检索结果-南通市图书馆

Outcomes of curative liver resection for hepatocellular carcinoma in patients with cirrhosis

World Journal of Gastrointestinal Oncology 2021年第5期13卷 424-439页

作者： omar elshaarawy Aya Aman Hazem Mohamed Zakaria Talaat Zakareya Asmaa Gomaa Esam Elshimi Eman Abdelsameea Department of Hepatology Gastroenterology and Liver TransplantationNational Liver InstituteMenoufia UniversityShebine Elkom 32511MenoufiaEgypt Department of Hepatobiliary Pancreatic Surgery National Liver InstituteMenoufia UniversityShebine Elkom 32511MenoufiaEgypt

BACKGROUND Given the poor synthetic function of cirrhotic liver,successful resection for patients with hepatocellular carcinoma(HCC)necessitates the ability to achieve resections with tumor free *** To validate post hepatectomy liver failure score(PHLF),compare it to other established systems and to stratify risks in patients with cirrhosis who underwent curative liver resection for *** Between December 2010 and January 2017,120 patients underwent curative resection for HCC in patients with cirrhosis were included,the pre-operative,operative and post-operative factors were recorded to stratify patients'risks of decompensation,survival,and *** The preoperative model for end-stage liver disease(MELD)score[odds ratio(OR)=2.7,95%CI:1.2-5.7,P=0.013],tumor diameter(OR=5.4,95%CI:2-14.8,P=0.001)and duration of hospital stay(OR=2.5,95%CI:1.5-4.2,P=0.001)were significant independent predictors of hepatic decompensation after *** the preoperative MELD score[hazard ratio(HR)=1.37,95%CI:1.16-1.62,P<0.001]and different grades of PHLF(grade A:HR=2.33,95%CI:0.59-9.24;Grade B:HR=3.15,95%CI:1.11-8.95;Grade C:HR=373.41,95%CI:66.23-2105.43;P<0.001)and HCC recurrence(HR=11.67,95%CI:4.19-32.52,P<0.001)were significant independent predictors for *** Preoperative MELD score and tumor diameter can independently predict hepatic ***,preoperative MELD score,different grades of PHLF and HCC recurrence can precisely predict survival.

关键词： Cirrhosis Liver Resection Scores Hepatocellular carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Platelet-albumin-bilirubin score - a predictor of outcome of acute variceal bleeding in patients with cirrhosis

引用

World Journal of Hepatology 2020年第3期12卷 99-107页

作者： omar elshaarawy Naglaa Allam Eman Abdelsameea Asmaa Gomaa Imam Waked Department of Hepatology and Gastroenterology National Liver InstituteMenoufia UniversityShebin Elkom 32511Egypt

BACKGROUND The albumin-bilirubin(ALBI)score was validated as a prognostic indicator in patients with liver disease and hepatocellular *** platelet count in the platelet-albumin-bilirubin(PALBI)score improved validity in predicting outcome of patients undergoing resection and *** To evaluate the PALBI score in predicting outcome of acute variceal bleeding in patients with *** The data of 1517 patients with cirrhosis presenting with variceal bleeding were *** Turcotte Pugh(CTP)class,Model of End-stage Liver Disease(MELD),ALBI and PALBI scores were calculated on admission,and were correlated to the outcome of variceal *** under the receivingoperator characteristic curve(AUROC)were calculated for survival and *** Mean age was 52.6 years;1176 were male(77.5%),69 CTP-A(4.5%),434 CTP-B(29.2%),1014 CTP-C(66.8%);306 PALBI-1(20.2%),285 PALBI-2(18.8%),and 926 PALBI-3(61.1%).Three hundred and thirty-two patients died during hospitalization(21.9%).Bleeding-related mortality occurred in 11%of CTP-B,28%of CTP-C,in 21.8%of PALBI-2 and 34.4%of PALBI-3 *** AUROC for predicting survival of acute variceal bleeding was 0.668,0.689,0.803 and 0.871 for CTP,MELD,ALBI and PALBI scores,*** predicting rebleeding the AUROC was 0.681,0.74,0.766 and 0.794 for CTP,MELD,ALBI and PALBI scores,*** PALBI score on admission is a good prognostic indicator for patients with acute variceal bleeding and predicts early mortality and rebleeding.

