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Association of physical activity with risk of chronic kidney disease in china:A population-based cohort study

Journal of Sport and Health Science 2024年第2期13卷 204-211页

作者： Kexiang Shi Yunqing Zhu Jun Lv Dianjianyi Sun Pei Pei Huaidong Du Yiping Chen Ling Yang Bing Han Rebecca Stevens Junshi Chen Zhengming Chen Liming Li Canqing Yu china kadoorie biobank collaborative group Department of Epidemiology&Biostatistics School of Public HealthPeking University Health Science CenterBeijing 100191China Peking University Center for Public Health and Epidemic Preparedness&Response Beijing 100191China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijing 100191China Clinical Trial Service Unit&Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK Medical Research Council Population Health Research Unit at the University of Oxford Oxford OX37LFUK NCDs Prevention and Control Department Henan Center for Disease Control and PreventionZhengzhou 450016China china National Center for Food Safety Risk Assessment Beijing 100022China 不详

Background:Information on the association between physical activity(PA)and the risk of chronic kidney disease(CKD)is *** aimed to explore the associations of total,domain-specific,and intensity-specific PA with CKD and its subtypes in ***:The study included 475,376 adults from the china kadoorie biobank aged 30-79 years during 2004-2008 at *** interviewer-administered questionnaire was used to collect the information about PA,which was quantified as metabolic equivalent of task hours per day(MET-h/day)and categorized into 4 groups based on *** regression was used to analyze the association between PA and CKD ***:During a median follow-up of 12.1 years,5415 incident CKD cases were documented,including 1159 incident diabetic kidney disease(DKD)cases and 362 incident hypertensive nephropathy(HTN)*** PA was inversely associated with CKD risk,with an adjusted hazard ratio(HR,95%confidence interval(95%CI))of 0.83(0.75-0.92)for incident CKD in the highest quartile of total PA as compared with participants in the lowest *** results were observed for risk of DKD and HTN,and the corresponding HRs(95%CIs)were 0.75(0.58-0.97)for DKD risk and 0.56(0.37-0.85)for HTN *** nonoccupational PA,low-intensity PA,and moderate-to-vigorous-intensity PA were significantly associated with a decreased risk of CKD,with HRs(95%CIs)of 0.80(0.73-0.88),0.85(0.77-0.94),and 0.85(0.76-0.95)in the highest quartile,***:PA,including nonoccupational PA,low-intensity PA,and moderate-to-vigorous-intensity PA,was inversely associated with the risk of CKD,including DKD,HTN,and other CKD,and such associations were dose dependent.

关键词： Chronic kidney disease Domain Intensity Physical activity

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Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese

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Stroke & Vascular Neurology 2024年第4期9卷 399-406,I0044-I0065页

作者： Songchun Yang Zhijia Sun Dong Sun Canqing Yu Yu Guo Dianjianyi Sun Yuanjie Pang Pei Pei Ling Yang Iona Y Millwood Robin G Walters Yiping Chen Huaidong Du Yan Lu Sushila Burgess Daniel Avery Robert Clarke Junshi Chen Zhengming Chen Liming Li Jun Lv on behalf of the china kadoorie biobank collaborative group Department of Epidemiology&Biostatistics School of Public HealthPeking UniversityBeijingChina Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunanChina Peking University Center for Public Health and Epidemic Preparedness&Response BeijingChina Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijingChina Fuwai Hospital Chinese Academy of Medical Sciences BeijingChina Medical Research Council Population Health Research Unit at the University of Oxford OxfordUK Clinical Trial Service Unit&Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxfordUK NCDs Prevention and Control Department Suzhou CDCSuzhouJiangsuChina china National Center for Food Safety Risk Assessment BeijingChina State Key Laboratory of Vascular Homeostasis and Remodeling Peking UniversityBeijingChina 不详

