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Synapsin Polymorphisms Could Be Correlated with Stroop Simple Reaction Time Scores

American Journal of Molecular Biology 2016年第1期6卷 25-32页

作者： Ahmet Buber Burge Kabukcu Basay Omer Basay onder Ozturk Huseyin Alacam Kemal Utku Yazici Ali Bacanli Mustafa Ertan Ay Mehmet Emin Erdal Hasan Herken Eyup Sabri Ercan Child and Adolescent Psychiatry Department Pamukkale University Medical Faculty Denizli Turkey Psychiatry Department Pamukkale University Medical Faculty Denizli Turkey Child and Adolescent Psychiatry Department Firat University Medical Faculty Elazig Turkey Child and Adolescent Psychiatry Department Gaziantep Children Hospital Gaziantep Turkey Medical Biology and Genetics Department Mersin University Medical Faculty Mersin Turkey Child and Adolescent Psychiatry Department Ege University Medical Faculty Izmir Turkey

Objective: The aim of this study was to research the relationship between Attention Deficit Hyperactivity Disorder (ADHD) and the synapsin III -196G>A and -631C>G polymorphisms and study their impact on neurocognition and behavior in Turkish children and adolescents. Methods: A total of 201 ADHD-diagnosed children and 100 control subjects aged between 8 and 15 years were recruited, and genetic material was obtained from saliva. In the diagnostic assessments, the KSADS- PL semi-structured interview was applied. Children with any comorbid psychiatric diagnosis (with the exclusion of oppositional defiant disorder (ODD)), medical conditions, prior psychotropic drug use history or IQ score below 80 were excluded. For the behavioral and ADHD symptom assessments, the Turgay DSM-IV Disruptive Behaviors Rating Scale, Teacher Report Form (TRF) and Child Behavior Checklist (CBCL) were completed by the parents and teachers. Neurocognitive profiles were evaluated with the CNS-Vital Signs computerized neurocognitive test battery. Results: No significant difference in ADHD prevalence was observed between subjects with the synapsin III gene -196G>A polymorphism and -631C>G polymorphisms. These polymorphisms were also not associated with subtypes of ADHD. We found a relationship between both polymorphisms and Stroop simple reaction time. Conclusion: Synapsin’s effect could be limited during childhood, but synapsin polymorphisms could be associated with Stroop simple reaction time.

关键词： Attention Deficit Hyperactivity Disorder Synapsin III Association Cognitive Function

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床垫支撑对仰卧人体腰骶椎矢状面形态的影响

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林业工程学报 2024年

作者：徐英娜黄嘉奇朱倩倩余肖红 onder Tor 张继雷翁妙华周永鑫胡玲玲浙江农林大学化学与材料工程学院喜临门家具股份有限公司卡斯塔莫努大学森林工程系密西西比州立大学可持续生物质产品系浙江绿城心血管病医院放射科

床垫材料对人体腰臀部的支撑是影响睡眠健康的关键因素。研究了床垫软硬度和腰臀区域床垫填充材料对不同臀围人群仰卧时腰骶椎矢状面形态的影响。首先对36名实验对象进行了身体尺寸和站姿腰骶椎脊柱点位距离测量。其次,使用自主研发的... 详细信息

床垫材料对人体腰臀部的支撑是影响睡眠健康的关键因素。研究了床垫软硬度和腰臀区域床垫填充材料对不同臀围人群仰卧时腰骶椎矢状面形态的影响。首先对36名实验对象进行了身体尺寸和站姿腰骶椎脊柱点位距离测量。其次,使用自主研发的卧姿腰骶椎矢状面形态测量装置,测试分析了3类实验对象(臀围≤90cm、90 cm100 cm,n=12)分别仰卧于9款具有不同软硬度(软、中、硬)与不同腰臀区域床垫填充材料[无、多功能热塑性聚酯氨弹性体(MTPU)、乳胶]的实验床垫上时腰臀部(T12、L4、S5)的下陷量。结果表明:床垫软硬度和腰臀区域填充材料交互项对仰卧时人体腰臀部下陷量和腰臀间隙值均影响显著,当人体仰卧于“软-乳胶”床垫组合上时,臀部最凸点(S5)下陷量、腰臀间隙值最大,此时人体站-卧姿腰臀间隙值吻合度最高。臀围对仰卧时人体腰臀部下陷量和腰臀间隙值影响显著,其中,臀围越大,仰卧时腰臀部下陷量越大。不同臀围人群与床垫的匹配结果显示,3类人群与“软-乳胶”床垫组合适配性最高,且该床垫组合对中臀围人群腰骶椎的支撑效果最好,小臀围人群次之。

