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Efficacy of methanol-water extract of Inula helenium root against oxidative DNA damage

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Journal of Traditional Chinese Medicine 2021年第2期41卷 293-300页

作者： onder Aybastıer Bursa Uludag University Faculty of Science and ArtsDepartment of ChemistryBursa 16059Turkey

OBJECTIVE:To investigate the efficacy of methanol-water extract of Inula helenium root against oxidative DNA ***:Antioxidant properties of methanol-water extract of Inula helenium root were revealed by 2,2'-azinobis(3-ethylbenzothiazoline-6-suphonic acid)di-ammonium salt(ABTS),Folin-Ciocalteu and high-performance liquid chromatography(HPLC)*** effect against oxidative DNA base damage was determined analyzing oxidative DNA base damage products by GC-MS/***:The methanol-water extract of Inula helenium root showed good antioxidant capacity[32.20 mg trolox equivalents(TE)/g dried weight(dw)by ABTS method,54.53 mg TE/g dw by chromium reducing antioxidant capacity method]and total phenolic content[29.83 mg gallic acid equivalent(GAE)/g dw].The chlorogenic acid,ferulic acid,rosmarinic acid and caffeic acid were determined in the extract by *** chlorogenic acid,ferulic acid and Inula helenium root extract were revealed to inhibit the oxidative DNA base damage by GC-MS/***:The studies showed a crucial decrease in the amount of the DNA base damage products when antioxidants were *** results showed that ferulic acid has better inhibition than chlorogenic acid for DNA *** methanol-water extract of Inula helenium root was determined to inhibit the oxidative DNA damage.

关键词： Inula DNA damage Antioxidants Phytochemicals Gas chromatography-mass spectrometry

BRAF mutation in colorectal carcinomas with signet ring cell component

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Cancer Biology & Medicine 2017年第3期14卷 287-292页

作者： Serap Yalcin onder Onguru Department of Molecular Biology and Genetic Ahi Evran UniversityKirsehir 40100Turkey Department of Pathology Gulhane School of MedicineHealth Sciences UniversityAnkara 06010Turkey

Objective:Signet ring cell carcinoma is a rare subtype of colorectal carcinoma(CRC)with an associated BRAFV600E *** investigated frequencies of BRAF mutation in 28 CRCs containing variable signet ring cell component and their relation with clinicopathologic ***:According to the presence of signet ring cell component,tumors were categorized into groups as follows:0%–9%,10%–24%,25%–49%,and>50%.Genomic DNA was isolated and analyzed for BRAF V600E gene mutation by polymerase chain reaction-restriction fragment length *** of 28 cases(39.3%)showed BRAFV600E mutation,which was also confirmed by Sanger *** elucidate the importance of existence of signet ring cell component at the molecular level,we separated cases into two groups with cut-off levels of 10%and 50%,which pertain to percentages of signet ring ***:Seven of 19 cases(36.8%)under the threshold of 50%and four of nine cases(44.4%)over this threshold value demonstrated BRAF *** of 7 cases(42.8%)featuring10%were BRAF ***:BRAF mutation must be closely associated with the presence of malignant signet ring cells regardless of their percentages.

关键词： BRAF mutations colon cancer signet ring cell

Enhanced catalytic activity of monodispersed AgPd alloy nanoparticles assembled on mesoporous graphitic carbon nitride for the hydrolytic dehydrogenation of ammonia borane under sunlight

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Nano Research 2017年第5期10卷 1627-1640页

作者： Hamza Kahri Melike Sevim onder Metin Department of Chemistry Faculty of Science Ataturk University 25240 Erzurum Turkey Laboratoire de Synthese Organique Asymetrique et Catalyse Homogene (UR11ES56) Faculte des Sciences de Monastir Universite de Monastir Bd. de I'Environnement 5019 Monastir Tunisia East Anatolian High Technology Research and Application Center (DAYTAM) Ataturk University 25240 Erzurum Turkey

We address the composition-controlled synthesis of monodispersed AgPd alloy nanoparticles （NPs）, their assembly for the first time on mesoporous graphitic carbon nitride （mpg-C3N4）, and the unprecedented catalysis of mpg-CgN4@AgPd in the hydrolytic dehydrogenation of ammonia borane （AB） at room temperature. Monodispersed AgPd alloy NPs were synthesized using a high-temperature organic-phase surfactant-assisted protocol comprising the co-reduction of silver（I） acetate and palladium（II） acetylacetonate in the presence of oleylamine, oleic acid, and 1-0ctadecene. This protocol allowed the synthesis of four different compositions of AgPd alloy NPs. The AgPd alloy NPs were then assembled on mpg-C3N4, reduced graphene oxide, and Ketjenblack using a liquid-phase self-assembly method. Among the three supports tested, the mpg-CBN4@AgPd catalysts provided the best activity because of the Mott-Schottky effect, which was driven by the favorable work function difference between mpg-CBN4 and the metal NPs. Moreover, the activity of the mpg-CBN4@AgPd catalyst was further enhanced by an acetic acid treatment （AAt）, and a record initial turnover frequency of 94.1 mOl（hydrogen）＇mOl（catalyst）-l-min-1 was obtained. Furthermore, the mpg-CBN4@Ag42Pdss-AAt catalyst also showed moderate durability for the hydrolysis of AB. This study also includes a wealth of kinetic data for the mpg-CBN4@AgPd-catalyzed hydrolysis of AB.

