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Adipose-derived cells:building blocks of three-dimensional microphysiological systems

Biomaterials Translational 2021年第4期2卷 301-306页

作者： Trivia P.Frazier Katie Hamel Xiying Wu Emma Rogers Haley Lassiter Jordan Robinson omair mohiuddin Michael Henderson Jeffrey M.Gimble Obatala Sciences Inc. New OrleansLAUSA International Centre for Chemical and Biological Sciences University of KarachiKarachiPakistan

Microphysiological systems(MPS)created with human-derived cells and biomaterial scaffolds offer a potential in vitro alternative to in vivo animal *** adoption of three-dimensional MPS models has economic,ethical,regulatory,and scientific implications for the fields of regenerative medicine,metabolism/obesity,oncology,and pharmaceutical drug *** opinion leaders acknowledge that MPS tools are uniquely positioned to aid in the objective to reduce,refine,and eventually replace animal experimentation while improving the accuracy of the finding’s clinical *** tissue has proven to be an accessible and available source of human-derived stromal vascular fraction(SVF)cells,a heterogeneous population available at point of care,and adipose-derived stromal/stem cells,a relatively homogeneous population requiring plastic adherence and culture expansion of the SVF *** adipose-derived stromal/stem cells or SVF cells,in combination with human tissue or synthetic biomaterial scaffolds,can be maintained for extended culture periods as three-dimensional MPS models under angiogenic,stromal,adipogenic,or osteogenic *** review highlights recent literature relating to the versatile use of adipose-derived cells as fundamental components of three-dimensional MPS models for discovery research and *** this context,it compares the merits and limitations of the adipose-derived stromal/stem cells relative to SVF cell models and considers the likely directions that this emerging field of scientific discovery will take in the near future.

关键词： adipose-derived stromal/stem cells extracellular matrix Food and Drug Administration microphysiological systems stromal vascular fraction cells three dimensional

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