关键词： Variceal bleeding Platelet-albumin-bilirubin score Albumin-bilirubin score Rebleeding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Liver stiffness reversibly increases during pregnancy and independently predicts preeclampsia

引用

World Journal of Gastroenterology 2018年第38期24卷 4393-4402页

作者： Franziska J Ammon Anna Kohlhaas omar elshaarawy Johannes Mueller Thomas Bruckner Christof Sohn Gabriele Fluhr Herbert Fluhr Sebastian Mueller Department of Obstetrics and Gynecology University of Heidelberg Department of Medicine and Center for Alcohol Research Liver Disease and NutritionSalem Medical CenterUniversity of Heidelberg Institute of Medical Biometry und Informatics University of Heidelberg

AIM To study liver stiffness(LS) during pregnancy and its association with complications during *** In this observational, diagnostic study, 537 pregnant women were prospectively enrolled at the Department of Obstetrics and Gynecology, University hospital Heidelberg and Salem Medical Center. LS was measured using the Fibroscan device(Echosens, Paris) in all women and in 41 cases 24 h after delivery. Clinical and morphological data were recorded and abdominal ultrasound and standard laboratory tests were performed. No complications were observed in 475 women(controls) while preeclampsia and intrahepatic cholestasis of pregnancy(ICP) developed in 22 and 40 women, *** In controls, LS increased significantly from initially 4.5 ± 1.2 kPa in the second trimester to 6.0 ± 2.3 kPa(P < 0.001) in the third trimester. In the third trimester, 41% of women had a LS higher than 6 kPa. Elevated LS in controls was significantly correlated with alkaline phosphatase, leukocytes, gestational age and an increase in body weight and body mass index(BMI). In women with pregnancy complications, LS was significantly higher as compared to controls(P < 0.0001). Moreover, in multivariate analysis, LS was an independent predictor for preeclampsia with an odds ratio of 2.05(1.27-3.31) and a cut-off value of 7.6 kPa. In contrast, ICP could not be predicted by LS. Finally, LS rapidly decreased in all women within 24 h after delivery from 7.2 ± 3.3 kPa down to 4.9 ± 2.2 kPa(P < 0.001).CONCLUSION During pregnancy, LS significantly and reversibly increases in the final trimester of pregnant women without complications. In women with preeclampsia, LS is significantly elevated and an independent noninvasive predictor.

关键词： Pregnancy Transient elastography Liver stiffness Pregnancy complications Hemolysis,elevated liver enzymes and low platelets syndrome Intrahepatic cholestasis of pregnancy Preeclampsia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Direct modulation of hepatocyte hepcidin signaling by iron

引用

World Journal of Hepatology 2021年第10期13卷 1378-1393页

作者： Lin-Na Yu Shi-Jin Wang Cheng Chen Vanessa Rausch omar elshaarawy Sebastian Mueller Center for Alcohol Research and Salem Medical Center University of HeidelbergHeidelberg 69121Germany Department of Hepatology Gastroenterology and Liver TransplantationNational Liver InstituteMenoufia UniversityShebine Elkom 35121El Salvador Department of Gastroenterology Royal Liverpool University HospitalLiverpool L78XPUnited Kingdom

