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Precision Medicine Research 2023年第2期5卷 16-31页

作者： Christopher Terseer Tarkaa Damilare Adebayo Oyaniyi Ridwan Abiodun Salaam Rachael Pius Ebuh olusola Abayomi Akangbe Sayo Ebenezer Oladokun Rodiat Omotola Sowemimo Oluwaponmile Florence Ajayi Cell Biology and Genetics Unit Department of ZoologyUniversity of IbadanIbadan 200005Nigeria Ecology and Environmental Biology Unit Department of ZoologyUniversity of IbadanIbadan 200005Nigeria

Background:To elucidate the molecular mechanisms of Curcuma longa(***)in breast cancer ***:Phytocompounds of *** were obtained from ***’s Phytochemical and Ethnobotanical *** active targets were retrieved from Bindingdb,SEA and Swiss Target Prediction *** cancer targets were retrieved from the Therapeutic Target *** Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were done using DAVID and KOBAS3.0 databases *** Cytoscape software was used to construct the phytocompound-target-pathway *** PyRx and Desmond software were utilized for molecular docking and molecular dynamics simulation ***:Out of one hundred and fifty-six phytocompounds,fifty-four modulated proteins involved in breast *** Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated *** exerts its therapeutic effect through regulating several key *** docking analysis revealed that most phytocompounds of *** had a good affinity with the key *** dynamics simulation showed that ethinylestradiol formed stable ligand-protein ***:The results of this study will enhance our understanding of the potential molecular mechanisms by which *** inhibits breast cancer and lay a foundation for future experimental studies.

关键词： Curcuma longa network pharmacology breast cancer mechanism molecular docking molecular dynamics simulation

Aqueous Extract of Newbouldia laevis Abrogates Cadmium-Induced Ovarian Dysfunction in Adult Wistar Rats Running Title:Newbouldia laevis Ameliorates Ovarian Disruption

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Journal of Pharmacy and Pharmacology 2019年第3期7卷 110-118页

作者： Adeoye O.Oyewopo Kehinde S.Olaniyi Adesola A.Oniyide olusola A.Sanya Oluwatobi A.Amusa Omosola F.Faniyan Olugbenga O.Eweoya Department of Anatomy University of IlorinIlorin240001Nigeria Department of Physiology Afe Babalola UniversityAdo-Ekiti360101Nigeria Department of Anatomy University of AbujaAbuja900241Nigeria

Background:The extract of Newbouldia laevis has been demonstrated to show antioxidant,antimicrobial,sedative,anticonvulsant,analgesic,anti-inflammatory,antinociceptive,hepatoprotective,anticancer,antiulcer,antihypertensive and antidiarrhea ***,its reproprotective effect is not well *** present study was designed to investigate the ameliorative effect of Newbouldia laevis in cadmium-induced ovarian ***:Adult female Wistar rats were randomly allotted into groups;Vehicle(received distilled water),cadmium-treated(received 5 mg/kg b.w.),***-treated(received 200 mg/kg b.w.)and cadmium+***-treated *** sulphate was administered for 3 days(i.p.)followed by oral administration of *** for 28 *** body weight change was monitored using animal weighing balance(Olympia SCL66110 model,Kent Scientific Corporation,Torrington,CT06790,USA),biochemical assay and histology of ovaries were performed as previously ***:The results showed weight loss,severe disruption of ovarian follicles and significant reduction of gonadotropic hormones(FSH and LH)in cadmium-treated group compared with vehicle-treated *** alterations were not associated with inflammatory ***,concomitant administration of aqueous extract of *** and cadmium sulphate significantly ameliorated ovarian ***:The study demonstrates that administration of aqueous extract of *** during treatment with cadmium sulphate preserves ovarian function,suggesting that possibly daily intake of aqueous extract of *** prevents the onset of ovarian disorders.

关键词： Cadmium hypertrophy Newbouldia laevis ovarian dysfunction reproprotective

Natural toxins and One Health:a review

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Science in One Health

Science in One Health 2022年第1期1卷 44-56页

作者： Azubuike Raphael Nwaji Onikisateinba Arieri Annabel Sharon Anyang Kaze Nguedia Etomi Barbara Abiade Gilead Ebiegberi Forcados olusola Olalekan Oladipo Sunday Makama Ishaku Leo Elisha Nonyelim Ozele Jurbe Gofwan Gotep Department of Physiology Faculty of Basic Medical SciencesAlex Ekwueme Federal UniversityNdufu-AlikeEbonyi StateNigeria Department of Industrial Chemistry and Petrochemical Technology Faculty of Science LaboratoryUniversity of PortharcourtNigeria Faculty of Veterinary Medicine University of AbujaNigeria Department of Biochemistry Faculty of Medicine and Biomedical SciencesUniversity of Yaounde ICameroon Faculty of Pharmaceutical Science University of JosPlateau StateNigeria Biochemistry Division National Veterinary Research InstituteVomPlateau StateNigeria Drug Development Division National Veterinary Research InstituteVomPlateau StateNigeria

