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Ginkgo biloba supplement modulates mTOR/ERK1/2 activities to mediate cardio-protection in cyclosporin-A-induced cardiotoxicity in Wistar rats

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Clinical Traditional Medicine and Pharmacology 2024年第2期5卷 32-42页

作者： Jerome Ndudi Asiwe Benneth Ben-Azu Godwin D.Yovwin Vincent-Junior Onoriode Igben Benjamin Oritsemuelebi Israel Ofejiro Efejene olusegun gafar adebayo Nicholas Asiwe Anthony Emeka Ojieh Department of Physiology Faculty of Basic Medical SciencesDelta State UniversityAbraka 330105Delta StateNigeria Department of Physiology Faculty of Basic Medical SciencesUniversity of IbadanIbadan 200223Oyo StateNigeria Department of Pharmacology Faculty of Basic Medical SciencesDelta State UniversityAbraka 330105Delta StateNigeria Department of Family Medicine Faculty of Clinical MedicineDelta State University330105Delta StateNigeria Department of Physiology Faculty of Basic Medical SciencesNovena UniversityOgume 322103Delta StateNigeria Department of Physiology PAMO University of Medical SciencesPort-HarcourtPort-Harcourt 500262Rivers StateNigeria Department of Anatomy University of Port-HarcourtPort-Harcourt 500262Rivers StateNigeria

Background:Cyclosporine-A(Cs-A),an immunosuppressant drug indicated for organ transplant patients has been associated with toxicities arising from activation of pathological *** Ginkgo biloba supplement(GBS)is an antioxidant-enhancing herbal product widely used for treating neurological and vascular ***:This study investigated the ameliorative effect of GBS on cyclosporine-A induced cardiotoxicity in Wistar ***:The study included 20 Wistar rats(n=5)and they were treated as follows:group 1 received distilled water(10 mL/kg),group 2 received Cs-A(25 mg/kg),group 3 received GBS(50 mg/kg)and group 4 received Cs-A(25 mg/kg)and GBS(50 mg/kg).All treatment were done intraperitoneal for 14 days and thereafter,animals were euthanised and heart tissues were harvested for biochemical assays as well as immunohistochemical *** was also collected for serum biochemical ***:Our results revealed that GBS reduces Cs-A induced increase of AST,ALT,ALP,LDH,and GGT levels in serum relative to Cs-A ***,increased oxido-nitrergic markers like MDA,NO,together with elevated concentrations of cholesterol,triglycerides,LDL,creatine kinase-MB,troponin-I,as well as pro-inflammatory cytokines(IL-6,and TNF-α)and heart weight index were reduced by *** Cs-A induced suppression of low-density lipoprotein,antioxidant(GSH,SOD,CAT),Na-K ATPase activities and antiapoptotic element,Bcl-2 were increased by ***,signalling pathways including ERK1/2,and mTOR as well as ventricular thickness were significantly alleviated by GBS ***:The findings suggest that GBS ameliorated Cs-A-induced cardiotoxicity by activating mTOR/ERK1/2 signalling pathways.

关键词： Apoptosis Antioxidant Cyclosporine-A Ginkgo biloba supplement Inflammation

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