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Ab externo implantation of the MicroShunt, a poly (styrene-block-isobutylene-blockstyrene) surgical device for the treatment of primary open-angle glaucoma: a review

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Eye and Vision 2019年第1期6卷 303-311页

作者： omar sadruddin Leonard Pinchuk Raymund Angeles Paul Palmberg Santen Inc EmeryvilleCAUSA. InnFocus Inc. a Santen CompanyMiamiFLUSA Bascom Palmer Eye Institute University of Miami Miller School of MedicineMiamiFLUSA

Trabeculectomy remains the‘gold standard’intraocular pressure(IOP)-lowering procedure for moderate-to-severe glaucoma;however,this approach is associated with the need for substantial post-operative *** glaucoma surgery(MIGS)procedures aim to reduce the need for intra-and post-operative management and provide a less invasive means of lowering ***,MIGS procedures are associated with only modest reductions in IOP and are targeted at patients with mild-to-moderate glaucoma,highlighting an unmet need for a less invasive treatment of advanced and refractory *** PRESERFLO®MicroShunt(formerly known as InnFocus MicroShunt)is an 8.5 mm-long(outer diameter 350μm;internal lumen diameter 70μm)glaucoma drainage device made from a highly biocompatible,bioinert material called poly(styrene-block-isobutylene-blockstyrene),or *** lumen size is sufficiently small that at normal aqueous flow hypotony is avoided,but large enough to avoid being blocked by sloughed cells or *** MicroShunt achieves the desired pressure range in the eye by draining aqueous humor from the anterior chamber to a bleb formed under the conjunctiva and Tenon’s *** device is implanted ab externo with intraoperative Mitomycin C via a minimally invasive(relative to incisional surgery)surgical procedure,enabling precise control of placement without the need for gonioscopy,suture tension control,or suture *** implantation procedure can be performed in combination with cataract surgery or as a standalone *** MicroShunt received ConformitéEuropéenne(CE)marking in 2012 and is intended for the reduction of IOP in eyes of patients with primary open-angle glaucoma in which IOP remains uncontrolled while on maximum tolerated medical therapy and/or in which glaucoma progression warrants *** clinical studies assessing the long-term safety and efficacy of the MicroShunt have been completed;a Phase 3 multicenter,randomized clinical study comp

关键词： Ab externo Glaucoma Micro-invasive glaucoma surgery MicroShunt Mitomycin C SIBS polymer

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Performance Analysis of the Reconfigurable Intelligent Surfaces Communication Systems

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Journal of Communications and Information Networks 2024年第2期9卷 184-191页

作者： omar Abu Ella Department of Electrical and Electronic Engineering Misurata University2659 Zawiat AlmahjoubMisurataLibya

Reconfigurable intelligent surfaces (RIS) play a vital role in meeting the growing demand for higher data rates and reliability in wireless systems. This study focuses on analyzing the performance of RIS systems to gain a deeper understanding of their *** paper presents a mathematical analysis of the RIS system,deriving closed-form formulae that express its characteristics including signal-to-noise ratio(SNR)distribution,ergodic and effective capacity,outage,and error probability. The obtained formulae are newly derived and unconditionally valid solutions. Numerical results demonstrate a close agreement between the derived formulae and MonteCarlo simulation outcomes.

关键词： ergodic capacity effective capacity outage probability bit error rate Rayleigh fading channel RISassisted communication system

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Critical assessment of R410A alternatives for mini-split air conditioners in the Egyptian market

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Energy and Built Environment 2024年第3期5卷 426-445页

作者： omar M.Zaki omar Abdelaziz Mechanical Power Engineering Department Faculty of EngineeringCairo UniversityGiza 12613Egypt Department of Mechanical Engineering The American University in CairoAUC AvenueNew Cairo 11835Egypt

In this study,the potential implementation of three different low-GWP refrigerants(R32,R452B,and R454B)as replacements for R410A was *** study was performed using a simulation tool developed by the authors called RACHP-Lab,which is a vapor compression system simulation tool developed based on physics-based simulation for typical mini-split air *** simulation study was carried out and validated using experimental performance data of 10 different air conditioning units available in the Egyptian *** units included fixed-speed or variable-speed compressors and operated in cooling or heating ***-in replace-ment with the new refrigerants was carried *** R32,the capacity increased between 4.9%and 13%for cooling cases,and 6.3%and 12.4%for heating ***,COP did not improve in all *** R452B and R454B with direct replacement,the capacity nearly remained the same,with an increase of COP between 1.6%and 8.0%.Soft optimization was also conducted on cooling cases where compressor suction superheat,condenser subcooling,and compressor volumetric speed were optimized to maximize COP while maintaining the original capacity of R410A.R32 showed an improvement of COP over R410A between 4.6%and 15.5%,while for R452B and R454B between 2.2%and 13.2%.

