检索结果-南通市图书馆

Structure-activity relationship of pyrazol-4-ylpyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor m4

引用

Acta Pharmaceutica Sinica B 2023年第1期13卷 213-226页

作者： Ahmed Haider Xiaoyun Deng olivia mastromihalis Stefanie K.Pfister Troels E.Jeppesen Zhiwei Xiao Vi Pham Shaofa Sun Jian Rong Chunyu Zhao Jiahui Chen Yinlong Li Theresa R.Connors April T.Davenport James B.Daunais Vahid Hosseini Wenqing Ran Arthur Christopoulos Lu Wang Celine Valant Steven H.Liang Department of Radiology Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital and Harvard Medical SchoolBostonMA 02114USA Department of Nuclear medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Drug Discovery Biology Monash Institute of Pharmaceutical SciencesMonash UniversityParkvilleVIC 3052Australia Neuromedicines Discovery Centre Monash Institute of Pharmaceutical SciencesMonash UniversityParkvilleVIC 3052Australia Hubei Collaborative Innovation Centre for Non-power Nuclear Technology College of Nuclear Technology&Chemistry and BiologyHubei University of Science and TechnologyXianning 437100China Department of Neurology Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Department of Physiology and Pharmacology Wake Forest School of MedicineWinston SalemNC 27157USA Terasaki Institute for Biomedical Innovation(TIBI) Los AngelesCA 90024USA Center of Cyclotron and PET Radiopharmaceuticals Department of Nuclear Medicine and PET/CT-MRI Centerthe First Affiliated Hospital of Jinan UniversityGuangzhou 510630China

There is an accumulating body of evidence implicating the muscarinic acetylcholine receptor4(m4)in schizophrenia and dementia with Lewy bodies,however,a clinically validated m4positron emission tomography(PET)radioligand is currently *** such,the aim of this study was to develop a suitable m4PET ligand that allows the non-invasive visualization of m4in the ***-activity relationship studies of pyrazol-4-yl-pyridine derivates led to the discovery of target compound 12—a subtype-selective positive allosteric modulator(PAm).The radiofluorinated analogue,[18F]12,was synthesized in 28±10%radiochemical yield,>37 GBq/μmol and an excellent radiochemical purity>99%.Initial in vitro autoradiograms on rodent brain sections were performed in the absence of carbachol and showed moderate specificity as well as a low selectivity of[18F]12 for the m4-rich ***,in the presence of carbachol,a significant increase in tracer binding was observed in the rat striatum,which was reduced by>60%under blocking conditions,thus indicating that orthosteric ligand interaction is required for efficient binding o f[18F]12 to the allosteric ***,however,the presence of carbachol was not required for high specific binding in the non-human primate(NHP)and human striatum,and did not further improve the specificity and selectivity of[18F]12 in higher *** results pointed towards significant species-differences and paved the way for a preliminary PET study in NHP,where peak brain uptake of[18F]12 was found in the putamen and temporal *** conclusion,we report on the identification and preclinical development of the first radiofluorinated m4PET radioligand with promising *** availability of a clinically validated m4PET radioligand harbors potential to facilitate drug development and provide a useful diagnostic tool for non-invasive imaging.

关键词： muscarinicacetylcholine receptor Positronemission tomography Neuroimaging Neuropharmacology Neurological disorders

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

海虾对大豆饼粕的利用

引用

粮食与饲料工业 1990年第4期 50-53页

作者： dean m. Akiyama 吴锦圃

鱼粉和其它水产品的粉一直是海虾饲料的传统组分。然而,植物蛋白粉比水产品粉便宜得多,用作海虾饲料组分在成本上是有利的。在这些植物蛋白粉中,大豆饼粕由于其营养价值和效价而具有最大的使用潜力。虾饲料中所用大豆饼柏的量大时,必须... 详细信息

鱼粉和其它水产品的粉一直是海虾饲料的传统组分。然而,植物蛋白粉比水产品粉便宜得多,用作海虾饲料组分在成本上是有利的。在这些植物蛋白粉中,大豆饼粕由于其营养价值和效价而具有最大的使用潜力。虾饲料中所用大豆饼柏的量大时,必须考虑到必需氨基酸、能量、脂肪酸、矿物质以及其它营养物。大豆饼粕在营养上并不优于水产品粉。而是在成本上有利得多。本文回顾了用大豆饼粕代替鱼粉所做的几项试验研究的情况。这些研究已成功地用大豆饼粕取代了大量的鱼粉而虾的生产性能未下降。海虾在利用大豆饼粕的营养上存在品种差异和大小差异。海虾饲料中可以使用大量的大豆饼粕,这是没有什么疑问的。

