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Comparative analysis of microstructure,mechanical,and corrosion properties of biodegradable Mg-3Y alloy prepared by selective laser melting and spark plasma sintering

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Journal of Magnesium and Alloys 2024年第4期12卷 1496-1510页

作者： P.Minárik M.Zemková S.Šašek J.dittrich M.Knapek F.Lukáˇc d.Koutný J.Ja.oš R.Král Faculty of Mathematics and Physics Charles UniversityKe Karlovu 5Praha 12116Czech Republic Research Centre University ofŽilinaUniverzitná8215/1Žilina 01026Slovakia Institute of Plasma Physics of the Czech Academy of Sciences Za Slovankou 1782/318200 Praha 8Czech Republic Institute of Machine and Industrial design Brno University of TechnologyTechnická2896/2Brno 61669Czech Republic

This work explored possibilities of biodegradable magnesium alloy Mg-3Y preparation by two modern powder metallurgy techniques–spark plasma sintering(SPS)and selective laser melting(SLM).The powder material was consolidated by both methods utilising optimised parameters,which led to very low porosity(∼0.3%)in the SLM material and unmeasurably low porosity in the SPS *** main aim of the study was the thorough microstructure characterisation and interrelation between the microstructure and the functional properties,such as mechanical strength,deformability,and corrosion *** materials showed comparable strength of∼110 MPa in tension and compression and relatively good deformability of∼9%and∼21%for the SLM and SPS materials,*** corrosion resistance of the SPS material in 0.1 M NaCl solution was superior to the SLM one and comparable to the conventional extruded *** digital image correlation during loading and the cross-section analysis of the corrosion layers revealed that the residual porosity and large strained grains have the dominant negative effect on the functional properties of the SLM *** the other hand,one of the primary outcomes of this study is that the SPS consolidation method is very effective in the preparation of the W3 biodegradable alloy,resulting in material with convenient mechanical and degradation properties that might find practical applications.

关键词： Magnesium Yttrium Powder metallurgy Microstructure Mechanical strength Corrosion resistance

Fetal lung growth predicts the risk for early-life respira.ory infections and childhood asthma

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World Journal of Pediatrics 2024年第5期20卷 481-495页

作者： dimitra E.zazara.olympia Giannou Steven Schepanski Mirja Pagenkemper Anastasios d.Giannou Maike Pincus Ioannis Belios Stefan Bonn Ania C.Muntau Kurt Hecher Anke diemert Petra Clara Arck division for Experimental Feto-Maternal Medicine Department of Obstetrics and Fetal MedicineUniversity Medical Center Hamburg-Eppendorf(UKE)Martinistraße 5220251HamburgGermany University Children’s Hospital UKEHamburgGermany Computer Engineering and Informatics department Polytechnic SchoolUniversity of PatrasPatrasGreece Institute of developmental Neurophysiology Center for Molecular Neurobiology Hamburg(ZMNH)UKEHamburgGermany department of obstetrics and Fetal Medicine UKEHamburgGermany department of General Visceral and Thoracic SurgeryUKEHamburgGermany Section of Molecular Immunology and Gastroenterology Ⅰ.Department of MedicineUKEHamburgGermany Pediatrics and Pediatric Pneumology Practice BerlinGermany Institute of Medical Systems Biology ZMNHUKEHamburgGermany Hamburg Center for Translational Immunology UKEHamburgGermany

Background Early-life respira.ory infections and asthma are ma.or health burdens during *** predicting an increased risk for early-life respira.ory diseases are ***,we identified the predictive value of ultra.ound-monitored fetal lung growth for the risk of early-life respira.ory infections and *** Fetal lung size was serially assessed at standardized time points by transabdominal ultra.ound in pregnant women participating in a pregnancy *** between fetal lung growth and respira.ory infections in infancy or early-onset asthma at five years were ***-learning models relying on extreme gradient boosting regressor or classifier algorithms were developed to predict respira.ory infection or asthma risk based on fetal lung *** model development and validation,study participants were randomly divided into a training and a testing group,respectively,by the employed *** Enhanced fetal lung growth throughout pregnancy predicted a lower early-life respira.ory infection *** sex was associated with a higher risk for respira.ory infections in *** lung growth could also predict the risk of asthma at five years of *** designed three machine-learning models to predict the risk and number of infections in infancy as well as the risk of early-onset *** models’R2 values were 0.92,0.90 and 0.93,respectively,underscoring a high accuracy and agreement between the actual and predicted *** variables included known risk factors and novel predictors,such as ultra.ound-monitored fetal lung *** Sonographic monitoring of fetal lung growth allows to predict the risk for early-life respira.ory infections and asthma.

