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Oncology Research 2024年第8期32卷 1323-1334页

作者： RUIFANG LI XINRONG NAN MING LI omar RAHHAL School of Stomatology Shanxi Medical UniversityTaiyuan030001China Department of Stomatology The First Hospital of Shanxi Medical UniversityTaiyuan030001China Department of Oral and Maxillofacial Surgery Xiangya Stomatology HospitalCentral South UniversityChangsha410005China

Background:Fibroblast activation protein(FAP),a cell surface serine protease,plays roles in tumor invasion and immune ***,there is currently no pan-cancer analysis of ***:We aimed to assess the pan-cancer expression proﬁle of FAP,its molecular function,and its potential role in head and neck squamous cell carcinoma(HNSC).Methods:We analyzed gene expression,survival status,immune inﬁltration,and molecular functional pathways of FAP in the Cancer Genome Atlas(tCGA)and Genotype tissue Expression(GtEx)***,to elucidate the role of FAP in HNSC,we performed proliferation,migration,and invasion assays post-FAP overexpression or ***:FAP expression was elevated in nine tumor types and was associated with poor survival in eight of *** the context of immune inﬁltration,FAP expression negatively correlated with CD8+t-cell inﬁltration inﬁve tumor types and positively with regulatory t-cell inﬁltration in four tumor *** enrichment analysis highlighted FAP’s involvement in the PI3K-Akt signaling *** HNSC cells,FAP overexpression activated the PI3K-Akt pathway,promoting tumor proliferation,migration,and ***,FAP knockdown showed inhibitory ***:Our study unveils the association of FAP with poor tumor prognosis across multiple cancers and highlights its potential as a therapeutic target in HNSC.

关键词： FAP Head and neck squamous cell carcinoma Cancer Prognosis tumor microenvironment Molecular function

Ballistic design and testing of a composite armour reinforced by CNts suitable for armoured vehicles

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Defence technology（防务技术） 2024年第2期32卷 173-195页

作者： Evangelos Ch.tsirogiannis Evangelos Daskalakis Mohamed H.Hassan Abdalla M.omar Paulo Bartolo EODH SA Research and Development DepartmentLakkoma Chalkidikis63080Greece School of Mechanical Aerospace and Civil EngineeringUniversity of ManchesterManchesterM139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological University639798Singapore

this paper is investigating the use of composite armour reinforced by nanomaterials, for the protection of light armoured(LAV) and medium armoured military vehicles(MAV), and the interaction between the composite materials and high-performance ballistic projectiles. Four armour materials, consisted of front hybrid fibre reinforced polymer cover layer, ceramic strike-face, fibre reinforced polymer intermediate layer and the metal matrix composite reinforced backplate, were manufactured and assembled by adhesive technology. the proposed laminated protection system is suitable for armoured ground vehicles;however, it could be used as armour on ground, air and naval platforms. the design of the protection system, including material selection and thickness, was elaborated depending on the performance requirements of Level 4 + StANAG 4569 military standard(projectile 14.5 mm × 114 mm API B32) and especially on a design philosophy which is analysed with the specifications. the backplate of this new composite is a hybrid material of Metal Matrix Composite(MMC) reinforced with carbon nanotubes(CNts), manufactured with the use of powder metallurgy technique. the composite backplate material was morphologically, mechanically and chemically analysed. Results show that all plates are presenting high mechanical properties and ballistic characteristics, compared to commonly used armour plates. Real military ballistic tests according to AEP-StANAG 4569 were carried out for the total composite armour systems. After the ballistic tests, AA2024-CNt3 showed the best protection results, compared with the other plates(AA2024-CNt1 and AA2024-CNt2), with the projectile being unable to fully penetrate the composite plate.

