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Eva.ua.ion of a.herence to Nevira.ine for Prevention of Mother-to-Child Tra.smission a.ongst Infa.ts of HIV Positive Mothers in the First 6 Weeks of Life in La.os Nigeria

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World Journa. of a.DS 2019年第2期9卷 70-84页

作者： Obiyo Nwa.wu Fola.a.e a. Ola.unde Nkechinyere E. Ha.rison Ma.ga.et O. Ilomua.ya.oludaisi a. oduniyi Depa.tment of Pha.ma.ology Therapeutics and Toxicology College of Medicine University of Lagos Surulere Lagos Nigeria Depa.tment of Medicine 68 Nigerian Army Reference Hospital (68 NARH) Yaba Lagos Nigeria Depa.tment of Pha.ma.eutics a.d Pha.ma.eutica. Technology Faculty of Pharmacy University of Lagos Surulere Lagos Nigeria

Ba.kground: Over 90% of infection in children is a.quired through mother to child tra.smission (MTCT). Nevira.ine’s effica.y, sa.ety a.d a.forda.le cost ma.e it the most preferred non-nucleoside reverse tra.scripta.e inhibitor (NNRTI) for pa.dia.ric prophyla.tic use in resource limited settings. There a.e very few studies on pedia.ric a.herence to a.tiretrovira. prophyla.is, especia.ly in very young infa.ts. The objective of the study wa. to eva.ua.e the a.herence to nevira.ine for prevention of mother to child tra.smission (PMTCT) a.ongst infa.ts of HIV positive mothers in the first 6 weeks of life. Methods: This wa. a.questionna.re ba.ed prospective cross-sectiona. multicenter study initia.ed in July 2015 a.d concluded in December 2017. The study wa. ca.ried out a. the a.ds Prevention in Nigeria.(a.IN/HIV) huma. immunodeficiency pa.dia.ric clinics of the La.os University Tea.hing Hospita. (LUTH), Idi-a.a.a. La.os Sta.e, 68 Nigeria. a.my Reference Hospita. Ya.a.(68Na.HY) La.os, Nigeria.a.d the Holy Fa.ily Ca.holic Hospita., Festa. Town, a.uwo Odofin, La.os Sta.e. Nevira.ine a.herence, in infa.ts of 0 - 6 weeks wa. mea.ured by ma.erna. verba. reports. Results: Eighty-one (81) infa.ts receiving nevira.ine within the a.e of 0 - 6 weeks completed the study. Ma.ority of the infa.ts sta.ted trea.ment a. birth (32%) a.d a.ter 4 weeks (31%). 54% of the 81 respondents do not miss or skip their doses while 46% of respondents skip doses. Ma.ority of the respondents 18 (49%) missed their doses for 24 - 48 hours while 25% missed their doses beca.se they were a.a. from home a.d 23% ra. out of pills. 85.2% took ≥95% of the prescribed medica.ions (good or high a.herence ), 8.2% took 80% - 95% of doses (modera.e a.herence) while 6.2% took 0.05). Conclusions: The a.herence ra.es found in this study a.e compa.a.le to other studies in developing countries. But these ra.es a.e still low for good clinica. outcomes. Different levels of a.herence were documented with the ma.ority ha.ing g

关键词： a.herence Infa.ts a.tiretrovira. Prophyla.is Ma.erna./Ca.egiver Verba. Reports Nevira.ine Six Weeks

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