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Dubin-Johnson syndrome coinciding with colon cancer and atherosclerosis

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World Journal of Gastroenterology 2013年第6期19卷 946-950页

作者： Eva Sticova Milan Elleder Helena Hulkova ondrej Luksan Martin Sauer Irena Wunschova-Moudra Jan Novotny Milan Jirsa Center for Experimental Medicine Institute for Clinical and Experimental Medicine14021 Prague 4Czech Republic Third Faculty of Medicine Charles University10000 Prague 10Czech Republic Institute of Inherited Metabolic Disorders First Faculty of MedicineCharles University and VFN12808 Prague 2Czech Republic Department of Surgery IPVZ Masaryk Hospital40113 Usti nad LabemCzech Republic Department of Thoracic Surgery Masaryk Hospital40113 Usti nad LabemCzech Republic Gastroenterology Department Masaryk Hospital40113 Usti nad LabemCzech Republic

Hyperbilirubinemia has been presumed to prevent the process of atherogenesis and cancerogenesis mainly by decreasing oxidative stress.Dubin-Johnson syndrome is a rare,autosomal recessive,inherited disorder characterized by biphasic,predominantly conjugatedhyperbilirubinemia with no progression to end-stage liver disease.The molecular basis in Dubin-Johnson syndrome is absence or deficiency of human canalicular multispecific organic anion transporter MRP2/cMOAT caused by homozygous or compound heterozygous mutation(s) in ABCC2 located on chromosome 10q24.Clinical onset of the syndrome is most often seen in the late teens or early adulthood.In this report,we describe a case of previously unrecognized Dubin-Johnson syndrome caused by two novel pathogenic mutations (c.2360_2366delCCCTGTC and c.3258+1G>A),coinciding with cholestatic liver disease in an 82-year-old male patient.The patient,suffering from advanced atherosclerosis with serious involvement of coronary arteries,developed colorectal cancer with nodal metastases.The subsequent findings do not support the protective role of Dubin-Johnson type hyperbilirubinemia.

关键词： Dubin-Johnson syndrome ABCC2 Hyperbilirubinemia Oxidative stress Atherosclerosis Cancer

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如何为便携式多媒体处理器供电

电子设计应用 2006年第7期 86-88页

作者： ondrej Tlaskal 意法半导体公司

引言在现代应用中,传统的低压降稳压器(LDO)正逐渐被开关电源(SMPS)所取代.虽然LDO是一个成本低廉而且强固耐用的电源解决方案,但是它耗电很大.越来越多的便携设备厂商,像数码相机、手机、PDA制造商,都在研究用效率更高的解决方案取代LD... 详细信息

引言在现代应用中,传统的低压降稳压器(LDO)正逐渐被开关电源(SMPS)所取代.虽然LDO是一个成本低廉而且强固耐用的电源解决方案,但是它耗电很大.越来越多的便携设备厂商,像数码相机、手机、PDA制造商,都在研究用效率更高的解决方案取代LDO的可行性.开关解决方案的大小,即电源的物理尺寸,通常是这些厂商无法逾越的障碍.

关键词：多媒体处理器便携式开关电源供电低压降稳压器现代应用便携设备数码相机 LDO 成本低

How divalent cations Ca2+, Mg2+, and Zn2+ influence the aborption and photoluminiscence of Er3+/Yb3+ doped silicate glass

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How divalent cations Ca2+, Mg2+, and Zn2+ influence the abor...

Relevance of low viral load in haemodialysed patients with chronic hepatitis C virus infection

2005年国际玻璃讨论会暨国际玻璃协会年会

作者： Martin Mika ondrej Kolek Fratisek Lahodny Jarmila Spirkova Jiri Oswaldb Institute of Chemical Technology Technicka 5 Prague Czech Republik 166 28 phone: 420 22044 4102 Institute of Chemical Technology Technicka 5 Prague Czech Republik 166 28 phone: 420 22044 4102 Institute of Chemical Technology Technicka 5 Prague Czech Republik 166 28 phone: 420 22044 4102 Institute of Chemical Technology Technicka 5 Prague Czech Republik 166 28 phone: 420 22044 4102 Institute of Physics Academy of Sciences of the Czech Republic Prague

We melted sodium silicate glasses with different concentrations of Ca2+, Mg2+, and Zn2+ and co-doped them with Er3+ and Yb3+ ions. We studied the effect of these cations on our glass absorption and ph

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World Journal of Gastroenterology 2015年第18期21卷 5496-5504页

