properly aged blanks in the hydromechanical deep drawing allows to increase the limit drawing ratio and to simplify the process since it is conducted at room temperature.

关键词： Aluminum alloy Aging Hydromechanical deep drawing Finite element analysis Mechanical characterization Formability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dating long thrust systems on Mercury:New clues on the thermal evolution of the planet

引用

Geoscience Frontiers 2020年第3期11卷 855-870页

作者： L.Giacomini M.Massironi V.Galluzzi S.Ferrari P.palumbo INAF-IAPS Istituto di Astrofisica e Planetologia SpazialiVia Fosso Del Cavaliere 100Rome00133Italy Dipartimento di Geoscienze University of PadovaVia G.Gradenigo 6Padova35131Italy Center of Studies and Activities for Space(CISAS)“G.Colombo” University of PadovaVia Venezia 15Padova35131Italy Dipartimento di Scienze e Tecnologie University of Naples“Parthenope”Centro DirezionaleIsola C4Napoli80143Italy

The global tectonics of Mercury is dominated by contractional features mainly represented by lobate scarps,high relief ridges,and wrinkle *** structures are the expression of thrust faults and are linear or arcuate features widely distributed on ***,these structures are arranged in long systems characterized by a preferential orientation and non-random spatial *** this work we identified five thrust systems,generally longer than 1000 *** were named after the main structure or crater encompassed by the system as:Thakur,Victoria,Villa Lobos,Al-Hamadhani,and *** order to gain clues about their formation,we dated them using the buffered crater counting technique,which can be applied to derive the ages of linear landforms such as faults,ridges and *** estimate the absolute age for the end of the thrust system's activity,we applied both Le Feuvre and Wieczorek Production Function and Neukum Production ***,to further confirm the results obtained with the buffered crater counting method,the classic stratigraphic approach has been adopted,in which a faulted and an unfaulted craters were dated for each *** results gave consistent ages and suggested that the most movements along major structures all over Mercury most likely ended at about 3.6-3.8 *** gives new clues to better understand the tectonics of the planet and,therefore,its thermal ***,the early occurrence of tectonic activity in the planet's history,well before than predicted by the thermophysical models,coupled with the orientation and spatial distribution of the thrust systems,suggests that other processes beside global contraction,like mantle downwelling or tidal despinning,could have contributed to the first stage of the planet's history.

关键词： Mercury Thrust systems Crater counting Thermal evolution Planetary geology Structural geology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The management of the long head of the biceps in rotator cuff repair:A comparative study of high *** tenodesis

引用

Journal of Sport and Health Science 2023年第5期12卷 613-618页

作者： Edoardo Franceschetti Edoardo Giovannetti de Sanctis Alessio palumbo Michele Paciotti Luca La Verde Nicola Maffulli Francesco Franceschi Department of Orthopaedic and Trauma Surgery Campus Biomedico University of RomeVia Alvaro del Portillo 20000100 RomeItaly Department of Orthopaedics and Traumatology Catholic UniversityAgostino Gemelli Hospital00100 RomeItaly Anca Surgical Center Via Francesco Maidalchini 20Roma00152RomeItaly Department of Musculoskeletal Disorders Via Salvador Allende4384081 BaronissiSalernoItaly Centre for Sports and Exercise Medicine Barts and The London School of Medicine and DentistryMile End Hospital275 Bancroft RoadLondon E14DGEnglandUK School of Pharmacy and Bioengineering Keele University School of MedicineThornburrow DriveStoke on Trent ST4EnglandUK

Background:Tenodesis of the long head of the biceps(LHB)is commonly undertaken during arthroscopic rotator cuff *** assessed the clinical and structural outcomes after high arthroscopic tenodesis(HAT)or mini-open subpectoral tenodesis(ST).We hypothesized that the clinical and structural results after HAT and ST are ***:We included 40 patients with rotator cuff tear and LHB *** patients(7 women and 13 men;mean age:57.9 years;range:56-63 years)were treated using HAT,and 20 patients(8 women and 12 men;mean age:58.5 years;range:55-64 years)were treated using *** evaluation was performed preoperatively and at 6 weeks,6 months,and 1 year after surgery,using the Constant Murley Score and Simple Shoulder Test scores;the LHB was evaluated using the LHB score.A Visual Analogue Scale was administered to all patients preoperatively and 2 days after ***:The postoperative total and pain subscale’s Constant scores were significantly higher in the ST ***,2 LHB score values were significantly different between the *** postoperative LHB total score in the ST and HAT groups averaged 86.9±4.1(mean±SD)points and 73.3±6.4 points,*** Pain/Cramps subscale in the ST and HAT groups averaged 47.1±5.9 and 33.2±4.6 points,*** 2 groups showed no difference in Visual Analogue Scale values(5.5 in the HAT group;5.8 in the ST group)*** patient in the HAT group reported a secondary onset of Popeye ***:Both high arthroscopic and mini-open ST of the LHB tendon produced reliably good functional results,but the ST group was associated with better postoperative clinical outcomes.

关键词： Long head of the biceps Shoulder Shoulder arthroscopy Subpectoral TenodesisTagedEnd

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of laser chirp on the polarization of terahertz from two-color plasma

引用

Photonics Research 2023年第6期11卷 978-985页

作者： SEN MOU LUCA TOMARCHIO ANNALISA D’ARCO MARTA DI FABRIZIO SALVATORE MACIS ALESSANDRO CURCIO LUIGI palumbo STEFANO LUPI MASSIMO PETRARCA INFN-Roma1 and Physics Department University of Rome“La Sapienza”00185 RomeItaly Physics Department University of Rome“La Sapienza”00185 RomeItaly SBAI Department of Basic and Applied Sciences for EngineeringUniversity of Rome“La Sapienza”00161 RomeItaly Centro de Laseres Pulsados(CLPU) 37185 VillamayorSalamancaSpain INFN-LNF 00044 FrascatiItaly

Two-color plasma,induced by two lasers of different colors,can radiate ultra-broadband and intense terahertz(THz)pulses,which is desirable in many technological and scientific *** was found that the polarization of the emitted THz depends on the phase difference between the fundamental laser wave and its second *** investigation suggests that chirp-induced change of pulse overlap plays an important role in the THz yield from two-color ***,the effect of laser chirp on THz polarization remains ***,we investigate the impact of laser chirp on THz *** is unveiled that the chirp-induced phase difference affects THz ***,positive and negative chirps have opposite effects on the variation of the THz polarization versus the phase *** polarization of THz generated by a positively chirped pump laser rotates clockwise with an increasing phase difference,while it rotates anticlockwise when generated by a negatively chirped pump laser.

关键词： polarization laser pump

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：