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Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： Damián Sánchez-ramírez Mónica G Mendoza-rodríguez om.r r alem.n Fernando A Candanedo-González Miriam rodríguez-Sosa Juan JoséMontesinos-Montesinos Mauricio Salcedo Ismael Brito-Toledo Felipe Vaca-Paniagua Luis I Terrazas Unidad de Investigacion en Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Department of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Department of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales Mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en Biomedicina y Oncologia Genomica Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de Colon y recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio nacional en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CrC)remains one of the most commonly diagnosed and deadliest types of cancer *** displays a desmoplastic reaction(Dr)that has been inversely associated with poor prognosis;less Dr is associated with a better *** reaction generates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form a part of the tumor *** are directly involved in tumorigenesis through different ***,their role in immunosuppression in CrC is not well understood,and the precise role of signal transducers and activators of transcription(STATs)in mediating CAF activity in CrC remains *** the myriad chemical and biological factors that affect CAFs,different cytokines mediate their function by activating STAT signaling ***,the harmful effects of CAFs in favoring tumor growth and invasion may be modulated using STAT ***,we analyze the impact of different STATs on CAF activity and their immunoregulatory role.

关键词： Cancer-associated fibroblasts Signal transducer and activator of transcription signaling Colorectal cancer Immunity Immunosuppression

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risk factors for long COVID in children and adolescents:a systematic review and meta-analysis

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World Journal of Pediatrics 2024年第2期20卷 133-142页

作者： Daniel G.rayner Elaine Wang Cloris Su om D.Patel Stephanie Aleluya Alessandra Giglia Evelyn Zhu Maha Siddique Department of Health research Methods Evidenceand ImpactFaculty of Health SciencesMcMaster University1280 Main St WHamiltonONL8S 4K1Canada Faculty of Health Sciences McMaster University1280 Main St WHamiltonON L8S 4K1Canada Faculty of Science McMaster University1280 Main St WHamiltonONL8S 4K1Canada

Background The long-term sequelae of COVID-19 in children and adolescents remain poorly understood and *** systematic review and meta-analysis sought to summarize the risk factors for long COVID in the pediatric *** We searched six databases from January 2020 to May 2023 for observational studies reporting on risk factors for long COVID or persistent symptoms those were present 12 or more weeks post-infection using multivariable regression *** registries,reference lists of included studies,and preprint servers were hand-searched for relevant ***-effects meta-analyses were conducted to pool odds ratios for each risk *** study risk of bias was rated using QUIPS,and the GrADE framework was used to assess the certainty of evidence for each unique *** Sixteen observational studies(n=46,262)were included,and 19 risk factors were amenable to *** moderate certainty in the evidence,age(per 2-year increase),allergic rhinitis,obesity,previous respiratory diseases,hospitalization,severe acute COVID-19,and symptomatic acute COVID-19 are probably associated with an increased risk of long *** sex,asthma,com.rbidity,and heart diseases may be associated with an increased risk of long COVID,and Asian and Black races may be associated with a decreased risk of long *** did not observe any credible subgroup effects for any risk *** The current body of literature presents several compelling risk factors for the development of long COVID in the pediatric *** research is necessary to elucidate the pathophysiology of long COVID.

关键词： COVID-19 Long COVID Post-acute COVID-19 syndrome Pediatrics risk factors

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Expression changes of mi rnA-regulated genes associated with the formation of the leafy head in cabbage

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Horticultural Plant Journal 2024年第4期10卷 1007-1019页

作者： Jorge alem.n-Baez Jose Fernando Acevedo-Zamora Johan Bucher Chengcheng Cai roeland E.Voorrips Guusje Bonnema Plant Breeding Wageningen University and ResearchWageningenThe Netherlands

