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Interindividual Age-Independent Differences in Human CX43 Impact Ventricular Arrhythmic Risk

Research 2024年第3期6卷 417-432页

作者： Laura García-Mendívil María p.rez-Zabalza Antoni oliver-Gelabert JoséMaría Vallejo-Gil Javier Fañanás-Mastral Manuel Vázquez-Sancho Javier AndréBellido-Morales Alexánder Sebastián Vaca-Núñez Carlos Ballester-Cuenca Emiliano Diez Laura Ordovás Esther pueyo Biomedical Signal Interpretation and Computational Simulation group(BSICoS) Aragón Institute of Engineering ResearchUniversity of ZaragozaZaragoza 50018Spain BSICoS Instituto de Investigación Sanitaria Aragón(IISA)Zaragoza 50018Spain Centro Universitario de la Defensa(CUD) Zaragoza 50090Spain. Department of Cardiovascular Surgery University Hospital Miguel ServetZaragoza 50009Spain. Institute of Experimental Medicine and Biology of Cuyo(IMBECU) CONICETMendoza 5500Argentina. Fundación Agencia Aragonesa para la Investigación y el Desarrollo(ARAID) Zaragoza 50018Spain. Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)Zaragoza 50018Spain.

Connexin 43 (CX43) is one of the major components of gap junctions, the structures responsible for the intercellular communication and transmission of the electrical impulse in the left ventricle. There is limited information on the histological changes of CX43 with age and their effect on electrophysiology, especially in humans. Here, we analyzed left ventricular biopsies from living donors starting at midlife to characterize age-related CX43 remodeling. We assessed its quantity, degree of lateralization, and spatial heterogeneity together with fibrotic deposition. We observed no significant age-related remodeling of CX43. Only spatial heterogeneity increased slightly with age, and this increase was better explained by biological age than by chronological age. Importantly, we found that CX43 features varied considerably among individuals in our population with no relevant relationship to age or fibrosis content, in contrast to animal species. We used our experimental results to feed computational models of human ventricular electrophysiology and to assess the effects of interindividual differences in specific features of CX43 and fibrosis on conduction velocity, action potential duration, and arrhythmogenicity. We found that larger amounts of fibrosis were associated with the highest arrhythmic risk, with this risk being increased when fibrosis deposition was combined with a reduction in CX43 amount and/or with an increase in CX43 spatial heterogeneity. These mechanisms underlying high arrhythmic risk in some individuals were not associated with age in our study population. In conclusion, our data rule out CX43 remodeling as an age-related arrhythmic substrate in the population beyond midlife, but highlight its potential as a proarrhythmic factor at the individual level, especially when combined with increased fibrosis.

关键词： CX43 rhythm Independent

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poplar Extrafloral Nectar Is protected against plant and Human pathogenic Fungus

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Molecular plant 2012年第5期5卷 1157-1159页

作者： María Escalante-p.rez Mario Jaborsky Jorg Reinders oliver Kurzai Rainer Hedrich peter Ache University Würzburg BiozentrumJulius-von-Sachs-Institut für BiowissenschaftenJulius-von-Sachs-Platz 2D-97082 WürzburgGermany University Regensburg Institute of Functional GenomicsJosef-Engert-Strasse 9D-93053 RegensburgGermany Friedrich-Schiller-University Jena Septomics Research CentreBeutenbergstr.11aD-07745 JenaGermany

Dear Editor, plants secrete nectar to attract mutualistic animals, which predominantly function as pollinators, as in the case of flo- ral nectar, or defenders against herbivores, as in the case of extrafloral nectar （Nicolson et al., 2007）. Because nectars usu- ally represent aqueous solutions containing sugars and other nutrient metabolites （Baker and Baker, 1983）, they are sus- ceptible to infestation by microbial organisms, which can use the nectar-secreting tissues as entry sites to infect the plant. Nectar-secreting tissues thus require an efficient shield against pathogen infections. To date, our knowledge about the way that plants protect their nectar from microorganisms is rather limited. Several reports have focused on ＇defensive chemicals＇,

关键词： poplar plant Human pathogenic Fungus

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Mechanical thrombectomy in children and adolescents:report of five cases and literature review

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Stroke & Vascular Neurology 2018年第4期3卷 245-252页

作者： pervinder Bhogal Victoria Hellstern Muhammad AlMatter oliver Ganslandt Hansjörg Bäzner Marta Aguilar p.rez Department of Interventional Neuroradiology Royal London HospitalLondonUK Neuroradiological Clinic NeurocenterKlinikum StuttgartStuttgartGermany Neurosurgical Clinic NeurocenterKlinikum StuttgartStuttgartGermany Medical Faculty University Duisburg-EssenDuisburgGerman

