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Clinical Research Communications 2023年第3期6卷 22-29页

作者： Seyi Samson Enitan Esther Ngozi Adejumo John Osaigbovoh Imaralu ayodele Ademola Adelakun Oluwakemi Anike Ladipo Comfort Bosede Enitan Department of Medical Laboratory Science Babcock UniversityIlishan-Remo 121103Nigeria Department of Gynaecology and Obstetrics Babcock University Teaching HospitalIlishan-Remo 121103Nigeria Department of Chemical Pathology Babcock University Teaching HospitalIlishan-Remo 121103Nigeria

Osteoporosis has emerged as a significant health issue among postmenopausal *** this concern necessitates a multifaceted approach encompassing genetics,pharmacogenomics,bone turnover markers,lifestyle factors,concurrent medical conditions,biomarkers,and advanced imaging ***,challenges in terms of cost-effectiveness and ethical considerations do ***,the convergence of technological progress and research endeavors offers a promising *** integration of genetic testing and pharmacogenomics into clinical practice holds substantial *** integration empowers healthcare professionals to forecast treatment responses and pinpoint individuals with elevated susceptibility,thereby enabling the implementation of tailored and efficacious interventions that optimize outcomes–personalized *** the intricate nature of osteoporosis,personalized strategies stand to greatly benefit women grappling with this *** research and collaborative efforts are imperative to propel advancements within this domain,paving the way for further breakthroughs.

关键词： osteoporosis management personalized medicine pharmacogenomics women

Nutritional Challenges of Children with Disabilities in Special Needs Center in Mainland, Lagos State, Nigeria

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Journal of Food Science and Engineering 2019年第8期9卷 297-304页

作者： Kemi Priscillia Ogbonna Victoria Omonigho Otobo Felicia Obiageli Maduabum Francisca Nonyelum Onyeka Olatokunboh ayodele Ashiru Chika Esther Ajuluchi Department of Home Economics&Hospitality Management Education Faculty of Vocational&Technical EducationUniversity of NigeriaNsukka 410001Nigeria Home Economics Department School of Vocational EducationFederal College of Education(Technical)Akoka 100001YabaLagos StateNigeria Department of Fashion Design School of Art Design and PrintingYaba College of TechnologyLagos 101212Nigeria Department of Home Economics Federal College of EducationOkene 260101Kogi StateNigeria

The study determined the nutritional challenges of persons with disability in special needs centers in mainland,Lagos *** research questions guided the *** research design was *** population of the study was *** sampling was done since the population was a manageable *** questionnaire was used for data *** collected were analyzed using mean and standard *** showed that the types of disabilities among children in special need centers in Lagos State included among others:physical disability,learning disability,cerebral palsy,Down syndrome,attention deficit disorder/attention deficit hyperactivity disorder(ADHD),autism and speech and language *** also revealed that the nutritional needs of children with disability included feeding on different foods,drinking water regularly,taking fruits daily,and ensuring that their nutrient requirements are met *** indicated that the nutritional challenges of children with disability included among others:excessive salivation,frequent constipation,inability to feed oneself,depending on care givers for feeding,food dropping from the mouth while being fed and difficulty in chewing and swallowing *** was *** recommendations made was that children with disabilities should be provided with variety of foods daily to meet their nutritional needs and parents/caregivers should devote more feeding time to the disabled child.

关键词： Nutrition challenges disabilities children special needs

Blood pressure,prevalence of hypertension and hypertension related complications in Nigerian Africans:A review

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World Journal of Cardiology 2012年第12期4卷 327-340页

