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中国非儿童癌症患者脓毒血症流行情况及地域分布:一项全国横断面研究

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Science Bulletin 2024年第11期69卷 1637-1641页

作者：陆斌胥洋李娜周月阳马旭东陈燕董润周翔代敏陈宏达翁利杜斌中国国家重症医学质控中心和中国重症医学临床试验组 Center for Prevention and Early Intervention National Infrastructures for Translational MedicineInstitute of Clinical MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Cancer Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pharmacy Administration and Clinical Pharmacy School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China Department of Medical Epidemiology and Biostatistics Karolinska InstitutetStockholm 17177Sweden Department of Medical Administration National Health Commission of the People’s Republic of ChinaBeijing 100044China Medical Intensive Care Unit State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Intensive Care Unit State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China 不详

Cancer poses a major public health burden worldwide,with approximately 18,094,716 newly diagnosed cases and 9,894,402 cancer-related deaths in 2020[1].Infections such as sepsis are among the leading causes of death in... 详细信息

关键词：脓毒血症横断面研究 death 地域分布

Ocular Trauma in a Rural Population of North China:The Handan Eye study

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Biomedical and Environmental Sciences 2015年第7期28卷 495-501页

作者： ZHOU Jun WANG Feng Hua LU Hai LIANG Yuan Bo WANG Ning Li the Handan Eye study group Beijing Tongren Eye Center Capital Medical University Handan Eye Hospital School of Optometry and Ophthalmology Eye Hospital Wenzhou Medical University

Objective To determine the prevalence of ocular trauma and the proportion of blindness and visua impairment due to trauma in a rural population in northern China. Methods The Handan Eye study is a population-based cross-sectional study that surveyed 6830 Chinese people aged 30＋ years from 13 randomly selected villages in Yongnian County, city of Handan, Hebei Province, in July, 2006. All participants underwent a standardized interview and extensive examinations. A structured questionnaire was used to collect information on ocular trauma. Results Of the 5837 participants who filled out the questionnaire, 124 subjects [2.1%; 95% confidence interval （CI）, 1.8%-2.5%] reported a history of ocular trauma in either eye, including 19 （0.3%） persons reporting trauma in both eyes. Men were more likely to have an eye injury than women [odds ratio （OR）, 3.3; 2.2-4.9]. In multiple logistic regression models, ocular trauma was significantly more frequent among normotensive participants when compared with hypertensive participants （hypertensive vs. normotensive＂ OR, 0.6; 0.4-0.9） and among participants who had a history of falls （OR, 2.4; 1.2-4.8）. The proportion of unilateral visual impairment and unilateral blindness due to trauma were 10.5% （13 subjects） and 21.0% （26 subjects）, respectively. Conclusion Our study reports the prevalence of severe ocular trauma among adults in rural China, revealing a high proportion of blindness and visual impairment due to trauma. These findings suggest the need for educational strategies to increase eye health awareness in this rural population with focus on providing at least appropriate first aid care to reduce blindness due to trauma.

关键词： Ocular trauma Population-based survey Prevalence Risk factor Handan Eye study

Focus on host/organ unregulated response:a common cause of critical illness

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Chinese Medical Journal 2023年第1期136卷 108-110页

作者： Wei Huang Dawei Liu Hongmin Zhang Xin Ding Xiaoting Wang On behalf of the Critical Care Ultrasound study group(CCUSG) Department of Critical Care Medicine First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenFujian 361000China Department of Critical Care Medicine Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China 不详

To the Editor:Given the high rates of pre-diseases and various initiating causes,critical illnesses have become the most heterogeneous group in clinical practice,which multiplies treatment *** different types of injurious“hit,”this response to various acute critical conditions is relatively homogenous and may eventually progress to a critical illness.

关键词： critical acute diseases

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科技兴贸的内涵与关键技术研究报告

财经研究 1994年第6期20卷 3-14页

作者： ( The study group)

科技兴贸的内涵与关键技术研究报告上海财经大学《科技兴贸与关键技术研究》课题组。．ＡＳｔｕｄｙｏｆＣｏｎｎｏｔａｔｉｏｎｉｎＤｅｖｅｌｏｐｉｎｇＣｏｍｍｅｒｃｅｂｙＳｃｉｅｎｃｅａｎｄＴｅｃｈｎｏｌｏｇｙ￥（ＴｈｅＳｔ... 详细信息

科技兴贸的内涵与关键技术研究报告上海财经大学《科技兴贸与关键技术研究》课题组。．ＡＳｔｕｄｙｏｆＣｏｎｎｏｔａｔｉｏｎｉｎＤｅｖｅｌｏｐｉｎｇＣｏｍｍｅｒｃｅｂｙＳｃｉｅｎｃｅａｎｄＴｅｃｈｎｏｌｏｇｙ￥（ＴｈｅＳｔｕｄｙＧｒｏｕｐ）Ｉｎｔｈｅｓｙｓ...