关键词： silver palladium alloy nanoparticles graphitic carbon nitride ammonia borane dehydrogenation

Real-Time Indoor Path Planning Using Object Detection for Autonomous Flying Robots

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Intelligent Automation & Soft Computing 2023年第6期36卷 3355-3370页

作者： onder Alparslan Omer Cetin National Defence University Hezârfen Aeronautics and Space Technologies InstituteIstanbul34039Turkiye

Unknown closed spaces are a big challenge for the navigation of robots since there are no global and pre-defined positioning options in the *** of the simplest and most efficient algorithms,the artificial potential field algorithm(APF),may provide real-time navigation in those places but fall into local mini-mum in some *** overcome this problem and to present alternative escape routes for a robot,possible crossing points in buildings may be detected by using object detection and included in the path planning *** study utilized a proposed sensor fusion method and an improved object classification method for detecting windows,doors,and stairs in buildings and these objects were classified as valid or invalid for the path planning *** performance of the approach was evaluated in a simulated environment with a quadrotor that was equipped with camera and laser imaging detection and ranging(LIDAR)sensors to navigate through an unknown closed space and reach a desired goal *** of crossing points allows the robot to escape from areas where it is *** navigation of the robot has been tested in different scenarios based on the proposed path planning algorithm and compared with other improved APF *** results showed that the improved APF methods and the methods rein-forced with other path planning algorithms were similar in performance with the proposed method for the same goals in the same *** the goals outside the current room,traditional APF methods were quite unsuccessful in reaching the *** though improved methods were able to reach some outside targets,the proposed method gave approximately 17%better results than the most success-ful example in achieving targets outside the current *** proposed method can also work in real-time to discover a building and navigate between rooms.

关键词： Aircraft navigation computer vision object detection path planning sensor fusion

Discriminating performance of macular ganglion cellinner plexiform layer thicknesses at different stages of glaucoma

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 464-471页

作者： Melih Ustaoglu Nilgun Solmaz Feyza onder Glaucoma Research Center Wills Eye Hospital Ophthalmology Clinic Sisli Hamidiye Etfal Training and Research Hospital Ophthalmology Clinic Haseki Training and Research Hospital

AIM: To determine the discriminating performance of the macular ganglion cell-inner plexiform layer(GCIPL) parameters between all the consecutive stages of glaucoma(from healthy to moderate-to-severe glaucoma), and to compare it with the discriminating performances of the peripapillary retinal nerve fiber layer(RNFL) parameters and optic nerve head(ONH) ***: Totally 147 eyes(40 healthy, 40 glaucoma suspects, 40 early glaucoma, and 27 moderate-to-severe glaucoma) of 133 subjects were included. Optical coherence tomography(OCT) was obtained using Cirrus HD-OCT 5000. The diagnostic performances of GC-IPL, RNFL, and ONH parameters were evaluated by determining the area under the curve(AUC) of the receiver operating characteristics. RESULTS: All GC-IPL parameters discriminated glaucoma suspect patients from subjects with healthy eyes and moderate-to-severe glaucoma from early glaucoma patients(P<0.017, for all). Also, minimum, inferotemporal and inferonasal GC-IPL parameters discriminated early glaucoma patients from glaucoma suspects, whereas no RNFL or ONH parameter could discriminate between the two. The best parameters to discriminate glaucoma suspects from subjects with healthy eyes were superonasal GC-IPL, superior RNFL and average c/d ratio(AUC=0.746, 0.810 and 0.746, respectively). Discriminating performances of all the parameters for early glaucoma vs glaucoma suspect comparison were lower than that of the other consecutive group comparisons, with the bestGC-IPL parameters being minimum and inferotemporal(AUC=0.669 and 0.662, respectively). Moreover, minimum GC-IPL, average RNFL, and rim area(AUC=0.900, 0.858, 0.768, respectively) were the best parameters for discriminating moderate-to-severe glaucoma patients from early glaucoma ***: GC-IPL parameters can discriminate glaucoma suspect patients from subjects with healthy eyes, and also all the consecutive stages of glaucoma from each other(from glaucoma suspect to moderate-tosevere

关键词： retinal nerve fiber layer optic nerve head cirrus HD-OCT ganglion cell-inner plexiform layer glaucoma suspect

A study on compatibility of experimental effective atomic numbers with those predicted by ZXCOM

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Nuclear Science and Techniques 2017年第5期28卷 35-42页

