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Is the neutrophil to lymphocyte ratio associated with liver fibrosis in patients with chronic hepatitis B?

World Journal of Gastroenterology 2015年第18期21卷 5575-5581页

作者： Murat Kekilli Alpaslan Tanoglu Yusuf Serdar Sakin Mevlut kurt Serkan Ocal Sait Bagci Department of Gastroenterology Hitit University Corum Training and Research Hospital Department of Gastroenterology GATA Haydarpasa Training Hospital Department of Gastroenterology Gulhane Military Medical Academy School of Medicine Department of Gastroenterology Abant ?zzet Baysal Faculty of Medicine Training and Research Hospital

AIM: To determine the association between the neutrophil to lymphocyte(N/L) ratio and the degree of liver fibrosis in patients with chronic hepatitis B(CHB) infection. METHODS: Between December 2011 and February 2013, 129 consecutive CHB patients who were admitted to the study hospitals for histological evaluation of chronic hepatitis B-related liver fibrosis were included in this retrospective study. The patients were divided into two groups based on the fibrosis score: individuals with a fibrosis score of F0 or F1 were included in the "no/minimal liver fibrosis" group, whereas patients with a fibrosis score of F2, F3, or F4 were included in the "advanced liver fibrosis" group. The Statistical Package for Social Sciences 18.0 for Windows was used to analyze the data. A P value of < 0.05 was accepted as statistically ***: Three experienced and blinded pathologists evaluated the fibrotic status and inflammatory activity of 129 liver biopsy samples from the CHB patients. Following histopathological examination, the "no/minimal fibrosis" group included 79 individuals, while the "advanced fibrosis" group included 50 individuals. Mean(N/L) ratio levels were notably lower in patients with advanced fibrosis when compared with patients with no/minimal fibrosis. The mean value of the aspartate aminotransferase-platelet ratio index was markedly higher in cases with advanced fibrosis compared to those with no/minimal ***: Reduced levels of the peripheral blood N/L ratio were found to give high sensitivity, specificity and predictive values in CHB patients with significant fibrosis. The prominent finding of our research suggests that the N/L ratio can be used as a novel noninvasive marker of fibrosis in patients with CHB.

关键词： Chronic hepatitis B Liver fibrosis Neutrophil to lymphocyte ratio Fibrotic stage Inflammatory activity Non-invasive marker

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Scoping review update on somatic symptom disorder that includes additional Chinese data

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General Psychiatry 2023年第3期36卷 198-213页

作者： Heng Wu Ayinuer Manglike Yixiao Chen Ziming Liu kurt Fritzsche Zheng Lu Department of Psychosomatic Medicine Shanghai Tongji HospitalTongji University School of MedicineShanghaiChina Department of Psychosomatic Medicine and Psychotherapy Medical CenterUniversity of FreiburgFreiburgGermany Department of Psychiatry Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina

Somatic symptom disorder(SSD)is a new diagnosis introduced into the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition(DSM-5),which is expected to solve the diagnostic difficulties of patients with medically unexplained *** on the previous work,this review aims to comprehensively synthesise updated evidence related to SSD from recent years in English publications and,more extensively,from data published in Chinese language *** scoping review update was based on an earlier scoping review and included Chinese language publication data from China National Knowledge Internet(CNKI),WANFANG and WEIPU between January 2013 and May 2022 and data from PubMed,PsyclNFO,and Cochrane Library between June 2020 and May ***,2984 articles were identified,of which 63 full texts were included for *** China,SSD is mainly applied in scientific research,but it also shows good predictive validity and clinical application *** mean frequency of SSD was 4.5%in the general population,25.2%in the primary care population and 33.5%in diverse specialised care *** factors,such as brain region changes and heart rate variability,are associated with the onset of *** impairment related to somatic symptoms is the best predictor of *** adolescent SSD is significantly associated with family function,SSD overall is associated with an increased dysfunction of cognition and emotion,decreased quality of life,and high comorbidity with anxiety and depressive *** research is needed on suicide risk and cultural and gender-related *** the data of Chinese language studies,our research enriches the evidence-based findings related to the topics addressed in the text sections of the SSD chapter of ***,research gaps remain about SSD reliability,population-based prevalence,suicide risk,and cultural and gender-related issues.