关键词：科技兴贸第三产业技术进步上海

COVID-19-induced transaminitis and hyperbilirubinemia:Presentation and outcomes

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World Journal of Gastroenterology 2023年第7期29卷 1123-1130页

作者： Zeinab Nabil Ahmed Said Safinaz Adel El Habashy Samy Zaky ESCMID study group for Viral Hepatitis Department of Medical Microbiology and Immunology Faculty of Medicine(For Girls)Al-Azhar UniversityCairo 11754Nasr CityEgypt Department of Pediatrics Ain Shams UniversityCairo 11391AbbaseiaEgypt Department of Hepato-gastroenterology and Infectious Diseases Faculty of Medicine(For Girls)Al-Azhar UniversityCairo 11754Egypt 不详

The risk of liver injury in patients with coronavirus disease 2019(COVID-19)infection is quite ***,liver function test abnormalities are still detected in COVID-19 patients despite the development of antivirals and the availability of several types of *** editorial describes liver involvement during COVID-19 infection in patients with or without preexisting liver injury,such as chronic liver disease,to elucidate COVID-19-induced liver function abnormalities and their severity,pathophysiology,clinical manifestations,and clinical and laboratory *** also discuss the effect of vaccination against COVID-19 to better understand host factors,such as age,gender,and race,on the incidence and severity of liver dysfunction at initial presentation and during the ***,we summarize the results of relevant meta-analyses published to date and highlight the importance of adequate liver function monitoring in the current climate of the overwhelming COVID-19 pandemic.

关键词： COVID-19 SARS-CoV-2 Liver injury Transaminases Hyperbilirubinemia Pathophysiology

维普期刊数据库评论

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重现遗失的文明纽约Bathhouse浴场

室内设计与装修 2024年第4期 12-15页

作者： [美国]ROCKWELL group 麦子(编译) ROCKWELL group

Bathhouse浴场位于美国纽约曼哈顿,是一个面积达3252 m2的豪华水疗中心和浴室。这是Bathhouse在曼哈顿的首家分店,它时尚和现代设计为焦点,将当代最好的康复实践融入社交环境,为客人提供轻松高雅的体验。设计团队为该项目的设计提出了... 详细信息

Bathhouse浴场位于美国纽约曼哈顿,是一个面积达3252 m2的豪华水疗中心和浴室。这是Bathhouse在曼哈顿的首家分店,它时尚和现代设计为焦点,将当代最好的康复实践融入社交环境,为客人提供轻松高雅的体验。设计团队为该项目的设计提出了“英雄之旅”的概念,这是神话中常见的比喻,涉及英雄踏上史诗般的旅程,遇到挑战,最后在个人成长的冒险中涅槃。从接待区域到理疗室,设计师一直都在讲述这个故事,最终帮助客人走上“康复”之路。为实现这一点,设计团队通过戏剧性地光影效果,融合了包括石材、玻璃、混凝土、瓷砖和带有古铜色饰面的金属等材料,营造出柔和与忧郁的色调。

关键词：光影效果纽约曼哈顿个人成长理疗室设计团队

Challenges of further studies on gliomas

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Chinese Medical Journal 2012年第24期125卷 4325-4327页

作者： Tianjin Neuro-oncology study group Department of Neurosurgery Tianjin Medical University General Hospital Tianjin 300052 China

Gliomas, particularly glioblastomas （GBMs）, are the most common and highly aggressive primary braintumors with poor prognosi-s, in {he past decade, a great many advances have been made in the study on cellular and molecular basis of gliomas. Numerous publications have explored the cell of origin of gliomas, the molecular genetic and epigenetic aberration in gliomas, the molecular classification of GBM subtypes, the possible oncometabolites, the application of targeted therapy for malignant gliomas, etc. However, considering all these findings in recent years, it is clear that a picture of the changes in gliomas is more complex and that it should be characterized further to gain a comprehensive and in-depth understanding of gliomagenesis and for translational application of the new insights into clinical practice, especially in the following important aspects.

关键词： glioma epigenomics cell metabolism glioma stem cells management

New loci for refractive errors and ocular biometric parameters in young Chinese Han adults

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Science China(Life Sciences) 2022年第10期65卷 2050-2061页

作者： Yunyun Sun Zi-Bing Jin Shifei Wei Hongyan Jia Kai Cao Jianping Hu Caixia Lin Wenzai An Jiyuan Guo He LiJing Fu Shi-Ming Li Ningli Wang the Anyang University Students Eye study group the Anyang University Students Eye study group Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Sciences Key LaboratoryBejing 100730China Beijing Institute of Ophthalmology Bejing 100730China Anyang Eye Hospital Anyang 455000China 不详

Myopia has become a major public health issue with an increasing *** are still individuals who experience similar environmental risk factors and,yet,remain ***,there might be genetic factors protecting people from *** the opposite ocular characteristics of primary angle closure glaucoma(PACG)to myopia and possible common pathway between them,we propose that certain risk genes for PACG might act as a protective factor for *** this study,2,678 young adults were genotyped for 37 targeted single nucleotide *** with emmetropia,rs1401999(allele C:OR=0.795,P=0.03;genotype in dominant model:OR=0.759,P=0.02)and rs1258267(allele A:OR=0.824,P=0.03;genotype in dominant model:OR=0.603,P=0.01)were associated with low to moderate myopia and high myopia,*** under recessive model of rs11024102 was correlated with myopia(OR=1.456,P=0.01),low to moderate myopia(OR=1.443,P=0.02)and high myopia(OR=1.453,P=0.02).However,these associations did not survive Bonferroni ***,rs1401999,rs1258267,and rs11024102 showed associations with certain ocular biometric parameters in different *** study suggests that ABCC5,CHAT and PLEKHA7 might be associated with refractive errors by contributing to the regulation of ocular biometry,in terms of uncorrected results and their biological functions.

