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Proteomics analysis of the phytopathogenic fungus Sclerotinia sclerotiorum:a narrative review

Journal of Bio-X Research 2022年第3期5卷 112-117页

作者： oluwatobi sarah otun Ikechukwu Achilonu Khayalethu Ntushelo Department of Molecular and Cell Biology University of Witwatersrand Department of Agriculture and Animal Health Science CampusUniversity of South AfricaJohannesburgSouth Africa

Sclerotinia sclerotiorum(Lib.)de Bary is a necrotrophic plant pathogen that causes cottony rot,watery soft rot,stem rot,white mold,and other disease symptoms in over 700 plant hosts around the *** of economically important crops,the lack of resistant cultivars,and the general challenge of controlling diseases caused by this broad-based pathogen call for continued ***,in recent years,mass spectrometry-based proteomics analyses have been used to acquire a fundamental and in-depth molecular understanding of this fungal *** this review,we describe the characteristics of the Sclerotinia sclerotiorum pathogen and examine its virulence factors,secreted proteins,and host suppression ***,we review recent proteomics studies and extrapolate their primary findings for the identification and functional characterization of Sclerotinia sclerotiorum ***,we discuss key findings that shape the understanding of the virulent factors and pathogenesis of Sclerotinia sclerotiorum and outline directions for future proteomic investigations of plant pathogens.

关键词： fungal pathogenesis mass spectrometry-based proteomics plant pathogen Sclerotinia sclerotiorum virulent proteins

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Protein engineering for natural product biosynthesis:expanding diversity for therapeutic applications

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Journal of Bio-X Research 2023年第2期6卷 49-60页

作者： sarah oluwatobi otun Jordy Alexis Lerma-Escalera Khayalethu Ntushelo Ikechukwu Achilonu Protein Structure-Function and Research Unit School of Molecular and Cell BiologyFaculty of ScienceUniversity of the WitwatersrandBraamfontein 2050JohannesburgSouth Africa Facultad de Ciencias Químicas Universidad Autónoma de Nuevo LeónSan Nicolás de los GarzaMexico Centro de Investigación en Biotecnología y Nanotecnología Facultad de Ciencias QuímicasParque de Investigación e Innovación TecnológicaUniversidad Autónoma de Nuevo LeónApodacaMexico Department of Agriculture and Animal Health University of South AfricaFlorida 1710South Africa

In this dispensation of the fourth industrial revolution,protein engineering has become a popular approach for increasing enzymatic activity,stability,and titer in the biosynthesis of natural *** is attributed to its numerous advantages(over direct isolation from plants or via chemical synthesis),including decreasing or eliminating reaction byproducts,high precision,moderate handling of intricate and chemically unstable chemicals,overall reusability,and cost ***,protein engineering tools have advanced to redesign and enhance natural product *** methods include direct evolution,substrate engineering,medium engineering,enzyme engineering and immobilization,structure-assisted protein engineering,and advanced *** successes in implementing these emerging protein engineering technologies were critically discussed in this ***,the advantages,limitations,and applications in industrial and medical biotechnology were ***,future research directions and potential were also highlighted.

关键词： antibodies engineering industrial enzymes natural product biosynthesis protein engineering polyketides synthetic biology

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