The vegetative development of cabbage(Brassica oleracea ***)passes through seedling,rosette,folding and heading *** that form the rosette are large and mostly *** the following developmental stages,the plants produce leaves that curve inward to produce the leafy *** micrornAs and their target genes have been described participating in leaf development and leaf *** aim of this study is to investigate the role of mirnA-regulated genes in the transition from the rosette to the heading *** compared the mi rnA and gene abundances between emerging rosette and heading *** remove transcripts(mirnAs and genes)whose regulation was most likely associated with plant age rather than the change from.rosette to heading stage,we utilized a non-heading collard green(*** ***)morphotype as *** resulted in 33 DEMs and 1998 DEGs with likely roles in the transition from.rosette to heading stage in *** these 1998 DEGs,we found enriched GO terms related to DnA-binding transcription factor activity,transcription regulator activity,iron ion binding,and *** predicted the target genes of these 33 DEMs and focused on the subset that was differentially expressed(1998DEGs)between rosette and heading stage leaves to construct mi rnA-target gene interaction *** main finding is a role for mir396b-5p targeting two Arabidopsis thaliana orthologues of GrOWTH rEGULATInG FACTOrs 3(GrF3)and 4(GrF4)in pointed cabbage head formation.

关键词： Brassica oleracea var.capitata rnA sequencing mirnA-target gene network leafy head formation

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Hepatic perivascular epithelioid cell tumors:Benign,malignant,and uncertain malignant potential

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World Journal of Gastroenterology 2024年第18期30卷 2374-2378页

作者： Marcelo Fabián Amante División Patología Hospital General de Agudos Cosme ArgerichBuenos Aires C1155AHAArgentina División Patología Hospital Alemán de Buenos AiresBuenos Aires C1155AHAArgentina

In 2013,the World Health Organization defined perivascular epithelioid cell tumor(PEComa)as“a mesenchymal tumor which shows a local association with vessel walls and usually expresses melanocyte and smooth muscle markers.”This generic definition seems to better fit the PEComa family,which includes angiomyolipoma,clear cell sugar tumor of the lung,lymphangioleiomyomatosis,and a group of histologically and immunophenotypically similar tumors that include primary extrapulmonary sugar tumor and clear cell myomelanocytic *** cell tumors with this immunophenotypic pattern have also had their malignant variants *** localizing to the liver,preoperative radiological diagnosis has proven to be very difficult,and most patients have been diagnosed with hepatocellular carcinoma,focal nodular hyperplasia,hemangioma,or hepatic adenoma based on imaging *** of a malignant variant of the liver have been ***,reports of malignant variants of these lesions have increased in recent ***,we support the use of the Folpe criteria,which in 2005 established the criteria for categorizing a PEComa as benign,malignant,or of uncertain malignant *** they are not considered ideal,they currently seem to be the best approach and could be used for the categorization of liver tumors.

关键词： PEComas Liver Pathology Malignant Benign Uncertain malignant potential

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Factors affecting farmers’participation in watershed management programs in the northeastern highlands of Ethiopia:a case study in the Teleyayen sub-watershed

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Ecological Processes 2018年第1期7卷 137-151页

作者： alem-meta Assefa Agidew K.n.Singh Department of Geography and Environmental Studies Wollo UniversityP.O.Box 1145DessieEthiopia Department of Geography and Environmental Studies Addis Ababa UniversityP.O.Box 1176Addis AbabaEthiopia