作者： Jan Sperl Sona Frankova Renata Senkerikova Magdalena Neroldova Vaclav Hejda Miroslava Volfova Dusan Merta ondrej Viklicky Julius Spicak Milan Jirsa Department of Hepatogastroenterology Institute for Clinical and Experimental Medicine Laboratory of Experimental Hepatology Institute for Clinical and Experimental Medicine Department of Internal Medicine Division of Gastroenterology and Hepatology Charles University Medical School and Teaching Hospital Hepato-gastroenterology 50012 Hradec Kralove Czech Republic Department of Anesthesiology Resuscitation and Intensive Care Institute for Clinical and Experimental Medicine Department of Nephrology Institute for Clinical and Experimental Medicine

AIM: To identify predictors of sustained virological response in hemodialysed patients treated by PEGinterferon α for chronic hepatitis C, genotype 1.METHODS: The sustained virological response(SVR) rate, IL28 B genotype, IFNL4 genotype, initial viral load(IVL) and other pretreatment variables in 39 endstage renal disease patients(ESRD) on maintenance haemodialysis(HD) infected with hepatitis C virus(HCV), genotype 1b, were compared with a control group of 109 patients with normal kidney function treated within the same period. All the patients were treatment nave and had well compensated liver disease. The ESRD patients received 135 μg of PEGylated interferon α-2a(Peg IFN-α) weekly and a reduced dose of ribavirin(RBV) was administered to 23/39 patients with an initial haemoglobin level > 10 g/d L. Control group patients were given standard doses of Peg IFN-α and RBV. SVR was assessed as HCV RNA negativity 24 wk post-treatment. A t-test or ANOVA were used for comparisons of the means and a χ2 testcompared the frequencies.Logistic regression was used to determine significant predictors of SVR.Cutoff values for continuous variables were obtained from Receiver Operating Characteristic analysis.RESULTS:The distribution of IL28B rs12979860 CC,CT and TT genotypes in the ESRD group was 28.2%,64.1%and 7.7%,respectively,and 19.3%,62.4%and18.3%in the controls.The IFNL4 genotype was in almost absolute linkage disequlibrium with IL28B.The proportion of patients with a low IVL(<600000 IU/m L)was significantly higher in the ESRD group than in the controls(28/39,71.8%vs 51/109,46.8%,P=0.009),as was the proportion of patients with low IVL in IL28B CC carriers compared with non-CC carriers in the ESRD group(10/11,90.9%vs 18/28,64.3%,P=0.0035).This difference was not found in the controls(7/22,31.8%vs 44/87,50.6%,P=0.9).The overall SVR rate was 64.1%(25/39)in the ESRD group and 50.5%(55/109)in the control group(P=0.19).11/11(100%)and 19/22(86.4%)IL28B CC patients achieved SVR in the ESRD and control groups,respectively.A statisti

关键词： End-stage renal disease Hepatitis C virus genotype 1 Interferon alpha IFNL4 Ribavirin

天然橡胶/丁苯橡胶硫化胶的热老化对稳态和动态磨耗性能的影响

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现代橡胶技术 2016年第5期42卷 27-33页

作者：韦匀 ondrej Kratina Radek Stocek

本文研究的目的是探讨不同配比天然橡胶(NR)/丁苯橡胶(SBR)并用胶的热老化对耐磨耗性能的影响。将硫化胶放在80℃的加热室内分别进行了4天和16天的热老化。分析了在稳态和动态条件下的磨耗性能。在采用两种方法进行的分析中,获得了定量... 详细信息

本文研究的目的是探讨不同配比天然橡胶(NR)/丁苯橡胶(SBR)并用胶的热老化对耐磨耗性能的影响。将硫化胶放在80℃的加热室内分别进行了4天和16天的热老化。分析了在稳态和动态条件下的磨耗性能。在采用两种方法进行的分析中,获得了定量参数"磨耗减量"。我们用实验说明了不同橡胶的配比和不同磨耗过程与热老化的关系。

关键词： NR/NBR硫化胶热老化稳态磨耗动态磨耗

Diode-pumped, electro-optically Q-switched, cryogenic Tm:YAG laser operating at 1.88 μm

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High Power Laser Science and Engineering 2021年第1期9卷 107-112页