关键词： Air conditioner Heat pump Alternative refrigerants Vapor compression cycle modeling

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Genotype-based precision nutrition strategies for the prediction and clinical management of type 2 diabetes mellitus

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World Journal of Diabetes 2024年第2期15卷 142-153页

作者： omar Ramos-Lopez Medicine and Psychology School Autonomous University of Baja CaliforniaTijuana 22390Baja CaliforniaMexico

Globally,type 2 diabetes mellitus(T2DM)is one of the most common metabolic disorders.T2DM physiopathology is influenced by complex interrelationships between genetic,metabolic and lifestyle factors(including diet),which differ between populations and geographic *** fact,excessive consumptions of high fat/high sugar foods generally increase the risk of developing T2DM,whereas habitual intakes of plant-based healthy diets usually exert a protective ***,genomic studies have allowed the characterization of sequence DNA variants across the human genome,some of which may affect gene expression and protein functions relevant for glucose *** comprehensive literature review covers the impact of gene-diet interactions on T2DM susceptibility and disease progression,some of which have demonstrated a value as biomarkers of personal responses to certain nutritional ***,novel genotype-based dietary strategies have been developed for improving T2DM control in comparison to general lifestyle ***,progresses in other omics areas(epigenomics,metagenomics,proteomics,and metabolomics)are improving current understanding of genetic insights in T2DM clinical *** more investigation is still needed,the analysis of the genetic make-up may help to decipher new paradigms in the pathophysiology of T2DM as well as offer further opportunities to personalize the screening,prevention,diagnosis,management,and prognosis of T2DM through precision nutrition.

关键词： Type 2 diabetes mellitus Nutrigenetics Single nucleotide polymorphism Genotype Diet Precision nutrition

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Explicit solutions to the time-fractional generalized dissipative Kawahara equation

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Journal of Ocean Engineering and Science 2024年第4期9卷 348-352页

作者： Marwan Alquran Mohammed Ali omar Alshboul Department of Mathematics and Statistics Jordan University of Science and TechnologyIrbid 22110Jordan

In this paper,the generalized dissipative Kawahara equation in the sense of conformable fractional derivative is presented and solved by applying the tanh-coth-expansion and sine-cosine function *** quadratic-case and cubic-case are investigated for the proposed *** solutions are obtained with highlighting to the effect of the presence of the alternative fractional-derivative and the effect of the added dissipation term to the generalized Kawahara *** graphical analysis is presented to support the findings of the ***,we believe that the obtained results in this work will be important and valuable in nonlinear sciences and ocean engineering.

关键词： Time-fractional Kawahara equation Conformable-derivative Tanh-coth-expansion method Sine-cosine function method

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Advanced Optimized Anomaly Detection System for IoT Cyberattacks Using Artificial Intelligence

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Computers, Materials & Continua 2024年第2期78卷 1525-1545页

作者： Ali Hamid Farea omar H.Alhazmi Kerem Kucuk Department of Computer Science Taibah UniversityMedina42315Saudi Arabia Department of Software Engineering Kocaeli UniversityKocaeli41001Turkey

While emerging technologies such as the Internet of Things(IoT)have many benefits,they also pose considerable security challenges that require innovative solutions,including those based on artificial intelligence(AI),given that these techniques are increasingly being used by malicious actors to compromise IoT *** an ample body of research focusing on conventional AI methods exists,there is a paucity of studies related to advanced statistical and optimization approaches aimed at enhancing security *** contribute to this nascent research stream,a novel AI-driven security system denoted as“AI2AI”is presented in this ***2AI employs AI techniques to enhance the performance and optimize security mechanisms within the IoT *** also introduce the Genetic Algorithm Anomaly Detection and Prevention Deep Neural Networks(GAADPSDNN)sys-tem that can be implemented to effectively identify,detect,and prevent cyberattacks targeting IoT ***,this system demonstrates adaptability to both federated and centralized learning environments,accommodating a wide array of IoT *** evaluation of the GAADPSDNN system using the recently complied WUSTL-IIoT and Edge-IIoT datasets underscores its *** an impressive overall accuracy of 98.18%on the Edge-IIoT dataset,the GAADPSDNN outperforms the standard deep neural network(DNN)classifier with 94.11%***,with the proposed enhancements,the accuracy of the unoptimized random forest classifier(80.89%)is improved to 93.51%,while the overall accuracy(98.18%)surpasses the results(93.91%,94.67%,94.94%,and 94.96%)achieved when alternative systems based on diverse optimization techniques and the same dataset are *** proposed optimization techniques increase the effectiveness of the anomaly detection system by efficiently achieving high accuracy and reducing the computational load on IoT devices through the adaptive selection of active features.