关键词：仰卧臀围腰臀部腰骶椎矢状面形态下陷量

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Behcet病患者血清白介素-18和肿瘤坏死因子水平升高

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世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 59-60页

作者： Oztas M.O. onder M. Gurer M.A. 张宪旗 Gazi Universitesi Tip Fakul tesi Dermatoloji Anabilim Dali 11 .kat 06510 Besevler Ankara Turkey

Inflammation in Behcet’s disease is thought to be mediated by cytokines deriv ed from T-helper type 1 (Th1) lymphocytes. In this study, we tried to determine serum interleukin (IL)18 and tumour necrosis factor (TNF)-|álevels of patient s with Behcet’s disease. Twenty-seven patients with active Behcet’s disease, and 20 healthy control subjects were included in this study. Differences between mean serum IL-18 and TNF-|álevel of patients with Behcet’s disease were sig nificantly increased when compared with the control group. A significant correla tion was found between serum IL-18 and TNF-|álevels of Behcet patients (rs = 0.627, P < 0.0 001). IL-18 and TNF-|á.levels may be related to disease pathog enesis. Increased levels of IL-18 also support Th1 predominance in Behcet’s di sease.

关键词：肿瘤坏死因子 Behcet病血清白介素细胞因子介导

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老年人中的药物治疗错误:因素与展望

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中国药物警戒 2011年第1期8卷 62-64页

作者：王嘉怡孙佩男复旦大学附属华山医院上海200040

联合国在1999年提议,所有国家都应为他们近期和未来的人口老龄化作好医疗保健、社会和经济保障体系的准备。在全球,无论是发达国家还是发展中国家,老龄人口均迅速增加。

关键词：药物治疗临床药学临床药理学有效性显式法药物学老年人处方集

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The predictors of long-COVID in the cohort of Turkish Thoracic Society-TURCOVID multicenter registry:One year follow-up results

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Asian Pacific Journal of Tropical Medicine 2022年第9期15卷 400-409页

