检索结果-南通市图书馆

International Journal of Ophthalmology(English edition) 2020年第8期13卷 1223-1230页

作者： omür O.Ucakhan Yagmur Seda Yesiltas Department of Ophthalmology Ankara University Faculty of MedicineAnkara 06550Turkey

AIM:To compare the sa.ety and efficacy of conventional versus accelerated(9 mW/cm^2)corneal collagen crosslinking(CXL)in progressive keratoconus at the 2-year ***:In this prospective study,consecutive progressive keratoconus patients were randomized to receive either conventional CXL(CCXL)or accelerated CXL(ACXL;using hydroxypropyl methylcellulose-assisted riboflavin imbibition for 10 min at 9 mW/cm^2).Visual,refractive,keratometric,topographic,and aberrometric outcomes and stromal demarcation line depth(DLD)measurements were compared at the end of a 2-year ***:Thirty-two eyes from 32 patients in the CCXL and 27 eyes from 27 patients in the ACXL groups completed 2-year *** 2y post-CXL,both uncorrected and corrected visual acuities improved significantly in both *** improvements in keratometric readings,flattening rate(flattening of the maximum keratometry more than 1 D),3 topographic indices,and vertical coma were significantly better in the CCXL group compared to the ACXL group(pptical coherence tomography or in vivo confocal microscopy was better detectable and significantly deeper in the CCXL group compared to the ACXL *** deeper DLD was found to be significantly correlated with improvements in the mean keratometry *** was noted in 11.1%of eyes in the ACXL group,whereas progression was not observed in any patient eye in the CCXL ***:In this prospective randomized study,ACXL is less effective in halting the progression of keratoconus at a 2-year follow-up compared to CCXL.

关键词： corneal collagen crosslinking keratoconus corneal ectasia riboflavin accelerated crosslinking

pYRIDINATION OF pOLY(VINYL CHLORIDE) via A HomOLYTIC pATHWAY

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of polymer Science 2007年第3期25卷 297-302页

作者： sa.d Moulay Zakia Zeffouni Laboratoire de Chimie-physique Moléculaire et Macromoléculaire Faculté des Sciences de l'Ingénieur Département de Chimie IndustrielleUniversité Sad Dahlab de BlidaRoute de SoumaB. P. 270Blida 09000Algeria

pVC was subjected to a chemical modification aiming at replacing the chlorine atoms by pyridine groups via a homolytic route. pyridine groups were peculiarly affixed to the pVC matrix via a carbon-carbon bond rather than a carbonnitrogen one. pVC was first iodinated using the Conant-Finkelstein reaction, followed by the application of the homolytic conditions of Minisci to generate pyridinated pVC with a varying degree of substitution. The extent of substitution was not high; the reaction on 30% iodinated pVC afforded a degree of modification no greater than 3%.

关键词： Conditions of Minisci Iodinated pVC pyridinated pVC

pepBind: A Comprehensive Database and Computational Tool for Analysis of protein-peptide Interactions

在线全文

学校读者我要写书评

暂无评论

Genomics, proteomics & Bioinformatics 2013年第4期11卷 241-246页

作者： Arindam Atanu Das om prakash Sharma Muthuvel Suresh Kumar Ramadas Krishna premendu p. Mathur Centre of Excellence in Bioinformatics School of Life Sciences Pondicherry UniversityPondicherry 605014 India School of Biotechnology KIIT UniversityBhubaneshwar 751024 India

protein-peptide interactions, where one partner is a globular protein （domain） and the other is a flexible linear peptide, are key components of cellular processes predominantly in signal- ing and regulatory networks, hence are prime targets for drug design. To derive the details of the protein-peptide interaction mechanism is often a cumbersome task, though it can be made easier with the availability of specific databases and tools. The peptide Binding protein Database （pep- Bind） is a curated and searchable repository of the structures, sequences and experimental observa- tions of 3100 protein^eptide complexes. The web interface contains a computational tool, protein inter-chain interaction （pICI）, for computing several types of weak or strong interactions at the pro- tein peptide interaction interface and visualizing the identified interactions between residues in Jmol viewer. This initial database release focuses on providing protein-peptide interface informa- tion along with structure and sequence information for protein-peptide complexes deposited in the protein Data Bank （pDB）. Structures in pepBind are classified based on their cellular activity. More than 40% of the structures in the database are found to be involved in different regulatory pathways and nearly 20% in the immune system. These data indicate the importance of protein- peptide complexes in the regulation of cellular processes. pepBind is freely accessible at http：// ***/.