关键词： Internet of Things security anomaly detection and prevention system artificial intelligence optimization techniques

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Evaluation of hand infections in the emergency department using point-of-care ultrasound

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World Journal of Emergency Medicine 2024年第4期15卷 283-288页

作者： David Ahmad Haidar David Mintz Brandon M Wubben omar Rizvi Srikar Adhikari Department of Emergency Medicine Michigan MedicineAnn Arbor 48109-1382USA University of Arizona College of Medicine Tucson 85724USA Department of Emergency Medicine University of IowaIowa City 52242-1009USA Department of Surgery University of Arizona College of MedicineTucson 85724USA Department of Emergency Medicine University of Arizona College of MedicineTucson 85724USA

BACKGROUND:We aimed to evaluate the utility of point-of-care ultrasound(POCUS)in the assessment of hand infections that present to the emergency department(ED)and its impact on medical decision making and patient ***:We conducted a retrospective review of patients who presented to two urban academic EDs with clinical presentations concerning for skin and soft tissue infections(SSTI)of the hand between December 2015 and December *** trained POCUS fellowship physicians reviewed an ED POCUS database for POCUS examinations of the *** then reviewed patients’electronic health records(EHR)for demographic characteristics,history,physical examination findings,ED course,additional imaging studies,consultations,impact of POCUS on patient care and final ***:We included a total of 50 cases(28 male,22 female)in the final *** most common presenting symptoms and exam findings were pain(100%),swelling(90%),and erythema(74%).The most common sonographic findings were edema(76%),soft tissue swelling(78%),and fluid surrounding the tendon(57%).POCUS was used in medical decision making 68%of the time(n=34),with the use of POCUS leading to changes in management 38%of the time(n=19).POCUS use led to early antibiotic use(11/19),early consultation(10/19),and led to the performance of a required procedure(8/19).The POCUS diagnosis was consistent with the discharge diagnosis of flexor tenosynovitis 8/12 times,abscess 12/16 times,and cellulitis 14/20 ***:POCUS is beneficial for evaluating of hand infections that present to the ED and can be used as an important part of medical decision making to expedite patient care.

关键词： Ultrasound Point-of-care ultrasound Cellulitis Abscess Flexor tenosynovitis

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Fibroblast activation protein (FAP) as a prognostic biomarker in multiple tumors and its therapeutic potential in head and neck squamous cell carcinoma

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Oncology Research 2024年第8期32卷 1323-1334页

作者： RUIFANG LI XINRONG NAN MING LI omar RAHHAL School of Stomatology Shanxi Medical UniversityTaiyuan030001China Department of Stomatology The First Hospital of Shanxi Medical UniversityTaiyuan030001China Department of Oral and Maxillofacial Surgery Xiangya Stomatology HospitalCentral South UniversityChangsha410005China

Background:Fibroblast activation protein(FAP),a cell surface serine protease,plays roles in tumor invasion and immune ***,there is currently no pan-cancer analysis of ***:We aimed to assess the pan-cancer expression proﬁle of FAP,its molecular function,and its potential role in head and neck squamous cell carcinoma(HNSC).Methods:We analyzed gene expression,survival status,immune inﬁltration,and molecular functional pathways of FAP in The Cancer Genome Atlas(TCGA)and Genotype Tissue Expression(GTEx)***,to elucidate the role of FAP in HNSC,we performed proliferation,migration,and invasion assays post-FAP overexpression or ***:FAP expression was elevated in nine tumor types and was associated with poor survival in eight of *** the context of immune inﬁltration,FAP expression negatively correlated with CD8+T-cell inﬁltration inﬁve tumor types and positively with regulatory T-cell inﬁltration in four tumor *** enrichment analysis highlighted FAP’s involvement in the PI3K-Akt signaling *** HNSC cells,FAP overexpression activated the PI3K-Akt pathway,promoting tumor proliferation,migration,and ***,FAP knockdown showed inhibitory ***:Our study unveils the association of FAP with poor tumor prognosis across multiple cancers and highlights its potential as a therapeutic target in HNSC.