作者： Serap Argun Baris Oya Baydar Toprak Pelin Duru Cetinkaya Fusun Fakili Nurdan Kokturk Seval Kul Ozgecan Kayalar Yildiz Tutuncu Emel Azak Mutlu Kuluozturk Pinar Aysert Yildiz Pelin Pinar Deniz Oguz Kilinc Ilknur Basyigit Hasim Boyaci Ismail Hanta Neslihan Kose Gulseren Sagcan Caglar Cuhadaroglu Hacer Kuzu Okur Hasan Selcuk Ozger Begum Ergan Mehtap Hafizoglu Abdullah Sayiner Esra Nurlu Temel onder Ozturk Tansu Ulukavak Ciftci Ipek Kivilcim Oguzulgen Vildan Avkan Oguz Firat Bayraktar Ozlem Ataoglu Merve Ercelik Pinar Yildiz Gulhan Aysegul Tomruk Erdem Muge Meltem Tor Oya Itil Hasan Bayram Department of Pulmonary Medicine Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonary Medicine Faculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine University of Health SciencesAdana City Training and Research HospitalAdanaTurkey Department of Pulmonary Medicine Faculty of MedicineGaziantep UniversityGaziantepTurkey Department of Pulmonary Medicine Faculty of MedicineGazi UniversityAnkaraTurkey Department of Biostatistics Faculty of MedicineGaziantep UniversityGaziantepTurkey Koc University Research Center for Translational Medicine(KUTTAM) Koc University School of MedicineIstanbulTurkey Department of Immunology Koc University Research Center for Translational Medicine(KUTTAM)Koc University School of MedicineIstanbulTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineKocaeli UniversityKocaeli Turkey Department of Pulmonary Medicine Faculty of MedicineFirat UniversityElazigTurkey Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineGazi UniversityAnkaraTurkey Department of Pulmonary Medicine Faculty of MedicineDokuz Eylul UniversityIzmirTurkey Department of Pulmonary Medicine Bilecik Training and Research HospitalBilecikTurkey Department of Pulmonary Medicine Altunizade Acibadem HospitalIstanbulTurkey Department of Pulmonary Medicine Faculty of MedicineEge UniversityIzmirTurkey Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey Department of Pulmonary Medicine Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineDokuz Eylul UniversityIzmirTurkey Department of Internal Medicine Faculty of MedicineDokuz Eylul UniversityIzmirTurkey Department of Pulmonary Medicine Faculty of MedicineDuzce UniversityDuzceTurkey Department of Pulmonary Medicine Faculty of MedicineZonguldak Bulent Ecevit UniversityZongu

Objective:To evaluate long-term effects of COVID-19,and to determine the risk factors in long-COVID in a cohort of the Turkish Thoracic Society(TTS)-TURCOVID multicenter ***:Thirteen centers participated with 831 patients;504 patients were enrolled after *** study was designed in three-steps:(1)Phone questionnaire;(2)retrospective evaluation of the medical records;(3)face-to-face ***:In the first step,93.5%of the patients were hospitalized;61.7%had a history of pneumonia at the time of diagnosis.A total of 27.1%reported clinical symptoms at the end of the first ***(17.00%),fatigue(6.30%),and weakness(5.00%)were the most prevalent long-term *** incidence of long-term symptoms was increased by 2.91 fold(95%CI 1.04-8.13,P=0.041)in the presence of chronic obstructive pulmonary disease and by 1.84 fold(95%CI 1.10-3.10,P=0.021)in the presence of pneumonia at initial diagnosis,3.92 fold(95%CI 2.29-6.72,P=0.001)of dyspnea and 1.69 fold(95%CI 1.02-2.80,P=0.040)fatigue persists in the early-post-treatment period and 2.88 fold(95%CI 1.52-5.46,P=0.001)in the presence of emergency service admission in the post COVID *** step 2,retrospective analysis of 231 patients revealed that 1.4%of the chest X-rays had not significantly improved at the end of the first year,while computed tomography(CT)scan detected fibrosis in 3.4%.In step 3,138(27.4%)patients admitted to face-to-face visit at the end of first year;at least one symptom persisted in 49.27%*** most common symptoms were dyspnea(27.60%),psychiatric symptoms(18.10%),and fatigue(17.40%).Thorax CT revealed fibrosis in 2.4%***:COVID-19 symptoms can last for extended lengths of time,and severity of the disease as well as the presence of comorbidities might contribute to increased ***-term clinical issues should be regularly evaluated after COVID-19.

关键词： Long COVID-19 Dyspnea Fatigue Comorbidity

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Post-discharge mortality in the first wave of COVID-19 in Turkey

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Asian Pacific Journal of Tropical Medicine 2022年第11期15卷 479-484页