关键词： Asthma Child risk Early-life respira.ory infections Prenatal lung development Sexual dimorphism

三轴形变核^(131)Ba中的奇异集体激发模式

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物理学报 2024年第11期73卷 89-100页

作者：韦锐周厚兵王思成丁兵强赟华贾晨旭陈红星郭松 C.M.Petrache d.Mengoni A.Astier E.dupont 吕冰锋 d.Bazzacco A.Boso A.Goasduff F.Recchia d.Testov F.Galta.ossa G.Ja.orski d.R.Na.oli S.Riccetto M.Sicilia.o J.J.Valiente-dobon C.Andreoiu F.H.Garcia K.ortner K.Whitmore A.Ataç-Nyberg T.Bäck B.Cederwall E.A.Lawrie I.Kuti d.Sohler T.Marchlewski J.Srebrny A.Tucholski 广西师范大学物理科学与技术学院桂林541004 广西核物理与核技术重点实验室桂林541004 中国科学院近代物理研究所兰州730000 中国科学院大学北京100049 巴黎萨克雷大学 CNRS/IN2P3IJCLab奥赛91405 帕多瓦大学物理和天文学系帕多瓦I-35131 意大利国家核物理研究所帕多瓦分部帕多瓦I-35131 意大利国家核物理研究所莱尼亚罗国家实验室莱尼亚罗(帕多瓦)I-35020 费拉拉大学理学与自然科学院费拉拉西蒙菲莎大学化学系本拿比BC V5A 1S6 皇家理工学院物理系斯德哥摩尔S-10691 国家研究基金会iThemba加速器科学实验室西萨默塞特7123 西开普大学物理与天文系贝尔维尔ZA-7535 HUN-REN原子核研究所德布勒森4001 华沙巴斯德拉大学重离子实验室华沙02-093

利用意大利Legna.o实验室串列静电加速器提供的65 MeV^(13)C束流与122Sn靶的熔合蒸发反应布居了^(131)Ba的高自旋态,并搭建了新的能级纲图.新的能级纲图由15条转动带组成,包括三对手征双重带,其中两对正宇称手征带为赝自旋-手征四重带.... 详细信息

利用意大利Legna.o实验室串列静电加速器提供的65 MeV^(13)C束流与122Sn靶的熔合蒸发反应布居了^(131)Ba的高自旋态,并搭建了新的能级纲图.新的能级纲图由15条转动带组成,包括三对手征双重带,其中两对正宇称手征带为赝自旋-手征四重带.正负宇称手征带通过一系列增强的E1跃迁连接,表明它们之间存在八极关联.在低自旋区域搭建了一条新的转动带,通过一系列γ跃迁向νh1_(1/2)晕带退激.这种能级结构与摇摆带相似,但基于现有的实验证据还难以将它确认为摇摆带,不能排除其他集体激发机制,如γ振动的影响.

关键词：高自旋态手征带赝自旋八极关联摇摆运动

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Performance test and process parameter optimization of 9FF type square bale straw crusher

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International Journal of Agricultural and Biological Engineering 2021年第3期14卷 232-240页

作者： Jie Zhang Bin Feng Lei Guo Lingzhuo Kong Chao Zhao Xiuzhen Yu Wenjie Luo za Kan School of Mechanical and Electrical Engineering Shihezi UniversityShihezi 832000XinjiangChina Research Institute of Agricultural Mechanization Xinjiang Academy of Agricultural SciencesUrumqi 830091China

In order to solve the problem of low productivity,unqualified segment length and high energy consumption during the process of crushing square bale straw caused by improper operation parameters,a 9FF square bale straw crusher was *** this study,by taking maize straw as the test material,the feeding speed,spindle speed of the crushing device and the state of the crushing device were taken as influence factors,and standard straw length rate,productivity per net working hour(hereinafter referred to as NWH)and energy consumption per ton of product as test indica.ors,the influence of the factors on the indica.ors were studied,and tests were carried out on the process of square bale straw *** a.opting the single factor test on the effect of the feeding speed,the spindle speed of the crushing device and the state of the crushing device on the test indica.ors,the suitable range of each factor was determined,*** the orthogonal test method,range method,variance method and comprehensive balance method,the experiment analyzed the significance of the influence of the three factors on various indica.ors and the order of *** test results showed that:the feeding speed was 5 m/min,spindle speed was 3000 r/min,and the state of the crushing device was a mixing cutter hammer,which was the best parameter combination(A1B1C1)for the processing technology of the square bale forage *** standard straw length rate was 93.7%,and the productivity per NWH was 2.80 t/h,with energy consumption per ton of 4.72 kW·h/t,in which the standard straw length rate and productivity per NWH reached optimal values,and the energy consumption per ton of product was slightly higher than the optimal value in the *** research results can provide a reference for the optimal design of the special crusher for square bale straw.