Introduction:This study investigated factors affecting farmers’participation in watershed management programs in the northeastern highlands of Ethiopia by taking the Teleyayen sub-watershed as a case *** were collected from 215 farm households which were selected from the four villages using a multistage sampling procedure,involving a combination of purposive and random *** were gathered using a structured survey questionnaire,focus group discussion,and key informant *** analysis,Pearson correlation analysis,and regression analysis were employed to analyze the ***:Findings of this study showed that farmer’s perception has a strong positive correlation(r=0.612,P=0.000)with the farmer’s decision to participate in the watershed management programs followed by government support(r=0.163,P=0.017),while the slope of the farmland and the gender of the household head have shown significant and negative *** binary logistic regression analysis also revealed that six independent variables were significant in explaining the factors affecting the farmers’decision to participate in watershed management *** variables were land redistribution,gender,agricultural labor force,extension service,farm size,and *** these,land redistribution,gender,agricultural labor force,extension service,and slope of the farmland indicated a negative influence,while farm size of a household exerted a positive *** study also examined the role of discrete variables in explaining variations of variables in affecting the farmers’decision to participate in the ***,two variables found to be *** variables are the gender of the household head and land tenure ***,the chi-square result of the variable(χ^(2)=9.052)of gender was found to be statistically significant at the 95%level of ***,the chi-square result(X^(2)=8.792)of land tenure security was found to be statistically

关键词： Binary logistic regression model Ethiopia Farmers’participation Watershed management

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Software Vulnerabilities Overview:A Descriptive Study

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Tsinghua Science and Technology 2020年第2期25卷 270-280页

作者： Mario Calín Sánchez Juan Manuel Carrillo de Gea José Luis Fernández-alem.n Jesús Garcerán Ambrosio Toval the Department of Informatics and Systems Faculty of Computer ScienceUniversity of Murcia

Computer security is a matter of great *** the last decade there have been numerous cases of cybercrime based on the exploitation of software *** fact has generated a great social concern and a greater importance of computer security as a *** this work,the most important vulnerabilities of recent years are identified,classified,and categorized individually.A measure of the impact of each vulnerability is used to carry out this classification,considering the number of products affected by each vulnerability,as well as its *** addition,the categories of vulnerabilities that have the greatest presence are *** on the results obtained in this study,we can understand the consequences of the most common vulnerabilities,which software products are affected,how to counteract these vulnerabilities,and what their current trend is.

关键词： descriptive study software security software vulnerabilities vulnerability databases

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Fault Detection for Microgrid Feeders Using Features Based on Superimposed Positive-sequence Power

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Journal of Modern Power Systems and Clean Energy 2023年第6期11卷 1948-1958页

作者： Salauddin Ansari om Hari Gupta om P.Malik Department of Electrical Engineering National Institute of TechnologyJamshedpur 831014India IEEE Department of Electrical and Software Engineering University of Calgary2500 University Drive NWCalgary Alberta T2N 1N4Canada

With the integration of distributed generation(DG) into a microgrid, fault detection has become a major task to accomplish. A scheme for microgrid feeder protection based on a newly proposed feature, ΔrP, defined as the ratio of the sum of positive-sequence real power(PSrP) at the two ends of the feeder to the larger of the PSrPs among the two ends, is proposed. If ΔrP is larger than a threshold, an internal fault is detected;otherwise, the fault is external or there is no fault. The proposed scheme is tested in various scenarios, including fault type, fault resistance, fault location, fault inception angle, varying DG penetration levels, and simultaneous, evolving, and composite faults. In addition to this, the proposed scheme offers a robust performance when subjected to noise, synchronization error, changes in sampling frequency, and changes in the topology of a microgrid. The dominancy of the proposed scheme is proven by a com.rehensive comparative study with various available recent schemes. Test results on the IEEE 13-bus network indicate the viability of the proposed protection scheme for a microgrid. Finally, the proposed scheme has been validated on a real-time simulator.

关键词： Fault detection distributed generation microgrid protection superimposed power

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Smallanthus sonchifolius roots ameliorate non-alcoholic fatty liver disease by reducing redox imbalance and hepatocyte damage in rats fed with a high fructose diet

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Asian Pacific Journal of Tropical Biomedicine 2019年第9期9卷 365-372页

作者： Mariano nicolás alem.n Sara Serafina Sánchez Stella Maris Honoré Instituto Superior de Investigaciones Biológicas (InSIBIO) Consejo Nacional de Investigaciones Científicas y Técnicas - Universidad Nacional de Tucumán (CONICET-UNT)