Background and purpose Previous studies,mostly focusing on the European population,have reported polygenic risk scores(PRSs)might achieve risk stratification of *** aimed to examine the association strengths of PRSs with risks of stroke and its subtypes in the Chinese *** Participants with genome-wide genotypic data in china kadoorie biobank were split into a potential training set(n=22191)and a population-based testing set(n=72150).Four previously developed PRSs were included,and new PRSs for stroke and its subtypes were *** PRSs showing the strongest association with risks of stroke or its subtypes in the training set were further evaluated in the testing *** proportional hazards regression models were used to estimate the association strengths of different PRSs with risks of stroke and its subtypes(ischaemic stroke(IS),intracerebral haemorrhage(ICH)and subarachnoid haemorrhage(SAH)).Results In the testing set,during 872919 person-years of follow-up,8514 incident stroke events were *** PRSs of any stroke(AS)and IS were both positively associated with risks of AS,IS and ICH(p<0.05).The HR for per SD increment(HR_(SD))of PRSAS was 1.10(95%CI 1.07 to 1.12),1.10(95%CI 1.07 to 1.12)and 1.13(95%CI 1.07 to 1.20)for AS,IS and ICH,*** corresponding HR_(SD) of PRS_(IS) was 1.08(95%CI 1.06 to 1.11),1.08(95%CI 1.06 to 1.11)and 1.09(95%CI 1.03 to 1.15).PRS_(ICH) was positively associated with the risk of ICH(HR_(SD)=1.07,95%CI 1.01 to 1.14).PRSS_(AH) was not associated with risks of stroke and its *** addition of current PRSs offered little to no improvement in stroke risk prediction and risk *** In this Chinese population,the association strengths of current PRSs with risks of stroke and its subtypes were moderate,suggesting a limited value for improving risk prediction over traditional risk factors in the context of current genome-wide association study under-representing the East Asia

关键词： testing prediction increment

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Development of a prediction model to identify undiagnosed chronic obstructive pulmonary disease patients in primary care settings in china

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Chinese Medical Journal 2023年第6期136卷 676-682页

作者： Buyu Zhang Dong Sun Hongtao Niu Fen Dong Jun Lyu Yu Guo Huaidong Du Yalin Chen Junshi Chen Weihua Cao Ting Yang Canqing Yu Zhengming Chen Liming Li on behalf of the china kadoorie biobank collaborative group Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina–Japan Friendship HospitalBeijing 100029China National Center for Respiratory Medicine and National Clinical Research Center for Respiratory Diseases Beijing 100029China Institute of Respiratory Medicine Chinese Academy of Medical SciencesBeijing 100007China Peking University Center for Public Health and Epidemic Preparedness and Response Beijing 100191China Key Laboratory of Molecular Cardiovascular Sciences(Peking University) Ministry of EducationBeijing 100191China National Center for Cardiovascular Diseases Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China Medical Research Council Population Health Research Unit at the University of Oxford Oxford OX37LFUK Clinical Trial Service Unit and Epidemiological Studies Unit Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK Maiji Center for Disease Control and Prevention TianshuiGansu 741020China china National Center for Food Safety Risk Assessment Beijing 100022China 不详

Background:At present,a large number of chronic obstructive pulmonary disease(COPD)patients are undiagnosed in ***,this study aimed to develop a simple prediction model as a screening tool to identify patients at risk for ***:The study was based on the data of 22,943 subjects aged 30 to 79 years and enrolled in the second resurvey of china kadoorie biobank during 2012 and 2013 in *** stepwisely selected the predictors using logistic regression *** we tested the model validity through P-P graph,area under the receiver operating characteristic curve(AUROC),ten-fold cross validation and an external validation in a sample of 3492 individuals from the Enjoying Breathing Program in ***:The final prediction model involved 14 independent variables,including age,sex,location(urban/rural),region,educational background,smoking status,smoking amount(pack-years),years of exposure to air pollution by cooking fuel,family history of COPD,history of tuberculosis,body mass index,shortness of breath,sputum and *** model showed an area under curve(AUC)of 0.72(95%confidence interval[CI]:0.72-0.73)for detecting undiagnosed COPD patients,with the cutoff of predicted probability of COPD=0.22,presenting a sensitivity of 70.13%and a specificity of 62.25%.The AUROC value for screening undiagnosed patients with clinically significant COPD was 0.68(95%CI:0.66-0.69).Moreover,the ten-fold cross validation reported an AUC of 0.72(95%CI:0.71-0.73),and the external validation presented an AUC of 0.69(95%CI:0.68-0.71).Conclusion:This prediction model can serve as a first-stage screening tool for undiagnosed COPD patients in primary care settings.

