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Phytochemical Study and Evaluation of Cytotoxicity, Antioxidant and Hypolipidemic Properties of <i>Launaea taraxacifolia</i>Leaves Extracts on Cell Lines HepG2 and PLB985

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American Journal of Plant Sciences 2015年第11期6卷 1768-1779页

作者： omédine koukoui Pascal Agbangnan Sylviane Boucherie Mahudro Yovo Oliver Nusse Laurent Combettes Dominique Sohounhloué Laboratoire de Physiologie Animale de Signalisation Cellulaire et de Pharmacologie FAST/Dassa Université Polytechnique d’Abomey Dassa Zoumè Bénin Laboratoire d’Etude et de Recherche en Chimie Appliquée Université d’Abomey-Calavi (LERCA/UAC) Cotonou Bénin Laboratoire d’Interactions Cellulaires et de Physiopathologie Hépatique UMR-S 1174 Université Paris Sud Paris France

Launaea taraxacifolia is a leafy vegetable of the family of Asteraceae (Compositae) found in several countries in West Africa including Ghana, Benin and Nigeria. The plant leaves are eaten either fresh as salad or cooked as sauces. They are also consumed as infusion to fight against several diseases including non-communicable diseases such as diabetes and hypertension. Several studies have been conducted in Ghana, Nigeria on the nutritional and medicinal values of this plant but no study has yet been conducted in Benin on the virtues of this plant. In this work we have achieved the phytochemical characterization and evaluated the cytotoxicity as well as hypolipidemic and anti-oxidant effects of the ethanol-aqueous extracts of Launaea taraxacifolia leaves. Cytotoxicity and hypolipidemic activities have been performed on HepG2 cells;the antioxidant effect has been performed on the PLB985 cells. The results showed that the ethanol-aqueous extracts of Launaea taraxacifolia leaves contained the following metabolites: catechic tannin, flavonoids, phenolic acids, mucilage and leucoanthocyanins. Only very high concentrations (>20 mg/ml) of leaves extracts are toxic for HepG2 cells. Launaea taraxacifolia leaves have significant antioxidant and hypolipidemic activities.

关键词： Launaea taraxacifolia Phytochemical Cytotoxicity Antioxidant Hypolipidemic

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Evaluation of the Safety and Efficacy of Extracts from the Leaves of Five Plants Used for the Treatment of Arterial Hypertension in Benin

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Pharmacology & Pharmacy 2022年第10期13卷 355-367页

作者： omédine koukoui Santorin Seton Mansouratou Betira Jean Baptiste Amagbegnon Fidèle Sonounameto Eudoxie Assou Alphonse Sezan Laboratory of Animal Physiology Cellular Signaling and Pharmacology ENSBBA/UNSTIM Dassa Zoumè Benin Laboratory of Pharmacology and Improved Traditional Medicines FAST/University of Abomey-Calavi Godomey Benin

Cardiovascular diseases (CVD) are nowadays real health problems in the world. High blood pressure is one of the most important risk factors for CVD and is affecting more and more people in Benin. The objective of our work is to evaluate the safety and the efficacy of the leaves of five plants used for the treatment of hypertension in Benin. Acute toxicity was evaluated on wistar rats which orally administered a single dose of 2000 mg/kg of body weight of hydro-ethanolic extract of the leaves of Phyllanthus amarus Schumach. & Thonn., Persea americana MILL., Ipomoaea fistulosa Mart. ex Choisy., Heliotropium indicum L., Schrankia leptocarpa DC., and were monitored over a period of 14 days. Subacute toxicity was evaluated on rats which received a daily dose of 200 mg/kg of body weight of the plant leaf extract over a period of 28 days. Plant efficacy was assessed by measuring potassium in plant leaves. Administration of the single dose of the extract did not cause any deaths in rats;the weight of the rats varied depending on the extracts administered. Concerning the subacute treatment, the levels of aspartate amino transaminases (AST) and Alanine amino transaminases (AST) did not vary significantly after the 28 days of treatment with the different extracts. On the other hand, a significant increase in serum creatinine was observed in rats treated with extracts of Phyllanthus amarus. The leaves of Heliotropium indicum, Ipomoaea fistulosa and Phyllanthus amarus contain the highest levels of potassium. Among the five plants studied, only the leaves of Phyllanthus amarus seem to induce renal toxicity. Extracts from the leaves of Heliotropium indicum, Ipomoaea fistulosa might be the most effective in inducing hypotensive activity and do not show toxicity.

