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Radium-223 in metastatic castration resistant prostate cancer

Asian Journal of Andrology 2014年第3期16卷 348-353页

作者： Winston Vuong oliver.sar.or.sumanta k pal Department of Medical Oncology and Experimental Therapeutics City of Hope Comprehensive Cancer Center Duarte CA Department of Medicine Tulane University School of Medicine New Orleans LA USA

In 2004, docetaxel was approved for the treatment of metastatic castration-resistant prostate cancer （mCRPC）. For the next several years, there was a lull in drug approvals. However, from 2010 onwards, 5 additional therapies have been approved on the basis of showing a survival benefit in phase III studies. These agents include sipuleuceI-T, cabazitaxel, abiraterone, enzalutamide and （most recently） radium-223. Amongst radiopharmaceuticals currently used for advanced prostate cancer （e.g. samarium-153 and strontium-89）, radium-223 possesses several unique properties. As an alpha-emitting compound, the agent produces a high-energy output over a short range, facilitating selective destruction of tissue within the bone in the region of osteoblastic lesions while sparing surrounding normal tissue. The current review will outline biological rationale for radium-223 and also provide an overview of preclinical and clinical development of the agent. Rational sequencing of radium-223 and combinations, in the increasingly complex landscape of mCRPC will be discussed, along with factors influencing clinical implementation.

关键词： alpharadin bone metastases metastatic castration-resistant prostate cancer radiopharmaceuticals radium-223 Xofigo

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Management of localized prostate cancer： the pendulum swings （back to the middle）

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Asian Journal of Andrology 2014年第4期16卷 570-571页

Herein, we discuss 18-year follow-up data from the Scandinavian ProstateCancer Group-4 （SPCG-4） trial, a randomized study comparing observation and radical prostatectomy （RP） in patients with localized prostate cancer. The results of this study are contrasted with another study employing a similar randomization, the Prostate Cancer Intervention Versus Observation Trial （PIVOT）. We highlight several key differences in study eligibility and enrollment that may account for distinct results, and describe how these datasets impact the complex landscape of therapy for localized prostate cancer.

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Metastasis in renal cell carcinoma:Biology and implications for therapy

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Asian Journal of Urology 2016年第4期3卷 286-292页

作者： Jun Gong Manuel Caitano Maia Nazli Dizman Ameish Govindarajan sumanta k.pal Department of Medical Oncology&Experimental Therapeutics City of Hope Comprehensive Cancer CenterDuarteCAUSA Division of Medical Oncology Instituto Hemomed de Oncologia e Hematologia.Av.Arnolfo de Azevedo121-Cerqueira Ce´sar-CEP 01248-040Sao PauloBrazil Department of Internal Medicine Istanbul Medeniyet University Goztepe Research and Training HospitalIstanbulTurkey

Although multiple advances have been made in systemic therapy for renal cell carcinoma(RCC),metastatic RCC remains *** the current review,we focus on the underlying biology of RCC and plausible mechanisms of *** further outline evolving strategies to combat metastasis through adjuvant ***,we discuss clinical patterns of metastasis in RCC and how distinct systemic therapy approaches may be considered based on the anatomic location of metastasis.

关键词： Renal cell carcinoma Metastasis Vascular endothelial growth factor Mammalian target of rapamycin Hypoxia inducible factor

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Investigation of Interaction of Some Chalcones and Cyclic Chalcone Analogues with Outer Mitochondrial Membrane by UV-VIS and Fluorescence Spectroscopy

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Spectral Analysis Review 2013年第1期1卷 1-9页

作者： Vladimíra Tomecková Miroslava Stefanisinová Beáta Veliká krisztina Fodor pal Perjési Marek Stupák Juraj Guzy Stefan Tóth Jr Tímea Pekárová Department of Medical Chemistry Biochemistry and Clinical BiochemistryFaculty of MedicinePavol Jozef Safárik University in KosiceKosiceSlovakia Institute of Pharmaceutical Chemistry Faculty of MedicineUniversity of PécsPécsHungary

Interaction of the synthetic chalcones (1b,1c) and their cyclic analogues (2b,2c) with bovine (BSA) and human serum albumin (HSA) as well as with rat liver mitochondria (RLM) was studied by fluorescence spectroscopy. The maxima of emission fluorescence spectra were changed only in the case of 2b and 2c during interaction with BSA, HSA as well as mitochondrial outer membrane showing a slight hypsochromic shift and decrease of fluorescence. Interaction of the methoxy-(1b,2b) and the dimethylamino-substituted (1c,2c) compounds with outer mitochondrial membrane were studied by fluorescence polarization. Fluorescence polarization of 1b in the presence of the two proteins and mitochondria was found to be unchanged. Under similar conditions (2b,1c,2c) showed continuously increasing fluorescence polarization signal during the 30 minute period of investigations. Since fluorescence polarization supposes that as a result of binding these substances to proteins and lipids. Compound 2c displayed a continuous increase of fluorescence polarization signal in the presence of proteins (BSA, HSA), yeast cytoplasm (YC) and mitochondria (YM and RLM). This compound displayed a significant cytotoxic effect. This pattern of interaction with proteins might be one of the contributing vectors of the observed cytotoxicity against several human carcinoma cell lines.

关键词： Chalcones Yeast Cytoplasm Yeast Mitochondria Rat Liver Mitochondria Fluorescence Polarization? Fluorescence Synchronous Fingerprint

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