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Recent advances in alginate based gastroretentive technologies for drug delivery applications

Medicine in Novel Technology and Devices 2023年第2期18卷 43-54页

作者： olivia sen Sreejan Manna Gouranga Nandi Subrata Jana Sougata Jana Department of Pharmaceutical Technology Brainware UniversityBarasatKolkataWest Bengal700125India Division of Pharmaceutics Department of Pharmaceutical TechnologyUniversity of North BengalRaja RammohunpurDist.–DarjeelingWest BengalPin–734013India Department of Chemistry Indira Gandhi National Tribal UniversityAmarkantakMadhya Pradesh484887India Department of Pharmaceutics Gupta College of Technological SciencesAshram MoreG.T.RoadAsansol713301West BengalIndia Department of Health and Family Welfare Directorate of Health ServicesKolkataIndia

The efficacy of orally delivered medicines can be maximized through enhancing the gastric residence period and modifying the drug release pattern according to therapeutic *** technologies were investigated through recent years for increasing gastric retention of *** are one of the widely studied materials for increasing the retention of drug delivery systems in the stomach *** biodegradability,biocompatibility and non-toxic behavior in combination with the easy fabrication technologies has made biopolymers an interesting option to pharmaceutical scientists for developing gastroretentive drug delivery systems(GRDDS).Several gastroretentive approaches are reported to be efficacious to localize the drug delivery system in the gastric *** are commonly employed polysaccharide for developing various GRDDS including low density systems,mucoadhesive systems,swellable systems,hydrogel forming systems,in situ gelling systems,raft forming systems,magnetic *** abundant availability from marine and bacterial sources in combination with its attractive physicochemical nature has encouraged pharmaceutical researchers to investigate its suitability in developing various drug delivery *** mucoadhesive,hydrogel forming and raft forming behavior of alginates makes alginate suitable for *** attractive properties of alginate makes it a useful biopolymer in the biomedical *** review focuses on the source and chemistry of alginates and describes the applications of alginates in developing novel gastroretentive drug delivery systems.

关键词： Gastroretentive drug delivery system Alginate Low density systems Mucoadhesive systems Hydrogel forming system Drug delivery applications

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Assessing the Effect of Global Travel and Contact Restrictions on Mitigating the COVID-19 Pandemic

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Engineering 2021年第7期7卷 914-923页

作者： Shengjie Lai Nick W.Ruktanonchai Alessandra Carioli Corrine W.Ruktanonchai Jessica R.Floyd olivia Prosper Chi Zhang Xiangjun Du Weizhong Yang Andrew J.Tatem WorldPop School of Geography and Environmental ScienceUniversity of SouthamptonSouthampton SO171BJUK Population Health Sciences Virginia TechBlacksburgVA 24061USA Department of Mathematics University of TennesseeKnoxvilleTN 37996USA School of Public Health(Shenzhen) Sun Yat-sen UniversityShenzhen 510275China School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Travel restrictions and physical distancing have been implemented across the world to mitigate the coronavirus disease 2019(COVID-19)pandemic,but studies are needed to understand their effectiveness across regions and *** on the population mobility metrics derived from mobile phone geolocation data across 135 countries or territories during the first wave of the pandemic in 2020,we built a metapopulation epidemiological model to measure the effect of travel and contact restrictions on containing COVID-19 outbreaks across *** found that if these interventions had not been deployed,the cumulative number of cases could have shown a 97-fold(interquartile range 79–116)increase,as of May 31,***,their effectiveness depended upon the timing,duration,and intensity of the interventions,with variations in case severity seen across populations,regions,and ***,before effective vaccines are widely available and herd immunity is achieved,our results emphasize that a certain degree of physical distancing at the relaxation of the intervention stage will likely be needed to avoid rapid resurgences and subsequent lockdowns.