关键词： include diagnosis update

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Land use changes in Istanbul＇s Black Sea coastal regions between 1987 and 2007

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Journal of Geographical Sciences 2013年第2期23卷 271-279页

作者： Sumeyra kurt Istanbul University Department of Geography 34452 Beyazlt Istanbul Turkey

Recently, important land use changes have occurred in the Black Sea coastal regions of istanbul due to urban growth and population increases. The objective of this study was to determine changes in land use in the Black Sea coastal regions of Jstanbul between 1987 and 2007. Landsat 30 m satellite images from 1987 and 2007 are used in the study. The study area is 1000 m in width from the coastline to the land and the study has been carried out using the controlled classification method to classify areas into residential, agricultural, forest, bare land, brush/grassland, and lake/pond land classes. Land use changes between 1987 and 2007 were analysed in detail. Residential areas of the Black Sea coastal regions of istanbul increased by 122% over the two decades. Also an increase of 55% in agriculture areas was observed, while there were decreases of 26% in forest areas and 15% in free land. A 21% increase in the area of brush and grassland took place. Furthermore 79% of the study area was covered by residential areas in 2007. It is probable that pressure on the Jstanbul coastal regions will continue due to migraton and rapid urbanization. Therefore, Istanbul＇s Black Sea coastal regions should be maintained using a sustainable coastal management plan.

关键词： coastal land use land use change remote sensing istanbul

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Two effective approaches for solving fractional generalized Hirota-Satsuma coupled KdV system arising in interaction of long waves

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Journal of Ocean Engineering and Science 2019年第1期4卷 24-32页

作者： Ali kurt Hadi Rezazadeh Mehmet Senol Ahmad Neirameh Orkun Tasbozan Mostafa Eslami Mohammad Mirzazadeh Department of Mathematics Mustafa Kemal UniversityHatayTurkey Faculty of Engineering Technology Amol University of Special Modern TechnologiesAmolIran Department of Mathematics Nevsehir Haci Bektas Veli UniversityNevsehirTurkey Department of Mathematics Faculty of SciencesGonbad Kavous UniversityGonbadIran Department of Mathematics Faculty of Mathematical SciencesUniversity of MazandaranBabolsarIran Department of Engineering Sciences Faculty of Technology and EngineeringEast of GuilanUniversity of GuilanRudsar-VajargahIran

In this article,two different methods,namely sub-equation method and residual power series method,have been used to obtain new exact and approximate solutions of the generalized Hirota-Satsuma system of equations,which is a coupled KdV *** fractional derivative is taken in the conformable *** of the obtained exact solutions were checked by substituting them into the corresponding system with the help of Maple symbolic computation *** results indicate that both methods are easy to implement,effective and *** are therefore ready to apply for various partial fractional differential equations.

关键词： Hirota-Satsuma coupled KdV system Sub-equation method Power series method Conformable fractional derivative

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Construction and Evaluation of a Combined Cyclophosphamide/Nanoparticle Anticancer Vaccine

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Journal of Cancer Therapy 2011年第3期2卷 384-393页

作者： kurt Andrew Yaeger Robert Anthony kurt Department of Biology Lafayette College

Tumor immunotherapy is a rapidly emerging form of cancer treatment. In the current study, a nanoparticle-based vaccine was constructed and the efficacy was assessed through analysis of immune cell populations, tumor growth rates, and metastasis. The vaccine was fabricated through encapsulation of plasmid DNA encoding the tumor-associated antigen Mage-b, and the TLR9 agonist CpG oligodeoxynucleotides by a biodegradable polymer, poly(L,D-lactic-coglycolic acid) (PLGA). The size and shape of the nanoparticles suggested that they were an appropriate size for uptake by professional antigen presenting cells;dendritic cells. Furthermore, effects of the immunopotentiating drug cyclo-phosphamide was included to decrease systemic populations of regulatory T cells (Treg);immune system sentinels that down-regulate immune responses. The vaccine was assessed using the 4T1 murine mammary carcinoma model which is a model for stage IV breast cancer. The combined cyclophosphamide/nanoparticle vaccine was shown to significantly reduce 4T1 tumor growth rates and lung metastasis in female BALB/c mice.

关键词： Nanoparticle Vaccine Breast Cancer Metastasis 4T1

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Biochar insights from laboratory incubations monitoring O_(2) consumption and CO_(2) production

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Biochar 2019年第3期1卷 249-258页

作者： Risely Ferraz Almeida kurt A.Spokas Daniel de Bortoli Teixeira Newton La Scala Junior University of Sao Paulo-USP PiracicabaBrazil United States Department of Agriculture-Agricultural Research Service St.PaulMNUSA University of Marília-Unimar MaríliaBrazil Universidade Estadual Paulista-UNESP JaboticabalBrazil