关键词： peptide-binding proteinsdatabase pepBind protein-peptide complex protein-peptide interface protein-peptide interactiontool protein inter-chaininteraction

Effect of irrigation schedule on growth and seed yield of camelina(Camelina sa.iva L.)in Tarai region of central Himalaya

在线全文

学校读者我要写书评

暂无评论

Oil Crop Science 2021年第1期6卷 8-11页

作者： Ankur Agarwal om prakash Madhu Bala Defence Institute of Bio-Energy Research Defence R&D OrganizationGoraparaoP.OArjunpurHaldwaniUttarakhand263139India

Camelina(Camelina sa.iva)has emerged as a potential biofuel crop globally with its suitability even as a jet fuel source with 75–80%less greenhouse gas emissions compared to common petroleum *** crop has originated from Mediterranean region and belongs to Brassicaceae ***,DRDO has made initial and pioneer efforts in successful introduction of this crop to India and its agro-technology *** a short duration crop with lesser input requirement,it fits well in the cropping pattern of hilly states of Indian *** areas experience fallow land due to shortage of irrigation water for growing other *** present study revealed that irrigation at flowering stage is more *** at this stage(if only one irrigation is available)exhibited grain yield of 1.004 kg·m^(-2)which was 21 and 80%higher over pod setting and rosette stage irrigation,*** maximum seed yield was observed under treatment where irrigation was provided at all three crop growth stages(2.044 kg·m^(-2)).It was 50%higher over T6 treatment(where two irrigations were given at rosette and flowering stage)and 104%higher over T3(where only one irrigation was given at flowering stage).

关键词： Irrigation scheduling Water requirement Water deficit Biofuel crop False flax

HALomETHYLATION OF pOLYSTYRENE AND SUBSEQUENT pYRIDINATION VIA A HomOLYTIC pATHWAY

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of polymer Science 2006年第6期24卷 627-635页

作者： sa.d Moulay Nadia Mehdi Laboratoire de Chimie-physique Moléculaire et Macromoléculaire Faculté des Sciences de l'Ingénieur Departement de Chimie IndustrielleUniversité de BlidaRoute de SoumaB. P. 270Blida 09000Algeria

Chloromethylation of polystyrene （pS） with two different chloromethylating systems methylal/thionyl chloride and paraformaldehyde/trimethylchlorosilane was studied. Soluble chloromethylated polystyrene with a degree of substitution of 89% was obtained. The Conant-Finkelstein reaction on the chloromethylated pS afforded soluble iodomethylated polystyrene with a degree of substitution as high as 96%. The reaction conditions of Minisci were employed to radically pyridinate pS via its iodomethylated derivative. polyelectrolytes were formed which could be converted to normal polymers by treatment with a 20% aqueous solution of NaOH.

关键词： Chloromethylated polystyrene Conditions of Minisci Iodomethylated polystyrene pyridinated polystyrene.

The role of functional polymorphisms of HTT-LpR and ComT in the occurrence of irritable bowel syndrome amongst children

在线全文

学校读者我要写书评

暂无评论

中国现代医学杂志 2013年第2期23卷 17-20页

作者： platonova om Shadrin OG SI "Research Institute of pediatrics Obstetrics and Gynecology"KyivUkraine

【Objective】 The study was aimed to assess the role of polymorphisms of HTT-LpR and ComT genes in the occurrence of IBS with a glance to the psychoemotional state of children.【Method】 The study was conducted in the gastroenterology department of children clinical hospital № 1 named after ***(Odessa.Ukraine).There were examined 122 children with IBS at the age of 6 to 17 *** genetic studies were performed in a specialized laboratory of the Center of Molecular and Genetic Medicine of *** sa.ples of genetic material were taken by using non-invasive *** was extracted using the bisulfate *** was performed by pCR using specific oligonucleotide *** characteristics of mental and emotional state of children were tested by the questionnaire of "profile of psychosomatic orientation".Statistical analysis was performed using nonparametric methods with software Statistics 8.0(StatSoft Inc.,Usa..【Result】 There was demonstrated that the frequency of homozygote variant of СОМТ*2 polymorphism was 14.8%,and by 5-HTTLpR polymorphism-9.8%.Children suffering IBS has these genotypes in every third case whereas the severity anxiety is correlated with the presence of these functional *** presence of mutant alleles in the homozygous state is closely correlated with the severity of anxiety in children suffering IBS(r =0.84 p presence of functional polymorphisms of HTT-LpR and ComT genes.

