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Asian Journal of Andrology 2014年第5期16卷 725-727,I0008,I0009页

作者： Abdulmuttalip Simsek Sinan Levent Kirecci onur kucuktopcu Faruk Ozgor Mehmet Fatih Akbulut Omer Sarilar Unsal Ozkuvanci Zafer Gokhan Gurbuz Department of Urology Haseki Research and Training Hospital Fatih Istanbul Department of Urology Sisli Etfal Research and Training Hospital Istanbul Turkey

Dapoxetine hydrochloride is a selective serotonin reuptake inhibitor and the first drug approved for the on-demand treatment of premature ejaculation （PE）, Our objective in this study was to characterize the efficacy of on-demand dapoxetine （30 and 60 mg） and daily paroxetine （20 mg） usage in treating PE, We conducted a 1 month study involving a total of 150 patients. Patients were divided into three groups of 50, Group 1 were treated with on-demand dapoxetine （30 mg）, Group 2 with on-demand dapoxetine （60 mg） and Group 3 with daily paroxetine （20 rag）, Our outcome measurement was increased from baseline intravaginal ejaculatory latency time （IELT） after treatment, The IELT increased from baseline to posttreatment by 117%, 117% and 170% in the paroxetine group （P 〈 0,01）, 30 mg dapoxetine group （P 〈 0,01） and 60 mg dapoxetine group （P 〈 0.01）, respectively, The increase from baseline IELT were similar for the 30 mg dapoxetine and paroxetine groups （P 〉 0,05）, while the 60 mg dapoxetine group had a larger posttreatment IELT increase compared with the 30 mg dapoxetine （P〈 0.05） and paroxetine （P〈 0.01） groups, Dapoxetine （60 mg） 1-3 h before planned intercourse is a very effective treatment modality for PE. However, an on-demand dose of 30 mg dapoxetine is no more effective than the currently prescribed paroxetine treatment.

关键词： dapoxetine paroxetine premature ejaculation selective serotonin reuptake inhibitor

An integrated spatial planning of the mountainous landscapes for ski sports in a case area at the eastern Türkiye

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Journal of Mountain Science 2024年第3期21卷 754-767页

作者： SATIR onur TOSUN Busra COSKUN OZYOL Funda OZDEMIR Omer Faruk BERBEROGLU Suha Dept.of Landscape Architecture Van Yuzuncu Yil UniversityVan 65090Türkiye School of Physical Education&Sports Van Yuzuncu Yil UniversityVan 65090Türkiye Van Yuzuncu Yil University Dept.of Architecture&Urban Planning Van 65090Türkiye Dept.of Remote Sensing&GIS Cukurova UniversityAdana 01330Türkiye

Mountainous regions have disadvantages in economic development because of harsh physical and climatic ***,winter tourism activities are one of the key components for supporting economic development in the *** a ski resort area supports direct and indirect employment in a region,and it stops immigration from mountainous regions to other *** research aimed to assess the potential ski areas using a multi criteria evaluation technique in the Van region which is located in the eastern part of Tü*** this context,snow cover duration,sun effect,slope,slope length,elevation,population density,distance from main roads and lake visibility were used as input factors in the decision making *** factor was standardized using a fuzzy technique based on existing well-known ski centers in Tü*** weight of inputs was defined by applying a survey to the professional *** most important factors were detected as transportation opportunities and snow covers whereas,the least important factors were elevation and population ***,lake visibility was very important to make a difference from other existing facilities in the ***,it was included as constraints and lake visible areas were extracted at the final stage of the *** ski areas were mapped in three levels as professional,intermediate and beginner *** of the suitable areas was selected as a sample projection and for the 3D simulation of the ski investment *** costs and benefits were *** was found that a ski tourism area investment can be amortized in 3 years in the region.

