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Targeting the HIV reservoir:chimeric antigen receptor therapy for HIV cure

Chinese Medical Journal 2023年第22期136卷 2658-2667页

作者： Shuang Li Hu Wang Na Guo Bin Su olivier lambotte Tong Zhang Beijing Key Laboratory for HIV/AIDS Research Sino-French Joint Laboratory for Research on Humoral Immune Response to HIV InfectionClinical and Research Center for Infectious DiseasesBeijing Youan HospitalCapital Medical UniversityBeijing 100069China Department of Internal Medicine AP-HPBicêtre HospitalUMR1184 INSERM CEALe Kremlin BicêtreUniversity Paris SaclayParis 94270France

Although antiretroviral therapy(ART)can reduce the viral load in the plasma to undetectable levels in human immunodeficiency virus(HIV)-infected individuals,ART alone cannot completely eliminate HIV due to its integration into the host cell genome to form viral *** achieve a functional cure for HIV infection,numerous preclinical and clinical studies are underway to develop innovative immunotherapies to eliminate HIV reservoirs in the absence of *** studies have tested adoptive T-cell therapies in HIV-infected individuals,but their effectiveness was *** recent years,with the technological progress and great success of chimeric antigen receptor(CAR)therapy in the treatment of hematological malignancies,CAR therapy has gradually shown its advantages in the field of HIV *** studies have identified a variety of HIV-specific CAR structures and types of cytolytic effector ***,CAR therapy may be beneficial for enhancing HIV immunity,achieving HIV control,and eliminating HIV reservoirs,gradually becoming a promising strategy for achieving a functional HIV *** this review,we provide an overview of the design of anti-HIV CAR proteins,the cell types of anti-HIV CAR(including CAR T cells,CAR natural killer cells,and CAR-encoding hematopoietic stem/progenitor cells),the clinical application of CAR therapy in HIV infection,and the prospects and challenges in anti-HIV CAR therapy for maintaining viral suppression and eliminating HIV reservoirs.

关键词： Functional HIV cure HIV reservoir Chimeric antigen receptor therapy CAR T cells CAR natural killer cells

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