作者： Okechukwu S Ogah Ikechi Okpechi Innocent I Chukwuonye Joshua O Akinyemi Basden JC Onwubere ayodele O Falase Simon Stewart Karen Sliwa Ministry of Health Nnamdi Azikiwe SecretariatUmuahia 440233Abia StateNigeria Division of Cardiovascular Medicine Department of MedicineUniversity College HospitalPMB 5116Dugbe GPOIbadan 200211Oyo StateNigeria Division of of Nephrology and Hypertension Department of MedicineE13Renal UnitGrootes Schuur HospitalObservatory 7925Cape TownSouth Africa Division of Renal Medicine(Nephrology) Department of MedicineFederal Medical CentreUmuahia 440233Abia StateNigeria Department of Epidemiology and Medical Statistics College of MedicineUniversity of IbadanIbadan 200211Oyo StateNigeria Division of Cardiology Department of MedicineUniversity of Nigeria Teaching HospitalEnugu 400001Nigeria NHMRC Centre of Research Excellence to Reduce Inequality in Heart Disease Baker IDI Heart and Diabetes Institute 75 Commercial RoadMelbourneVIC 3004Australia Hatter Cardiovascular Research Institute Faculty of Health SciencesUniversity of Cape TownCape TownPrivate Bag X3Observatory 7935South Africa

To review studies on hypertension in Nigeria over the past five decades in terms of prevalence,awareness and treatment and *** our search on Pubmed,African Journals Online and the World Health Organization Global cardiovascular infobase,1060 related references were identified out of which 43 were found to be relevant for this *** overall prevalence of hypertension in Nigeria ranges from 8%-46.4% depending on the study target population,type of measurement and cut-off value used for defining *** prevalence is similar in men and women(7.9%-50.2% vs 3.5%-68.8%,respectively) and in the urban(8.1%-42.0%) and rural setting(13.5%-46.4%).The pooled prevalence increased from 8.6% from the only study during the period from 1970-1979 to 22.5%(2000-2011).Awareness,treatment and control of hypertension were generally low with attendant high burden of hypertension related *** order to improve outcomes of cardiovascular disease in Africans,public health education to improve awareness of hypertension is *** epidemiological studies on hypertension are required to adequately understand and characterize the impact of hypertension in society.

关键词： Blood pressure Hypertension Prevalence Non-communicable disease Nigeria

Chemical Composition of Gossypium herbaceum linn and its Antioxidant, Antibacterial, Cytotoxic and Antimalarial Activities

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Clinical Complementary Medicine and Pharmacology 2021年第1期1卷 68-76页

作者： Rotimi Abisoye Larayetan Gideon Ayeni Abdulrazaq Yahaya Abayomi ajayi Sunday Omale Umar Ishaq Dauda Joseph Abiodun Chijioke Olisah Julius Aigbogun Swesme Enyioma-Alozie Department of Chemistry Kogi State UniversityPMB 1008AnyigbaKogi StateNigeria Department of Pure and Applied Chemistry University of Fort Hare Alice 5700South Africa Department of Biochemistry Kogi State UniversityPMB 1008AnyigbaKogi StateNigeria Department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalWestville CampusDurban 4000South Africa Department of Anatomy Faculty of Basic Medical SciencesCollege of Health SciencesKogi State University AnyigbaPMB 1008AnyigbaKogi StateNigeria Botany Department Institute for Costal and Marine ResearchNelson Mandela UniversityPort Elizabeth 6031South Africa Jacio Environmental Limited 3 Airoboyi EstatesKM 2RefineryRefinery RoadEffurunDelta StateNigeria Department of Anatomy Faculty of Basic Medical SciencesBaze UniversityPlot 686Cadastral Zone C 00Jabi Airport Road Bypass(Ring Road)Behind National Judicial InstituteAbujaNigeria