作者： onder Eyecioglu A. M. El-Khayatt Yasar Karabul Orhan Icelli Department of Computer Engineering Engineering and Architecture Faculty Nisantasi University Istanbul Turkey Physics Department College of Science Al Imam Mohammad Ibn Saud Islamic University (IMSIU) RiyadhSaudi Arabia Reactor Physics Department Nuclear Research CentreAtomic Energy Authority Cairo 13759 Egypt Department of Physics Science and Art Faculty Y1ld1z Technical University Istanbul Turkey

In this study, effective atomic numbers(Zeff) of materials determined at different experimental conditions by measuring the elastic-to-inelastic γ-ray scattering ratios are compared to ZXCOM predictions. It also presents the experimental data obtained via the transmission technique The agreement and disagreement between ZXCOM and experimental values are investigated. The theoretical basics of determining Zeffby scattering mode are outlined. The study shows that choosing appropriate experimental conditions can provide a good compatibility between the experimental results and theoretical ZXCOM

关键词： Effective atomic number ZXCOM Rayleigh scattering Compton scattering

THREE COOLING SEASONS MONITORING OF ENERGETIC PERFORMANCE ANALYSIS OF AN EAHE(EARTH TO AIR HEAT EXCHANGER)ASSISTED SOLAR GREENHOUSE BUILDING

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Journal of Green Building 2013年第2期8卷 153-161页

作者： onder Ozgener Leyla Ozgener Solar Energy Institute Ege UniversityBornovaIzmirTurkey.Currently as a visiting Associate Professor in Cornell Energy InstituteCornell University2102A Snee Hall14853 IthacaNew YorkUSA. Department of Mechanical Engineering Faculty of Engineering Celal Bayar University MuradiyeManisaTurkey. Cornell Energy Institute Cornell University2102A Snee Hall14853 IthacaNew YorkUSA

In the summer of 2009,the project entitled Utilization of Earth to Air Heat Exchangers for Solar Greenhouses pre Heating and Performance Analysis(UEAHESGHPA)in the Ege University Project No:09GEE003 was *** solar greenhouse building is expected to have an annual cooling load of *** decreasing the energy consumption rate of the system the authors suggest a hybrid system,incorporating a solar photovoltaic cell system(PV)assisted Earth-to-Air Heat Exchanger,which was developed in *** principal idea is to use the PVs to meet the electricity expenses of the fan during summer cooling seasons when the required summer peak load cooling can be generated very efficiently and *** first three cooling seasons were monitored;the results of which were then presented.(See Appendix 1 for nomenclature.)

关键词： energy efficiency monitoring

Analytical solutions of simplified modified Camassa-Holm equation with conformable and M-truncated derivatives:A comparative study

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Journal of Ocean Engineering and Science 2024年第3期9卷 240-250页

作者： Ismail onder Melih Cinar Aydin Secer Mustafa Bayram Department of Mathematical Engineering Yildiz Technical UniversityIstanbulTurkey Graduate School of Natural and Aplied Sciences Yildiz Technical UniversityIstanbulTurkey Department of Computer Engineering Biruni UniversityIstanbulTurkey

This paper extracts some analytical solutions of simplified modified Camassa-Holm(SMCH)equations with various derivative operators,namely conformable and M-truncated derivatives that have been recently *** SMCH equation is used to model the unidirectional propagation of shallowwater *** extended rational sine−cosine and sinh−cosh techniques have been successfully implemented to the considered equations and some kinds of the solitons such as kink and singular have been *** have checked that all obtained solutions satisfy the main equations by using a computer algebraic ***,some 2D and 3D graphical illustrations of the obtained solutions have been *** effect of the parameters in the solutions on the wave propagation has been examined and all figures have been *** derived solutions may contribute to comprehending wave propagation in shallow ***,the solutions might help further studies in the development of autonomous ships/underwater vehicles and coastal zone management,which are critical topics in the ocean and coastal engineering.

关键词： Modified Camassa-Holm equation Conformable derivative M-truncated derivative Extended rational sine−cosine technique Extended rational sinh−cosh technique Exact solutions

Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus

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World Journal of Gastroenterology 2008年第29期14卷 4697-4700页

作者： Gokhan Okan Serpil Yaylaci onder Peker Sabahattin Kaymakoglu Murat Saruc Dermatology Department Acibadem Bakirkoy HospitalIstanbul 34140 Turkey mergency Department Acibadem Bakirkoy HospitalIstanbul 34140 Turkey Pathology Department Acibadem HospitalBakirkoy 34140 Turkey Division of Gastroenterohepatology Istanbul University Istanbul Medical FacultyIstanbul 34140 Turkey Gastroenterohepatology Department Acibadem Bakirkoy HospitalIstanbul 34140 Turkey

Stevens-Johnson syndrome (SJS) is a serious and potentially life-threatening disease. Vanishing bile duct syndrome (VBDS) is a rare cause of progressive cholestasis. Both syndromes are mostly related with drugs. We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature. It is the fi rst case of ciprofloxacin-induced VBDS successfully treated with tacrolimus. This case reminds physicians of the importance of drug reactions, their severity, techniques for diagnosis and methods of management.

关键词： Stevens-Johnson syndrome Vanishing bileduct syndrome Ciprofloxacin Tacrolimus