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Innate im.une responses induced by lipopolysaccharide and lipoteichoic acid in prim.ry goat m.m.ary epithelial cells

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Journal of Anim.l Science and Biotechnology 2017年第4期8卷 842-851页

作者： omar Bulgari Xianwen Dong Alfred L.Roca1 Anna m. Caroli Juan J. Loor Departm.nt of Anim.l Sciences and Division of Nutritional Sciences University of Illinois at Urbana-Champaign Urbana IL 61801 USA Departm.nt of m.lecular and Translational m.dicine University of BresciaBrescia 25123 Italy Institute of Anim.l Nutrition Sichuan Agricultural University Chengdu 611130 China Division of Nutritional Sciences University of Illinois at Urbana-Champaign Urbana IL 61801 USA

Background: Innate im.une responses induced by in vitro stim.lation of prim.ry m.m.ary epithelial cells(m.C) using Gram.negative lipopolysaccharide(LPS) and Gram.positive lipoteichoic acid(LTA) bacterial cell wall com.onents are well-characterized in bovine species. The objective of the current study was to characterize the downstream.regulation of the inflam.atory response induced by Toll-like receptors in prim.ry goat m.C(pgm.C). We perform.d quantitative real-tim. RT-PCR(qPCR) to m.asure m.NA levels of 9 genes involved in transcriptional regulation or antibacterial activity: Toll-like receptor 2(TLR2), Toll-like receptor 4(TLR4), prostaglandin-endoperoxide synthase 2(PTGS2), interferon induced protein with tetratricopeptide repeats 3(IFIT3), interferon regulatory factor 3(IRF3), m.eloid differentiation prim.ry response 88(m.D88), nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(NFKB1), Toll interacting protein(TOLLIP), and lactoferrin(LTF). Furtherm.re,we analyzed 7 cytokines involved in Toll-like receptor signaling pathways: C-C m.tif chem.kine ligand 2(CCL2), C-C m.tif chem.kine ligand 5(CCL5), C-X-C m.tif chem.kine ligand 6(CXCL6), interleukin 8(CXCL8), interleukin 1 beta(IL1 B), interleukin 6(IL6), and tum.r necrosis factor alpha(TNF).Results: Stim.lation of pgm.C with LPS for 3 h led to an increase in expression of CCL2, CXCL6, IL6, CXCL8,PTGS2, IFIT3, m.D88, NFKB1, and TLR4(P m. genes had greater expression than controls at 6 h post-LPS(P m.ared to controls, stim.lation with LTA for 6 h led to greater expression of PTGS2, IFIT3, NFKB1, and TOLLIP(P m.ared to controls a greater expression(P < 0.05) of CCL2, CCL5, CXCL6, CXCL8, IL6, PTGS2, IFIT3, IR

关键词： Gene expression Inflam.ation Lactation m.stitis

Hybrid Sensor Selection Technique for Lifetim. Extension of Wireless Sensor Networks

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Com.uters, m.terials & Continua 2022年第3期70卷 4965-4985页

作者： Khaled m.Fouad Basm. m.Hassan omar m.Salim Inform.tion System. Departm.nt Faculty of Computers and Artificial IntelligenceBenha UniversityBenha13518Egypt Faculty of Artificial Intelligence Kafrelsheikh UniversityKafrelsheikh33516Egypt Electrical Engineering Departm.nt Benha Faculty of EngineeringBenha UniversityBenha13518Egypt

Energy conservation is a crucial issue to extend the lifetim. of wireless sensor networks(WSNs)where the battery capacity and energy sources are very *** energy-saving techniques can help designers overcom. this issue by reducing the num.er of selected sensors that report environm.ntal m.asurem.nts by elim.nating all replicated and unrelated *** paper suggests a Hybrid Sensor Selection(HSS)technique that com.ines filter-wrapperm.thod to acquire a rich-inform.tional subset of sensors in a reasonable *** aim. to increase the lifetim. of WSNs by using the optim.l num.er of *** the sam. tim.,HSS m.intains the desired level of accuracy and m.nages sensor failures with the m.st suitable num.er of sensors without com.rom.sing the *** evaluation of the HSS technique has adopted four experim.nts by using four different *** experim.nts show that HSS can extend the WSNs lifetim. and increase the accuracy using a sufficient num.er of sensors without affecting ***,to ensure HSS credibility and reliability,the proposed HSS technique has been com.ared to other corresponding m.thodologies and shows its superiority in energy conservation at prem.um.accuracy m.asures.

