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Serum Levels of Reproductive Hormones and Their Relationship with Age in Men with Benign Prostatic Hyperplasia in Benin City, Edo State

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Health 2020年第9期12卷 1121-1131页

作者： Babatunde Ishola Gabriel Adejumo omolei lilian williams Efosa Bolaji Odigie Ifeoma Gloria Unachukwu Oladimeji Nasiru Abdulrahman Uchechukwu Dimkpa Simon Uzor Oyarazi Margaret Adebowale Ojo Moses Oke Department of Medical Laboratory Science University of Benin Benin City Nigeria Department of Medical Laboratory Science College of Health Technology Offa Nigeria Department of Human Physiology Nnamdi Azikwe University Nnewi Campus Nnewi Nigeria Department of Applied Science Faculty of Health and Applied Sciences University of West of England Bristol UK Department of Virology/Immunology Federal School of Medical Laboratory Science Jos Nigeria Department of Medical Laboratory Science College of Health Technology Akure Nigeria

Background: Benign Prostatic Hyperplasia (BPH) is a common condition which occurs as men get older. Aim: We aimed at investigating the reproductive hormone profile of men with BPH and the relationship of these hormones with age. Methods: Twenty-nine men of age > 40 years were screened for prostate symptoms. The prostate examination included digital rectal examination and measurement of serum prostate-specific antigen levels. Demographic and clinical characteristics of subjects were obtained using a structured questionnaire. The serum levels of Testosterone (Te), Luteinizing hormone (LH), Follicle stimulating hormone (FSH) and Prolactin (PRL) were measured using ELISA method. Results: Our study indicated that age and levels of prostate specific antigen (PSA), LH and FSH were significantly (p Conclusion: This study suggests that the rise in serum levels of the hypothalamic-pituitary-testicular axis hormones in BPH patients as demonstrated by the present findings may be age-related since testicular dysfunction in aging men is associated with the decrease in androgen production which may stimulate an increased production of gonadotropins by negative feedback.

关键词： Hormones Age Men Prostate Hyperplasia

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Reproductive Hormone Profiles and Their Relationships with Sexual Function in Patients with Prostate Cancer after Rapid Prostatectomy in Benin City

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Advances in Sexual Medicine 2020年第4期10卷 119-130页

作者： Babatunde Ishola Gabriel Adejumo omolei lilian williams Efosa Bolaji Odigie Ifeoma Gloria Unachukwu Oladimeji Nasiru Abdulrahman Uchechukwu Dimkpa Simon Uzor Oyarazi Margaret Adebowale Ojo Moses Oke Department of Medical Laboratory Science University of Benin Benin Nigeria Department of Medical Laboratory Science College of Health Technology Ilorin Nigeria Department of Human Physiology Nnamdi Azikwe University Nnewi Campus Awka Nigeria Department of Applied Science Faculty of Health and Applied Sciences University of West of England Bristol UK Department of Virology/Immunology Federal School of Medical Laboratory Science Jos Nigeria Department of Medical Laboratory Science College of Health Technology Akure Nigeria

There are limited studies examining the relationship between serum reproductive hormone levels and sexual functions among prostate cancer (PCa) patients after rapid prostatectomy (RP). Aim: The present study aimed at evaluating the correlation between post-operative serum levels of some male reproductive hormones of PCa patients and their sexual functions in the months following RP. A total of 20 male patients with clinically localized PCa who had undergone RP within the last 12 months prior to commencement of the study, were invited to participate. The postoperative serum levels of their luteinizing hormone (LH), follicle stimulating hormone (FSH) and total testosterone (Te) were measured. They also completed a structured health and lifestyle questionnaire to obtain information on their demographic characteristics and detailed medical history. Our data indicated normal mean levels of post-operative Te (4.34 ± 4.38 ng/ml) in the patients following RP, while the mean levels of FSH (39.24 ± 34.12 miu/ml) and LH (21.67 ± 25.73 miu/ml) were on the increase and far above normal ranges for healthy men. Data indicated a significant positive correlation between Te and frequency of sexual intercourse (r = 508;p < 0.05), libido (r = 0.429;p <

关键词： Reproductive Hormone Sexual Function Prostate Cancer Rapid Prostatectomy

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Serum Levels of Reproductive Hormones and Their Relationship with Age in Men with Benign Prostatic Hyperplasia in Benin City, Edo State

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Health（健康） 2020年第9期

作者： Babatunde Ishola Gabriel Adejumo omolei lilian williams Efosa Bolaji Odigie

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