Biochar has been touted as a long-term carbon sequestration ***,there are no studies evaluating biochar’s effect on oxygen(O_(2))consumption as a measure of the microbial respiration response to *** gain insight into this aspect,we evaluated O_(2) consumption rates to test the hypothesis that biochar is an efficient agent for carbon dioxide(CO_(2))sequestration in *** different biochar types and one activated charcoal were incubated alone and associated with three different soils for approximately 2 months in laboratory *** concentration of CO_(2) and O_(2) was periodically *** data presented here confirm that the CO_(2) production following biochar’s addition to soils results in a process that is correlated to oxygen ***,this overall stimulation is not clearly related to biochar *** carbon resulted in the highest statistically significant stimulation of activity,despite it possessing the lowest quantity of volatile carbon and mineral nutrient *** into consideration our results,we conclude that using biochar does achieve total carbon ***,the amount of available soil organic carbon following soil incorporation appears to be reduced following biochar addition and its long-term implication on this mineralizable soil organic carbon pool does deserve more research attention.

关键词： Biochar activation Charcoal CO_(2)sequestration CO_(2)sorption

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Fluoroquinolone-macrolide combination therapy for chronic bacterial prostatitis： retrospective analysis of pathogen eradication rates, inflammatory findings and sexual dysfunction

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Asian Journal of Andrology 2011年第6期13卷 819-827页

作者： Vittorio Magri Emanuele Montanari Visnja Skerk Alemka Markotic Emanuela Marras Antonella Restelli kurt G Naber Gianpaolo Perletti Urology and Sonography Secondary Care Clinic Azienda Ospedaliera Istituti Clinici di Perfezionamento Milano 20132 Italy Clinica Urologica III University of Milan/San Paolo Hospital Milano 20142 Italy University Hospital for Infectious Diseases Dr. Fran Mihaljevic Zagreb 10000 Croatia Laboratory of Toxicology and Pharmacology Department of Biomedical Informatic Environmental and Communication Sciences Universita degli Studi dell＇Insubria Busto A.Narese 21052 Italy Microbiology Unit Fondazione I RCCS Osp. Maggiore Policlinico Mangiagalli Regina Elena Milano 20122 Italy Technical University Munich 80333 Germany

We previously demonstrated the safety and efficacy of fluoroquinolone-macrolide combination therapy in category Ⅱ chronic bacterial prostatitis （CBP）. The aim of this study is to retrospectively compare the microbiological and clinical findings of two treatment schemes for CBP based on the combination of azithromycin （500 rag, thrice-weekly） with a once-daily 500- or 750-mg dose of ciprofloxacin （Cipro-500 or Cipro-750 cohort, respectively）. Combined administration of azithromycin （1500 mg week^-1） with ciprofloxacin at the rate of 750 mg day^- 1 for 4 weeks rather than at 500 mg day^- 1 for 6 weeks increased the eradication rates from 62.35% to 77.32% and the total bacteriological success from 71.76% to 85.57%. A significant decrease in pain and voiding signs/symptoms and a significant reduction in inflammatory leukocyte counts and serum prostate-specific antigen （PSA） were sustained throughout an 18-month follow-up period in both groups. Ejaculatory pain, haemospermia and premature ejaculation were significantly attenuated on microbiological eradication in both groups, but the latter subsided more promptly in the Cipro-750 cohort. In total, 59 Cipro-750 patients showed mild-to-severe erectile dysfunction （ED） at baseline, while 22 patients had no ED on microbiological eradication and throughout the follow-up period. In conclusion fluoroquinolone-macrolide therapy resulted in pathogen eradication and CBP symptom attenuation, including pain, voiding disturbances and sexual dysfunction. A once-daily 750-mg dose of ciprofloxacin for 4 weeks showed enhanced eradication rates and lower inflammatory white blood cell counts compared to the 500-mg dose for 6 weeks. Our results are open to further prospective validation.

关键词： azithromycin chronic bacterial prostatitis chronic pelvic pain syndrome ciprofloxacin erectile dysfunction InternationalIndex of Erectile Function (IIEF) National Institutes of Health Chronic Prostatitis Symptom Index (NiH-CPSI)

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Cell Wall Lignin is Polymerised by Class Ⅲ Secretable Plant Peroxidases in Norway Spruce

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Journal of Integrative Plant Biology 2010年第2期52卷 186-194页

作者： kurt V.Fagerstedt Eija M.Kukkola Ville V.T.Koistinen Junko Takahashi Kaisa Marjamaa Department of Biological and Environmental Sciences Plant BiologyP.O. Box 65 FI-00014 Helsinki UniversityFinland Technical Research Center of Finland (VTT) PL 100002044 VTTFinland

Class Ⅲ secretable plant peroxidases occur as a large family of genes in plants with many functions and probable redundancy. In this review we are concentrating on the evidence we have on the catalysis of lignin polymerization by class Ⅲ plant peroxidases present in the apoplastic space in the xylem of trees. Some evidence exists on the specificity of peroxidase isozymes in lignin polymerization through substrate specificity studies, from antisense mutants in tobacco and poplar and from tissue and cell culture lines of Norway spruce （Picea abies） and Zinnia elegans. In addition, real time （RT-）PCR results have pointed out that many peroxidases have tissue specific expression patterns in Norway spruce. Through combining information on catalytic properties of the enzymes, on the expression patterns of the corresponding genes, and on the presence of monolignols and hydrogen peroxide in the apoplastic space, we can show that specific peroxidases catalyze lignin polymerization in the apoplastic space of Norway spruce xylem.

