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Vitamin D3Recepto. Activatio. Rescued Co.tico.triatal Neural Activity and Impro.ed Mo.o. Functio. in –D2R Tardive Dyskinesia Mice Mo.el

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Jo.rnal o. Bio.edical Science and Engineering 2015年第8期8卷 520-530页

作者： oluwamolakun o. bankole Babafemi J. Lao.e Mujittapha U. Sirjao.Azeez o. Isho.a Damilo.a E. o.eleke Wasiu G. Balo.un Amin Abdulbasit Ansa E. Co.ham Ibukun D. Akinrinade o.alekan M. o.undele Department o. Bio.o.ical Sciences College of Sciences Afe Babalola University Ado-Ekiti Nigeria Department o. Anato.y College of Medicine and Health Sciences Afe Babalola University Ado-Ekiti Nigeria Department o. Anato.y College of Health Sciences University of Ilorin Ilorin Nigeria Department o. Physio.o.y College of Health Sciences University of Ilorin Ilorin Nigeria Department o. Anato.y College of Medicine University of Calabar Calabar Nigeria Instituto.Gulbenkian de Ciencia Oerias Portugal Department o. Anato.y Bingham University College of Medicine Karu Nigeria

Halo.erido.-induced dyskinesia has been linked to.a reductio. in do.amine activity characterized by the inhibitio. o. do.amine receptive sites o. D2-recepto. (D2R). As a result o. D2R inhibitio., calcium-linked neural activity is affected and seen as a decline in mo.to.-co.nitive functio. after pro.o.ged halo.erido. use in the treatment o. psycho.ic diso.ders. In this study, we have elucidated the relatio.ship between halo.erido.-induced tardive dyskinesia and the neural activity in mo.o. co.tex (M1), basal nucleus (CPu), prefro.tal co.tex (PFC) and hippo.ampus (CA1). Also. we explo.ed the ro.e o. Vitamin D3 recepto. (VD3R) activatio. as a therapeutic target in impro.ing mo.o.-co.nitive functio.s in dyskinetic mice. Dyskinesia was induced in adult BALB/c mice after 28 days o. halo.erido. treatment (10 mg/Kg;intraperito.eal). We established the presence o. abno.mal invo.untary mo.ements (AIMs) in the halo.erido. treated mice (-D2) thro.gh assessment o. the thresho.d and amplitude o. abno.mal invo.untary mo.ements (AIMs) fo. the Limbs (Li) and o.o.ingual (o.) area (Li and o. AIMs). As a co.firmato.y test, the dyskinetic mice (-D2) sho.ed high glo.al AIMs sco.e when co.pared with the VD3RA interventio. gro.p (-D2/+VDR) fo. Li and o. AIMs. Furthermo.e, in the behavio.al tests, the dyskinetic mice exhibited a decrease in latency o. fall (Lo.;Ro.aro.-P 2/+VDR), 100 mg/Kg fo. 7 days, CPu-CA1 burst activity was resto.ed leading to.a decrease in abno.mal mo.ement, and an increase in mo.o. functio.. Ultimately, we deduced that VD3RA activatio. reduced the thresho.d o. abno.mal mo.ement in halo.erido. induced dyskinesia.

关键词： Halo.erido. VD3R Dyskinesia D2R Neural Activity Co.tico.triatal

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VitaminD3Recepto. Activatio. Rescued Co.tico.triatal Neural Activity and Impro.ed Mo.o.-Co.nitive Functio. in -D2R Parkinso.ian Mice Mo.el

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Jo.rnal o. Bio.edical Science and Engineering 2015年第9期8卷 601-615页

作者： Azeez o. Isho.a Babafemi J. Lao.e Damilo.a E. o.eleke oluwamolakun o. bankole Mujittapha U. Sirjao.Ansa E. Co.ham Wasiu G. Balo.un Amin Abdulbasit Ibukun D. Akinrinade o.alekan M. o.undele Department o. Anato.y College of Medicine and Health Sciences Afe Babalola University Ado-Ekiti Nigeria Department o. Bio.o.ical Sciences College of Sciences Afe Babalola University Ado-Ekiti Nigeria Department o. Bio.o.ical Sciences College of Sciences Afe Babalola University Ado-Ekiti Nigeria Department o. Anato.y College of Medicine University of Calabar Calabar Nigeria Department o. Anato.y College of Health Sciences University of Ilorin Ilorin Nigeria Department o. Physio.o.y College of Health Sciences University of Ilorin Ilorin Nigeria Instituto.Gulbenkian de Ciencia Oerias Portugal Department o. Anato.y Bingham University College of Medicine Karu Nigeria

Backgro.nd: fo.rth generatio. antipsycho.ics have been implicated in the blo.kade o. calcium signalling thro.gh inhibitio. o. do.amine receptive sites o. do.aminergic D2 Recepto. (D3R). As a result o. the abno.mal calcium signalling asso.iated with D2R inhibitio., changes o.cur in the mo.o. and memo.y neural axis leading to.the o.served behavio.ral deficits after pro.o.ged halo.erido.. Thus, Vitamin D3 recepto. (VD3R), a calcium co.tro.ling recepto. in the striatum can be targeted to.relief the neuro.o.ical sympto.s asso.iated with halo.erido. (-D2R) induced PD. Aim: This study sets to.investigate the ro.e o. VD3R activatio. in vitro.and in vivo.after halo.erido.-induced Do.aminergic (D2R) blo.kade. In additio., we examined the asso.iated neural activity and behavio.ral changes in parkinso.ian and VDRA interventio. mice. Metho.s: Do.aminergic D2R inhibitio. was investigated in vitro.using Melano.ytes iso.ated fro. the scale o. a Tilapia. In fo.r separate set ups, the cells were cultured in calcium free Ringer’s so.utio. as fo.lo.s;300 μM halo.erido., 100 μM VD3, 100 mM calcium chlo.ide and a co.binatio. o. 300 μM halo.erido. and 100 μM VD3. Subsequently, do.aminergic vesicle accumulatio. and calcium signalling were o.served in bright field micro.co.y using blue and green fluo.escence pro.es. In the seco.d phase, PD was induced in adult BALB/c mice (-D2;n = 8) after 14 days o. intraperito.eal halo.erido. treatment (10 mg/Kg). A set o. n = 4 mice were untreated (-D2) while the o.her gro.p (n = 4) received 100 mg/Kg o. VD3 fo. 7 days (-D2/+VDR). The co.tro. gro.ps (n = 4 each) were treated with no.mal saline (NS) and VD3 (+VDR) fo. 14 days. At the end o. the treatment phase, the animals were assessed in Ro.aro., parallel bar-, cylinder-, Y-Maze-, o.e trial place reco.nitio.- and no.el o.ject reco.nitio.-(No.) tests. Neural activity was measured using chro.ic electro.e implants placed in the M1 (mo.o. co.tex), CPu (striatum), CA1 (hippo.ampus) and PFC (prefro.tal co.tex

关键词： Do.amine Calcium Signalling D2R VD3R Co.tico.triatal Neural System

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