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Trombinol,a bioactive fraction of Psidium guajava,stimulates thrombopoietin expression in HepG2 cells

Asian Pacific Journal of Tropical Biomedicine 2017年第5期7卷 437-442页

作者： Guntur Berlian olivia mayasari tandrasasmita Raymond Rubianto Tjandrawinata Section of Molecular Pharmacology Dexa Laboratories of Biomolecular Sciences Dexa MedicaIndustri Selatan VBlock PP No.7Jababeka Industrial Estate IICikarangWest Java 17550Indonesia

Objective:To study the regulation of trombinol on thrombopoietin,an essential regulator of thrombocyte ***:Effect of trombinol on thrombopoietin regulation was evaluated at the m RNA and protein levels in human hepatoma Hep G2 *** m RNA expressions were revealed by PCR and real-time PCR,while the protein expressions were analyzed using western blotting and human ELISA *** differences between the test were determined by student's t-test with P < 0.05 was considered statistically ***:Trombinol significantly increased the expression of thrombopoietin at the level of m RNA and protein secretion in Hep G2 cell *** with the concentration of15 mg/m L,positively induces 2.5-fold of thrombopoietin ***-regulation of GABP,a transcription factor of thrombopoietin,is suggested to be involved in cellular regulatory mechanisms of ***,our result shows convincing evidence that trombinol affects the thrombopoietin productions in *** molecular explanation of thrombopoietin's stimulating function is in line with the traditional use of Psidium guajava for treatment of diseases involving ***:Thrombopoietin stimulating function of trombinol could be potentially considered as one of alternative treatment for thrombocytopenia-related cases,including post chemotherapy shock,dengue fever and liver failure.

关键词： Trombinol Thrombopoietin Thrombocyte Anti-thrombocytopenia Thrombopoietin stimulating agent

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Standardized bioactive fraction of Phaleria macrocarpa(Proliverenol) prevents ethanol-induced hepatotoxicity via down-regulation of NF-kB-TNFα-caspase-8 pathway

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Asian Pacific Journal of Tropical Biomedicine 2016年第8期6卷 686-691页

作者： Guntur Berlian olivia mayasari tandrasasmita Raymond Rubianto Tjandrawinata Dexa Laboratories of Biomolecular Sciences PT Dexa Medica Industri Selatan V Block PP no.7 Kawasan Industri Jababeka Ⅱ

Objective: To verify that Proliverenol has a potential ability in protecting cells from ethanol-induced ***: Activity of Proliverenol against ethanol-induced apoptosis was evaluated at m RNA and protein levels in Hep G2 cell exposed to Proliverenol for 1 and 3 ***: Proliverenol conferred hepatoprotective activity through increasing cell survival up to 53%–69% via up-regulation of APEX1 DNA repair enzyme for 3.0–4.7 fold and down-regulating of nuclear factor-kB, tumor necrosis factora and caspase-8 expression,allowing them to prevent 4.5–6.9 fold of alanine aminotransferase(ALT) leakage in Hep G2 cells. Our finding revealed that Proliverenol repressed expression of ALT, which is significantly important as possible alternative mechanism for increased blood transaminase activities. In addition, the result also showed that caspase-8 pathway seemed to be involved in the molecular pathway rather than directly inducing mitochondrial ***: The data support our hypothesis that Proliverenol has a potential ability in protecting cells from ethanol-induced hepatotoxicity. We propose that Proliverenol provides hepatoprotective activity through up-regulating expression of APEX1 that repress DNA fragmentation, and down-regulating expression of nuclear factor-kB, tumor necrosis factora and caspase-8, which therefore repress ALT leakage and its expression.

关键词： Phaleria macrocarpa Hepatoprotector Liver injury Cirrhosis HepG2

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