关键词：医学临床诊断疾病

不同干扰方式形成的内蒙古大兴安岭白桦次生林的土壤肥力

在线全文

学校读者我要写书评

暂无评论

东北林业大学学报 2024年第2期52卷 60-67页

作者：翟凯涛梁晶文李静王冰萨如拉内蒙古农业大学呼和浩特010018

在内蒙古大兴安岭北部林区(根河林业局的潮查林场、木瑞林场、上央格气林场),选择经火烧干扰(重度火烧、中度火烧)、渐伐干扰(重复样地2块)、渐伐干扰后进行补植(重复样地2块)、皆伐干扰、未干扰形成的白桦次生林,共设置8块样地;在每个... 详细信息

在内蒙古大兴安岭北部林区(根河林业局的潮查林场、木瑞林场、上央格气林场),选择经火烧干扰(重度火烧、中度火烧)、渐伐干扰(重复样地2块)、渐伐干扰后进行补植(重复样地2块)、皆伐干扰、未干扰形成的白桦次生林,共设置8块样地;在每个样地内按对角线均匀设置3个土壤样方,采用环刀法在土层深度(h)0pH、有机质质量分数、全氮质量分数、全磷质量分数、全钾质量分数、速效氮质量分数、速效磷质量分数、速效钾质量分数共计9个因素为评价指标,采用改进的内梅罗综合指数法综合评价土壤肥力、采用Margalef丰富度指数法分析群落物种丰富度、采用单因素方差分析法(One-way ANOVA)分析各土壤因素间显著性、采用皮尔逊(pearson)相关性分析法分析土壤因素与植物多样性的相关性。结果表明:白桦次生林的土壤含水量、有机质质量分数、全磷质量分数、速效钾质量分数、全钾质量分数、速效磷质量分数均值较高,土壤全氮质量分数、速效氮质量分数均值较低。白桦次生林表层土壤(0ppH与草本丰富度呈显著正相关(ppp<0.05)。不同干扰方式形成的白桦次生林土壤营养元素质量分数偏高(除氮元素外),土壤肥力较好,植物丰富度较高;采伐、火烧干扰显著降低了土壤肥力,而通过合理的人为干扰可以恢复部分土壤肥力。

关键词：干扰白桦次生林土壤肥力植物丰富度

Role of malaria induced oxidative stress on anaemia in pregnancy

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Asian pacific Journal of Tropical Medicine 2010年第3期3卷 211-214页

作者： Akanbi om Odaibo AB Olatoregun R Ademowo AB Department of Environmental Biology and Fisheries Faculty of ScienceAdekunle Ajasin University Department of Zoology Parasitology UnitUniversity of Ibadan Institute of Advanced Medical Research and Training College of MedicineUniversity of Ibadan

Objective:To assess the role of oxidative stress on anaemia in ***:Blood sa.ples were collected from pregnant and non-pregnant women who came for antenatal clinic and medical check at Comprehensive Health Center,Akungba-Akoko and Iwaro General Hospital in Akoko Area of Ondo State,*** and thin blood films were prepared and used for malaria parasite *** level was determined by colorimetric method using Drabkin’s *** status was determined using malondiadelhyde level as an indicator of lipid peroxidation,while ascorbic acid and reduced glutathione levels were measured by standard spectrophotometric ***:Mean parasite density was significantly higher in pregnant women than non-pregnant women(ppositive pregnant and non-pregnant women than malaria negative(8.3-10.0 g/dL)(ppregnant[(2.5±0.7) nmol/mL]than non-pregnant women[(1.8±0.1) nmol/mL] (pperoxide dismutase(SOD) levels were significantly reduced in pregnant than non-pregnant women(ppregnant women *** correlation was observed between the mean MDA level and parasite density(r = 0.53).The Hb level decreased as the parasite density and MDA level increased in pregnant ***:This study shows that oxidative stress, caused by malaria infection could be part of the contributing factors responsible for anaemia in pregnancy.