作者： Fusun Fakili Pelin Duru Cetinkaya Oya Baydar Serap Argun Baris Nurdan Kokturk Seval Kul Oguz Karcioglu Pinar Aysert Yildiz Ilim Irmak Yonca Sekibag Emel Azak Sait Mulamahmutoglu Caglar Cuhadaroglu Bugra Kerget Burcu Baran Ketencioglu Hasan Selcuk Ozger Gulcihan Ozkan Zeynep Ture Merve Ercelik Tansu Ulukavak Ciftci Ozlem Alici Esra Nurlu Temel Ozlem Ataoglu Neslihan Kose Muge Meltem Tor Gulsah Gunluoglu Sedat Altin onder Ozturk Pinar Yildiz Gulhan Ilknur Basyigit Hasim Boyaci I Kivilcim Oguzulgen Sermin Borekci Bilun Gemicioglu Ismail Hanta Hacer Kuzu Okur Gulseren Sagcan Metin Akgun Ali Fuat Kalyoncu Oya Itil Hasan Bayram Department of Pulmonary Medicine Faculty of MedicineGaziantep UniversityGaziantepTurkey Department of Pulmonary Medicine University of Health SciencesAdana City Training and Research HospitalFaculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine Faculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonary Medicine Faculty of MedicineGazi UniversityAnkaraTurkey Department of Biostatistics Faculty of MedicineGaziantep UniversityGaziantepTurkey Department of Pulmonary Medicine Halil Sivgin Cubuk State HospitalAnkaraTurkey Department of Infectious Disease Faculty of MedicineGazi UniversityAnkaraTurkey Department of Pulmonary Medicine Faculty of MedicineHacettepe UniversityAnkaraTurkey Department of Pulmonary Medicine Cerrahpasa Faculty of MedicineIstanbul University−CerrahpasaIstanbulTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonary Medicine Altunizade Acibadem HospitalIstanbulTurkey Department of Pulmonary Medicine Faculty of MedicineAtaturk UniversityErzurumTurkey Department of Pulmonary Medicine Faculty of MedicineErciyes UniversityKayseriTurkey Department of Pulmonary Medicine Maslak Acibadem HospitalIstanbulTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineErciyes UniversityKayseriTurkey Department of Pulmonary Medicine Faculty of MedicineDuzce UniversityDuzceTurkey Department of Infectious Disease Faculty of MedicineTurkiye Gazetesi Private HospitalIstanbulTurkey Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey Department of Pulmonary Medicine Bilecik Training and Research HospitalBilecikTurkey Department of Pulmonary Medicine Faculty of MedicineZonguldak Bulent Ecevit UniversityZonguldakTurkey Department of Pulmonary Medicine Universi

Objective:To determine post-discharge mortality and associated factors of the first-wave multicenter Turkish Thoracic Society(TTD)-TURCOVID ***:In this retrospective cohort study,we analyzed the data of 18 of 26 centers included in the first TTD-TURCOVID study,and 1112 cases diagnosed with COVID-19 between 11 March and 31 July 2020 participated in the *** causes of death after COVID-19 discharge were ***:The mean age of the patients was(51.07±16.93)years,with 57.6%male *** the cohort group,89.1%of COVID-19 treatment locations were hospital wards,3.6%were intensive care units(ICUs),and 7.2%were community *** the longterm follow-up,the in-hospital mortality rate was 3.6%(95%CI 2.6-4.8),the post-discharge mortality rate was 2.8%(95%CI 1.9-3.9),and the total mortality was 6.3%(95%CI 5.0-7.8).After discharge,63.3%of mortality overall occurred during the first six *** rates in post-discharge follow-ups were 12.7%(95%CI 8.0-30.6)in cancer patients,10.8%(95%CI 6.3-22.9)in chronic obstructive pulmonary disease patients,11.1%(95%CI 4.4-22.7)in heart failure patients,7.8(95%CI 3.8-14.3)in atherosclerotic heart disease patients,and 2.3%(95%CI 0.8-5.6)in diabetes mellitus *** smokers/ex-smokers,the all-mortality rates were higher than in ***:This multicenter study showed that patients over 65 years of age,males,former/active smoker,ICU stay,lung,heart disease,and malignancy should be followed up for at least the first six months after discharge due to COVID-19.