关键词： Chronic obstructive pulmonary disease Screening Prediction model china kadoorie biobank

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Multimorbidity patterns and association with mortality in 0.5 million Chinese adults

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Chinese Medical Journal 2022年第6期135卷 648-657页

作者： Junning Fan Zhijia Sun Canqing Yu Yu Guo Pei Pei Ling Yang Yiping Chen Huaidong Du Dianjianyi Sun Yuanjie Pang Jun Zhang Simon Gilbert Daniel Avery Junshi Chen Zhengming Chen Jun Lyu Liming Li on behalf of the china kadoorie biobank collaborative group Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Peking University Center for Public Health and Epidemic Preparedness and Response Peking UniversityBeijing 100191China National Clinical Research Center of Cardiovascular Diseases National Center for Cardiovascular DiseasesFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China china kadoorie biobank National Coordination Centre Chinese Academy of Medical SciencesBeijing 100730China Nuffield Department of Population Health Medical Research Council Population Health Research UnitUniversity of OxfordOxford OX37LFUnited Kingdom Nuffield Department of Population Health University of OxfordClinical Trial Service Unit and Epidemiological Studies Unit(CTSU)Oxford OX37LFUnited Kingdom Suzhou Center for Disease Control and Prevention SuzhouJiangsu 215004China china National Center for Food Safety Risk Assessment Beijing 100022China Key Laboratory of Molecular Cardiovascular Sciences Peking UniversityMinistry of EducationBeijing 100191China 不详

Background:Few studies have assessed the relationship between multimorbidity patterns and mortality risk in the Chinese *** aimed to identify multimorbidity patterns and examined the associations of multimorbidity patterns and the number of chronic diseases with the risk of mortality among Chinese middle-aged and older ***:We used data from the china kadoorie biobank and included 512,723 participants aged 30 to 79 *** was defined as the presence of two or more of the 15 chronic diseases collected by self-report or physical examination at *** patterns were identified using hierarchical cluster *** regression was used to estimate the associations of multimorbidity patterns and the number of chronic diseases with all-cause and cause-specific ***:Overall,15.8%of participants had *** prevalence of multimorbidity increased with age and was higher in urban than rural *** multimorbidity patterns were identified,including cardiometabolic multimorbidity(diabetes,coronary heart disease,stroke,and hypertension),respiratory multimorbidity(tuberculosis,asthma,and chronic obstructive pulmonary disease),gastrointestinal and hepatorenal multimorbidity(gallstone disease,chronic kidney disease,cirrhosis,peptic ulcer,and cancer),and mental and arthritis multimorbidity(neurasthenia,psychiatric disorder,and rheumatoid arthritis).During a median of 10.8 years of follow-up,49,371 deaths *** with participants without multimorbidity,cardiometabolic multimorbidity(hazard ratios[HR]=2.20,95%confidence intervals[CI]:2.14-2.26)and respiratory multimorbidity(HR=2.13,95%CI:1.97-2.31)demonstrated relatively higher risks of mortality,followed by gastrointestinal and hepatorenal multimorbidity(HR=1.33,95%CI:1.22-1.46).The mortality risk increased by 36%(HR=1.36,95%CI:1.35-1.37)with every additional ***:Cardiometabolic multimorbidity and respiratory multimorbidity

关键词： Multimorbidity Pattern Mortality Chinese

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Minimal improvement in coronary artery disease risk prediction in Chinese population using polygenic risk scores:evidence from the china kadoorie biobank

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Chinese Medical Journal 2023年第20期136卷 2476-2483页

作者： Songchun Yang Dong Sun Zhijia Sun Canqing Yu Yu Guo Jiahui Si Dianjianyi Sun Yuanjie Pang Pei Pei Ling Yang Iona YMillwood Robin GWalters Yiping Chen Huaidong Du Zengchang Pang Dan Schmidt Rebecca Stevens Robert Clarke Junshi Chen Zhengming Chen Jun Lv Liming Li on behalf of the china kadoorie biobank collaborative group Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Peking University Center for Public Health and Epidemic Preparedness&Response Beijing 100191China Fuwai Hospital Chinese Academy of Medical Sciences Beijing 100730China Medical Research Council Population Health Research Unit at the University of Oxford Oxford OX37LFUK Clinical Trial Service Unit and Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK Qingdao Center of Disease Control and Prevention QingdaoShandong 266033China china National Center for Food Safety Risk Assessment Beijing 100738China 不详