关键词： Winter sports and tourism Decision making 3D simulation and modelling Landscape planning GIS

Role of biomarkers in community-acquired pneumonia management

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Journal of Acute Disease 2024年第3期13卷 87-92页

作者： Bahaeddin onur Hakan BarışDemirbas Arif Gulmez Department of Emergency Medicine Istanbul Health and Technology UniversityIstanbulTurkey Department of Emergency PHCCAl Karaana Health CenterDohaQatar Department of Emergency PHCCUmm Slala Health CenterDohaQatar Department of Family Medicine PHCCAl Thumama Health CenterDohaQatar

Community-acquired pneumonia(CAP)poses a significant global health threat,particularly affecting vulnerable *** and scoring systems play a crucial role in diagnosing,assessing severity,and guiding treatment decisions for CAP *** like C reactive protein,procalcitonin,and the neutrophil-to-lymphocyte ratio aid in diagnosis and severity assessment,while scoring systems such as CURB-65 and Pneumonia Severity Index classify patients into risk *** biomarkers(uremia,elevated respiratory rate,hypotension,and age≥65)like serum amyloid A and S100 proteins show promise in predicting disease severity and ***,further research is needed to determine their precise roles and clinical utility in CAP management.

关键词： CURB-65 Community-acquired pneumonia Procalcitonin Alpha-1 antitrypsin Serum amyloid A

乙酰左旋肉碱在缺氧条件下对人视网膜色素上皮-19细胞的影响（英文）

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国际眼科杂志 2024年第10期 1515-1521页

作者： Ali Dal onur ?atak Murat ■ Mehmet Canleblebici Ebru ?nalan Ilay Buran F?rat大学医学院眼科穆斯塔法凯末尔大学AtaS?kmen医学院眼科土耳其开塞利州立医院眼科 F?rat大学医学院医学生物学系

目的：使用缺氧模型探究乙酰左旋肉碱（ALCAR）对人视网膜色素上皮（ARPE-19）细胞活力、形态完整性和血管内皮生长因子（VEGF）表达的影响。方法：第一组实验通过暴露ARPE-19细胞培养物于不同浓度确定最佳CoCl2剂量。建立五组ARPE-19... 详细信息

目的：使用缺氧模型探究乙酰左旋肉碱（ALCAR）对人视网膜色素上皮（ARPE-19）细胞活力、形态完整性和血管内皮生长因子（VEGF）表达的影响。方法：第一组实验通过暴露ARPE-19细胞培养物于不同浓度确定最佳CoCl2剂量。建立五组ARPE-19细胞培养物，包括对照组，假手术组（200μM CoCl2）和分别接受1、10、100 mM ALCAR联合200μM CoCl2组，以评估ALCAR对细胞活力的影响。使用MTT法测量细胞活力。通过倒置相差显微镜观察细胞的形态特征。采用酶联免疫吸附实验（ELISA）检测ARPE-19细胞分泌VEGF和HIF-1α的水平。结果：ARPE-19细胞暴露于不同剂量的CoCl2中，以创建缺氧模型。然而，暴露于浓度为200μM CoCl2时，细胞活力显著降低至83%。ALCAR在1 mM和10 mM浓度下可增加细胞活力，而最大浓度（100 mM）没有额外效果。与假手术组相比，浓度为1 mM和10 mM ALCAR组的细胞活力显著更高（P=0.041、0.019）。细胞活力和形态不受最大剂量ALCAR （100 mM）的影响。与假手术组相比，10 mM ALCAR组VEGF和HIF-1α水平显著降低（P=0.013、0.033）。结论：ALCAR是可行的治疗选择，可为视网膜疾病开辟新的治疗途径，与年龄相关性黄斑变性（AMD）特别相关。然而，仍需开展进一步研究明确定义其确切机制，以期充分阐明ALCAR对抗视网膜疾病的应用潜力。

关键词：乙酰左旋肉碱(ALCAR) 人视网膜色素上皮细胞(ARPE-19) 血管内皮生长因子(VEGF) 缺氧诱导因子(HIF-1α)

Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy

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Cancer Communications 2024年第1期44卷 178-182页

作者： Okan Safak Shenghan Wang Carmen Mota Reyes Ibrahim Halil Gürcinar Sergey Tokalov Nedim Can Cevik Kivanc Görgülü Bengi Su Yilmaz Emre Erdogan Linhan Ye Qiaolin Li Elif Arik Sever SamedÖzer Güldal Süyen Helmut Friess Güralp onur Ceyhan Rouzanna Istvanffy Hana Algül Ihsan Ekin Demir Department of Surgery Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of General Surgery HPB-UnitSchool of MedicineAcibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Comprehensive Cancer Center München Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of Hematology Oncology and Tumor ImmunologyCharitéUniversity Medicine BerlinCampus Virchow ClinicBerlinBerlinGermany Graduate School of Health Sciences Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Department of Physiology Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Else Kröner Clinician Scientist Professorship for Translational Pancreatic Surgery MunichGermany Neural Influences in Cancer(NIC)International Research Consortium MunichGermany