关键词： Secretable Plant Peroxidases in Norway Spruce

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Proteome-wide alterations in an industrial clavulanic acid producing strain of Streptomyces clavuligerus

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Synthetic and Systems Biotechnology 2017年第1期2卷 39-48页

作者： EserÜnsaldı Aslıhan kurt-Kızıldogan Birgit Voigt Dorte Becher Gülay Ozcengiz Department of Biological Sciences Middle East Technical University06800AnkaraTurkey Department of Agricultural Biotechnology Ondokuz Mayıs University55139SamsunTurkey Institute of Microbiology Ernst-Moritz-Arndt-University of GreifswaldD-17487GreifswaldGermany

The usefulness of genetic/metabolic engineering for further improvement of industrial strains is subject of discussion because of the general lack of knowledge on genetic alterations introduced by iterative cycles of random mutagenesis in such *** industrial clavulanic acid(CA)-overproducer Streptomyces clavuligerus DEPA was assessed to understand proteome-wide changes that have occurred in a local industrial CA overproducer developed through succesive mutagenesis *** proteins that could be identified corresponded to 33 distinct ORFs for underrepresented ones and 60 ORFs for overrepresented *** CA biosynthetic enzymes were overrepresented in *** DEPA;carboxyethylarginine synthase(Ceas2),clavaldehyde dehydrogenase(Car)and carboxyethyl-arginine betalactam-synthase(Bls2)whereas the enzymes of two other secondary metabolites were underrepresented along with two important global regulators[two-component system(TCS)response regulator(SCLAV_2102)and TetR-family transcriptional regulator(SCLAV_3146)]that might be related with CA production and/or differentiation.g-butyrolactone biosynthetic protein AvaA2 was 2.6 fold underrepresented in *** *** levels of two glycolytic enzymes,2,3-bisphosphoglycerate-dependent phosphoglycerate mutase and phosophoglycerate kinase were found decreased while those of dihydrolipoyl dehydrogenase(E3)and isocitrate dehydrogenase,with two isoforms were found as significantly increased.A decrease of amino acid metabolism,methionine biosynthesis in particular,as well as S-adenosylmethionine synthetase appeared as one of the prominent mechanisms of success of *** DEPA strain as a prolific producer of *** levels of two enzymes of shikimate pathway that leads to the production of aromatic amino acids and aromatic secondary metabolites were also *** of the overrepresented stress proteins in *** DEPA included polynucleotide phosphorylase/polyadenylase(PNPase),ATP

关键词： Clavulanic acid Streptomyces clavuligerus Industrial strain Proteomics 2DE MALDI-TOF/MS

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Large-area photonic lift-off process for flexible thin-film transistors

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npj Flexible Electronics 2022年第1期6卷 115-124页

作者： Adam M.Weidling Vikram STurkani Vahid Akhavan kurt A.Schroder Sarah L.Swisher Department of Electrical and Computer Engineering University of Minnesota Twin Cities4-174 Keller Hall200 Union Street S.E.MinneapolisMN 55455USA NovaCentrix 400 Parker DriveSuite 1110AustinTX 78728USA

Fabricating flexible electronics on plastic is often limited by the poor dimensional stability of polymer *** mitigate,glass carriers are used during fabrication,but removing the plastic substrate from a carrier without damaging the electronics remains *** we utilize a large-area,high-throughput photonic lift-off(PLO)process to rapidly separate polymer films from rigid *** uses a 150µs pulse of broadband light from flashlamps to lift-off functional thin films from glass carrier substrates coated with a light absorber layer(LAL).Modeling indicates that the polymer/LAL interface reaches above 800℃ during PLO,but the top surface of the PI remains below 120℃.An array of indium zinc oxide(IZO)thin-film transistors(TFTs)was fabricated on a polyimide substrate and photonically lifted off from the glass *** TFT mobility was unchanged by *** flexible TFTs were mechanically robust,with no reduction in mobility while flexed.

关键词： film process absorber

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