BACKGROUND Liver-secreted hepcidin is the systemic master switch of iron homeostasis and decreased levels of hepcidin are considered to cause iron overload not only in hereditary hemochromatosis but also in hemolytic anemia and chronic liver *** regulation of hepcidin is complex and its response to iron is still not completely *** To study the direct effect of iron on various established hepcidin signaling pathways in hepatoma cells or primary *** Hepcidin mRNA expression was studied by quantitative real-time(qRT)-PCR in the presence of various forms of iron including ferric ammonium citrate(FAC)in hepatoma cells(Huh7),murine primary hepatocytes and an established co-culture model of phorbol myristate acetate-differentiated THP-1 monocytes and Huh7 *** analyze hepcidin signaling,the response to bone morphogenetic protein 6(BMP6),interleukin(IL)-6,IL-1β,hypoxia and lipopolysaccharide(LPS)were *** and small mothers against decapentaplegic 6(SMAD6)mRNA levels were assessed by qRT-PCR and the expression of phosphorylated signal transducer and activator of transcription 3(phospho-STAT3),STAT3,phospho-SMAD1/5/8 and SMAD1 proteins were analyzed by western *** All iron III forms including FAC efficiently blocked hepcidin mRNA expression at non-toxic dosages in Huh7 cells or primary hepatocytes in a time and dosedependent manner(P<0.001;P<0.05).Hepcidin blockage could be efficiently blunted by iron chelators salicylaldehyde isonicotinoyl hydrazone(SIH)and Desferal(P<0.001).FAC also inhibited BMP6,hypoxia,IL-1βand IL-6-mediated hepcidin induction(P<0.001;P<0.001;P<0.05;P<0.001),and FAC also inhibited LPS-mediated hepatic hepcidin induction in co-culture model(P<0.001).Moreover,FAC reduced SMAD6 mRNA and p-SMAD1/5/8 protein expression at basal or upon stimulation by BMP6(P<0.05;P<0.01),and FAC also reduced SMAD6 and p-SMAD1/5/8 expression under hypoxia(P<0.01;P<0.05).However,FAC has no significant effect on p-STAT3

关键词： Hepcidin/iron metabolism Iron overload Inflammation Hypoxia BMP/SMAD STAT3

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Validation of modified albumin-bilirubin-TNM score as a prognostic model to evaluate patients with hepatocellular carcinoma

引用

World Journal of Hepatology 2019年第6期11卷 542-552页

作者： omar elshaarawy Alzhraa Alkhatib Mostafa Elhelbawy Asmaa Gomaa Naglaa Allam Ayman Alsebaey Eman Rewisha Imam Waked Departemnt of Hepatology Gastroenterology and Liver Transplantation National Liver Institute Menoufia University

BACKGROUND An ideal staging system for hepatocellular carcinoma(HCC)should rely on the hepatic reserve function and tumor *** the improvement in diagnostic and treatment strategies for HCC,in addition to recent treatment of viral hepatitis,finding a suitable assessment tool for hepatic reserve has become *** To validate a recently proposed modified albumin-bilirubin-TNM(mALBI-T)grade as a prognostic model for patients with HCC in *** For patients diagnosed with HCC,Child-Turcotte-Pugh(CTP)score,Barcelona Clinic Liver Cancer(BCLC)stage,albumin-bilirubin(ALBI),plateltetalbumin– bilirubin(PALBI),ALBI-based BCLC,ALBI-T and mALBI-T grades were *** were followed from time of diagnosis to date of death or date of data collection if they remained *** survival and received treatments were *** data were *** A total of 1910 patients were included(mean age,57 years;1575 males).At presentation,50.6%had CTP A,36.1%had CTP B and 13.4%had CTP C;12%had ALBI grade 1,62.3%had ALBI grade 2 and 24.7%had ALBI grade *** median survival was 13 mo;survival was better in patients with ALBI 1 than in those with ALBI 2 and 3(28.6 vs 14 and 5.8 mo,respectively,P<0.001).Patients with ALBI-T grades 0 and 1 had better survival than those with ALBI-T grades 2,3,4 and 5(P<0.001).The modified ALBI-T showed better stratification and significant improvement in prediction of *** ALBI-T grade is a superior prognostic tool that selects patients with HCC who have better liver reservoir and tumor ***-T is a better prognostic model in patients with HCC.