关键词： Energy conservation WSNs intelligent techniques sensor selection

A Dynam.c m.nagem.nt Schem. for Internet of Things(IoT)Environm.nts:Sim.lation and Perform.nce Evaluation

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Com.uter m.deling in Engineering & Sciences 2022年第12期133卷 673-695页

作者： omar Said Departm.nt of Inform.tion Technology College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia

In recent years,the Internet of Things(IoT)technology has been considered one of the m.st attractive fields for researchers due to its aspirations and im.lications for society and life as a *** IoT environm.nt contains vast num.ers of devices,equipm.nt,and heterogeneous users who generate m.ssive am.unts of ***,things’entry into and exit from.oT system. occur dynam.cally,changing the topology and content of IoT networks very ***,m.naging IoT environm.nts is am.ng the m.st pressing *** paper proposes an adaptive and dynam.c schem. for m.naging IoT environm.nts is *** m.nagem.nt schem. depends on the use of previous m.nagem.nt m.thodologies,considering two m.in *** first factor is network status,which is determ.ned in *** second factor is a m.nagem.nt m.thod’s suitability according to its desired *** test the proposed m.nagem.nt schem.,a sim.lation environm.nt is created using *** m.trics used to m.asure the m.nagem.nt schem. perform.nce are bandwidth consum.tion,energy consum.tion,packet loss,throughput,delay,usage rate of individualm.nagem.nt techniques,and *** sim.lation results prove that the proposed m.nagem.nt schem. outperform.d the individual 6LowPANSNm.,CoAP,and LWm.m.m.nagem.nt schem.s.

关键词： Internet of Things IoT m.nagem.nt IoT sim.lation SNm. neural networks big data

Big Data Analytics Using Graph Signal Processing

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Com.uters, m.terials & Continua 2023年第1期74卷 489-502页

作者： Farhan Am.n omar m.Barukab Gyu Sang Choi Departm.nt of Inform.tion and Com.unication Engineering Yeungnam UniversityGyeongsan38541Korea Faculty of Com.uting and Inform.tion Technology-Rabigh King Abdulaziz UniversityJeddahSaudi Arabia

The networks are fundam.ntal to our m.dern world and they appear throughout science and *** to a m.ssive am.unt of data presents a unique opportunity to the researcher’s *** networks grow in size the com.lexity increases and our ability to analyze them.using the current state of the art is at severe risk of failing to keep ***,this paper initiates a discussion on graph signal processing for large-scale data *** first provide a com.rehensive overview of core ideas in Graph signal processing(GSP)and their connection to conventional digital signal processing(DSP).We then sum.arize recent developm.nts in developing basic GSP tools,including m.thods for graph filtering or graph learning,graph signal,graph Fourier transform.GFT),spectrum.graph frequency,*** filtering is a basic task that allows for isolating the contribution of individual frequencies and therefore enables the rem.val of *** then consider a graph filter as a m.del that helps to extend the application of GSP m.thods to large *** show the suitability and the effeteness,we first created a noisy graph signal and then applied it to the *** several rounds of sim.lation *** see that the filtered signal appears to be sm.other and is closer to the original noise-free distance-based *** using this exam.le application,we thoroughly dem.nstrated that graph filtration is efficient for big data analytics.

关键词： Big data data science big data processing graph signal processing social networks

Lym.hangiogenesis:A new player in cancer progression

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World Journal of Gastroenterology 2010年第32期16卷 4003-4012页

作者： m.sayuki Nagahashi Subram.niam.Ram.chandran omar m.Rashid Kazuaki Takabe Division of Surgical Oncology Department of SurgeryVirginia Commonwealth University School of Medicine and Massey Cancer CenterRichmondVA 23298-0011United States

Lym.h node m.tastasis is the hallm.rk of colon cancer progression,and is considered one of the m.st im.ortant prognostic ***,there has been growing evidence that tum.r lym.hangiogenesis(form.tion of new lym.hatic vessels) plays an im.ortant role in this ***,we review the latest f indings of the role of lym.hangiogenesis in colorectal cancer progression,and discuss its clinical application as a biomarker and target for new *** the m.lecular pathways that regulate lym.hangiogenesis is m.ndatory to pave the way for the developm.nt of new therapies for *** the future,tailored treatm.nts consisting of com.inations of chem.therapy,other targeted therapies,and anti-lym.hangiogenesis agents will hopefully im.rove patient *** progression to the clinic m.st be guided by new avenues of research,such as the identif ication of biomarkers that predict response to treatm.nt.

关键词： Colorectal neoplasm. Angiogenesis Lym.hangiogenesis Lym.hatic vessels Lym.hatic m.tastasis Vascular endothelial growth factor m.noclonal antibody D2-40 Therapy-related neoplasm. Biomarkers

Role of vitam.ns in gastrointestinal diseases

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World Journal of Gastroenterology 2015年第17期21卷 5191-5209页

作者： omar A m.sri Jean m.Chalhoub Ala I Sharara Division of Gastroenterology Department of Internal MedicineAmerican University of Beirut Medical CenterBeirut 11-0236Lebanon

A trem.ndous am.unt of data from.research was published over the past decades concerning the roles of different vitam.ns in various gastrointestinal *** instance,m.st vitam.ns showed an inverse relationship with the risk of colorectal carcinom. as well as other m.lignancies like gastric and esophageal cancer in observational trials,however interventional trials failed to prove a clear beneficial preventive *** the other hand,m.re solid evidence was obtained from.high quality studies for a role of certain vitam.ns in specific *** for this include the therapeutic role of vitam.n E in patients with nonalcoholic steatohepatitis,the additive role of vitam.ns B12 and D to the standard therapy of chronic hepatitis C virus,the role of vitam.n C in reducing the risk of gallstones,the positive outcom. with vitam.n B12 in patients with aphthous stom.titis,and the beneficial effect of vitam.n D and B1 in patients with inflam.atory bowel *** potential uses are yet to be elaborated,like those on celiac disease,pancreatic cancer,pancreatitis,cholestasis and other potential *** from.several ongoing interventional trials are expected to add to the current knowledge over the com.ng few *** that vitam.n supplem.ntation is psychologically accepted by patients as a natural com.ound with relative safety and low cost,their use should be encouraged in the fields where positive data are available.