Background:Several studies have reported that polygenic risk scores(PRSs)can enhance risk prediction of coronary artery disease(CAD)in European ***,research on this topic is far from sufficient in non-European countries,including *** aimed to evaluate the potential of PRS for predicting CAD for primary prevention in the Chinese ***:Participants with genome-wide genotypic data from the china kadoorie biobank were divided into training(n=28,490)and testing sets(n=72,150).Ten previously developed PRSs were evaluated,and new ones were developed using clumping and thresholding or LDpred *** PRS showing the strongest association with CAD in the training set was selected to further evaluate its effects on improving the traditional CAD risk-prediction model in the testing *** risk was computed by summing the product of the weights and allele dosages across genome-wide single-nucleotide *** of the 10-year first CAD events was assessed using hazard ratios(HRs)and measures of model discrimination,calibration,and net reclassification improvement(NRI).Hard CAD(nonfatal I21-I23 and fatal I20-I25)and soft CAD(all fatal or nonfatal I20-I25)were analyzed ***:In the testing set,1214 hard and 7201 soft CAD cases were documented during a mean follow-up of 11.2 *** HR per standard deviation of the optimal PRS was 1.26(95%CI:1.19-1.33)for hard *** on a traditional CAD risk prediction model containing only non-laboratory-based information,the addition of PRS for hard CAD increased Harrell’s C index by 0.001(-0.001 to 0.003)in women and 0.003(0.001 to 0.005)in *** the different high-risk thresholds ranging from 1%to 10%,the highest categorical NRI was 3.2%(95%CI:0.4-6.0%)at a high-risk threshold of 10.0%in *** association of the PRS with soft CAD was much weaker than with hard CAD,leading to minimal or no improvement in the soft CAD ***:In this Chinese population sam

关键词： Coronary artery disease Polygenic risk score Risk prediction model Chinese population

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生命早期饥荒暴露与成年期体质指数的关联分析

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中华流行病学杂志 2016年第11期37卷 1450-1453页

作者：孟若谷司佳卉吕筠郭彧卞铮余灿清周汇燕谭云龙裴培陈君石陈铮鸣李立明北京大学公共卫生学院流行病与卫生统计学系 100191 中国医学科学院北京100730 国家食品安全风险评估中心北京100022 英国牛津大学临床试验与流行病学研究中心

目的研究生命早期饥荒暴露对成年期BMI的影响。方法研究对象来自中国慢性病前瞻性研究的基线调查，共94 052名研究对象纳入分析。将出生于1956年10月至1958年9月、1959年10月至1961年9月和1962年10月至1964年9月的研究对象分别划分为... 详细信息

目的研究生命早期饥荒暴露对成年期BMI的影响。方法研究对象来自中国慢性病前瞻性研究的基线调查，共94 052名研究对象纳入分析。将出生于1956年10月至1958年9月、1959年10月至1961年9月和1962年10月至1964年9月的研究对象分别划分为饥荒前出生组、饥荒期内出生组和饥荒后出生组（对照组）。采用线性回归模型计算饥荒暴露组成年期BMI的回归系数及其95%CI。采用似然比检验计算吸烟、饮酒和体力活动与饥荒暴露交互作用的P值。结果在调整了其他影响因素后，仅在女性中发现，与饥荒后出生组相比，饥荒期内出生组成年期BMI较高（β=0.12，95%CI：0.03-0.22）。吸烟、饮酒均对饥荒与BMI间的关联存在效应修饰作用（交互作用均P〈0.001），体力活动不存在（交互作用P=0.077）。结论生命早期经历饥荒，尤其是胎儿期经历饥荒的女性成年期BMI较高。因此，保证生命早期营养水平对预防成年后超重/肥胖的发生具有重要意义。

关键词：体质指数生命早期饥荒

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中国成年人气流受限与慢性病主要死亡风险的前瞻性研究

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中华流行病学杂志 2017年第1期38卷 13-19页

作者：兰丰铃李嘉琛余灿清郭彧卞铮谭云龙裴培陈君石陈铮呜曹卫华吕筠李立明无北京大学公共卫生学院流行病与卫生统计学系 100191 中国医学科学院北京100730 国家食品安全风险评估中心北京100022 牛津大学临床试验中心和流行病研究中心/纳菲尔德人群健康部 OX12JD 中国慢性病前瞻性研究项目协作组

目的探讨气流受限与慢性病总死亡和死因别死亡风险间的关联性。方法基于中国慢性病前瞻性研究项目，剔除基线自报患有心脏病、脑卒中和恶性肿瘤的个体，共纳入基线时项目地区30-79岁的男女性研究对象各199 099和287 895例。气流受限... 详细信息