Background:The One Health concept considers the interconnectivity,interactions and interdependence of humans,animals and the ***,animals and other organisms are constantly exposed to a wide range of natural toxins present in the ***,there is growing concern about the potential detrimental effects that natural toxins could pose to achieve One ***,alkaloids,steroids and bioactive peptides obtained from natural toxins could be used for the development of therapeutic ***:Our literature search focused on the following keywords;toxins,One Health,microbial toxins,mycotoxins,phytotoxins,phycotoxins,insect toxins and toxin *** Scholar,Science Direct,PubMed and Web of Science were the search engines used to obtain primary *** chose relevant full-text articles and review papers published in English language *** research was done between July 2022 and January ***:Natural toxins are poisonous substances comprising bioactive compounds produced by microorganisms,invertebrates,plants and *** compounds possess diverse structures and differ in biological function and toxicity,posing risks to human and animal health through the contamination of the environment,causing disease or death in certain *** from the articles reviewed revealed that effects of natural toxins on animals and humans gained more attention than the impact of natural toxins on the environment and lower organisms,irrespective of the significant roles that lower organisms play to maintain ecosystem ***,systematic approaches for toxin control in the environment and utilization for beneficial purposes are inadequate in many ***,bioactive compounds present in natural toxins have potential for the development of therapeutic *** findings suggest that global,comprehensive and coordinated efforts are required for improved management of natural toxins through an interdisciplinar

关键词： One Health Mycotoxins Phytotoxins Phycotoxins Insect toxins Aqua toxins

Protective effects of naringin on fipronil-induced cardiovascular and renal dysfunctions in rats

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Clinical Traditional Medicine and Pharmacology 2024年第3期5卷 13-21页

作者： Temitayo Olabisi Ajibade Esther Oluwaseyi Oliyide Oluwaseun Olanrewaju Esan Moses olusola Adetona Omolola Victoria Awoyomi Taiwo Olaide Oyagbemi Adewumi Victoria Adeogun Ademola Adetokunbo Oyagbemi Temidayo Olutayo Omobowale Kehinde Olugboyega Soetan Sanah Malomile Nkadimeng Lyndy Joy McGaw Prudence Ngalula Kayoka-Kabongo Momoh Audu Yakubu Evaristus Nwulia Oluwafemi Omoniyi Oguntibeju Department of Veterinary Physiology and Biochemistry Faculty of Veterinary MedicineUniversity of IbadanIbadanOyo State 200001Nigeria Department of Veterinary Medicine Faculty of Veterinary MedicineUniversity of Ibadan IbadanOyo State 200001Nigeria Department of Anatomy Faculty of Basic Medical SciencesCollege of MedicineUniversity of IbadanIbadanOyo State 200001Nigeria Federal College of Animal Health and Production Technology Moor PlantationIbadanOyo State 200001Nigeria Department of Life and Consumer Sciences Collage of Agriculture and Environmental SciencesUniversity of South Africa Florida CampusUniversity of South AfricaUnisa 0003South Africa Department of Paraclinical Science Faculty of Veterinary ScienceUniversity of PretoriaOnderstepoort01100028South Africa Department of Environmental&Interdisciplinary Sciences College of ScienceEngineering&TechnologyCOPHSTexas Southern UniversityHoustonTX 77587USA Howard University College of MedicineDepartment of Psychiatry and Behavioral SciencesHoward University Hospital2041 Georgia AvenueWashingtonDC 20060USA Department of Biomedical Sciences Faculty of Health and Wellness SciencesCape Peninsula University of TechnologyBellvill 7535South Africa

Background:Naringin as a bioflavanone glycoside is abundant in citrus fruits,which since ancient times have been utilized as natural herbal treatments in traditional *** has potent antioxidant effect that may mitigate oxidative stress mediated cardiovascular and renal dysfunctions in mammalian ***:To explore probable modulatory actions of naringin on fipronil-induced cardio-renal ***:Twenty-four Wistar rats weighing 140±3.0 g were divided into four groups including normal control(saline),10 mg/kg Fipronil(FIP),FIP+100 mg/kg naringin,and 100 mg/kg *** of naringin and fipronil was by oral gavage for 28 consecutive ***,blood pressure monitoring,biochemical assays,histology,and immunohistochemical evaluations were ***:Naringin significantly(P<0.001)lessened blood pressure parameters,oxidative stress markers but significantly(P<0.001)heightened the systemic ***,naringin prevented fipronil-induced histopathological lesions such as congestion and cellular infiltration in cardiac and renal ***,naringin attenuated the immunohistochemical expression of troponin 1 and matrix metalloperoxidase-2 in cardiac tissues,but heightened angiotensin converting enzyme 2 expression in contrast to that of fipronil ***:The observation in this study shows potent attenuation of fipronil-induced toxicity by naringin,through inhibiting processes related to oxidation and inflammation.

