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Epidemiologic evidence linking oxidative stress and pulmonary function in healthy populations

Chronic Diseases and Translational Medicine 2021年第2期7卷 88-99页

作者： Lateef Olabisi Okeleji Ayodeji Folorunsho Ajayi Grace adebayo-Gege Victoria Oyetayo Aremu oluwadunsin iyanuoluwa adebayo Emmanuel Tayo adebayo Cardio-thoracic Unit Obafemi Awolowo University Teaching Hospitallle-IfeOsun stateNigeria Department of Physiology Ladoke Akintola University of TechnologyOgbomosoOyo StateNigeria Department of Physiology Baze UniversityKuchigoroJabiAbujaNigeria

Respiratory health in the general population declines regardless of the presence of pulmonary *** stress has been implicated as one of the mechanisms involved in respiratory *** review was to evaluate studies that relate oxidative stress factors with pulmonary function among the general population without prior respiratory *** search yielded 54 ***-one studies qualified for incorporation in this *** to the heterogeneity of the review,studies were discussed based on identified oxidative stress factors responsible for pulmonary *** stress biomarkers,including gene polymorphisms of nuclear factor erythroid 2-related factor 2,heme oxygenase 1,glutathione S transferase,superoxide dismutase,and lipid peroxidation products were involved in lung function *** addition,the antioxidant status of individuals in reference to dietary antioxidant intake and exposure to environmental pollutants affected oxidative stress and pulmonary function,as indicated by forced expired volume in one second,forced vital capacity,and forced expiratory flow at 25%-75%.This review indicated that oxidative stress is implicated in the gradual decline of lung function among the general population,and gene polymorphism along the antioxidant defense line and/or their interaction with air pollutants reduce lung *** polymorphic forms among individuals explain why the rate of lung function decline differs among *** antioxidants have respiratory health benefits in antioxidant gene polymorphic ***,the genetic composition of an individual may be considered for monitoring and identifying people at risk of respiratory illnesses.

关键词： Pulmonary diseases Oxidative stress Respiratory function test Epidemiology

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