目的探讨气流受限与慢性病总死亡和死因别死亡风险间的关联性。方法基于中国慢性病前瞻性研究项目，剔除基线自报患有心脏病、脑卒中和恶性肿瘤的个体，共纳入基线时项目地区30-79岁的男女性研究对象各199 099和287 895例。气流受限情况采用COPD全球倡议标准（GOLD）判断。使用Cox比例风险回归模型分析气流受限与死亡之间的关联。结果平均随访7.2年，累计随访3 494 079人年。21 649例在随访期间死亡。气流正常、GOLD-1-GOLD-4等级的全人群粗死亡率（/1 000人年）分别为5.5、9.9、13.1、32.4和63.3。调整可能的混杂因素后，与气流正常人群相比，GOLD-1-GOLD-4的HR值（95% CI）依次为0.98（0.88-1.09）、1.03（0.97-1.09）、1.62（1.53-1.73）和2.83（2.59-3.10）。气流受限等级上升，缺血性心脏病、脑血管病和COPD的死亡风险也上升。结论存在气流受限或气流受限程度越严重，个体发生死亡的风险越高。

关键词：肺疾病慢性阻塞性气流受限慢性病死亡

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Associations of muscle mass,strength,and quality with all-cause mortality in china:a population-based cohort study

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Chinese Medical Journal 2022年第11期135卷 1358-1368页

作者： Man Wu Yuxia Wei Jun Lv Yu Guo Pei Pei Jiachen Li Huaidong Du Ling Yang Yiping Chen Xiaohui Sun Hua Zhang Junshi Chen Zhengming Chen Canqing Yu Liming Li 无 Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Key Laboratory of Molecular Cardiovascular Sciences Ministry of EducationPeking UniversityBeijing 100191China Peking University Center for Public Health and Epidemic Preparedness&Responses Beijing 100191China National Coordinating Center of china kadoorie biobank Chinese Academy of Medical SciencesBeijing 102308China Medical Research Council Population Health Research Unit the University of OxfordOxford OX37LFUK Clinical Trial Service Unit and Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK NCDs Prevention and Control Department Qingdao CDCQingdaoShandong 266033China NHC Key Laboratory of Food Safety Risk Assessment China National Center for Food Safety Risk AssessmentBeijing 100022China. on behalf of the china kadoorie biobank collaborative group

Background It remains unclear about the association of muscle mass,strength,and quality with death in the general Chinese population of diverse economical and geographical *** present study aimed to comprehensively examine such associations across different regions in *** Based on the china kadoorie biobank study,the present study included 23,290 participants who were aged 38 to 88 years and had no prevalent cardiovascular diseases or *** mass and grip strength were measured using calibrated *** muscle quality was defined as the ratio of grip strength to arm muscle *** muscle mass,grip strength,and arm muscle quality were defined as the sex-specific lowest quintiles of muscle mass index,grip strength,and arm muscle quality,*** proportional hazards models yielded hazard ratios(HRs)and 95%confidence intervals(CIs)for risks of all-cause mortality in relation to muscle mass,strength,and *** During a median follow-up of 3.98 years,739 participants *** HR(95%CI)of all-cause mortality risk was 1.28(1.08–1.51)for low appendicular muscle mass index,1.38(1.16–1.62)for low total muscle mass index,1.68(1.41–2.00)for low grip strength,and 1.41(1.20–1.66)for low arm muscle quality in models adjusted for sociodemographic characteristics,lifestyle factors,and medical *** Low muscle mass,grip strength,and arm muscle quality are all associated with short-term increased risks of mortality,indicating the importance of maintaining normal muscle mass,strength,and quality for general Chinese adults.

关键词： Muscle All-cause mortality Chinese Prospective Muscle mass Muscle strength Muscle quality

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中国10个地区成年女性初潮年龄与身高和腿长的关联研究

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中华流行病学杂志 2016年第11期37卷 1454-1458页

作者：林丽玲郑棒吕筠郭彧卞铮余灿清杨玲周汇燕谭云龙裴培陈君石陈铮鸣李立明北京大学公共卫生学院流行病与卫生统计学系 100191 中国医学科学院北京100730 国家食品安全风险评估中心北京100022 英国牛津大学临床试验与流行病学研究中心

目的描述中国慢性病前瞻性研究（CKB）项目覆盖的10个地区30-79岁成年女性初潮年龄与身高和腿长的地区及出生年代分布，并分析初潮年龄与身高和腿长的关联性。方法剔除初潮年龄缺失或初潮年龄在生理范围外（〈9岁或〉18岁）个体后，28... 详细信息