关键词： FAP Head and neck squamous cell carcinoma Cancer Prognosis Tumor microenvironment Molecular function

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The Impact of Network Topologies and Radio Duty Cycle Mechanisms on the RPL Routing Protocol Power Consumption

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Computers, Materials & Continua 2024年第5期79卷 1835-1854页

作者： Amal Hkiri Hamzah Faraj omar Ben Bahri Mouna Karmani Sami Alqurashi Mohsen Machhout Physic Department Electronics and Micro-Electronics LaboratoryFaculty of Sciences of MonastirMonastir5000Tunisia Department of Science and Technology College of RanyahTaif UniversityP.O.Box 11099Taif21944Saudi Arabia

The Internet of Things(IoT)has witnessed a significant surge in adoption,particularly through the utilization of Wireless Sensor Networks(WSNs),which comprise small internet-connected *** deployments span various environments and offer a multitude of ***,the widespread use of battery-powered devices introduces challenges due to their limited hardware resources and communication *** response to this,the Internet Engineering Task Force(IETF)has developed the IPv6 Routing Protocol for Low-power and Lossy Networks(RPL)to address the unique requirements of such *** the critical role of RPL in maintaining high performance,this paper proposes a novel approach to optimizing power ***,it introduces a developed sensor motes topology integrated with a Radio Duty Cycling(RDC)mechanism aimed at minimizing power *** rigorous analysis,the paper evaluates the power efficiency of this approach through several simulations conducted across different network topologies,including random,linear,tree,and elliptical ***,three distinct RDC mechanisms—CXMAC,ContikiMAC,and NullRDC—are investigated to assess their impact on power *** findings of the study,based on a comprehensive and deep analysis of the simulated results,highlight the efficiency of ContikiMAC in power *** research contributes valuable insights into enhancing the energy efficiency of RPL-based IoT networks,ultimately facilitating their widespread deployment and usability in diverse environments.

关键词： WSN IoT radio duty cycles topologies

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Secure and Reliable Routing in the Internet of Vehicles Network:AODV-RL with BHA Attack Defense

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 633-659页

作者： Nadeem Ahmed Khalid Mohammadani Ali Kashif Bashir Marwan omar Angel Jones Fayaz Hassan School of Electronic Science Beijing University of Post and TelecommunicationBeijing100086China Department of Computer Science Huanggang Normal UniversityHuanggangChina Department of Computing and Mathematics Manchester Metropolitan UniversityManchesterUK Woxsen School of Business Woxsen UniversityHyderabad502345India Department of Computer Science and Mathematics Lebanese American UniversityBeirutLebanon Information Technology and Management Illinois Institute of TechnologyChicagoUSA College of Computing Capital Technology UniversityLaurelUSA

Wireless technology is transforming the future of transportation through the development of the Internet of Vehicles(IoV).However,intricate security challenges are intertwinedwith technological progress:Vehicular ad hoc Networks(VANETs),a core component of IoV,face security issues,particularly the Black Hole Attack(BHA).This malicious attack disrupts the seamless flow of data and threatens the network’s overall reliability;also,BHA strategically disrupts communication pathways by dropping data packets from legitimate nodes *** the importance of this challenge,we have introduced a new solution called ad hoc On-Demand Distance Vector-Reputation-based mechanism Local Outlier Factor(AODV-RL).The significance of AODVRL lies in its unique approach:it verifies and confirms the trustworthiness of network components,providing robust protection against *** additional safety layer is established by implementing the Local Outlier Factor(LOF),which detects and addresses abnormal network *** testing of our solution has revealed its remarkable ability to enhance communication in ***,Our experimental results achieve message delivery ratios of up to 94.25%andminimal packet loss ratios of just 0.297%.Based on our experimental results,the proposedmechanismsignificantly improves VANET communication reliability and *** results promise a more secure and dependable future for IoV,capable of transforming transportation safety and efficiency.

关键词： Black hole attack IoV vehicular ad hoc network AODV routing protocol

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