关键词： Hypertension Plant Extracts Toxicity Efficacy Potassium

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Evaluation of the Preventive and Therapeutic Activities of <i>Tridax procumbens</i>against Hyperglycemia and Hyperlipidemia Induced in Wistar Rats

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Pharmacology & Pharmacy 2021年第7期12卷 127-140页

作者： Jean-Baptiste Amagbegnon omédine koukoui Pascal C. Agbangnan Santorin Seton Mansouratou Betira Sedami Medegan Laura Loko Victorin Dougnon Luc Djogbenou Alphonse Sezan Laboratory of Animal Physiology Cellular Signalisation and Pharmacology University of Sciences Technologies Engineering and Mathematics Dassa Zoume Benin Laboratory of Study and Research in Applied Chemistry Unity of Research and Molecular Interactions (URIM/LERCA/UAC) Cotonou Benin Medicinal and Organic Chemistry Laboratory Faculty of Health Sciences Cotonou Benin Laboratory of Applied Entomology University of Sciences Technologies Engineering and Mathematics Dassa Zoume Benin Research Unit in Applied Microbiology and Pharmacology of Natural Substances Research Laboratory for Applied Biology Polytechnic School of Abomey-Calavi University of Abomey-Calavi Abomey-Calavi Benin Laboratory of Infectious Vector Borne Diseases Regional Institute of Public Health University of Abomey-Calavi Abomey-Calavi Benin Laboratory of Biomembranes and Cellular Signalisation University of Abomey-Calavi Cotonou Benin

From the Asteraceaes family, Tridax procumbens is a wild species frequently found in fields, meadows and roadsides. It is traditionally used to treat yellow fever, typhoid fever, high blood pressure and diabetes. In this work we used the hydro-ethanolic extract of the leaves and stems of the plant and also the fractions of this extract to determine the preventive and therapeutic activities of the plant against obesity, hyperglycemia and hyperlipidemia. The yields of the fractions obtained by decantation of the hydro-ethanolic extract are respectively 0.160% with hexane, 0.073% with dichloromethane, 0.09% with diethyl ether and 0.150% with ethyl acetate. Hyperglycemia and hyperlipidemia were induced in the rats submitted to a fatty and sweet diet for 28 days. Our results showed a significant increase in glycemia, weight and triglyceride level in rats that were subjected to the diet. On the other hand, the rats treated with the dose of 500 mg/kg of body weight of Tridax procumbens extract during the induction showed a reduction in weight gain and an absence of increase in blood sugar and triglyceride levels. The ethyl acetate fraction of Tridax procumbens extract administered to fatty and hyperglycemic rats at 50 mg/kg of body weight for 14 days did not induce change in the blood sugar and triglycerides level of fatty and hyperglycemic rats. If it seems obvious that the extract of Tridax procumbens prevents hyperglycemia and hyperlipidemia, the ethyl acetate fraction does not seem to have a therapeutic effect.

关键词： Tridax procumbens Prevention Treatment Hyperglycemia Hyperlipidemia

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On Green’s Relations, 2~0-regularity and Quasi-ideals in Γ-semigroups

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Acta Mathematica Sinica,English Series 2013年第3期29卷 609-624页

作者： Kostaq HILA Jani dine Department of Mathematics and Computer Science Faculty of Natural SciencesUniversity of Gjirokastra

In this paper, we introduce the definition of （m, n）0-regularity in Г-semigroups. we in- vestigate and characterize the 20-regular class of F-semigroups using Green＇s relations. Extending and generalizing the Croisot＇s Theory of Decomposition for F-semigroups, we introduce and study the absorbent and regular absorbent Г-semigroups. We approach this problem by examining quasi-ideals using Green＇s relations.

