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Signal Transduction and Targeted Therapy 2022年第8期7卷 2670-2672页

作者： Yahya Sohrabi Holger Reinecke oliver Soehnlein Department of Cardiology I—Coronary and Peripheral Vascular Disease Heart FailureUniversity Hospital MünsterWestfälische Wilhelms-UniversitätMünsterGermany Institutes of Molecular Genetics of the Czech Academy of Sciences PragueCzechia Institute of Experimental Pathology(ExPat) Center for Molecular Biology of Inflammation(ZMBE)University Hospital MünsterWestfälische Wilhelms-UniversitätMünsterGermany Department of Physiology and Pharmacology(FyFa) Karolinska InstitutetStockholmSweden

A recent study by Mohanta et *** a new understanding of neuroimmune interactions in *** atherosclerotic plaques are not innervated,ablating the sympathetic innervation to these regions attenuated atherosclerosis,suggesting a potential novel therapeutic *** continues to be the leading cause of death in industrialized countries due to its complications such as acute myocardial infarction or *** disease is the result of a complex process,consisting of sub-endothelial lipid retention,immune cell migration,proteolytic injury,altogether leading to a chronic inflammatory responses in the wall of large arteries and ultimately plaque development.2 The inner layer of the blood vessels is not innervated and hence the nervous system connects with the vessel through its most outer layer,the lamina adventitia,hereby controlling important functions including arterial blood *** such homeostatic control of vessel function,increasing evidence demonstrates that activation of the sympathetic nervous system can modulate the degree of arterial inflammation.

关键词： sympathetic acute hence

Early Cardiac Catheterizations within 30 Days Post Congenital Heart Surgery in Children

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Congenital Heart Disease 2023年第1期18卷 79-95页

作者： Daniel Quandt Alessia Callegari oliver Niesse Martin Christmann Anke Meinhold Hitendu Dave Walter Knirsch oliver Kretschmar Pediatric Heart Centre-Division of Pediatric Cardiology University Children’s Hospital ZurichZurichSwitzerland Department Neonatology and Pediatric Intensive Care University Children’s Hospital ZurichZurichSwitzerland Department of Congenital Cardiothoracic Surgery University Children’s Hospital ZurichZurichSwitzerland Children’s Research Centre ZurichSwitzerlandUniversity Children’s Hospital ZurichZurichSwitzerland University of Zurich ZurichSwitzerland

Background:This study set out to assess the indications,feasibility,safety,and outcome of early cardiac catheterizations(CC)within 30 days after congenital heart surgery(CHS)in *** and Results:This is a retrospective,single-center case review study of all CC within 30 days after CHS between 1/2010-12/2020.A total of 317(138 diagnostic,179 interventional)CC were performed in 245 patients at a median of 4 days(IQR 13)after *** median age was 3 months(IQR 6),and body weight was 5 kg(IQR 4).A total of 194(61.2%)CC were performed in patients with univentricular *** revealed significant pathologies leading to early redo-surgery in 37 patients(12%).The transcatheter interventions primarily were needed in patients after cavo-pulmonary connection(n=69%,21.8%),right ventricle to pulmonary artery conduit(n=39%,12.3%),and Norwood-I surgery(n=34%,10.7%)presenting with hypoxemia,prolonged postoperative course,and suspected arterial stenosis on *** clinical impact of an early postoperative transcatheter intervention for the following clinical course was high in most *** were nine(2.8%)major and 20(6.3%)minor intra-procedural *** factor analysis revealed no difference for the occurrence of complications for patients’age,weight,and time from initial CHS,underlying *** heart disease,or ***:Early CC within 30 days after CHS in children can be performed safely with a high diagnostic and therapeutic *** rate of complications is low,while the therapeutic consequence is relevant.