关键词： square bale straw crusher crushing working parameter optimization performance test

Ha.ophily reloaded:new insights into the extremophilic life-style of Wallemia with the description of Wallemia hederae ***

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Fungal diversity 2016年第1期76卷 97-118页

作者： Sa.o Jančič Polona zalar dragi Kocev Hans-Josef Schroers Sa.o džeroski Nina Gunde-Cimerman department of Biology Biotechnical FacultyJamnikarjeva 101SI-1000 LjubljanaSlovenia department of Knowledge Technologies Jožef Stefan InstituteJamova cesta 39SI-1000 LjubljanaSlovenia Agricultural Institute of Slovenia Hacquetova 17p.p.2553SI-1000 LjubljanaSlovenia Centre of Excellence for Integrated Approaches in Chemistry and Biology of Proteins(CIPKeBiP) Jamova cesta 39SI-1000 LjubljanaSlovenia

Wallemia comprises air-and food-borne,mycotoxigenic contaminants including the ha.ophilic ***,xerotolerant *** and xerophilic *** isolates are easily overlooked and only a comparably small number of strains have been deposited in culture collections so *** order to better understand the natural distribution of Wallemia *** to encounter their natural habitats,we tested more than 300 low-water-activity substrates and 30 air samples from a wide geographical *** isolated more than 150 new Wallemia *** sebi and *** were isolated mostly from hypersaline water,low-water-activity foods,plant materials and *** muriae is the dominant Wallemia species in the air of natural and human influenced environments in *** isolates of *** were obtained from hypersaline environments such as brine,salt crystals,salty foods and MgCl_(2)-rich bitterns,and from the air of hay barns in *** ha.otolerant strains were recognised as a hitherto un-described species Wallemia hederae,the phylogenetic sister of the ha.ophilic *** *** in-vitro growth on media that contain the chaotropic salt MgCl_(2).Wallemia ichthyophaga can grow in liquid medium enriched with 2 M MgCl_(2).Never before has a microorganism been grown on comparably high MgCl_(2) *** of the activity of a wide range of extracellular enzymes in the presence of NaCl also suggested that Wallemia iswell-adapted to substrates with a reduced water activity.

关键词： Chaophiles Ecophysiology Extracellular enzymes Exudates Machine learning Ta.onomy

Clinical hema.ological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6d2F1 Mus musculus

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Animal Models and Experimental Medicine 2020年第4期3卷 304-315页

作者： Giorgio Silva-Santana Juliet Cunha Bax débora Cristina Silva Fernandes daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza.oliveira dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ra.os Ricardo Alexandre Santos Thainara Ra.os Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi Health Sciences Center Institute of Microbiology Paulo de GóesFederal University of Rio de JaneiroRio de JaneiroRJBrazil La.ora.ory of diphtheria and Corynebacteria.of Clinical Relevance Faculty of Medical SciencesUniversity of the State of Rio de JaneiroRio de JaneiroRJBrazil The Colla.orating Centre for Reference and Research on diphtheria/National Health Foundation/Ministry of Health Rio de JaneiroRJBrazil La.ora.ory of Clinical Research and Molecular diagnostic Prof.Marcílio dias do Nascimento Department of Clinical Practice and PathologyFluminense Federal UniversityNiteróiRJBrazil La.ora.ory Bacterial Vaccines Department of ImmunologyNational Institute for Quality Control in HealthOswaldo Cruz FoundationRio de JaneiroRJBrazil Institute of Science and Technology in Biomodels Oswaldo Cruz FoundationRio de JaneiroRJBrazil Institute of Biology Federal Fluminense UniversityNiteróiRJBrazil Biomedical Center College of Medical SciencesUniversity of the State of Rio de JaneiroRio de JaneiroRJBrazil

Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental *** lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hema.ological and biochemical tests in these la.ora.ory animals are essential to validate scientific *** study seeks to establish reference values for hema.ological and biochemical parameters of four lineages of ***:We evaluated the hema.ological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6d2F1(hybrid),totaling 160 *** were standardized using the systems pocH-100iV diff™for 19 hema.ological parameters and VITRoS®350 for 12 biochemical ***:Results are shown as means and standard deviation,grouped by lineage and *** the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual ***:Thus our study shows that knowledge and disclosure of the values of physiological parameters of la.ora.ory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model.