关键词： COVID-19 Pandemic Population mobility Travel restriction Physical distancing

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Enhancement of SARS-CoV-2 vaccine-induced immunity by a Toll-like receptor 7 agonist adjuvant

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2481-2484页

作者： Gen Li Meixing Yu Qiong Ke Jing Sun Yanwen Peng Chuanfeng Xiong olivia Monteiro COVID-Infection and Immunity Investigation Group Jincun Zhao Andy P.Xiang Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhouChina Center for Stem Cell Biology and Tissue Engineering Key Laboratory for Stem Cells and Tissue EngineeringMinistry of EducationSun Yat-sen UniversityGuangzhouChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthFirst Affiliated HospitalGuangzhou Medical UniversityGuangzhouChina Center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and TechnologyMacaoChina 不详

Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an enveloped positive-sense single-stranded RNA(ssRNA)virus responsible for the global COVID-19 *** vaccines for SARS-CoV-2 have been developed and applied worldwide,research on vaccine adjuvant is *** infections normally elicit a range of innate immune responses through the activation of pattern recognition receptors(PRRs).

关键词： immunity vaccine pattern

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SARS-CoV-2 pathogenesis in the gastrointestinal tract mediated by Spike-induced intestinal inflammation

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Precision Clinical Medicine 2024年第1期7卷 84-86页

作者： Zhanyu Li Jianzhong He Yun Yin Lei Tang Ye Liu olivia Monteiro Famin Zeng Department of Pathology The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 5190ooChina City University of Macao Macao 999078China Faculty of Medicine Macao University of Science and TechnologyMacao 999078China

Dear Editor,The pathogenesis of COVID-19 in the gastrointestinal(GI)tract is well-documented[1].However,due to a lack of simple animal models,the pathogenic mechanisms of SARS-CoV-2 in the GI tract is not well ***,com... 详细信息

关键词： pathogenesis gastrointestinal inflammation

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Handwashing quality assessment via deep learning:a modelling study for monitoring compliance and standards in hospitals and communities

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Intelligent Medicine 2022年第3期2卷 152-160页

作者： Ting Wang Jun Xia Tianyi Wu Huanqi Ni Erping Long Ji-Peng olivia Li Lanqin Zhao Ruoxi Chen Ruixin Wang Yanwu Xu Kai Huang Haotian Lin State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhouGuangdong 510275China School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong 510275China Key Laboratory of Adaptive Optics Institute of Optics and ElectronicsChinese Academy of SciencesChengduSichuan 610209China Moorfields Eye Hospital NHS Foundation Trust LondonUnited Kingdom Cixi Institute of Biomedical Engineering Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboZhejiang 315300China Center for Precision Medicine Sun Yat-sen UniversityGuangzhouGuangdong 510275China

Background Hand hygiene can be a simple,inexpensive,and effective method for preventing the spread of infectious ***,a reliable and consistent method for monitoring adherence to the guidelines within and outside healthcare settings is *** aim of this study was to provide an approach for monitoring handwashing compliance and quality in hospitals and *** We proposed a deep learning algorithm comprising three-dimensional convolutional neural networks(3D CNNs)and used 230 standard handwashing videos recorded by healthcare professionals in the hospital or at home for training and internal *** assessment scheme with a probability smoothing method was also proposed to optimize the neural network’s output to identify the handwashing steps,measure the exact duration,and grade the standard level of recognized ***-two videos by healthcare professionals in another hospital and 28 videos recorded by civilians in the community were used for external *** Using a deep learning algorithm and an assessment scheme,combined with a probability smoothing method,each handwashing step was recognized(ACC ranged from 90.64%to 98.87%in the hospital and from 87.39%to 96.71%in the community).An assessment scheme measured each step’s exact duration,and the intraclass correlation coefficients were 0.98(95%CI:0.97-0.98)and 0.91(95%CI:0.88-0.93)for the total video duration in the hospital and community,***,the system assessed the quality of handwashing,similar to the expert panel(kappa=0.79 in the hospital;kappa=0.65 in the community).Conclusions This work developed an algorithm to directly assess handwashing compliance and quality from videos,which is promising for application in healthcare settings and communities to reduce pathogen transmis-sion.