关键词： pregnancy Anaemia Oxidative stress Malaria primigravidae Malondialdehyde(MDA) Superoxide dismutase(SOD)

胎儿心脏定量分析技术评估小于胎龄儿和生长受限儿心室功能

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华超声影像学杂志 2024年第7期33卷 580-588页

作者：王漫琪冯帆吴娟刘云王新霞陈飒栗河舟郑州大学第三附属医院超声科郑州450052

目的探讨胎儿心脏定量分析(fetal HQ)技术在评估小于胎龄儿(SGA)及生长受限(FGR)胎儿心室收缩功能中的应用价值。方法前瞻性选取2022年8月至2023年9月郑州大学第三附属医院胎儿预估体重(EFW)或腹围小于第10百分位数的单胎胎儿152例,其... 详细信息

目的探讨胎儿心脏定量分析(fetal HQ)技术在评估小于胎龄儿(SGA)及生长受限(FGR)胎儿心室收缩功能中的应用价值。方法前瞻性选取2022年8月至2023年9月郑州大学第三附属医院胎儿预估体重(EFW)或腹围小于第10百分位数的单胎胎儿152例,其中胎儿EFW或腹围位于第3~10百分位数且不伴有血流动力学异常为SGA组(n=79),其余为FGR组(n=73);匹配同期正常单胎胎儿161例作为对照组。依据FGR发生孕周,将FGR组分为早发组(ppp0.6(均ppp>0.05)。心室收缩功能参数观察者间及观察者内ICC均>0.75,具有较好的重复性。结论Fetal HQ可定量评估SGA及FGR胎儿心室收缩功能,SGA及FGR胎儿心室整体、纵向及局部横向收缩功能均减低,心室收缩功能异常与不良围产期结局相关。

关键词：超声检查胎儿心脏定量分析小于胎龄儿胎儿生长受限心室功能

利用反向遗传技术产生表达外源基因的重组sa.1轮状病毒

在线全文

学校读者我要写书评

暂无评论

中国人兽共患病学报 2024年第2期40卷 140-146页

作者：柴萨萨蔡昊刘夏飞赵静宋敬东李金松裴银辉李利利段招军华北理工大学基础医学院河北省慢性疾病基础医学重点实验室唐山063000 中国疾病预防控制中心病毒病预防控制所国家卫生健康委员会医学病毒和病毒病重点实验室北京102206 甘肃中医药大学公共卫生学院兰州730000

目的利用反向遗传技术产生NSp1基因插入和表达外源基因的重组sa.1轮状病毒,构建可表达外源基因的轮状病毒载体。方法本研究将轮状病毒sa.1株的NSp1基因片段的223位(5端)至1388位的核苷酸删除,并直接插入连接了终止-再启动元件(p2A)的增... 详细信息

目的利用反向遗传技术产生NSp1基因插入和表达外源基因的重组sa.1轮状病毒,构建可表达外源基因的轮状病毒载体。方法本研究将轮状病毒sa.1株的NSp1基因片段的223位(5端)至1388位的核苷酸删除,并直接插入连接了终止-再启动元件(p2A)的增强绿色荧光蛋白(EGFp)基因,采用已建立的“12质粒”轮状病毒反向遗传系统拯救NSp1基因插入和表达EGFp的重组sa.1轮状病毒。通过观察细胞病变效应和插入基因(EGFp)的荧光表达初步确定重组病毒的成功拯救,再结合电镜的形态学观察、RT-pCR的测序结果及病毒基因组的检测结果,进一步证明重组轮状病毒的成功拯救和传代扩增。利用TCID 50法和qRT-pCR法,测定了rsa.1和rsa.1/NSp1-EGFp的病毒滴度并绘制了基因组复制动力曲线。结果基于“12质粒系统”成功拯救了重组轮状病毒rsa.1/NSp1-EGFp,证明NSp1片段截短并插入外源基因后病毒仍可正常复制,且具有良好的遗传稳定性,但病毒滴度低于其亲本株。结论基于NSp1基因插入和表达EGFp的重组轮状病毒能够实现稳定遗传,为利用反向遗传学构建表达外源基因的轮状病毒载体的深入探索提供了基础。

关键词： A组轮状病毒反向遗传外源基因 NSp1基因