关键词： Early postoperative cardiac catheterization congenital heart surgery children

Strategies to increase tolerance and robustness of industrial microorganisms

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Synthetic and Systems Biotechnology 2022年第1期7卷 533-540页

作者： Marta Tous Mohedano oliver Konzock Yun Chen Division of Systems and Synthetic Biology Department of Biology and Biological EngineeringChalmers University of TechnologyGöteborgSweden

The development of a cost-competitive bioprocess requires that the cell factory converts the feedstock into the product of interest at high rates and ***,microbial cell factories are exposed to a variety of different stresses during the fermentation *** stresses can be derived from feedstocks,metabolism,or industrial production processes,limiting production capacity and diminishing *** stress tolerance and robustness allows for more efficient production and ultimately makes a process more economically *** review summarises general trends and updates the most recent developments in technologies to improve the stress tolerance of *** first look at evolutionary,systems biology and computational methods as examples of non-rational *** we review the(semi-)rational approaches of membrane and tran-scription factor engineering for improving tolerance *** further discuss challenges and perspectives associated with these different approaches.

关键词： Toxicity Novel synthetic biology tools Systems biology Genome-scale model Membrane engineering Transcription factor engineering

Parallel Factories for Smart Industrial Operations:From Big AI Models to Field Foundational Models and Scenarios Engineering

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IEEE/CAA Journal of Automatica Sinica 2022年第12期9卷 2079-2086页

作者： Jingwei Lu Xingxia Wang Xiang Cheng Jing Yang oliver Kwan Xiao Wang Qingdao Academy of Intelligent Industries Qingdao 266114 The State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100190 Motion G Inc.Singapore 068898Singapore IEEE School of Artificial Intelligence Anhui UniversityHefei 230031

The rapid advancement of fundamental theories and computing capacity has brought artificial intelligence,internet of things, extended reality, and many other new intelligent technologies into our daily lives. Due to the lack of interpretability and reliability guarantees, it is extremely challenging to apply these technologies directly to real-world industrial systems. Here we present a new paradigm for establishing parallel factories in metaverses to accelerate the deployment of intelligent technologies in real-world industrial systems: QAII-1.0. Based on cyber-physical-social systems,QAII-1.0 incorporates complex social and human factors into the design and analysis of industrial operations and is capable of handling industrial operations involving complex social and human behaviors. In QAII-1.0, a field foundational model called Eu Artisan combined with scenarios engineering is developed to improve the intelligence of industrial systems while ensuring industrial interpretability and reliability. Finally, parallel oil fields in metaverses are established to demonstrate the operating procedure of QAII-1.0.

关键词： Cyber-physical-social system(CPSS) Industry5.0 Metaverses Parallel factories Parallel intelligence

Immediate and Long-Term Results of Transcatheter Closure of Patent Ductus Arteriosus—Comparison of Two Decades before and after Change in Antibiotic Infective Endocarditis Prophylaxis Guidelines

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Congenital Heart Disease 2022年第2期17卷 215-230页

作者： Annina Dietrich Daniel Quandt oliver Kretschmar Walter Knirsch Pediatric Cardiology Pediatric Heart CenterDepartment of Surgery and Children’s Research CenterUniversity Children’s Hospital ZurichZurichSwitzerland University of Zurich ZurichSwitzerland

Objectives:To determine immediate and long-term follow-up of transcatheter closure of patent ductus arteriosus(PDA)in ***:National antibiotic prophylaxis(AP)guideline for infective endocarditis changed after 2009,the effect on practice of PDA closure is ***:Observational single center study analyzing follow-up of PDA closure comparing two time periods before(2002–2009)and after(2010–2019)changes in AP ***:332 patients(68.1%female),median(interquartile range)age 3.0 years(1.5–5.7)and body weight 14.0 kg(10.0–19.3),were *** morphology was conical type A(50.3%),window type B(1.2%),tubular type C(40.1%),complex type D(2.1%),elongated type E(0.9%)and other(5.4%).Minimal PDA diameter and length were 1.9 mm(1.3–2.5)and 8.0 mm(6.2–10.2).PDA was closed using coils(56.3%),Amplatzer Duct Occluders(41.9%)and others(1.8%).Complete closure rate was 61.1%at catheter intervention,72.3%on day 1,87.7%after 6 months and 98.4%at last follow-up on *** complication rate(severity level 3)was 4.2%and major complication rate(severity level 4)0.3%,with no catastrophic complications(severity level 5).Annual PDA closure rate declined in the second time period(22.6/year vs.15.5/year,p=0.018),PDA size increased(1.6 mm vs.2.0 mm,p=0.002)and proportion of coils decreased(72.4%vs.37.1%,p98%)and only a small number of complications leading to reintervention or *** in AP guidelines changed indication for and practice of PDA closure.