Background:Gossypium herbaceum(***),a plant commonly found in the wild in Nigeria,is said to possess some therapeutic ***,there is a dearth of information on its chemical ***,there is a need to investigate its therapeutic ***:To investigate the qualitative and quantitative phytochemical components of the leaf extracts of ***,as well as its antioxidant,antimalarial and cytotoxic ***:Gas chromatography-mass spectrometry(GC-MS)analysis was used to determine the components of ethanol and hexane extracts of *** leaf while 2,2-diphenyl-1-picrylhydrazyl(DPPH)and nitric oxide assays were used to determine the antioxidant *** parasites viability was examined using parasite lactate dehydrogenase(pLDH)technique and HeLa cell was used for the cytotoxicity ***:Bioactive compounds identified in ethanol and hexane extracts of *** were 37 and 30 kinds,respectively,with major components as linoleic acid(36.10%and 33.82%),vitamin E(7.15%and 5.98%)and caryophyllene(4.21%and 5.08%).It also has tannins,saponins,alkaloids,flavonoids steroids,phenols and *** antibacterial test,significant inhibitory potentials against multidrug-resistant bacteria strains were *** vitro antioxidant potentials(IC 50)of ethanol and hexane extracts were 3.33 and 4.12μg/mL for DPPH assays,and 3.87 and 5.00μg/mL for nitric oxide assays,*** activities(IC 50)were 9.99 and 9.76μg/mL for ethanol and hexane extracts,***:*** leaf may provide novel plant-derived therapeutic agents,effective in treating infectious diseases arising from multiple drug-resistant bacteria and a target in the management of oxidative stress.

关键词： Antimalarial Antimicrobial Antioxidant Bioactive components MBC MBF GC-MS Gossypium herbaceum

Elucidating the molecular targets of Curcuma longa for breast cancer treatment using network pharmacology,molecular docking and molecular dynamics simulation

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Precision Medicine Research 2023年第2期5卷 16-31页

作者： Christopher Terseer Tarkaa Damilare Adebayo Oyaniyi Ridwan Abiodun Salaam Rachael Pius Ebuh Olusola Abayomi Akangbe Sayo Ebenezer Oladokun Rodiat Omotola Sowemimo Oluwaponmile Florence ajayi Cell Biology and Genetics Unit Department of ZoologyUniversity of IbadanIbadan 200005Nigeria Ecology and Environmental Biology Unit Department of ZoologyUniversity of IbadanIbadan 200005Nigeria

Background:To elucidate the molecular mechanisms of Curcuma longa(***)in breast cancer ***:Phytocompounds of *** were obtained from ***’s Phytochemical and Ethnobotanical *** active targets were retrieved from Bindingdb,SEA and Swiss Target Prediction *** cancer targets were retrieved from the Therapeutic Target *** Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were done using DAVID and KOBAS3.0 databases *** Cytoscape software was used to construct the phytocompound-target-pathway *** PyRx and Desmond software were utilized for molecular docking and molecular dynamics simulation ***:Out of one hundred and fifty-six phytocompounds,fifty-four modulated proteins involved in breast *** Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated *** exerts its therapeutic effect through regulating several key *** docking analysis revealed that most phytocompounds of *** had a good affinity with the key *** dynamics simulation showed that ethinylestradiol formed stable ligand-protein ***:The results of this study will enhance our understanding of the potential molecular mechanisms by which *** inhibits breast cancer and lay a foundation for future experimental studies.

关键词： Curcuma longa network pharmacology breast cancer mechanism molecular docking molecular dynamics simulation

阿列马嗪对Nissen胃底折叠术后干呕的控制效果

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世界核心医学期刊文摘（儿科学分册） 2006年第4期2卷 46-46页

作者： Antao B. Ooi K. Ade-ajayi N. L. Spitz 刘凯 Institute of Child Health 31 Guilford Street WC1N 1EP London United Kingdom

Background: Retching, an early component of the emetic reflex, is a common and distressing symptom in children after Nissen fundoplication. Alimemazine (trimeprazine, Vallergan; Castlemead, Herts, UK) is a phenothiazine derivative histamine1 antagonist, which anecdotally relieves the retching symptoms. Material and Methods: A prospective, double-blind, randomized, crossover, placebo-controlled study of 15 neurologically impaired children with retching after Nissen fundoplication over a period of 1 year (December 2002- December 2003). Patients were randomly allocated to receive 1 week each of alimemazine and placebo with crossover. A diary was maintained of retching episodes 1 week before, during, and 1 week after the trial. Dosage of alimemazine used was 0.25 mg/kg 3 times a day (maximum, 2.5 mg per dose). Statistical analysis was done using a paired Student’s t test, where P value of less than .05 was considered significant. Results are presented as mean ± SD. Results: Twelve parents completed the diaries (9 open, 3 laparoscopic Nissen fundoplication). Median age of the child was 36 months (8- 180 months), median duration of retching was 4.5 months (1- 52 months), and mean number of retching episodes per week was 60 ± 29.40. Mean number of retching episodes with alimemazine was 10.42 ± 9.48 vs 47.67 ± 27.79 with a placebo (P < .0001). No adverse effects were reported in those cases that completed the study. Conclusion: At low dose, alimemazine (Vallergan) is a safe and effective drug in the management of retching after Nissen fundoplication.