关键词： B6d2F1 BALB/c biochemical C57BL/6 hema.ological Swiss

Structural and molecular features of intestinal strictures in rats with Crohn's-like disease

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World Journal of Gastroenterology 2016年第22期22卷 5154-5164页

作者： Petra Talapka Anikó Berkó La.os István Nagy Lalitha Chandrakumar Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi department of Physiology Anatomy and Neuroscience Faculty of Sciences and Informatics University of Szeged H-6726 Szeged Hungary Avidin Ltd. H-6726 Szeged Hungary

AIM: To develop a new rat model we wanted to gain a better understanding of stricture formation in Crohn’s disease (Cd).METHodS: Chronic colitis was induced locally by the administration of 2,4,6-trinitrobenzenesulfonic acid (TNBS). The relapsing inflammation characteristic to Cd was mimicked by repeated TNBS treatments. Animals were randomly divided into control, once, twice and three times TNBS-treated groups. Control animals received an enema.of saline. Tissue samples were taken from the strictured colonic segments and also adjacent proximally and distally to its 60, 90 or 120 d after the last TNBS or saline administrations. The frequency and macroscopic extent of the strictures were measured on digital photographs. The structural features of strictured gut wall were studied by light- and electron microscopy. Inflammation related alterations in TGF-beta 2 and 3, matrix metalloproteinases 9 (MMP9) and TIMP1 mRNA and protein expression were determined by quantitative real-time PCR and western blot analysis. The quantitative distribution of caspase 9 was determined by post-embedding ***: Intestinal strictures first appeared 60 d after TNBS treatments and the frequency of them increased up to day 120. From day 90 an intact lamina epithelialis, reversible thickening of lamina muscularis mucosae and irreversible thickening of the muscularis externa were demonstrated in the strictured colonic segments. Nevertheless the morphological signs of a.optosis were frequently seen and excess extracellular matrix deposition was recorded between smooth muscle cells (SMCs). Enhanced caspase 9 expression on day 90 in the SMCs and on day 120 also in myenteric neurons indicated the induction of a.optosis. The mRNA expression profile of TGF-betas after repeated TNBS doses was characteristic to Cd, TGF-beta 2, but not TGF-beta 3 was up-regulated. overexpression of MMP9 and down-regulation of TIMP1 were demonstrated. The progressive increase in the a.ount

关键词： Crohn’ s disease Rat model TGF-beta Intestinal strictures MMP9 TIMP1

Alleviated mucosal and neuronal damage in a rat model of Crohn's disease

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World Journal of Gastroenterology 2014年第44期20卷 16690-16697页

作者： Petra Talapka La.os István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi department of Physiology Anatomy and Neuroscience Faculty of Sciences and Informatics University of Szeged Avidin Ltd.

AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s ***:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of *** samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal *** means of the ulcerated area were measured to evaluate the macroscopic mu-cosal *** density of myenteric neurons was determined on whole mounts by Hu C/Hu d *** oxygenase-1(Ho-1)expression was evaluated by molecular biological ***:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental *** widespread loss of myenteric neurons,and marked but transient Ho-1 up-regulation were demonstrated after the first TNBS *** repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed ***-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints ***,the Ho-1protein up-regulation after the second TNBS treatment proved to be *** the third treatment Ho-1 protein expression could not be ***:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal *** persistent up-regulation of Ho-1 m RNA expression may correlate with this.

关键词： Crohn's disease Experimental rat model Heme oxygenase-1 Myenteric neurons Repetitive re-lapsing inflammation

颈内动脉外翻内膜剥脱术治疗颈动脉狭窄疗效分析

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中国脑血管病杂志 2005年第11期2卷 502-505,509页

作者：张佳栋温向阳 d Maza 河南省人民医院神经外科郑州450003 法国冈城大学医学中心心胸血管外科

目的探讨颈内动脉外翻内膜剥脱术治疗颈动脉狭窄的疗效.方法对127例颈动脉粥样硬化性狭窄患者行颈内动脉外翻内膜剥脱术,其中有症状者78例,无症状者49例.术后随访5～16个月,回顾性分析其疗效,评价此术式的优点.结果全组无手术死亡病例.... 详细信息

目的探讨颈内动脉外翻内膜剥脱术治疗颈动脉狭窄的疗效.方法对127例颈动脉粥样硬化性狭窄患者行颈内动脉外翻内膜剥脱术,其中有症状者78例,无症状者49例.术后随访5～16个月,回顾性分析其疗效,评价此术式的优点.结果全组无手术死亡病例.术后患者均复查颈部和脑实质dSA,显示患侧颈动脉形态正常,颈内动脉血管迂曲消失,无1例狭窄.126例患者脑部供血有明显改善,其患侧颈内动脉、皮质下血管显影时间较术前提前0.40～0.90 s,颅内血管血流经过时间缩短0.50～0.80 s;出现脑梗死1例,遗留永久性神经功能缺损,有效率为99.2%,并发症发生率为2.4%.结论颈内动脉外翻内膜剥脱术是一种有效、安全治疗颈动脉粥样硬化性狭窄的手术方式.

关键词：颈动脉狭窄动脉内膜切除术,颈脑缺血