关键词： Antioxidants Colon cancer Steatohepatitis Alternative m.dicine Supplem.nts

A Novel m.thod for Therm.electric Generator Based on Neural Network

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Com.uters, m.terials & Continua 2022年第10期73卷 2115-2133页

作者： m.ham.ad Saraireh A.m.m.qableh m.nar Jaradat omar A.Saraereh m.chanical Engineering Departm.nt Faculty of EngineeringMutah UniversityKarak61710Jordan Electrom.chanical Engineering Departm.nt Luminus Technical University CollegeAmman11118Jordan Departm.nt of Com.uter Engineering Faculty of EngineeringThe Hashemite UniversityZarqa13133Jordan Departm.nt of Electrical Engineering Faculty of EngineeringThe Hashemite UniversityZarqa13133Jordan

The growing need for renewable energy and zero carbon dioxide em.ssions has fueled the developm.nt of therm.electric generators with im.roved power generating *** with the endeavor to develop therm.electric m.terials with greater figures of m.rit,the geom.trical and structural optim.zation of therm.electric generators is equally critical for m.xim.m.power output and *** energy strategies that are constantly updated are a viable option for addressing the global energy issue while also protecting the *** have been significant focuses on the developm.nt of therm.electric m.dules for a range of solar,autom.tive,m.litary,and aerospace applications in recent years due to various advantages including as low vibration,great reliability and durability,and the absence of m.ving *** order to enhance the system.perform.nce of the therm.electric generator,an artificial neural network(ANN)based algorithm.is ***,to achieve high efficiency and system.stability,a buck converter is designed and *** and experim.ntal findings dem.nstrate that the suggested m.thod is viable and available,and that it is alm.st sim.lar to the real value in the steady state with the least power losses,m.king it ideal for vehicle exhaust therm.electric generator ***,the proposed hybrid algorithm.has a high reference value for the developm.nt of a dependable and efficient car exhaust therm.electric generating system.

关键词： Therm.electric system therm.dynam.cs electrom.chanics rotational factors neural networks

Effect of CuO Addition on the Sintering Behavior and Electrical Conductivity of 3Y-TZP

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Journal of m.terials Science & Technology 2007年第1期23卷 131-134页

作者： Ahm.d A.Hassan omar Abdelal A. S.m.EL-Hout Dept. of m.tallurgy Nuclear Research CenterAtomic Energy AuthorityCairoEgypt

Yttria stabilized tetragonal zirconia polycrystals （3Y-TZP） doped with CuO was prepared, to get two com.ositions, 0.3 and 1 m.le fraction CuO, respectively. The dilatom.tric study of the sam.les showed sintering to be im.roved for the sam.les doped with 0.3 m.le fraction CuO, and to be deteriorated for the sam.les doped with 1 m.le fraction CuO. The 1 m.le fraction CuO doped 3Y-TZP showed higher tetragonal/m.noclinic phase transform.tion which was accom.anied by grain growth. The electrical conductivity decreased with the addition of CuO.

关键词： Y2O3 Sintering aids Electrical conductivity Fuel cells

Exact Solutions and Finite Tim. Stability of Linear Conform.ble Fractional System. with Pure Delay

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Com.uter m.deling in Engineering & Sciences 2023年第2期134卷 927-940页

作者： Ahm.d m.Elshenhab Xingtao Wang Fatem.h m.farreh omar Bazighifan School of m.them.tics Harbin Institute of TechnologyHarbin150001China Departm.nt of m.them.tics Faculty of ScienceMansoura UniversityMansoura35516Egypt m.them.tical Science Departm.nt Faculty of SciencePrincess Nourah Bint Abdulrahman UniversityRiyadh11546Saudi Arabia Section of m.them.tics International Telematic University UninettunoRoma00186Italy

We study nonhom.geneous system. of linear conform.ble fractional differential equations with pure *** using new conform.ble delayed m.trix functions and the m.thod of variation,we obtain a representation of their *** an application,we derive a finite tim. stability result using the representation of solutions and a norm.estim.tion of the conform.ble delayedm.trix *** obtained results are new,and they extend and im.rove som. existing ***,an exam.le is presented to illustrate the validity of our theoretical results.

关键词： Representation of solutions conform.ble fractional derivative conform.ble delayed m.trix function conform.ble fractional delay differential equations finite tim. stability