关键词： Patent arterial duct device closure congenital heart disease infective endocarditis

Medium-Term Results of Balloon Valvuloplasty of Native Pulmonary Valve Stenosis with and without Supravalvular Obstruction in Childhood

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Congenital Heart Disease 2022年第2期17卷 161-172页

作者： Olivia Lenoir Daniel Quandt oliver Kretschmar Walter Knirsch Pediatric Cardiology Pediatric Heart CenterChildren’s Research CenterUniversity Children’s Hospital ZurichZurichSwitzerland University of Zurich ZurichSwitzerland

Objectives:Factors influencing results of balloon valvuloplasty(BVP)of pulmonary valve stenosis(PS)in children are ***:BVP has become the standard of care for PS,medium-term results are not uniform and depend on various ***:We analysed the medium-term results of BVP of PS in children in an observational,single centre *** for additional procedure was defined as outcome after initial ***:We included 143 children(83 female)at a median(IQR)age of 2.6(0.26–9.24)months and body weight of 5(3.4–8)kg at BVP with a follow–up of 5.04(1.6–10.2)*** used balloon size of 10(9–14)mm and maximal balloon pressure of 4(3.5–10)atm,resulting in balloon–to–pulmonary annulus ratio of 1.28(1.2–1.4).Systolic pressure gradient of PS was reduced with BVP(43.5 mmHg vs.14.0 mmHg,p<0.001)and confirmed by echocardiography(68.0 mmHg vs.25.0 mmHg,p<0.001)day 1 post *** BVP with associated supravalvular PS resulted in a relevant reduction of systolic pressure gradient in 23 of 31 patients(74.2%).Early additional procedure was necessary in 14 patients(9.8%)after 0.2(0.1–0.7)years due to residual PS(n=13)and infective endocarditis(n=1).Factors for additional procedures were associated supravalvular PS with a higher residual pressure gradient,but not genetic *** further follow–up of 5.04(1.6–10.2)years no further additional procedures were ***:Pulmonary BVP of native pulmonary valve stenosis leads to excellent medium-term results,even in 3 of 4 infants with associated supravalvular obstruction sufficient pressure relief can be obtained.

关键词： Pediatric catheter congenital pulmonary balloon valvuloplasty

Detecting abrupt change in land cover in the eastern Hindu Kush region using Landsat time series(1988-2020)

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Journal of Mountain Science 2022年第6期19卷 1699-1716页

作者： Saeed A.KHAN Kim A.VANSELOW oliver SASS Cyrus SAMIMI Department of Earth Sciences University of Bayreuth95447 BayreuthGermany Institute of Geography Friedrich-Alexander-University of Erlangen-Nürnberg91058 ErlangenGermany Bayreuth Centre of Ecology and Environmental Research University of Bayreuth95448 BayreuthGermany

Land cover change in the semi-arid environment of the eastern Hindu Kush region is driven by anthropogenic activities and environmental change impacts. Natural hazards, such as floods presumably influenced by climatic change, cause abrupt change of land cover. So far, little research has been conducted to investigate the spatiotemporal aspects of this abrupt change in the valleys. In order to explore the abrupt change in land cover and floods as its possible drivers in the eastern Hindu Kush, a semi-arid mountain region characterized by complex terrain, vegetation variation, and precipitation seasonality, we analyzed long-term Landsat image time series from 1988 to 2020 using Breaks For Additive Seasonal and Trend(BFAST). Overall, BFAST effectively detected abrupt change by using Landsat-derived Modified Soil Adjusted Vegetation Index(MSAVI). The results of our study indicate that approximately 95% of the study area experienced at least one abrupt change during 1988-2020. The years 1991, 1995, 1998, 2007, and 2016 were detected as the peak years, with the peaks occurring in different seasons. The annual trend of abrupt change is decreasing for the study area. The seasonality of abrupt change at the catchment level shows an increasing trend in the spring season for the southern catchments of Panjkora and Swat. The spatial distribution patterns show that abrupt change is primarily concentrated in the floodplains indicating that flooding is the primary driver of the land cover change in the region. We also demonstrated the accurate detection of past flood events(2015) based on the two case examples of Ayun, Rumbur, and Kalash valleys. The detection of the flood events was verified by fieldwork and historical high-resolution Google Earth imagery. Finally, our study provides an example of applying Landsat time series in a dry mountain region to detect abrupt changes in land cover and analyze impact of natural hazards such as floods.