关键词： F-semigroup Green's relation (m n)^-regular F-semigroup 2-regular F-semigroup com-pletely 0-simple absorbency 0-minimal left (right quasi)-ideal

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Fault Detection for Microgrid Feeders Using Features Based on Superimposed Positive-sequence Power

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Journal of Modern Power Systems and Clean Energy 2023年第6期11卷 1948-1958页

作者： Salauddin Ansari om Hari Gupta om P.Malik Department of Electrical Engineering National Institute of TechnologyJamshedpur 831014India IEEE Department of Electrical and Software Engineering University of Calgary2500 University Drive NWCalgary Alberta T2N 1N4Canada

With the integration of distributed generation(DG) into a microgrid, fault detection has become a major task to accomplish. A scheme for microgrid feeder protection based on a newly proposed feature, ΔRP, defined as the ratio of the sum of positive-sequence real power(PSRP) at the two ends of the feeder to the larger of the PSRPs among the two ends, is proposed. If ΔRP is larger than a threshold, an internal fault is detected;otherwise, the fault is external or there is no fault. The proposed scheme is tested in various scenarios, including fault type, fault resistance, fault location, fault inception angle, varying DG penetration levels, and simultaneous, evolving, and composite faults. In addition to this, the proposed scheme offers a robust performance when subjected to noise, synchronization error, changes in sampling frequency, and changes in the topology of a microgrid. The dominancy of the proposed scheme is proven by a comprehensive comparative study with various available recent schemes. Test results on the IEEE 13-bus network indicate the viability of the proposed protection scheme for a microgrid. Finally, the proposed scheme has been validated on a real-time simulator.

关键词： Fault detection distributed generation microgrid protection superimposed power

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Solitary kinetic Alfvén waves in a dense electron–positron–ion plasma with degenerate electrons and positrons

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Plasma Science and Technology 2017年第12期19卷 42-49页

作者： Monzurul K AHMED om P SAH Depatment of Physics Birjhora MahavidyalayaBongaigaon-783380AssamIndia

Through the use of a reductive perturbation technique, solitary kinetic Alfvén waves（KAWs） are investigated in a low but finite b（particle-to-magnetic pressure ratio） dense electron–positron–ion plasma where electrons and positrons are degenerate. The degenerate plasma model considered here permits the existence of sub-Alfvénic compressive solitary KAWs. The influence of r（equilibrium positron-to-ion density ratio）, sF（electron-to-positron Fermi temperature ratio）, b and obliqueness parameter lzon various characteristics of solitary KAWs are examined through numerical plots. We have shown that there exists a critical value of lzat which a soliton width attains its maximum value which decreases with an increase in r and *** is also found that solitons with a higher energy propagate more obliquely in the direction of an ambient magnetic field. The results of the present investigation may be useful for understanding low frequency nonlinear electromagnetic wave propagation in magnetized electron–positron–ion plasmas in dense stars. Specifically, the relevance of our investigation to a pulsar magnetosphere is emphasized.

关键词： kinetic Alfvén waves solitons electron–positron–ion plasma degenerate plasma Thomas–Fermi approximation

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Frequency regulation by fuzzy and binary control in a hybrid islanded microgrid

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Journal of Modern Power Systems and Clean Energy 2015年第3期3卷 429-439页

作者： Pamela MANJARRES om MALIK Department of Electrical and Computer Engineering University of CalgaryCalgaryABCanada

Islanded microgrids must be self-sufficient in terms of frequency and voltage control due to their islanded operation.A control strategy for frequency regulation by combining the operation of a wind generator,a diesel generator,a battery energy storage system and a dump load in a microgrid is proposed in this *** the proposed strategy,the control task is partitioned into two subtasks:1)choosing the appropriate element to be used for regulation,and 2)providing frequency regulation.A global controller chooses the element to ***,the frequency regulation is provided by separate individual *** proposed control strategy is tested on a microgrid with mixed types of generation and modeled on *** monitoring the power of individual elements and system frequency,it is shown that the proposed control strategy operates *** proposed strategy facilitates the integration of renewable energy sources and enhances frequency regulation.