关键词：海虾饲料大豆饼粕利用

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A General Hermitian Nonnegative-Definite Solution to the matrix Equation <i>AXB</i>= <i>C</i>

引用

Advances in Linear Algebra & matrix Theory 2017年第1期7卷 7-17页

作者： Phil D. Young dean m. Young marsha m. Young Department of Information Systems Baylor University Waco TX USA Department of Statistical Science Baylor University Waco TX USA

We derive necessary and sufficient conditions for the existence of a Hermitian nonnegative-definite solution to the matrix equation AXB = C. moreover, we derive a representation of a general Hermitian nonnegative-definite solution. We then apply our solution to two examples, including a comparison of our solution to a proposed solution by Zhang in [1] using an example problem given from [1]. Our solution demonstrates that the proposed general solution from Zhang in [1] is incorrect. We also give a second example in which we derive the general covariance structure so that two matrix quadratic forms are independent.

关键词： matrix Equation AXB = C Generalized Inverse matrices Parallel Summable matrices Symmetrization Device

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

FOLFIRI regimen in metastatic pancreatic adenocarcinoma resistant to gemcitabine and platinum-salts

引用

World Journal of Gastroenterology 2012年第33期18卷 4533-4541页

作者： Cindy Neuzillet olivia Hentic Benot Rousseau Vinciane Rebours Léla Bengrine-Lefèvre Franck Bonnetain Philippe Lévy Eric Raymond Philippe Ruszniewski Christophe Louvet Pascal Hammel Service de Gastroentérologie-Pancréatologie Hpital Beaujon 100 Boul-evard du Général Leclerc 92110 Clichy La Garenne AP-HP France Service d'Oncologie médicale Hpital Saint Antoine 184 Rue du Faubourg Saint-Antoine 75012 Paris AP-HP France Unité de Biostatistique et d'Epidémiologie EA 4184 Centre Georges Franois Leclerc 1 Rue du Pr Marion 21079 Dijon France Service d'Oncologie médicale Hpital Beau-jon 100 Boulevard du Général Leclerc 92110 Clichy La Garenne AP-HP France Département d'Oncologie médicale Institut Mutualiste Montsouris 42 Boulevard Jourdan 75014 Paris France

AIm: To evaluate the efficacy and safety of the FOLFIRI regimen in patients with metastatic pancreatic adenocarcinoma (PAC) after the failure of gemcitabine and platinum salts. mETHODS: All consecutive patients with histologically confirmed, metastatic PAC and World Health Organiza-tion performance status (PS) ≤ 2 received FOLFIRI-1 [irinotecan 180 mg/m2 on day 1 and leucovorin 400 mg/m2 followed by 5-fluorouracil (5-FU) 400 mg/m2 bolus, then 5-FU 2400 mg/m2 as a 46-h infusion, biweekly] or FOLFIRI-3 (irinotecan 100 mg/m2 on day 1 and leucovorin 400 mg/m2, then 5-FU 2400 mg/m2 as a 46-h infusion and irinotecan 100 mg/m2 repeated on day 3, biweekly) after failure of gemcitabine and platinum-based chemotherapies as a systematic policy in two institutions between January 2005 and may 2010. Tumor response, time to progression (TTP), overall survival rate (OS) and grade 3-4 toxicities were retrospectively studied. Subgroup analyses were performed to search for prognostic factors. RESULTS: Sixty-three patients (52.4% male, median age 59 years) were analyzed. Among them, 42.9% were PS 0, 38.1% were PS 1 and 19.0% were PS 2. Fifty one patients (81.0%) had liver metastases. Before the FOLFIRI regimen, patients had received 1 line (n = 19), 2 lines (n = 39) or 3 lines (n = 5) of chemotherapy. median TTP obtained with the line before FOLFIRI was 3.9 mo (95% CI: 3.4-5.3 mo). A total of 480 cycles was completed (median: 6 cycles, range: 1-51 cycles). The main reason for discontinuing FOLFIRI was tumor progression (90.3%). Tumor control was achieved in 25 patients (39.7%) (partial response: n = 5, stable disease: n = 20) with FOLFIRI. median TTP was 3.0 mo (95% CI: 2.1-3.9 mo) and median OS was 6.6 mo (95% CI: 5.3-8.1 mo). Dose adaptation was required in 36 patients (57.1%). Fifteen patients (23.8%) had grade 3-4 toxicities, mainly hematological (n = 11) or digestive (n = 4). Febrile neutropenia occurred in 3 patients. There was no toxic death. PS 2 was significantly associated w