关键词： COVID-19 Post-discharge Mortality Comorbidity

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土耳其人Duane眼球后退综合征的临床特点及手术疗效分析（英文）

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国际眼科杂志 2019年第5期19卷 714-718页

作者： Osman Melih Ceylan Adem Turk Gken Gkce ?nder Ayyildiz Fatih Mehmet Mutlu Halil Ibrahim Altinsoy Diskapi Yildirim Beyazit 培训及研究医院眼科土耳其安卡拉06110 Karadeniz 工业大学医学院眼科土耳其特拉布宗61080 开塞利纪念医院眼科土耳其开塞利38010 Gülhane 培训及研究医院眼科土耳其06010 土耳其伊斯坦布尔世界眼科医院 34337

目的:分析Duane眼球后退综合征(DRS)患者的临床特点及手术疗效。方法:评估94例DRS患者临床数据。记录完整的眼科数据,包括年龄、性别、侧位、DRS类型、偏角、异常头部姿势(AHP)、眼球后退、过冲及手术入路类型。结果:患者年龄为15.4±9... 详细信息

目的:分析Duane眼球后退综合征(DRS)患者的临床特点及手术疗效。方法:评估94例DRS患者临床数据。记录完整的眼科数据,包括年龄、性别、侧位、DRS类型、偏角、异常头部姿势(AHP)、眼球后退、过冲及手术入路类型。结果:患者年龄为15.4±9.18岁,其中78例男性,16例女性。单侧和双侧受累分别为87%和13%。在单侧DRS患者中,左眼占65%。94例患者中,59.5%的患者为I型,29.7%的患者为II型,8.5%的患者为III型,2.1%的患者为IV型。大多数患者(36,38%)为嗜热性,43例(96%)患者术前AHP出现10°以上。有40例(43%)患者出现过度调校,通常为II型。对45例(48%)患者进行手术治疗。共32例(78%)行水平直肌手术后获得了较好疗效,24例(53%)患者AHP改善。结论:侧直肌的Y分裂和后榫固定在有明显过校的情况下都有令人满意的结果。垂直直肌转位增强术在限制外展方面取得了最佳效果。

关键词： Duane眼球后退综合征斜视手术结果

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基于模拟的中心性肥胖等级对坐姿臀腿部体压分布的影响

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家具 2024年第6期45卷 20-24页

作者：林珈好葛海林 onder Tor 魏佳丽齐蔚胡玲玲浙江农林大学化学与材料工程学院杭州311300 圣奥科技股份有限公司杭州310000 卡斯塔莫努大学森林工程系卡斯塔莫努37100

中心性肥胖人群是指由于腹部脂肪的过量堆积引起诸多问题的一类人群。本研究通过使用不同重量等级的硅胶假肚子模拟腹部脂肪,表征不同程度的中心性肥胖,并测量分析了不同中心性肥胖等级人群在多种坐姿下臀腿部的压力分布。同时,对中心... 详细信息

中心性肥胖人群是指由于腹部脂肪的过量堆积引起诸多问题的一类人群。本研究通过使用不同重量等级的硅胶假肚子模拟腹部脂肪,表征不同程度的中心性肥胖,并测量分析了不同中心性肥胖等级人群在多种坐姿下臀腿部的压力分布。同时,对中心性肥胖体型人群的身体尺寸和坐姿体压分布进行了相关性分析,重点探讨了腰围、腰臀比、和腰围身高比与坐姿体压指标的相互关系。结果显示:腹部大小与臀腿部最大压力和最大压力梯度显著相关,整体上呈正相关,但并非是腹部越大压力越大的线性关系,与平均压力、座椅压力分布SPD%(Percentage of Seat Pressure Distribution)以及接触面积无显著相关。此外,腰围与体压指标的相关性相对较高,最大压力梯度与腰围之间存在较高的正相关性,腰围的增加伴随着最大压力梯度的上升。该研究所取得结果能够为中心性肥胖人群的坐姿建议和座椅研发提供科学依据。

关键词：中心性肥胖坐姿体压分布相关性分析

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