关键词： Biomarkers of cardiorenal dysfunction Fipronil toxicity Naringin Immunohistochemistry

Outcome of Symptom-Based RT-PCR Testing for SARS-CoV-2: Experience from a Large Public Testing Centre in Nigeria

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Advances in Infectious Diseases 2022年第4期12卷 799-812页

作者： Aigbe Gregory Ohihoin Kazeem Adewale Osuolale Patrick Azuka Okwuraiwe Adesola Zaidat Musa Ayorinde Babatunde James Chika Kingsley Onwuamah Olufemi Samuel Amoo Joseph Ojonugwa Shaibu Fehintola Ige Esther Ngozi Ohihoin Emelda Chukwu Ngozi Mirabel Otuonye Tajudeen Bamidele Adeola Olukosi olusola Ajibaye Yekeen Raheem David Oladele Agatha Nkiru David Babatunde Adewale Rosemary Audu Oliver Ezechi Nkiruka Nnonyelum Odunukwe Richard Adegbola Babatunde Lawal Salako Clinical Sciences Department Nigerian Institute of Medical Research Yaba Lagos Grants and M/E Unit (Biostatistics) Nigerian Institute of Medical Research Yaba Lagos Centre for Human Virology and Genomics Microbiology Department Nigerian Institute of Medical Research Yaba Lagos Department of Biochemistry and Nutrition Nigerian Institute of Medical Research Yaba Lagos Centre of Infectious Disease Research Microbiology Department Nigerian Institute of Medical Research Yaba Lagos Central Research Laboratory Nigerian Institute of Medical Research Yaba Lagos Department of Molecular Biology and Biotechnology Nigerian Institute of Medical Research Yaba Lagos Clinical Diagnostic Laboratory Nigerian Institute of Medical Research Yaba Lagos Department of Public Health Nigerian Institute of Medical Research Yaba Lagos

Background: Access to testing for SARS-CoV-2 in Nigeria is still highly restricted. Only patients who are symptomatic for SARS-CoV-2 are selected for testing. This pattern of testing will miss a large proportion of individuals with the infection who are asymptomatic and presymptomatic. This study reports the experience of a symptom-based study from a large testing centre in Nigeria. Methods: A cross-sectional study, reviewing data collected from respondents presenting at the Nigerian Institute of Medical Research (NIMR) modified drive-through center for COVID-19 test between the period March 31st and August 31st, 2020 were included in the analysis. Results: A total of 9891 participants were recruited into the study and 2465 participants (24.9%) had a positive PCR result for SARS-CoV-2. The majority of the respondents were above 18 years old, n = 9163 (93.4%). The average age of the respondents was 36.7 years (sd 13.8 years). The age of the participants has a significant effect on SARS-CoV-2 status (AOR = 1.009, CI, 1.005 to 1.012, p = 0.0001). There was a male preponderance, n = 5652 (57.6%). The odds of having a positive status for SARS-CoV-2 were 0.9 times lower for female participants. The majority of the respondents had a history of travel, n = 6788 (68.6%). Cough was the commonest symptom, n = 1062 (10.7%) followed by fever, n = 979 (9.9%). The mortality rate was 0.1%. Among the participants with comorbidity, 31 (51.7%) had positive results for SARS-CoV-2 while 29 (48.3%) had negative results. Conclusion: Symptom-based approach to testing for SARS-CoV-2 in Nigeria revealed a high positivity rate, while mortality from those tested in the study is low. Age and gender appear to play a significant role in the dynamics of the disease.

关键词： SARS-CoV-2 COVID-19 Symptoms RT-PCR Nigeria

COVID-19 Spread Patterns Is Unrelated to Malaria Co-Infections in Lagos, Nigeria

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Advances in Infectious Diseases 2020年第4期10卷 200-215页