关键词：转移性胰腺癌铂盐治疗 5-FU 亚叶酸钙中性粒细胞 TTP

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tissue distribution of perfluoroalkyl acids and health status in wild mozambique tilapia(Oreochromis mossambicus) from Loskop Dam, mpumalanga, South Africa

引用

Journal of Environmental Sciences 2017年第11期29卷 59-67页

作者： Jacqueline T.Bangma Jessica L.Reiner Hannes Botha Theresa m.Cantu marco A.Gouws matthew P.Guillette Jeremy P.Koelmel Wilmien J.Luus-Powell Jan myburgh olivia Rynders Joseph R.Sara Willem J.Smit John A.Bowden medical University of South Carolina Department of Obstetrics and Gynecology Charleston SC 29412 United States National Institute of Standards and Technology Chemical Sciences Division Hollings Marine Laboratory Charleston SC 29412 United States Department of Biodiuersity University of Limpopo Souenga South Africa Scientific Services Mpumalanga Tourism and Parks Agency Nelspruit 1200 South Africa Department of Science School of Natural Resource Management Nelson Mandela Metropolitan University George 6529 South Africa Uniuersity of Florida Department of Chemistry Gainesville FL 32611 United States Department of ParaclinieaI Sciences Faculty of Veterinary Science University of Pretoria Onderstepoort South Africa

This study examined concentrations of 15 perfluoroalkyl acids（PFAAs） in tissues from male mozambique tilapia（Oreochromis mossambicus） collected at Loskop Dam, mpumalanga,South Africa in 2014 and 2016. Nine of the 15 PFAAs were detected frequently and were included in statistical analysis and included two of the most commonly known PFAAs,perfluorooctanesulfonic acid（PFOS）（median, 41.6 ng/g） and perfluorooctanoic acid（PFOA）（median, 0.0825 ng/g）. Of the tissues measured, plasma（2016 and 2014 median, 22.2 ng/g）contained the highest PFAA burden followed by（in descending order）： liver（median,11.6 ng/g）, kidney（median, 9.04 ng/g）, spleen（median, 5.92 ng/g）, adipose（median, 2.54 ng/g）, and muscle（median, 1.11 ng/g）. Loskop Dam tilapia have been affected by an inflammatory disease of the adipose tissue known as pansteatitis, so this study also aimed to investigate relationships between PFAA tissue concentrations and incidence of pansteatitis or fish health status. Results revealed that healthy tilapia exhibited an overall higher（p-value 〈 0.05） PFAA burden than pansteatitis-affected tilapia across all *** analysis showed that organs previously noted in the literature to contain the highest PFAA concentrations, such as kidney, liver, and plasma, were the organs driving the difference in PFAA burden between the two tilapia groups. Care must be taken in the interpretations we draw from not only the results of our study, but also other PFAA measurements made on populations（human and wildlife alike） under differing health status.

关键词： Perfluoroalkyl acids Liquid chromatography mass spectrometry Pansteatitis Perfluorooctanesulfonic acid Tissue distribution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

抛丸清理设备的选择

引用

国外机车车辆工艺 1996年第4期 21-24页

作者：于慧娟 dean m.Peters

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

multifocal structured illumination optoacoustic microscopy

引用

Light(Science & Applications) 2020年第1期9卷 568-576页

作者： Zhenyue Chen Ali Ozbek Johannes Rebling Quanyu Zhou Xose Luis dean-Ben Daniel Razansky Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology University of Zurich and ETH ZurichZurichSwitzerland