关键词：阿列马嗪 Nissen胃底折叠胃底折叠术安慰剂对照呕吐反射吩噻嗪开腹手术交叉研究拮抗剂

Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants:The case of Artemisia vulgaris *** for Artemisia annua *** Western Uganda

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TMR Integrative Medicine 2023年第4期7卷 1-13页

作者： Ivan Kahwa Clement Olusoji ajayi Reenu Yadav Nagendra Singh Chauhan Kamal Shah Abdelgadir Alamin Abdelgadir Efrata Ashuro Shegena Salome Daniel Timothy Omara John Baptist Asiimwe Hilda Ikiriza Shabnoor Iqbal Casim Umba Tolo Anke Weisheit Patrick Engeu Ogwang Pharm-BioTechnology and Traditional Medicine Centre Mbarara University of Science and TechnologyP.O.Box 1410MbararaUganda Department of Pharmacy Faculty of MedicineMbarara University of Science and TechnologyP.O.Box 1410MbararaUganda Department of Pharmacy IES UniversityBhopal-462044Madhya PradeshIndia Drugs Testing Laboratory Avam Anusandhan Kendra Raipur(CG)492010India Institute of Pharmaceutical Research GLA UniversityMathuraUttar Pradesh 281406India Department of Pharmacognosy Faculty of PharmacyUniversity of GeziraP.O Box 20Wad MadaniSudan Department of Pharmaceutics and Pharmacy Practice Kampala International UniversityP.O.Box 9790Dares SalaamTanzania Institute of Chemistry of Renewable Resources Department of ChemistryUniversity of Natural Resources and Life Sciences Vienna(BOKU)Konrad-Lorenz-Straße 243430Tulln an der DonauAustria Aga Khan University P.O.Box 8842KampalaUganda Department of Biology Mbarara University of Science and TechnologyP.O.Box 1410MbararaUganda Department of Zoology Government College UniversityFaisalabadPunjab 38000Pakistan

Background:Different parts of Artemisia vulgaris L.(***)are ethno-medicinally used as an emmenagogue and for the treatment of ailments such as malaria fever,ulcers,and ***,anecdotal evidence shows that the plant is often substituted for Artemisia annua L.(***)by herbalists in Western Uganda due to similarities in their *** of medicinal plants and mislabelling of herbal products have been incriminated in toxicity and adverse health outcomes in traditional medicine *** safety continues to be a major issue with the use of herbal remedies,it becomes imperative therefore that medicinal plants should be correctly ***:This study focused on investigating the macroscopic,microscopic,physicochemical characteristics and phytochemical composition of *** leaves compared to *** to ease its correct ***:The results showed that there are some colour differences between the leaves of the two species,with a close arrangement of microscopic features but different leaf *** leaves of the two Artemisia species had similar tastes,but their shapes and colours(greenish-yellow for *** and dark green for ***)can be used by the local community to distinguish between *** artemisinin content was higher in *** leaves(1.72%)than in ***(1.43%),but the reverse was observed for the total flavonoid ***:This observation could justify the change in the use of *** by the indigenous community in western *** studies should consider the pharmacognostic comparison of *** with other species in the genus Artemisia and the use of molecular techniques such as DNA barcoding.

关键词： Artemisinin traditional medicine misidentification microscopic studies