关键词： Staging Hepatocellular carcinoma Albumin-bilirubin grade Scores

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Performance Analysis of the Reconfigurable Intelligent Surfaces Communication Systems

引用

Journal of Communications and Information Networks 2024年第2期9卷 184-191页

作者： omar Abu Ella Department of Electrical and Electronic Engineering Misurata University2659 Zawiat AlmahjoubMisurataLibya

Reconfigurable intelligent surfaces (RIS) play a vital role in meeting the growing demand for higher data rates and reliability in wireless systems. This study focuses on analyzing the performance of RIS systems to gain a deeper understanding of their *** paper presents a mathematical analysis of the RIS system,deriving closed-form formulae that express its characteristics including signal-to-noise ratio(SNR)distribution,ergodic and effective capacity,outage,and error probability. The obtained formulae are newly derived and unconditionally valid solutions. Numerical results demonstrate a close agreement between the derived formulae and MonteCarlo simulation outcomes.

关键词： ergodic capacity effective capacity outage probability bit error rate Rayleigh fading channel RISassisted communication system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Critical assessment of R410A alternatives for mini-split air conditioners in the Egyptian market

引用

Energy and Built Environment 2024年第3期5卷 426-445页

作者： omar M.Zaki omar Abdelaziz Mechanical Power Engineering Department Faculty of EngineeringCairo UniversityGiza 12613Egypt Department of Mechanical Engineering The American University in CairoAUC AvenueNew Cairo 11835Egypt

In this study,the potential implementation of three different low-GWP refrigerants(R32,R452B,and R454B)as replacements for R410A was *** study was performed using a simulation tool developed by the authors called RACHP-Lab,which is a vapor compression system simulation tool developed based on physics-based simulation for typical mini-split air *** simulation study was carried out and validated using experimental performance data of 10 different air conditioning units available in the Egyptian *** units included fixed-speed or variable-speed compressors and operated in cooling or heating ***-in replace-ment with the new refrigerants was carried *** R32,the capacity increased between 4.9%and 13%for cooling cases,and 6.3%and 12.4%for heating ***,COP did not improve in all *** R452B and R454B with direct replacement,the capacity nearly remained the same,with an increase of COP between 1.6%and 8.0%.Soft optimization was also conducted on cooling cases where compressor suction superheat,condenser subcooling,and compressor volumetric speed were optimized to maximize COP while maintaining the original capacity of R410A.R32 showed an improvement of COP over R410A between 4.6%and 15.5%,while for R452B and R454B between 2.2%and 13.2%.

关键词： Air conditioner Heat pump Alternative refrigerants Vapor compression cycle modeling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimization of biliary drainage in inoperable distal malignant strictures

引用

World Journal of Gastrointestinal Endoscopy 2020年第9期12卷 285-296页

作者： Esam Elshimi Wesam Morad omar elshaarawy Ahmed Attia Department of Hepatology and Gastroenterology National Liver InstituteMenoufia UniversityShebine Elkom 32111Egypt Department of Epidemiology and Preventive Medicine National Liver InstituteMenoufia UniversityShebine Elkom 32111Egypt

BACKGROUND Given most patients with distal malignant biliary obstruction present in the nonresectable stage,palliative endoscopic biliary drainage with fully covered metal stent(FCMS)or uncovered metal stent(UCMS)is the only available measure to improve patients’quality of *** covered metal stent(HCMS)has been recently introduced *** adverse effects and stent function between FCMS and UCMS have been extensively *** To study the duration of stent patency of HCMS and compare it with FCMS and UCMS to optimize biliary drainage in inoperable patients with distal malignant *** aims in our study included evaluation of patients’survival and the rates of adverse events for each type of *** We studied 210 patients and randomized them into three equal groups;HCMS,FCMS and UCMS were inserted *** Stent occlusion occurred in(18.6%,17.1%and 15.7%in HCMS,FCMS and UCMS groups,respectively,P=0.9).Stent migration occurred only in patients with FCMS(8.6%of patients).Cholangitis and cholecystitis occurred in 11.4%and 5.7%of patients,respectively,in *** growth occurred only in 10 cases among patients with UCMS after a median of 140 d,sludge occurred in nine,seven and one patients in HCMS,FCMS and UCMS,respectively(P=0.04).CONCLUSION Given the prolonged stent functioning time,the use of HCMS is preferred over the use of UCMS and FCMS for optimizing biliary drainage in patients with distal malignant biliary obstruction.