Optoacoustic(OA)imaging has the capacity to effectively bridge the gap between macroscopic and microscopic realms in biological ***-resolution OA microscopy has so far been performed via point-by-point scanning with a focused laser beam,thus greatly restricting the achievable imaging speed and/or field of *** we introduce multifocal structured illumination OA microscopy(mSIOAm)that attains real-time 3D imaging *** this purpose,the excitation laser beam is shaped to a grid of focused spots at the tissue surface by means of a beamsplitting diffraction grating and a condenser and is then scanned with an acousto-optic deflector operating at kHz *** both phantom and in vivo mouse experiments,a 10mm wide volumetric field of view was imaged with 15 Hz frame rate at 28μm spatial *** proposed method is expected to greatly aid in biological investigations of dynamic functional,kinetic,and metabolic processes across multiple scales.

关键词： illumination beam excitation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

molecular investigations on avian reoviruses from turkey and chicken

Molecular investigations on avian reoviruses from turkey and...

引用

The 15th World Veterinary Poultry Congress

作者： Drte Lüschow olivia Gooss Christine Prusas Hafez m.Hafez Institute of Poultry Diseases Free University BerlinBerlinGermany Institute of Poultry Diseases Free University BerlinBerlinGermany Institute of Poultry Diseases Free University BerlinBerlinGermany Institute of Poultry Diseases Free University BerlinBerlinGermany

＜正＞Introduction Avian reoviruses（ARVs）are a diverse group of pathogens,ubiquitous in *** exist as non-,moderate,or highly pathogenic strains and are involved in a wide variety of diseases in domestic poults. The most important disease caused by ARV is the viral arthritis/tenosynovitis,a predominantly disease of meat

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

A Comparison of Two Linear Discriminant Analysis methods That Use Block monotone missing Training Data

引用

Open Journal of Statistics 2016年第1期6卷 172-185页

作者： Phil D. Young dean m. Young Songthip T. Ounpraseuth Department of Information Systems Baylor University Waco TX USA Department of Statistical Science Baylor University Waco TX USA Department of Biostatistics University of Arkansas for Medical Sciences Little Rock AK USA

We revisit a comparison of two discriminant analysis procedures, namely the linear combination classifier of Chung and Han (2000) and the maximum likelihood estimation substitution classifier for the problem of classifying unlabeled multivariate normal observations with equal covariance matrices into one of two classes. Both classes have matching block monotone missing training data. Here, we demonstrate that for intra-class covariance structures with at least small correlation among the variables with missing data and the variables without block missing data, the maximum likelihood estimation substitution classifier outperforms the Chung and Han (2000) classifier regardless of the percent of missing observations. Specifically, we examine the differences in the estimated expected error rates for these classifiers using a monte Carlo simulation, and we compare the two classifiers using two real data sets with monotone missing data via parametric bootstrap simulations. Our results contradict the conclusions of Chung and Han (2000) that their linear combination classifier is superior to the mLE classifier for block monotone missing multivariate normal data.

关键词： Linear Discriminant Analysis monte Carlo Simulation maximum Likelihood Estimator Expected Error Rate Conditional Error Rate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dimension Reduction for Detecting a Difference in Two High-Dimensional mean Vectors

引用

Open Journal of Statistics 2021年第1期11卷 243-257页

作者： Whitney V. Worley dean m. Young Phil D. Young Department of mathematics University of Central Arkansas Conway AR USA Department of Statistical Science Baylor University Waco TX USA Department of Information Systems and Business Analytics Baylor University Waco TX USA

We consider the efficacy of a proposed linear-dimension-reduction method to potentially increase the powers of five hypothesis tests for the difference of two high-dimensional multivariate-normal population-mean vectors with the assumption of homoscedastic covariance matrices. We use monte Carlo simulations to contrast the empirical powers of the five high-dimensional tests by using both the original data and dimension-reduced data. From the monte Carlo simulations, we conclude that a test by Thulin [1], when performed with post-dimension-reduced data, yielded the best omnibus power for detecting a difference between two high-dimensional population-mean vectors. We also illustrate the utility of our dimension-reduction method real data consisting of genetic sequences of two groups of patients with Crohn’s disease and ulcerative colitis.

关键词： Homoscedastic Covariance matrices Test Power monte Carlo Simulation moore-Penrose Inverse Singular Value Decomposition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：