关键词： Handwashing Infectious control Deep learning Action recognition Standard level grading

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全球旅行和接触限制对减缓COVID-19疫情大流行作用的评估

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Engineering 2021年第7期7卷 57-78页

作者：赖圣杰 Nick W.Ruktanonchai Alessandra Carioli Corrine W.Ruktanonchai Jessica R.Floyd olivia Prosper 张弛杜向军杨维中 Andrew J.Tatem World Pop School of Geography and Environmental Science University of Southampton Population Health Sciences Department of Mathematics University of Tennessee School of Public Health (Shenzhen) Sun Yat-sen University School of Population Medicine and Public Health Chinese Academy of Medical Sciences & Peking Union Medical College

为了减缓新冠病毒肺炎(COVID-19)疫情的大流行,全球已广泛实施了旅行限制和保持社交距离的措施,但这些干预措施在不同地区和时间方面的有效性尚待深入研究。基于2020年第一波疫情期间135个国家或地区手机定位数据获得的人口流动指标,我... 详细信息

为了减缓新冠病毒肺炎(COVID-19)疫情的大流行,全球已广泛实施了旅行限制和保持社交距离的措施,但这些干预措施在不同地区和时间方面的有效性尚待深入研究。基于2020年第一波疫情期间135个国家或地区手机定位数据获得的人口流动指标,我们构建了一个元人口流行病学模型(metapopulation epidemiological model),用于评估全球旅行和接触限制对遏制不同地区COVID-19传播的影响。研究发现,如果未采取这些干预措施,截至2020年5月31日,研究地区(135个国家或地区)的累计COVID-19病例数可能已增加97倍(四分位距为79～116)。然而,这些措施的有效性取决于干预的及时性、强度和持续时长,并且不同人群、地区和季节的发病严重程度有所差异。此外,本研究结果强调,在放松干预措施期间,并且在有效的疫苗普及和实现群体免疫之前,在一定程度上,仍需采取减少人员接触的措施,以避免下一波疫情的快速出现和再次采取全面封锁措施。

关键词： COVID-19 大流行人口流动旅行限制保持社交距离

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Sub-percent precision measurement of neutrino oscillation parameters with JUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Chi Chan Jinfan Chang Yun Chang Guoming Chen Pingping Chen Po-An Chen Shaomin Chen Xurong Chen Yixue Chen Yu Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng Yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso olivia Dalager Christophe De La Taille Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko Jianmeng Dong Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Ran Du Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan Lei Fan Jian Fang Wenxing Fang Marco Fargetta Dmitry Fedoseev Zhengyong Fei Li-Cheng Feng Qichun Feng Richard Ford Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong Hui Gong Yuri Gornushkin Alexandre Göttel Marco Grassi Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera YuenKeung Ho Yerevan Physics Institute YerevanArmenia UniversiéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO

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JUNO sensitivity on proton decay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich Marcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 Marco Fargetta Dmitry Fedoseev Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Agnese Giaz Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel Marco Grassi Christian Grewing Vasily Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone Maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han Muhammad Sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear Science and Technology IslamabadPakistan INFN Catania and Dipartimento di Fisica e Astronomia dell Universitàdi Catania CataniaItaly East China University of Science and Technology ShanghaiChina University of Science and Technology of China HefeiChina Joint Institute for Nuclear Research DubnaRussia INFN Sezione di Milano and Dipartimento di Fisica dell Universitàdi Milano MilanoItaly Department of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Physics and Earth Science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN Milano Bicocca and University of Milano Bicocca MilanoItaly INFN Sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina SUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Physics National Taiwan UniversityTaipei Dipartimento di Fisica e Astronomia dell’Universitàdi Padova and INFN Sezione di Padova PadovaItaly University of Roma Tre and INFN Sezione Roma Tre RomaItaly Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN Milano Bicocca and Politecnico of Milano MilanoItaly National United University Miao-Li Dongguan University of Technology DongguanChina Tsinghua University BeijingChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power University BeijingChina Sun Yat-sen University GuangzhouChina Beijing Institute of Spacecraft Environment Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN Sez

The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental *** this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data *** estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid scintillator detector

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