关键词： candidate gene myopia high myopia ocular biometry primary angle-closure glaucoma

Male genitourinary schistosomiasis-related symptoms among long-term Western African migrants in Spain: a prospective population-based screening study

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贫困所致传染病(英文) 2024年第2期13卷 1-10页

作者： Roure Sílvia Vallès Xavier Pérez-Quílez Olga López-Mu?oz Israel Chamorro Anna Abad Elena Valerio Lluís Soldevila Laura Espa?a Sergio Hegazy Alaa H. A. Fernández-Rivas Gema Gorriz Ester Herena Dolores Oliveira Mário Miralles Maria Carme Conde Carmen Montero-Alia Juan José Fernández-Pedregal Elia Miranda-Sánchez Jose Llibre Josep M. Isnard Mar Bonet Josep Maria Estrada Oriol Prat Núria Clotet Bonaventura The Schisto-Stop study group International Health Program (PROSICS) Barcelona North Metropolitan Territorial Directorate for Infectious Diseases Catalan Institute for Health CAP La Salut Passatge dels Encants S/N Badalona Spain Fundació Lluita contra les Infeccions c/Can Ruti s/n Badalona Spain Infectious Diseases Department Hospital Universitari Germans Trias i Pujol c/Can Ruti s/n Badalona Spain Germans Trias i Pujol Research Institute c/Can Ruti s/n Badalona Spain Microbiology Department Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Department of Genetics and Microbiology Universitat Autònoma de Barcelona c/Can Ruti s/n Badalona Spain Faculty of Medicine University of Asyut El Fateh Assiut Governorate Egypt Department of Urology Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Canovelles Primary Health Care Unit Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Indústria Canovelles Spain Primary Health Care Unit Mataró-(Rocafonda-Palau) Barcelona North Metropolitan Health Directorate Catalan Institute for Health Camí Ral el Ravalet Mataró Barcelona Spain Barcelona North Metropolitan Primary Care Directorate Catalan Institute for Health Ctra. de Barcelona Sabadell Barcelona Spain Directorate for Innovation and Interdisciplinary Cooperation Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Can Ruti S/N Badalona Spain IrsiCaixa-AIDS Research Institute Hospital Universitari Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Infectious Diseases Directorate Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Can Ruti S/N Badalona Spain

Background Schistosomiasis is highly endemic in sub-Saharan Africa and frequently imported to Europe. Male urogenital manifestations are often neglected. We aimed to ascertain the prevalence of genitourinary clinical signs and symptoms among long-term African migrants in a non-endemic European country using a serology *** We carried out a prospective, community-based cross-sectional study of adult male migrants from sub-Saharan Africa living in *** serology tests and microscopic urine examinations were carried out, and clinical data were obtained from an electronic medical record search and a structured *** We included 388 adult males, mean age 43.5 years [Standard Deviation (SD) = 12.0, range: 18–76]. The median time since migration to the European Union was 17 [Interquartile range (IQR): 11–21] years. The most frequent country of origin was Senegal (N = 179, 46.1%). Of the 338, 147 (37.6%) tested positive forSchistosoma. Parasite eggs were present in the urine of only 1.3%. Nine genitourinary clinical items were significantly associated with positiveSchistosoma serology results: pelvic pain (45.2%;OR = 1.57, 95%CI: 1.0–2.4), pain on ejaculation (14.5%;OR = 1.85, 95%CI: 1.0–3.5), dyspareunia (12.4%;OR = 2.45, 95%CI: 1.2–5.2), erectile dysfunction (9.5%;OR = 3.10, 95%CI: 1.3–7.6), self-reported episodes of infertility (32.1%;OR = 1.69, 95%CI: 1.0–2.8), haematuria (55.2%;OR = 2.37, 95%CI: 1.5–3.6), dysuria (52.1%;OR = 2.01, 95%CI: 1.3–3.1), undiagnosed syndromic STIs (5.4%), and orchitis (20.7%;OR = 1.81, 95%CI: 1.0–3.1). Clinical signs tended to *** Urogenital clinical signs and symptoms are prevalent among male African long-term migrants with a positiveSchistosoma serology results. Genital involvement can be frequent even among those with long periods of non-residence in their sub-Saharan African countries of origin. Further research is needed to develop diagnostic tools and validate therapeutic approaches to

关键词： Schistosomiasis Chronic schistosomiasis Urogenital schistosomiasis Male genital schistosomiasis Longterm migrant