关键词： Passive armour protection Protective armour Ballistic performance Hybrid composites Vehicle protection

Contemporary Study for Detection of COVID-19 Using Machine Learning with Explainable AI

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Computers, Materials & Continua 2024年第7期80卷 1075-1104页

作者： Saad Akbar Humera Azam Sulaiman Sulmi Almutairi omar Alqahtani Habib Shah Aliya Aleryani Department of Computer Science University of KarachiKarachi75270Pakistan Department of Computing Faculty of Engineering Science and TechnologyHamdard UniversityKarachi75540Pakistan Department of Health Informatics College of Applied Medical SciencesQassim UniversityQassim51452Saudi Arabia Department of Computer Science College of Computer ScienceKing Khalid UniversityAbha61421Saudi Arabia

the prompt spread of COVID-19 has emphasized the necessity for effective and precise diagnostic *** this article,a hybrid approach in terms of datasets as well as the methodology by utilizing a previously unexplored dataset obtained from a private hospital for detecting COVID-19,pneumonia,and normal conditions in chest X-ray images(CXIs)is proposed coupled with Explainable Artificial Intelligence(XAI).Our study leverages less preprocessing with pre-trained cutting-edge models like InceptionV3,VGG16,and VGG19 that excel in the task of feature *** methodology is further enhanced by the inclusion of the t-SNE(t-Distributed Stochastic Neighbor Embedding)technique for visualizing the extracted image features and Contrast Limited Adaptive Histogram Equalization(CLAHE)to improve images before extraction of ***,an AttentionMechanism is utilized,which helps clarify how the modelmakes decisions,which builds trust in artificial intelligence(AI)*** evaluate the effectiveness of the proposed approach,both benchmark datasets and a private dataset obtained with permissions from Jinnah PostgraduateMedical Center(JPMC)in Karachi,Pakistan,are *** 12 experiments,VGG19 showcased remarkable performance in the hybrid dataset approach,achieving 100%accuracy in COVID-19 *** classification and 97%in distinguishing normal ***,across all classes,the approach achieved 98%accuracy,demonstrating its efficiency in detecting COVID-19 and differentiating it fromother chest disorders(Pneumonia and healthy)while also providing insights into the decision-making process of the models.

关键词： COVID-19 detection deep neural networks support vector machine CXIs InceptionV3 VGG16 VGG19 t-SNE embedding CLAHE attention mechanism XAI

Comparison of fungal vs bacterial infections in the medical intensive liver unit:Cause or corollary for high mortality?

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World Journal of Hepatology 2024年第3期16卷 379-392页

作者： Sarah Khan Hanna Hong Stephanie Bass Yifan Wang Xiao-Feng Wang omar t Sims Christine E Koval Aanchal Kapoor Christina C Lindenmeyer Department of Internal Medicine Cleveland ClinicClevelandOH 44195United States Cleveland Clinic Lerner College of Medicine Cleveland ClinicClevelandOH 44195United States Department of Pharmacy Cleveland ClinicClevelandOH 44195United States Department of Quantitative Health Sciences/Biostatistics Section Cleveland ClinicClevelandOH 44195United States Department of Gastroenterology Hepatology and NutritionCleveland ClinicClevelandOH 44195United States Department of Infectious Disease Cleveland ClinicClevelandOH 44195United States Department of Critical Care Medicine Cleveland ClinicClevelandOH 44195United States

BACKGROUND Due to development of an immune-dysregulated phenotype,advanced liver disease in all forms predisposes patients to sepsis acquisition,including by opportunistic pathogens such as *** data exists on fungal infection within a medical intensive liver unit(MILU),particularly in relation to acute on chronic liver *** to investigate the impact of fungal infections among critically ill patients with advanced liver disease,and compare outcomes to those of patients with bacterial *** From our prospective registry of MILU patients from 2018-2022,we included 27 patients with culture-positive fungal infections and 183 with bacterial *** compared outcomes between patients admitted to the MILU with fungal infections to bacterial *** was extracted through chart *** All fungal infections were due to Candida species,and were most frequently blood *** among patients with fungal infections was significantly worse relative to the bacterial cohort(93%vs 52%,Pthe majority of the fungal cohort developed grade 2 or 3 acute on chronic liver failure(ACLF)(90%vs 64%,P=0.02).Patients in the fungal cohort had increased use of vasopressors(96%vs 70%,P=0.04),mechanical ventilation(96%vs 65%,Pto acute kidney injury(78%vs 52%,P=0.014).On MILU admission,the fungal cohort had significantly higher Acute Physiology and Chronic Health Evaluation(108 vs 91,P=0.003),Acute Physiology Score(86 vs 65,P=0.003),and Model for End-Stage Liver Disease-Sodium scores(86 vs 65,P=0.041).there was no significant difference in the rate of central line use preceding culture(52%vs 40%,P=0.2).Patients with fungal infection had higher rate of transplant hold placement,and lower rates of transplant;however,differences did not achieve statistical *** Mortality was worse among patients with fungal infections,likely attributable to severe ACLF *** studies examinin

