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Outcome of curative resection for perihilar cholangiocarcinoma in Northeast Thailand

World Journal of Gastrointestinal Oncology 2015年第12期7卷 503-512页

作者： Attapol Titapun Ake Pugkhem Vor Luvira Tharatip Srisuk ongart somintara O-tur Saeseow Anan Sripanuskul Anongporn Nimboriboonporn Bandit Thinkhamrop Narong Khuntikeo Department of Surgery Faculty of Medicine Khon Kaen University CASCAP Program Khon Kaen University Liver Fluke and Cholangiocarcinoma Research Center Faculty of Medicine Khon Kaen University Department of Epidemiology and Biostatistics Faculty of Public Health Khon Kaen University

AIM: To examine survival outcomes of perihilar cholangiocarcinoma(PCCA) resection including mortality, morbidity and prognostic factors. METHODS: Multivariate analyses were carried out based on the survival data of all patients with histologically confirmed PCCA who underwent curative resection at Srinagarind Hospital from January 2006 to December 2011. RESULTS: There were 29(19%) cases of intrahepatic CCA that involved hilar and 124(81%) with hilar bileduct cancer. R0 resection was carried out on 66(43.1%) patients of whom 50(32.7%) also had lymph node metastasis. The other patients underwent R1 resection. The overall 5-year survival rate was 20.6%(95%CI: 13.8-28.4) and median survival time was 19.9 mo. Postoperative mortality was 2%, and 30% of patients had complications. Patients without lymph node metastasis were 60% less likely to die than those with metastasis. Achieving R0 led to a 58% reduction in the chance of mortality as compared to R1. CONCLUSION: To achieve a better survival outcome, focus should center on performing radical surgery and detection of patients with early stage cancer.

关键词： Perihilar cholangiocarcinoma Thailand Curative res

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