Objective: To evaluate the potential of Smallanthus sonchifolius(S. sonchifolius) roots in ameliorating hepatic damage of rats fed with a high fructose ***: The effect of S. sonchifolius roots on energy intake, body weight, fat and liver mass was determined in male rats fed with a high-fructose diet. Plasma glucose, triglycerides, total cholesterol, lipoproteins and aspartate aminotransferase and alanine aminotransferase were analyzed. Histological changes of the livers were evaluated by electronic microscopy and apoptosis was examined using the TUnEL method. The levels of malondialdehyde, reducedglutathione and antioxidant enzymes(catalase, superoxide dismutase, glutathione peroxidase, glutathione S-transferase) activities were also ***: S. sonchifolius roots significantly decreased energy intake, body weight, fat and liver mass(P nchifolius roots ameliorated liver steatosis and mitochondrial morphology, avoiding cellular apoptosis and normalizing transaminase activity in the liver of rats fed with high fructose. Enzymatic assays revealed that S. sonchifolius roots had a modulatory effect on the oxidative stress induced by fructose-feeding by reducing lipid peroxidation(P nd antioxidant enzyme activities(P n ***: S. sonchifolius roots can ameliorate non-alcoholic fatty liver disease by improving oxidative stress and liver injury.

关键词： Smallanthus sonchifolius roots non-alcoholic fatty liver disease Oxidative stress Apoptosis Liver

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Solitary kinetic Alfvén waves in a dense electron–positron–ion plasma with degenerate electrons and positrons

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Plasma Science and Technology 2017年第12期19卷 42-49页

作者： Monzurul K AHMED om P SAH Depatment of Physics Birjhora MahavidyalayaBongaigaon-783380AssamIndia

Through the use of a reductive perturbation technique, solitary kinetic Alfvén waves（KAWs） are investigated in a low but finite b（particle-to-magnetic pressure ratio） dense electron–positron–ion plasma where electrons and positrons are degenerate. The degenerate plasma model considered here permits the existence of sub-Alfvénic com.ressive solitary KAWs. The influence of r（equilibrium positron-to-ion density ratio）, sF（electron-to-positron Fermi temperature ratio）, b and obliqueness parameter lzon various characteristics of solitary KAWs are examined through numerical plots. We have shown that there exists a critical value of lzat which a soliton width attains its maximum value which decreases with an increase in r and *** is also found that solitons with a higher energy propagate more obliquely in the direction of an ambient magnetic field. The results of the present investigation may be useful for understanding low frequency nonlinear electromagnetic wave propagation in magnetized electron–positron–ion plasmas in dense stars. Specifically, the relevance of our investigation to a pulsar magnetosphere is emphasized.

关键词： kinetic Alfvén waves solitons electron–positron–ion plasma degenerate plasma Thomas–Fermi approximation

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Solitary kinetic Alfven waves in dense plasmas with relativistic degenerate electrons and positrons

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Plasma Science and Technology 2019年第4期21卷 85-93页

作者： Monzurul K AHMED om P SAH Department of Physics Biijhora MahavidyalayaBongaigaon-783380AssamIndia

Propagation of solitary kinetic Alfven waves(KAWs)is investigated in small but finite/3(particle-to-magnetic pressure ratio)collisionless dense plasma whose constituents are non degenerate wann ions,and relativistic degenerate electrons and *** the use of reductive perturbation technique,Kortweg-de Vries equation is derived to obtain small amplitude localized wave solution of *** effects of plasma 0,positron concentration,electron relativistic degeneracy parameter,ion thermal temperature and obliqueness parameter on solitary KAWs are *** results of this theoretical investigation are aimed at elucidating characteristics of kinetic Alfven solitary waves in relativistic degenerate e-p-i plasmas found in dense astrophysical objects specifically neutron stars and white dwarfs.

关键词： solitary kinetic Alfven waves dense plasmas electron-positron-ion plasma,relativistic degenerate plasma reductive perturbation technique

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