关键词： Frequency regulation Fuzzy control Hybrid microgrid Automatic operation

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Solitary kinetic Alfven waves in dense plasmas with relativistic degenerate electrons and positrons

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Plasma Science and Technology 2019年第4期21卷 85-93页

作者： Monzurul K AHMED om P SAH Department of Physics Biijhora MahavidyalayaBongaigaon-783380AssamIndia

Propagation of solitary kinetic Alfven waves(KAWs)is investigated in small but finite/3(particle-to-magnetic pressure ratio)collisionless dense plasma whose constituents are non degenerate wann ions,and relativistic degenerate electrons and *** the use of reductive perturbation technique,Kortweg-de Vries equation is derived to obtain small amplitude localized wave solution of *** effects of plasma 0,positron concentration,electron relativistic degeneracy parameter,ion thermal temperature and obliqueness parameter on solitary KAWs are *** results of this theoretical investigation are aimed at elucidating characteristics of kinetic Alfven solitary waves in relativistic degenerate e-p-i plasmas found in dense astrophysical objects specifically neutron stars and white dwarfs.

关键词： solitary kinetic Alfven waves dense plasmas electron-positron-ion plasma,relativistic degenerate plasma reductive perturbation technique

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Design of a USIM and ECC based handover authentication scheme for 5G-WLAN heterogeneous networks

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Digital Communications and Networks 2020年第3期6卷 341-353页

作者： Amit Kumar Hari om Department of Computer Science and Engineering Indian Institute of Technology(ISM)DhanbadJharkhand826004India

A variety of wireless communication technologies have been developed to provide services to a large number of *** future integrated 5G-WLAN wireless networks will support seamless and secure roaming,and various types of real-time applications and services,which will be the trend of next-generation computing *** this paper,we discuss the privacy and security problems in 5G-WLAN heterogeneous networks and present a logical 5G-WLAN integrated *** also propose a novel USIM and ECC based design of handover authentication for next-generation 5G-WLAN heterogeneous networks that can provide secure and seamless Internet *** scheme has the features of strong security and better performance in terms of computation cost,energy cost,and storage cost as compared with the state-of-the-art schemes.

关键词： 5G ECC WLAN Handover Heterogeneous

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An improved and secure multiserver authentication scheme based on biometrics and smartcard

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Digital Communications and Networks 2018年第1期4卷 27-38页

作者： Ashish Kumar Hari om Department of Compeer Science & Engineering Indian Iustitute of Technology (ISM) Dhnnbad dhnrkhand 826004 India

With the advancement in internet technologies, the number of servers has increased remarkably to provide more services to the end users. These services are provided over the public channels, which are insecure and susceptible to interception, modification, and deletion. To provide security, registered entities are authenticated and then a session key is established between them to communicate securely. The conventional schemes anow a user to access services only after their independent registration with each desired server in a multiserver system. Therefore, a user must possess multiple smartcards and memorize various identities and passwords for obtaining services from multiple servers. This has led to the adoption of multiserver authentication in which a user accesses services of multiple servers after registering himself at only one central authority. Recently, Kumar and om discussed a scheme for multiserver environment by using smartcard. Since the user-memorized passwords are of low entropy, it is possible for an attacker to guess them. This paper uses biometric information of user to enhance the security of the scheme by Kumar and Ore. Moreover, we conducted rigorous security analyses （informal and formal） in this study to prove the security of the proposed scheme against all known attacks. We also simulated our scheme by using the automated tool, ProVerif, to prove its secrecy and authentication properties. A comparative study of the proposed scheme with the existing related schemes shows its effectiveness.

关键词： Smartcard Password Security Authentication Multi-server Biometric ProVerif

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