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Ameliorative effects of glycine on cobalt chloride-induced hepato-renal toxicity in rats

Animal Models and Experimental Medicine 2023年第2期6卷 168-177页

作者： Oluwafikemi Temitayo Iji Temitayo Olabisi Ajibade Oluwaseun Olanrewaju Esan omolola victoria awoyomi Ademola Adetokunbo Oyagbemi Moses Olusola Adetona Temidayo Olutayo Omobowale Momoh Audu Yakubu Oluwafemi Omoniyi Oguntibeju Evaristus Nwulia Federal College of Animal Health and Production Technology Moor PlantationIbadanNigeria Department of Veterinary Physiology and Biochemistry Faculty of Veterinary MedicineUniversity of IbadanIbadanNigeria Department of Veterinary Medicine Faculty of Veterinary MedicineUniversity of IbadanIbadanNigeria Department of Anatomy Faculty of Basic Medical SciencesUniversity of IbadanIbadanNigeria Department of Environmental and Interdisciplinary Sciences College of ScienceEngineering&TechnologyCOPHSTexas Southern UniversityHoustonTexasUSA Department of Biomedical Sciences Faculty of Health and Wellness SciencesCape Peninsula University of TechnologyBellvilleSouth Africa Department of Psychiatry and Behavioral Sciences Howard University HospitalCollege of MedicineHoward UniversityWashingtonDistrict of ColumbiaUSA

Background:The important roles of liver and kidney in the elimination of injurious chemicals make them highly susceptible to the noxious activities of various toxicants including cobalt chloride(CoCl_(2)).This study was designed to investigate the role of glycine in the mitigation of hepato-renal toxicities associated with CoCl_(2)***:Forty-two(42)male rats were grouped as Control;(CoCl_(2);300 ppm);CoCl_(2)+Glycine(50 mg/kg);CoCl_(2)+Glycine(100 mg/kg);Glycine(50 mg/kg);and Glycine(100 mg/kg).The markers of hepatic and renal damage,oxidative stress,the antioxidant defense system,histopathology,and immunohistochemical localization of neutrophil gelatinase associated lipocalin(NGAL)and renal podocin were ***:Glycine significantly reduced the markers of oxidative stress(malondialdehyde content and H_(2)O_(2) generation),liver function tests(ALT,AST,and ALP),markers of renal function(creatinine and BUN),and decreased the expression of neutrophil gelatinase-associated lipocalin(NGAL)and podocin compared with rats exposed to CoCl_(2)toxicity without glycine *** lesions including patchy tubular epithelial necrosis,tubular epithelial degeneration and periglomerular inflammation in renal tissues,and severe portal hepatocellular necrosis,inflammation,and duct hyperplasia were observed in hepatic tissues of rats exposed to CoCl_(2)toxicity,but were mild to absent in glycine-treated ***:The results of this study clearly demonstrate protective effects of glycine against CoCl_(2)-induced tissue injuries and derangement of physiological activities of the hepatic and renal systems in *** protective effects are mediated via augmentation of total antioxidant capacity and upregulation of NGAL and podocin expression.

关键词： cobalt chloride hepatotoxicity nephrotoxicity oxidative stress podocin

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Protective effects of naringin on fipronil-induced cardiovascular and renal dysfunctions in rats

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Clinical Traditional Medicine and Pharmacology 2024年第3期5卷 13-21页

作者： Temitayo Olabisi Ajibade Esther Oluwaseyi Oliyide Oluwaseun Olanrewaju Esan Moses Olusola Adetona omolola victoria awoyomi Taiwo Olaide Oyagbemi Adewumi victoria Adeogun Ademola Adetokunbo Oyagbemi Temidayo Olutayo Omobowale Kehinde Olugboyega Soetan Sanah Malomile Nkadimeng Lyndy Joy McGaw Prudence Ngalula Kayoka-Kabongo Momoh Audu Yakubu Evaristus Nwulia Oluwafemi Omoniyi Oguntibeju Department of Veterinary Physiology and Biochemistry Faculty of Veterinary MedicineUniversity of IbadanIbadanOyo State 200001Nigeria Department of Veterinary Medicine Faculty of Veterinary MedicineUniversity of Ibadan IbadanOyo State 200001Nigeria Department of Anatomy Faculty of Basic Medical SciencesCollege of MedicineUniversity of IbadanIbadanOyo State 200001Nigeria Federal College of Animal Health and Production Technology Moor PlantationIbadanOyo State 200001Nigeria Department of Life and Consumer Sciences Collage of Agriculture and Environmental SciencesUniversity of South Africa Florida CampusUniversity of South AfricaUnisa 0003South Africa Department of Paraclinical Science Faculty of Veterinary ScienceUniversity of PretoriaOnderstepoort01100028South Africa Department of Environmental&Interdisciplinary Sciences College of ScienceEngineering&TechnologyCOPHSTexas Southern UniversityHoustonTX 77587USA Howard University College of MedicineDepartment of Psychiatry and Behavioral SciencesHoward University Hospital2041 Georgia AvenueWashingtonDC 20060USA Department of Biomedical Sciences Faculty of Health and Wellness SciencesCape Peninsula University of TechnologyBellvill 7535South Africa

Background:Naringin as a bioflavanone glycoside is abundant in citrus fruits,which since ancient times have been utilized as natural herbal treatments in traditional *** has potent antioxidant effect that may mitigate oxidative stress mediated cardiovascular and renal dysfunctions in mammalian ***:To explore probable modulatory actions of naringin on fipronil-induced cardio-renal ***:Twenty-four Wistar rats weighing 140±3.0 g were divided into four groups including normal control(saline),10 mg/kg Fipronil(FIP),FIP+100 mg/kg naringin,and 100 mg/kg *** of naringin and fipronil was by oral gavage for 28 consecutive ***,blood pressure monitoring,biochemical assays,histology,and immunohistochemical evaluations were ***:Naringin significantly(P<0.001)lessened blood pressure parameters,oxidative stress markers but significantly(P<0.001)heightened the systemic ***,naringin prevented fipronil-induced histopathological lesions such as congestion and cellular infiltration in cardiac and renal ***,naringin attenuated the immunohistochemical expression of troponin 1 and matrix metalloperoxidase-2 in cardiac tissues,but heightened angiotensin converting enzyme 2 expression in contrast to that of fipronil ***:The observation in this study shows potent attenuation of fipronil-induced toxicity by naringin,through inhibiting processes related to oxidation and inflammation.

关键词： Biomarkers of cardiorenal dysfunction Fipronil toxicity Naringin Immunohistochemistry

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