关键词： Fungal Infection Sepsis Acute on chronic liver failure Intensive care

Genotype-based precision nutrition strategies for the prediction and clinical management of type 2 diabetes mellitus

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World Journal of Diabetes 2024年第2期15卷 142-153页

作者： omar Ramos-Lopez Medicine and Psychology School Autonomous University of Baja CaliforniaTijuana 22390Baja CaliforniaMexico

Globally,type 2 diabetes mellitus(t2DM)is one of the most common metabolic disorders.t2DM physiopathology is influenced by complex interrelationships between genetic,metabolic and lifestyle factors(including diet),which differ between populations and geographic *** fact,excessive consumptions of high fat/high sugar foods generally increase the risk of developing t2DM,whereas habitual intakes of plant-based healthy diets usually exert a protective ***,genomic studies have allowed the characterization of sequence DNA variants across the human genome,some of which may affect gene expression and protein functions relevant for glucose *** comprehensive literature review covers the impact of gene-diet interactions on t2DM susceptibility and disease progression,some of which have demonstrated a value as biomarkers of personal responses to certain nutritional ***,novel genotype-based dietary strategies have been developed for improving t2DM control in comparison to general lifestyle ***,progresses in other omics areas(epigenomics,metagenomics,proteomics,and metabolomics)are improving current understanding of genetic insights in t2DM clinical *** more investigation is still needed,the analysis of the genetic make-up may help to decipher new paradigms in the pathophysiology of t2DM as well as offer further opportunities to personalize the screening,prevention,diagnosis,management,and prognosis of t2DM through precision nutrition.

关键词： type 2 diabetes mellitus Nutrigenetics Single nucleotide polymorphism Genotype Diet Precision nutrition

Engineering nanomedicines for immunogenic eradication of cancer cells:Recent trends and synergistic approaches

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2475-2504页

作者： Ahmed O.Elzoghby omar Samir Hagar E.Emam Ahmed Soliman Riham M.Abdelgalil Yomna M.Elmorshedy Kadria A.Elkhodairy Mahmoud L.Nasr Division of Engineering in Medicine and Division of Renal Medicine Department of MedicineBrigham and Women's HospitalHarvard Medical SchoolBoston 02115MAUSA Cancer Nanotechnology Research Laboratory(CNRL) Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt

Resistance to cancer immunotherapy is mainly attributed to poor tumor immunogenicity as well as the immunosuppressive tumor microenvironment(tME)leading to failure of immune *** therapeutic strategies including chemotherapy,radiotherapy,photodynamic,photothermal,magnetic,chemodynamic,sonodynamic and oncolytic therapy,have been developed to induce immunogenic cell death(ICD)of cancer cells and thereby elicit immunogenicity and boost the antitumor immune ***,many challenges hamper the clinical application of ICD inducers resulting in modest immunogenic ***,we outline the current state of using nanomedicines for boosting ICD of cancer ***,synergistic approaches used in combination with ICD inducing nanomedicines for remodeling the tME via targeting immune checkpoints,phagocytosis,macrophage polarization,tumor hypoxia,autophagy and stromal modulation to enhance immunogenicity of dying cancer cells were *** further highlight the emerging trends of using nanomaterials for triggering amplified ICD-mediated antitumor immune *** reticulum localized ICD,focused ultrasound hyperthermia,cell membrane camouflaged nanomedicines,amplified reactive oxygen species(ROS)generation,metallo-immunotherapy,ion modulators and engineered bacteria are among the most innovative *** challenges,merits and demerits of ICD inducer nanomedicines were also discussed with shedding light on the future role of this technology in improving the outcomes of cancer immunotherapy.

