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Acute hemorrhagic edema of infancy: the experience of a large tertiary pediatric center in Israel

World Journal of Pediatrics 2017年第4期13卷 341-345页

作者： Limor Parker Keren Shahar-Nissan Liat Ashkenazi-Hoffnung Liora Harel Jacob Amir omer trivizki Efraim Bilavsky Department of Pediatrics B Assaf Harofeh Medical CenterZriffinIsrael Departments of Pediatrics C Schneider Children's Medical CenterPetah TiqvaIsrael Sackler Faculty of Medicine Tel Aviv UniversityTel AvivIsrael

Background:Acute hemorrhagic edema of infancy (AHEI) is a rare leukocytoclastic vasculitis of the small vessels occurring at a young age and considered as a benign self-limited *** to its low prevalence,there are limited data on the presentation and complications of this ***:All computerized files of children who were hospitalized at a tertiary pediatric center due to AHEI over a 10 year period were ***,laboratory and histopathological data were ***:Twenty-six patients were included in our study,accounting for 0.7 cases per 1000 admissions of children aged 2 years or *** age was 12.9 *** than two thirds of the children had preceding symptoms compatible with a viral *** admission,all patients presented with typical findings of a rash and *** was most profound over the lower extremities (73%).Concomitant viral or bacterial infections were found in six *** biopsy was performed in six patients revealing leukocytoclastic *** children (50%) had systemic involvement including joint involvement (n=9),gastrointestinal hemorrhage (n=4),microscopic hematuria (n=1) and compartment syndrome of the limb (n=1).The latter was diagnosed in a patient with familial Mediterranean ***:Our largest data series highlighted what is known regarding clinical and histological findings in children with ***,contrary to what was previously reported,we found a higher rate of systemic *** AHEI is a rare entity,pediatricians should be familiar with its presentation,management and our reported complications.

关键词： acute hemorrhagic edema Finkelstein-Seidlmayer disease Henoch-Sch(o)nlein purpura vasculitis

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