关键词： Land cover change Floods Natural hazards BFAST Chitral Pakistan

Environmentally Responsible Lightweight Passenger Vehicle Design and Manufacturing

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Automotive Innovation 2023年第3期6卷 300-310页

作者： Glenn S.Daehn Katrin E.Daehn oliver Kuttner Department of Materials Science and Engineering The Ohio State UniversityColumbusUSA Department of Materials Science and Engineering Massachusetts Institute of TechnologyCambridgeUSA Edision2 CharlottesvilleUSA

The mass reduction of passenger vehicles has been a great focus of academic research and federal policy initiatives of the United States with coordinated funding efforts and even a focus of a Manufacturing USA *** potential benefit of these programs can be described as modest from a societal point of view,for example reducing vehicle mass by up to 25%with modest cost implications(under$5 per pound saved)and the ability to implement with existing manufacturing *** more aggressive reductions in greenhouse gas production are necessary and possible,while delivering the same *** is demonstrated with a higher-level design thinking exercise on an environmentally responsible lightweight vehicle,leading to the following criteria:lightweight,low aerodynamic drag,long-lived(over 30 years and 2 million miles),adaptable,electric,and used in a shared manner on average over 8 h per *** these specifications,passenger-mile demand may be met with around 1/10 of the current *** vehicles would likely have significantly different designs and construction than incumbent *** is likely future automotive production will be more analogous to current aircraft produc-tion with higher costs per pound and lower volumes,but with dramatically reduced financial and environmental cost per passenger mile,with less material per vehicle,and far less material required in the national or worldwide *** benefits of this vision include far fewer parking lots,greater accessibility to personal transportation,and improved pedestrian safety,while maintaining a vibrant and engaging *** systemic changes to the business models and research and development directions(including lightweight design and manufacturing)are discussed,which could bring forth far more sustainable personal transportation.

关键词： Sustainability Personal transportation Lighgweighting Design

Is EAAT2 a potential therapeutic intervention target for Alzheimer's disease?

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Neural Regeneration Research 2023年第8期18卷 1721-1722页

作者： oliver WG Wood Jason HY Yeung Andrea Kwakowsky Centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreOllscoil na Gaillimhe-University of GalwayGalwayIreland

Alzheimer's disease(AD)is the most common form of dementia worldwide,impairing memory and cognitive functions due to widespread neuronal *** global incidence of this neurodegenerative disorder is predicted to increase... 详细信息

关键词： Alzheimer death EAAT2

Investigation of incipient faults in 66 kV oil-filled cable sealing ends

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High Voltage 2022年第4期7卷 666-675页

作者： Vidyadhar Peesapati Christos Zachariades George Callender Siyu Gao oliver Cwikowski Richard Gardner Department of Electrical and Electronics Engineering The University of ManchesterManchesterUK Department of Electrical Engineering and Electronics University of LiverpoolLiverpoolUK Tony Davies High Voltage Laboratory University of SouthamptonSouthamptonUK National Grid plc WarwickUK

This paper reports on the investigation of incipient fault mechanisms of a widely used family of Cable Sealing Ends(CSEs)which use an earthed metallic clip on top of the stress cone to fasten the cable termination stress *** element simulations indicate that the clip is causing localised electric field enhancement which could also cause impurities in the oil to move towards the clip under the influence of the dielectrophoretic *** ageing tests of stress cones in the laboratory have corroborated the simulation results,with the high electric field causing degradation of the semi-conducting tape underneath the clip as well as initiation of tracking on the surface of the stress cone originating from the edges of the *** discharge(PD)testing using a bespoke test rig in the high voltage laboratory has shown that incipient faults originating from the ageing of the solid CSE materials can only be detected after surface tracking has pro-gressed *** then,the intermittent nature of PD activity can pose a risk to the accurate condition assessment of CSEs if continuous monitoring is not employed and if the ultra-high frequency method is used on its own.

关键词： incipient sealing filled