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Plasma total homocysteine (THCY) level and other biochemical risk factors in hypertensives with and without cardiovascular events

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海南医学院学报 2009年第11期15卷 1387-1390,1394页

作者： Akande AA Salisu OT omotoso abo Kolo PM Department of Chemical Pathology and Immunology University of Ilorin Teaching Hospital Department of Medicine University of Ilorin Teaching Hospital

Objective:The aim of this study is to assess the correlation between traditional cardiovascular risk factors and elevated plasma tHcy level in Nigerian ***:Thirty-six hypertensive patients were recruited with 36 age and sex-matched *** age,sex and anthropometric measurements including height,weight and body mass index(BMI)were *** total cholesterol,low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),triglycerides and tHcy were *** results of the two groups were ***:The mean total cholesterol and LDL-C were significantly higher in the subjects than in the controls(P=0.01 and 0.03 respectively).On the other hand,means of HDL-C and triglycerides were not significantly different between the two groups(P=0.06 and 0.68 respectively).Mean total plasma tHcy was(12.95±4.9)μmol/L in hypertensive patients when compared with(11.29±3.6)μmol/L in the controls(P=0.09),however the mean tHcy was significantly higher in hypertensive patients who had stroke or myocardial infarction than those without these complications(one way Anova F=3.63,P=0.04).Significant positive correlation was seen between tHcy and systolic blood pressure,diastolic blood pressure,BMI and ***:The study suggests that elevated plasma tHcy may predict occurrence of cardiovascular complications in hypertensive individuals.

关键词：心血管高血压保健知识身体素质

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