作者： Olufemi Samuel Amoo Olugbenga Olanrewaju Aina Azuka Patrick Okwuraiwe Chika Kingsley Onwuamah Joseph Ojonugwa Shaibu Fehintola Ige Kelly Owaneze Hammed Olanrewaju Agboola Dorcas Njeri Kareithi Tochukwu Ifeanyi Onuigbo Amaka Stephanie Ikemefuna Joy Isioma Oraegbu Ebenezer Olusoji Odewale Leona Chika Okoli olusola Ajibaye Ayorinde Babatunde James Ganiyu Idris Greg Ohihoin Bosun Tijani Temmie Giwa-Tunbosun Richard Adegbola Babatunde Lawal Salako Rosemary Ajuma Audu Centre for Human Virology and Genomics Microbiology Department Nigerian Institute of Medical Research Lagos Nigeria Biochemistry Department Nigerian Institute of Medical Research Lagos Nigeria Co-Creation Hub Lagos Nigeria Lifebank Lagos Nigeria

Malaria and COVID-19, though caused by different organisms, share a significant number of symptoms like fever, headaches, difficulty in breathing and fatigue. Therefore, determining if a patient is positive for COVID-19 or Malaria based on symptoms alone, might be misleading, especially during pandemic response. It has been reported that an individual begins to manifest Malaria symptoms between 10 - 15 days after infection with malaria parasite, although some individuals may be asymptomatic. Some COVID-19 infected patients, like Malaria, are also asymptomatic but could contribute to transmission of SARS-CoV-2 virus. These similarities in symptoms have led to misconception about COVID-19 being real and misdiagnoses of both infections, especially in Nigeria. However, there are possibilities that Malaria and COVID-19 could co-exist in some individuals thereby leading to mismanagement and treatment of only one infection while neglecting the possibility of the patient being infected with both diseases. We aim to determine possible correlation between Malaria and COVID-19 in a Malaria endemic country like Nigeria. This study was carried out using the qPCR molecular testing approach, a gold standard for COVID-19 testing and rapid diagnostic test kits to detect Malaria parasites in 617 individuals residing in urban settings. We demonstrated that COVID-19 and Malaria infection amongst adults in urban settings are unrelated thereby focusing on symptoms alone may result in misdiagnosis. Our findings show that Malaria is not among the underlying medical conditions strongly associated with increased risk for severe COVID-19 illness amongst adults in urban settings.

关键词： Malaria COVID-19 Symptoms

Curtailing the spread of COVID-19 in Nigeria using digital framework and data driven approaches

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EngMedicine

EngMedicine 2024年第2期1卷 22-30页

作者： Bolanle Adefowoke Ojokoh Benjamin S.Aribisala Oluwafemi A.Sarumi Tobore V.Igbe Abimbola H.Afolayan Arome J.Gabriel Abiola Ezekiel Taiwo Olatunji M.Omisore Uchechukwu M.Chukwuocha olusola T.Babalola Tolulope A.Adebayo Department of Information Systems Federal University of TechnologyP.M.B.704 AkureOndo StateNigeria Department of Computer Science Lagos State UniversityOjoLagos StateNigeria Department of Mathematics and Computer Science University of Marburg35037 MarburgGermany Center for Diabetes Technology Department of Psychiatry&Neurobehavioral SciencesUniversity of VirginiaCharlottesvilleVA 22903USA Department of Cyber Security Federal University of TechnologyP.M.B.704 AkureOndo StateNigeria Faculty of Engineering Mangosuthu University of TechnologyDurban 4026South Africa Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518055China Department of Public Health Federal University of TechnologyIhiagwaOwerriNigeria Department of Computer Science Federal University of TechnologyP.M.B.704 AkureOndo StateNigeria

The onset of the coronavirus disease 2019(COVID-19)pandemic had profound economic and societal repercussions *** nations managed to mitigate the spread of the virus sufficiently early through implementing digital frameworks and other containment ***,many countries in Africa faced significant challenges due to limited technological infrastructure for infection *** study investigated the efficacy of digital frameworks,with a specific focus on contact tracing apps,in stemming the spread of COVID-19 within *** investigated the potential impact of the use of these apps on reducing infection rates and improving public health ***,this study provided insights into the practical implementation of such frameworks and the challenges associated with their nationwide deployment.A structured user-oriented questionnaire was distributed to participants across different geopolitical zones in *** study employed association rule mining and descriptive statistics,setting a support threshold of 0.001 and confidence of 0.8,to uncover patterns of interest among *** analysis using Barnes–Hut t-Distributed Stochastic Neighbor Embedding was conducted to derive reliable inferences from the *** findings revealed adoption rates of 69.7%and 93.8%for the minimum and maximum,respectively,in favor of using a COVID-19 contact tracing ***,71.6%of participants expressed concerns about the privacy of their personal information,whereas 74%showed an interest in receiving daily reports on estimated COVID-19 infection in their *** study presents empirical evidence highlighting the potential of contact tracing apps as valuable tools for monitoring and curbing the spread of COVID-19 and related diseases in Nigeria.

关键词： Digital technology COVID-19 Contact tracing Mobile app Data analytics