Dear Editor,Targeting the immune compartment in pancreatic duc-tal adenocarcinoma(PDAC)holds promise for prognostic improvement,yet our knowledge on the spatial and tem-poral dynamics and the molecular modulators of t... 详细信息

关键词： immune adenocarcinoma immunotherapy

Cue the volatility spillover in the cryptocurrency markets during the COVID-19 pandemic:evidence from DCC-GARCH and wavelet analysis

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Financial Innovation 2022年第1期8卷 366-403页

作者： onurÖzdemir Department of International Trade and Finance(English) Istanbul Gelisim UniversityIstanbulTurkey

This study investigates the dynamic mechanism of financial markets on volatility spillovers across eight major cryptocurrency returns,namely Bitcoin,Ethereum,Stellar,Ripple,Tether,Cardano,Litecoin,and Eos from November 17,2019,to January 25,*** study captures the financial behavior of investors during the COVID-19 pandemic as a result of national lockdowns and slowdown of *** different methods,namely,EGARCH,DCC-GARCH,and wavelet,are used to understand whether cryp-tocurrency markets have been exposed to extreme *** GARCH family models provide information about asset returns at given time scales,wavelets capture that information across different frequencies without losing inputs from the time *** overall results show that three cryptocurrency markets(i.e.,Bitcoin,Ethereum,and Litecoin)are highly volatile and mutually dependent over the sample *** result means that any kind of shock in one market leads investors to act in the same direction in the other market and thus indirectly causes volatility spillovers in those *** results also imply that the volatility spillover across cryptocurrency markets was more influential in the second lockdown that started at the beginning of November ***,to calculate the financial risk,two methods—namely,value-at-risk(VaR)and conditional value-at-risk(CVaR)—are used,along with two additional stock indices(the Shanghai Composite Index and S&P 500).Regardless of the confidence level investigated,the selected crypto assets,with the exception of the USDT were found to have substantially greater downside risk than SSE and S&P 500.

关键词： Volatility spillover EGARCH DCC-GARCH Wavelets COVID-19

Polarization multiplexed diffractive computing:all-optical implementation of a group of linear transformations through a polarization-encoded diffractive network

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Light(Science & Applications) 2022年第7期11卷 1423-1442页

作者： Jingxi Li Yi-Chun Hung onur Kulce Deniz Mengu Aydogan Ozcan Electrical and Computer Engineering Department University of CaliforniaLos AngelesCA 90095USA Bioengineering Department University of CaliforniaLos AngelesCA 90095USA California NanoSystems Institute(CNSI) University of CaliforniaLos AngelesCA 90095USA

Research on optical computing has recently attracted significant attention due to the transformative advances in machine *** different approaches,diffractive optical networks composed of spatially-engineered transmissive surfaces have been demonstrated for all-optical statistical inference and performing arbitrary linear transformations using passive,free-space optical ***,we introduce a polarization-multiplexed diffractive processor to all-optically perform multiple,arbitrarily-selected linear transformations through a single diffractive network trained using deep *** this framework,an array of pre-selected linear polarizers is positioned between trainable transmissive diffractive materials that are isotropic,and different target linear transformations(complex-valued)are uniquely assigned to different combinations of input/output polarization *** transmission layers of this polarization-multiplexed diffractive network are trained and optimized via deep learning and error-backpropagation by using thousands of examples of the input/output fields corresponding to each one of the complex-valued linear transformations assigned to diffferent input/output polarization *** results and analysis reveal that a single diffractive network can successfully approximate and all-optically implement a group of arbitrarily-selected target transformations with a negligible error when the number of trainable diffractive features/neurons(N)approaches N_(p)N_(i)N_(o),where Ni and N_(o) represent the number of pixels at the input and output fields-of-view,respectively,and N_(p) refers to the number of unique linear transformations assigned to different input/output polarization *** polarization-multiplexed all-optical diffractive processor can find various applications in optical computing and polarization-based machine vision tasks.