目的描述中国慢性病前瞻性研究（CKB）项目覆盖的10个地区30-79岁成年女性初潮年龄与身高和腿长的地区及出生年代分布，并分析初潮年龄与身高和腿长的关联性。方法剔除初潮年龄缺失或初潮年龄在生理范围外（〈9岁或〉18岁）个体后，285 187名女性纳入分析。使用多元线性回归模型分析初潮年龄与身高和腿长的关系，并根据出生年代和城乡进行亚组分析。结果 10个项目地区女性的平均初潮年龄为（15.2±1.7）岁，平均身高和腿长分别为（154.2±6.0）cm和（71.0±3.7）cm。女性身高和腿长呈现出随出生年代逐渐增加的趋势（线性趋势检验均P〈0.001）。而初潮年龄在1940-1949年代出生的个体略有推迟，之后出生的女性则表现为逐渐提前的趋势（线性趋势检验P〈0.001）。在调整了年龄、地区、教育程度和臀围（仅在分析腿长时调整）后，初潮年龄每晚一岁，身高和腿长分别平均增加0.17 cm和0.20 cm（P值均〈0.001）。相比出生年代较早的女性，出生年代越晚的女性中，初潮年龄与身高和腿长的回归系数越大（交互检验P值均〈0.001）。结论 CKB的10个项目地区女性的初潮年龄与身高和腿长均存在正相关关联。

关键词：初潮年龄身高腿长

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中国10个地区成年人腌制蔬菜摄入情况的流行病学特征分析

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中华流行病学杂志 2024年第1期45卷 19-25页

作者：喻唯兰勇兵吕筠孙点剑一裴培杜怀东陈君石陈铮鸣李立明余灿清中国慢性病前瞻性研究项目协作组北京大学公共卫生学院流行病与卫生统计学系北京100191 北京大学公众健康与重大疫情防控战略研究中心北京100191 重大疾病流行病学教育部重点实验室(北京大学) 北京100191 牛津大学医学研究委员会人口健康研究组牛津OX37LF 牛津大学临床与流行病学研究中心纳菲尔德人群健康系牛津OX37LF 国家食品安全风险评估中心北京100022 不详

目的描述中国慢性病前瞻性研究(CKB)队列10个地区不同种类腌制蔬菜摄入的地区、时间和人群分布特征。方法CKB项目分别在2004-2008年、2008年和2013-2014年开展了基线调查、第一次和第二次重复调查。根据10个地区第二次重复调查对象的咸... 详细信息

目的描述中国慢性病前瞻性研究(CKB)队列10个地区不同种类腌制蔬菜摄入的地区、时间和人群分布特征。方法CKB项目分别在2004-2008年、2008年和2013-2014年开展了基线调查、第一次和第二次重复调查。根据10个地区第二次重复调查对象的咸菜和酸泡菜平均摄入频率,将调查地区分为摄入咸菜为主地区、摄入酸泡菜为主地区和几乎不摄入腌制蔬菜地区。然后分别在前两组地区中运用logistic回归描述腌制蔬菜摄入的时间变化趋势和人群分布特征,并分析其他膳食特征的分布情况。结果摄入咸菜为主地区包括青岛、哈尔滨、苏州、浙江项目点,而摄入酸泡菜为主地区包括甘肃、四川项目点,两类地区分别纳入204036和105573名基线调查对象。摄入咸菜为主地区在基线调查、第一次和第二次重复调查腌制蔬菜的平均摄入频率分别为3.1、3.3、1.8 d/周;摄入酸泡菜为主地区相应的频率为2.8、2.7、1.6 d/周,均呈下降趋势(P<0.001)。基线调查时两类地区的已婚、文化程度较低者腌制蔬菜摄入频率均更高;摄入咸菜为主地区年龄较大者腌制蔬菜摄入频率更高,而摄入酸泡菜为主地区相反(P<0.001)。随着腌制蔬菜摄入频率的增加,两类地区经常摄入辣食、口味偏咸等人群比例也呈增加趋势(P<0.05)。结论CKB项目人群的腌制蔬菜摄入种类和水平存在明显的地区和人群分布差异,摄入频率呈下降趋势,且与其他膳食特征存在相关。

关键词：腌制蔬菜咸菜酸泡菜趋势分析地区差异人群差异

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