关键词： Obstructive jaundice Endoscopic retrograde cholangio-pancreatography Half covered metal stent Fully covered and uncovered metal stents

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genotype-based precision nutrition strategies for the prediction and clinical management of type 2 diabetes mellitus

引用

World Journal of Diabetes 2024年第2期15卷 142-153页

作者： omar Ramos-Lopez Medicine and Psychology School Autonomous University of Baja CaliforniaTijuana 22390Baja CaliforniaMexico

Globally,type 2 diabetes mellitus(T2DM)is one of the most common metabolic disorders.T2DM physiopathology is influenced by complex interrelationships between genetic,metabolic and lifestyle factors(including diet),which differ between populations and geographic *** fact,excessive consumptions of high fat/high sugar foods generally increase the risk of developing T2DM,whereas habitual intakes of plant-based healthy diets usually exert a protective ***,genomic studies have allowed the characterization of sequence DNA variants across the human genome,some of which may affect gene expression and protein functions relevant for glucose *** comprehensive literature review covers the impact of gene-diet interactions on T2DM susceptibility and disease progression,some of which have demonstrated a value as biomarkers of personal responses to certain nutritional ***,novel genotype-based dietary strategies have been developed for improving T2DM control in comparison to general lifestyle ***,progresses in other omics areas(epigenomics,metagenomics,proteomics,and metabolomics)are improving current understanding of genetic insights in T2DM clinical *** more investigation is still needed,the analysis of the genetic make-up may help to decipher new paradigms in the pathophysiology of T2DM as well as offer further opportunities to personalize the screening,prevention,diagnosis,management,and prognosis of T2DM through precision nutrition.

关键词： Type 2 diabetes mellitus Nutrigenetics Single nucleotide polymorphism Genotype Diet Precision nutrition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advanced Optimized Anomaly Detection System for IoT Cyberattacks Using Artificial Intelligence

引用

Computers, Materials & Continua 2024年第2期78卷 1525-1545页

作者： Ali Hamid Farea omar H.Alhazmi Kerem Kucuk Department of Computer Science Taibah UniversityMedina42315Saudi Arabia Department of Software Engineering Kocaeli UniversityKocaeli41001Turkey

While emerging technologies such as the Internet of Things(IoT)have many benefits,they also pose considerable security challenges that require innovative solutions,including those based on artificial intelligence(AI),given that these techniques are increasingly being used by malicious actors to compromise IoT *** an ample body of research focusing on conventional AI methods exists,there is a paucity of studies related to advanced statistical and optimization approaches aimed at enhancing security *** contribute to this nascent research stream,a novel AI-driven security system denoted as“AI2AI”is presented in this ***2AI employs AI techniques to enhance the performance and optimize security mechanisms within the IoT *** also introduce the Genetic Algorithm Anomaly Detection and Prevention Deep Neural Networks(GAADPSDNN)sys-tem that can be implemented to effectively identify,detect,and prevent cyberattacks targeting IoT ***,this system demonstrates adaptability to both federated and centralized learning environments,accommodating a wide array of IoT *** evaluation of the GAADPSDNN system using the recently complied WUSTL-IIoT and Edge-IIoT datasets underscores its *** an impressive overall accuracy of 98.18%on the Edge-IIoT dataset,the GAADPSDNN outperforms the standard deep neural network(DNN)classifier with 94.11%***,with the proposed enhancements,the accuracy of the unoptimized random forest classifier(80.89%)is improved to 93.51%,while the overall accuracy(98.18%)surpasses the results(93.91%,94.67%,94.94%,and 94.96%)achieved when alternative systems based on diverse optimization techniques and the same dataset are *** proposed optimization techniques increase the effectiveness of the anomaly detection system by efficiently achieving high accuracy and reducing the computational load on IoT devices through the adaptive selection of active features.

关键词： Internet of Things security anomaly detection and prevention system artificial intelligence optimization techniques

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：