作者： J?rg K?rner Venkatesan Jambunathan Fangxin Yue Jürgen Reiter ondrej Slezák Petr Navrátil Samuel Paul David Antonio Lucianetti Joachim Hein Tomá? Mocek Malte C.Kaluza HiLASE Centre Institute of Physics of the Czech Academy of Sciences Institute of Optics and Quantum Electronics Friedrich Schiller University Jena Helmholz Institute Jena Hi LASE Centre Institute of Physics of the Czech Academy of Sciences

We present a diode-pumped, electro-optically Q-switched Tm:YAG laser with a cryogenically cooled laser crystal at120 K. Output pulses of up to 2.55 mJ and 650 ns duration were demonstrated in an actively Q-switched configuration with a repetition rate of 1 Hz. By using cavity dumping the pulse duration was shortened to 18 ns with only a slightly lower output energy of 2.22 mJ. Furthermore, using a simplified rate equation model, we discuss design constraints on the pump fluence in a pulse pump approach for Tm:YAG to maximize the energy storage capability at a given pump power.

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铸铭之前的书写:论西周青铜器铭文制作使用的写本

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出土文献 2021年第3期 125-153,158页

作者：石安瑞王翔宇(译) 汉堡大学科罗拉多大学博尔德分校

近年来,战国秦汉简牍研究已成为热潮。相比之下,战国以前的写本由于出土材料的阙失,其使用情况不甚明朗。本文根据西周铜器铭文的布局特征及特殊现象,对铜器铭文制作过程中使用易腐材质制作的写本的痕迹进行了探讨,并对其物理性质及在... 详细信息

近年来,战国秦汉简牍研究已成为热潮。相比之下,战国以前的写本由于出土材料的阙失,其使用情况不甚明朗。本文根据西周铜器铭文的布局特征及特殊现象,对铜器铭文制作过程中使用易腐材质制作的写本的痕迹进行了探讨,并对其物理性质及在铭文制作过程中的具体作用进行了复原。基于分析,本文指出在铜器铭文制作过程中使用了两种不同的写本:一种是用于校对的“底本”,另一种是用于铭文实际制作的“蓝本”。制作一套同铭器时(包括不同器类的器物),工匠们会轮流使用同一份蓝本。不少铭文在起草过程中已对铭文字数、文字布局进行了细心设计。因此,每一篇铭文的释读工作应该从考察铭文的视觉特征入手。此外,本文为泥条堆塑法在铭文制作过程中的应用提供了明证,复原了西周晚期铜器铭文制作的全部流程。再者,本文还涉及西周时期铜器作坊中工匠的读写能力、劳动分工以及西周时期青铜铭刻的展示功能等问题。

关键词：青铜器铭文写本底本蓝本泥条堆塑法

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捷克阿莫斯小学

现代装饰 2020年第4期 60-69页

作者： ondrej Pihrt Tefan sulek ondrej Laciga BoysPlayNice(摄影) 舒禹方钰丹 Irena Vojtova Pavel Smetak Tereza Brezovska 无不详 SOA Architekt

这座新建的小学完善了郊区村庄的空间发展,并以其独特的外形展现出了新的视觉形象。教室以群组方式布置,并按照被动能源标准设计,打造了一个高质量的公共空间,同时为当地提供了一个社区中心。

关键词：幼儿园

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捷克MY DVA家具展厅

现代装饰 2017年第6期 70-75页

作者： ondrej Chybik Michal Krstof Victor Cojocaru Martin Holy Vojtech Kouril Sarka Kubinova ondrej Mundl Mateij Strba Lukas Pelech 范嘉苑捷克共和国OHYBIK+KRSTOF Architects & Urben Designers

来自布尔诺的年轻建筑公司CHYBIK＋KRISTOF Architects＆Urban Designers近日为MYDVA集团完成了一项改造项目，该集团聚焦于生产办公、学校及金属家具，最近希望将居民区外围的一间汽车展示厅改造成其团队的办公室及家具展示厅。原先的... 详细信息

来自布尔诺的年轻建筑公司CHYBIK＋KRISTOF Architects＆Urban Designers近日为MYDVA集团完成了一项改造项目，该集团聚焦于生产办公、学校及金属家具，最近希望将居民区外围的一间汽车展示厅改造成其团队的办公室及家具展示厅。原先的单层建筑并不美观，如今被翻新成了一座立面由900多把黑色塑料椅构成的全新建筑，改造后的立面抽象且醒目，同时也传递出了这家家具公司的宣传信息。空间内部也经过了翻新，呈现出简洁明了的布局，灵活的展厅能根据不同主题的设定来展示其产品。

关键词：金属家具展厅 DVA MY 捷克改造项目建筑公司单层建筑