关键词： Immunogenic cell death Immunogenic eradication Nanomedicines Drug delivery Cancer immunotherapy Antitumor immunity t cells tumor associated antigens Synergistic immune response

Melittin analog p5RHH enhances recombinant adeno-associated virus transduction efficiency

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Journal of Integrative Medicine 2024年第1期22卷 72-82页

作者： Jing-shun Meng Yun He Heng-bin Yang Li-ping Zhou Si-yuan Wang Xi-lin Feng omar Yahya Al-shargi Xiao-min Yu Li-qing Zhu Chang-quan Ling Shanghai University of traditional Chinese Medicine Shanghai 201203China Oncology Department of traditional Chinese Medicine Changhai HospitalNaval Medical UniversityShanghai 200433China Faculty of traditional Chinese Medicine Naval Medical UniversityShanghai 200043China State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene technology(Ministry of Education) School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200438China Yantai Fuheng Biological technology Co. Ltd.YantaiShandong Province 264006China. Department of Clinical Laboratory the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

Objective Melittin and its derivatives have been characterized to establish effective gene delivery *** capability of facilitating endosomal release enhances the nanoparticles-based gene ***,little investigation has been conducted to explore its potential application in the context of viral *** Various melittin-derived peptides were inserted into the loop VIII of the capsid proteins of recombinant adeno-associated virus *** vectors carrying either gfp or fluc genes were subjected to qPCR assays and transduction assays of HEK293t cells to investigate the efficiency of vector production and gene *** addition,the ability of a specific p5RHH-rAAV vector to deliver genes was examined through in vitro transduction of different cultured cells and in vivo tail vein administration to C57BL/6 ***,the intricate details of the vector-mediated transduction mechanisms were revealed by specific pharmacological inhibitors of every stage of the rAAV2 intracellular life *** A total of 76 melittin-related peptides were compiled from existing *** them,cMA2,Melt13,p5RHH and aAR3 were found to significantly enhance the gene delivery efficiency of rAAV2 *** p5RHH-rAAV2 vectors efficiently transduced not only rAAV-potent cell lines but also cell lines previously considered resistant to ***,bafilomycin A1,a vacuolar endosome acidification inhibitor,completely inhibited the transgene expression mediated by the p5RHH-rAAV2 *** importantly,p5RHH-rAAV8 vectors also demonstrated increased hepatic transduction in vivo in C57BL/6 *** the incorporation of melittin analogues into the rAAV capsids results in a significant improvement in rAAV-mediated transgene *** further modifications remain an area of interest,our studies have substantially broadened the pharmacological prospects of melittin in the context of viral vector-mediated gene delivery.

关键词： Melittin Recombinant adeno-associated virus Capsid engineering transduction efficiency

Security Monitoring and Management for the Network Services in the Orchestration of SDN-NFV Environment Using Machine Learning techniques

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Computer Systems Science & Engineering 2024年第2期48卷 363-394页

作者： Nasser Alshammari Shumaila Shahzadi Saad Awadh Alanazi Shahid Naseem Muhammad Anwar Madallah Alruwaili Muhammad Rizwan Abid omar Alruwaili Ahmed Alsayat Fahad Ahmad Department of Computer Science College of Computer and Information SciencesJouf UniversitySakakaAl Jouf72341Saudi Arabia Department of Computer Sciences Kinnaird College forWomenLahorePunjab54700Pakistan Department of Information Sciences Division of Sciences and TechnologyUniversity of EducationLahore54770Pakistan Department of Computer Engineering and Networks College of Computer and Information SciencesJouf UniversitySakaka72341Saudi Arabia Computer Science Florida Polytechnic UniversityLakelandFlorida33805USA Delta3t LahorePunjab54700Pakistan Department of Basic Sciences Common First YearJouf UniversitySakaka72341Saudi Arabia