关键词： valued arbitrarily Polarization

The role of small non-coding RNAs(sncRNAs)in male infertility:A scoping review

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亚太生殖杂志:英文版 2023年第5期12卷 201-210页

作者： Cakir Kaya Hacer Eroglu onur Department of Molecular Biology and Genetics Faculty of ScienceBilecik Seyh Edebali UniversityBilecikTurkey

Objective:To give a brief overview of the field of epigenetics and the potential predictive power that small non-coding RNA(sncRNA)may hold in relation to improving the treatment and diagnosis of male ***:PRISMA-ScR was used as the scoping review guideline for this *** article data here have been accessed from MEDLINE–PubMed,Science Direct,EBSCO,Scopus,Sage Journals,and Google *** terms"small non coding RNA,male,infertility,miRNA,sperm"were used in the search between 2015 and ***:The study comprised 35 publications in *** sncRNAs,miR-155,miR-16,miR-196,miR-525-3p,miR-891 were found to be effective in regulating the mechanism of spermatozoa processing in the infertility of *** can be used as a biomarker of male ***:sncRNAs can act as biomarkers for the diagnosis of reproductive ***,by recognizing sncRNAs and their mechanisms,a new way to treat infertile men would be *** functional annotation of sncRNAs in spermatogenesis is still in its infancy but has enormous *** is despite the fact that many potential sncRNAs have been found to date with the use of cutting-edge technology and publicly accessible sncRNA annotation tools.

关键词： Male infertility miRNA Small untranslated RNA sncRNAs Sperm Next-generation sequencing Real-time PCR

Structure of human NCC:insights into the inhibition mechanism of thiazides

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3549-3550页

作者： Livia de Souza Goncalves Pattareeya Yottasan onur Cil Department of Pediatrics University of CaliforniaSan FranciscoSan FranciscoCAUSA

A recent study published in Nature by Fan et al.1 identified the structure of human NCC alone and in complex with a thiazide diuretic using cryo-electron *** extensive clinical use of NCC inhibitor thiazide diuretics since 1950s,the structure and inhibition mechanisms of NCC have remained elusive,and Fan et *** is a major step toward better understanding the NCC biology and mechanism of action of thiazide ***-chloride cotransporter(NCC,also known as SLC12A3)is expressed in the kidney where it facilitates electroneutral NaCl absorption.

关键词： azide mechanism

Fermented Spirulina products with Saccharomyces and non- Saccharomyces yeasts:Special reference to their microbial,physico-chemical and sensory characterizations

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Food Bioscience 2022年第3期47卷 829-839页

作者： Busra Sahin Muge Isleten Hosoglu onur Guneser Yonca Karagul-Yuceer Gebze Technical University Department of BiotechnologyGebzeKocaeliTürkiye Uşak University Department of Food Engineering1 Eylül CampusUşakTürkiye Canakkale Onsekiz Mart University Department of Food EngineeringTerzioglu CampusCanakkaleTürkiye

Innovative products produced from various sources through fermentation processes have been a resurgence of *** study was designed to determine the performance of fermented Spirulina (FS) products by three different yeast species including Debaryomyces hansenii ,Kluyveromyces marxianus and Saccharomyces cerevisiae and investigate the microbial,physicochemical and sensory characteristics of *** results showed that the increase in yeast cell number was around 3 log after 48 h fermentation in Spirulina medium without additional carbon *** bands with a molecular weight of ∼51 kDa seemed less visible and bands 14–22 kDa disappeared after 48 h fermentation by *** showed strong hydrolysis of proteins during *** amino acid compositions of the three kinds of FS were different also compared to unfermented Spirulina (unFS).Glutamic acid,methionine,lysine,isoleucine and valine became more dominant in FS *** to GC–MS analysis,there was a decrease in the concentration of pyrazine,ketone and aldehyde compounds of FS compared to *** flavor notes of “seaweed”,“cardboard”,“earthy/muddy” and “cereal/straw” were found to be the highest in unFS than in FS detected by panelists during sensory *** by *** is highly characterized as having the lowest “seaweed” and “umami” flavor attributes and higher “fermented” and “rose” ***,the current study revealed that the potential of Spirulina biomass to be a suitable substrate for yeasts and fermentation of Spirulina with different yeast species led to different kinds of products.

关键词： Spirulina platensis Yeast fermentation Total and free amino acids Volatile organic compounds Sensory evaluation