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Chrysobalanus icaco:A review of its phytochemistry and pharmacology

Journal of Integrative Medicine 2021年第1期19卷 13-19页

作者： Hammed Ayantola Onilude Mutiu Idowu Kazeem oluwatosin benedict adu Department of Biochemistry Faculty of ScienceLagos State UniversityOjoLagos 102101Nigeria

The genus Chrysobalanus is one of the classes of medicinal plants used in the treatment and management of several *** study is aimed at providing up-to-date information on the phytochemical composition and pharmacological uses of Chrysobalanus *** literature on the Chrysobalanus species was obtained by searching electronic databases such as Pub Med,Google Scholar and Web of *** the species in this genus,four have been reported in the literature,but only one(***)has been extensively *** is rich in several minerals,including potassium,magnesium,calcium and *** plant also contains a host of phytochemicals,such as flavonoids,diterpenes and triterpenes,which have been shown to have pharmacological *** can be concluded that *** is a good source of phytochemicals that contribute to its therapeutic ***,bioassay-guided isolation of its bioactive compounds is necessary for promoting the development of drugs from this medicinal plant.

关键词： Chrysobalanaceae Cocoplum Diabetes mellitus Triterpenes Fruit

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Pentazocine Abuse in Two Siblings with Sickle Cell Anaemia

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Open Journal of Pediatrics 2019年第2期9卷 148-153页

作者： Samuel Kolade Ernest Israel Kayode Kolawole benedict Oluwasesan Olorunsola Oluwaseun Taofik Ogunkunle oluwatosin Adeniyi Ojuola Tryphena Jadesola Oyedepo Segun Opeyemi Jenyo Department of Paediatrics University of Ilorin Teaching Hospital Ilorin Nigeria Department Anaesthesia and Palliative Care University of Ilorin Teaching Hospital Ilorin Nigeria

Vaso-occlusive crisis is a common clinical manifestation in children with sickle cell anaemia, frequently warranting in-patient management with intravenous fluids, analgesics and occasionally anti-malaria and antibiotics. Pain is the principal symptom of vaso-occlusive crisis and it can affect any part of the body. Pentazocine is a well-known opioid analgesic, commonly used in the treatment of painful crisis in children affected by sickle cell anaemia. It was discovered in the 1950s and was initially thought to be addiction—proof, but this has been disproved over the years by reports of pentazocine dependence/addiction especially in patients living with chronic pain. There have been some case reports of pentazocine abuse/dependence among sickle cell disease patients in the literature, most of which are from Nigeria but none involved joint addiction by siblings. We therefore, report the case of two siblings, known sickle cell anaemia (HbSS) patients, referred to our emergency paediatric unit with history of recurrent painful crisis over a 10-month period leading to abuse of pentazocine. They were jointly managed successfully by the paediatric hematology and the pain and palliative units of the University of Ilorin Teaching Hospital and helped to overcome their abuse and addiction.

关键词： Pentazocine Abuse Siblings Sickle Cell Anaemia

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