Software Defined Network(SDN)and Network Function Virtualization(NFV)technology promote several benefits to network operators,including reduced maintenance costs,increased network operational performance,simplified network lifecycle,and policies *** vulnerabilities try to modify services provided by Network Function Virtualization MANagement and Orchestration(NFV MANO),and malicious attacks in different scenarios disrupt the NFV Orchestrator(NFVO)and Virtualized Infrastructure Manager(VIM)lifecycle management related to network services or individual Virtualized Network Function(VNF).this paper proposes an anomaly detection mechanism that monitors threats in NFV MANO and manages promptly and adaptively to implement and handle security functions in order to enhance the quality of experience for end *** anomaly detector investigates these identified risks and provides secure network *** enables virtual network security functions and identifies anomalies in Kubernetes(a cloud-based platform).For training and testing purpose of the proposed approach,an intrusion-containing dataset is used that hold multiple malicious activities like a Smurf,Neptune,teardrop,Pod,Land,IPsweep,etc.,categorized as Probing(Prob),Denial of Service(DoS),User to Root(U2R),and Remote to User(R2L)*** anomaly detector is anticipated with the capabilities of a Machine Learning(ML)technique,making use of supervised learning techniques like Logistic Regression(LR),Support Vector Machine(SVM),Random Forest(RF),Naïve Bayes(NB),and Extreme Gradient Boosting(XGBoost).the proposed framework has been evaluated by deploying the identified ML algorithm on a Jupyter notebook in Kubeflow to simulate Kubernetes for validation *** classifier has shown better outcomes(99.90%accuracy)than other classifiers in detecting anomalies/intrusions in the containerized environment.

关键词： Software defined network network function virtualization network function virtualization management and orchestration virtual infrastructure manager virtual network function Kubernetes Kubectl artificial intelligence machine learning

Practical guide:Glucagon-like peptide-1 and dual glucosedependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonists in diabetes mellitus

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World Journal of Diabetes 2024年第3期15卷 331-347页

作者： Saleh Fahad Alqifari omar Alkomi Abdullah Esmail Khadijeh Alkhawami Shahd Yousri Mohamad Ayham Muqresh Nawwarah Alharbi Abdullah A Khojah Ahmed Aljabri Abdulrahman Allahham Kousalya Prabahar Hanan Alshareef Mohammed Aldhaeefi tariq Alrasheed Ali Alrabiah Laila A AlBishi Department of Pharmacy Practice Faculty of PharmacyUniversity of TabukTabuk 71491Saudi Arabia Department of Clinical Sciences Sulaiman Alrajhi University-College of MedicineAl Bukayriyah 52726Saudi Arabia Department of Family Medicine Dr.Soliman Fakeeh Hospital DSFHJeddah 21461Saudi Arabia Department of Pharmacy Practice Faculty of PharmacyKing Abdulaziz UniversityJeddah 22252Saudi Arabia Clinical and Administrative Pharmacy Sciences College of PharmacyHoward UniversityWashingtonDC 20059United States Department of Internal Medicine Faculty of MedicineUniversity of TabukTabuk 71491Saudi Arabia Department of Pharmacy Practice Raabe College of PharmacyOhio Northern UniversityOhioOH 45810United States Department of Pediatric Faculty of MedicineUniversity of TabukTabuk 71491Saudi Arabia

Practical guide:Glucagon-like peptide-1 and dual glucosedependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonists in diabetes mellitus common second-line choice after metformin for treating *** considerations can make selecting and switching between different GLP-1 RAs *** study aims to provide a comprehensive guide for the usage of GLP-1 RAs and dual GIP and GLP-1 RAs for the management of t2DM.

关键词： Glucagon-like peptide-1 receptor agonist Diabetes mellitus Metabolic syndrome Dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist Clinical practice Endocrinology

Simple operated multipurpose temperature control cryostat

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第5期8卷 793-796页

作者： ABBAS t.A. omar M.S. Department of Physics College of Science University of SalahaddinArbilIraqi KurdistanIraq

A suitable simple optical cryostat for optical, magneto-optical, electrical and thermo-electrical measurements was designed. It is suitable for use in a magnetic pool gap as narrow as less than 1 cm. throughout a long period of time, the heat diffusion process of the cryostat can be easily operated at slow increase in sample temperature in a range 1.25 K/min at 200 K that will be reduced gradually to 0.66 K at room temperature. Liquid nitrogen was used to cool down the temperature. During the operation, the change in the measured energy gap of a semiconductor sample and other physical parameters resulting from the change of temperature can be corrected through the temperature coefficient of that parameter at the corresponding temperature. the cryostat was successfully used for all experiments mentioned above to measure the properties of a single crystal of GaP (Gallium Phosphate) semiconductor.

关键词： Optical cryostat Electrical cryostat Magneto-optical cryostat