Background paediatric arterial ischaemic stroke is an important cause of morbidity and mortality among ***,there are no recommendations regarding mechanical thrombectomy in children despite overwhelming evidence of improved outcomes in ***,the need for individual case reports and case series is important to highlight potential advantages and disadvantages in this *** descriptions We retrospectively searched our prospectively maintained database of patients undergoing mechanical thrombectomy for ischaemic *** describe five children,aged between 7 and 17,who underwent mechanical thrombectomy for acute ischaemic *** provide an account of their clinical presentations,operative treatment and postoperative *** Mechanical thrombectomy in children,especially older children,can be performed safely and with existing *** a randomised controlled trial would provide compelling evidence of the potential advantages to this technique,the lack of this should not prevent the use of this procedure by trained neurointerventionists.

关键词： maintained throm treatment

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proteoliposome and polysaccharide-Based Meningococcal Vaccine Are Immunogenic in Infants and Toddlers and primes for Memory against Serogroup C polysaccharide

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World Journal of Vaccines 2013年第2期3卷 77-87页

作者： oliver p.rez Belkis Romeu Judith del Campo Caridad Zayas Miriam Lastre Immunology Department Basic Research Vice Direction Finlay Institute Havana Cuba

Neisseria meningitidis capsular polysaccharides are the main target of the protective immune response against bacterial meningitis. They are thymus-independent type 2 (TI-2) antigens that are poorly immunogenic and not protective in young children, and their administration may impair subsequent challenge with the same polysaccharide. These problems have been addressed using three different vaccines consisting of 1) polysaccharide alone, 2) polysaccharide covalently conjugated to a carrier protein, and 3) polysaccharide with proteoliposome (pL) adsorbed onto Al(OH)3. VA-MENGOC-BC? is one of the third types of vaccine. It contains pL (detergent-extracted external membrane proteins forming vesicles) and polysaccharide (ps) from N. meningitidis serogroups B and C (psC), respectively. Nevertheless, there is a concern that to overcome the TI-2 nature of ps the covalently conjugation to a carrier is mandatory. Therefore, we evaluated the immune response induced by VA-MENGOC-BC? in infants and toddlers in order to determine whether it stimulates the response against the psC. High IgG anti psC and anti pL responses were seen following the administration of two doses in infants and toddlers, after a 3rd dose in pre-teenagers, and after confirmed carrier stages in young adults. The anti pL IgG response persisted longer than anti psC IgG response and IgM response against both antigens was maintained. An IgG1 anti pL response predominated, as well as IgG4 > IgG3 > IgG1 anti psC responses. These results suggest that non-covalent incorporation of psC onto Al(OH)3 containing?pL as adjuvant is immunogenic, primes for memory, and induces long-lasting specific antibody response. The improved psC immunogenicity of this vaccine may be due to the preferential and potent Th1 response induced in mice and human by the pL as adjuvant.

关键词： proteoliposome Meningococcal Vaccine Infants Memory Response polysaccharide

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Adjuvants Derived from <i>Neisseria meningitidis</i>Serogroup B Induce a Cross Reactive Response against <i>Neisseria gonorrhoeae</i>in Mice

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Open Journal of Immunology 2020年第3期10卷 47-58页

作者： Laura M. Reyes Miriam Lastre Maribel Cuello Osmir Cabrera Yusnaby Borrego Raúl Ramos pupo Steve Black oliver p.rez Department of Immunology Instituto de Ciencias Básicas y Preclínicas “Victoria de Girón” Universidad de Ciencias Médicas de la Habana Havana Cuba Facultad de Ingenierías Universidad Técnica “Luis Vargas Torres” de Esmeraldas Esmeralda Ecuador Biomedical Research Institute (BIOMED). Faculty of Medicine and Life Sciences Hasselt University Hasselt Belgium Cincinnati Children’s Hospital Cincinnati USA

Introduction: Neisseria is a large genus of bacteria that colonize mucosal surfaces. Of the 11 species that colonize humans, only two are pathogens, N. meningitidis and N. gonorrhoeae. Both are obligate human pathogens;the last is causal agent of gonorrhea disease. Although curable with timely antibiotic treatment, an annual incidence of more than 62 million cases is estimated by the World Health Organization and there are no successful vaccines available. In contrast, several prophylactic vaccine options for Neisseria meningitidis meningitis do exist. Of note, there is trace of cross parenteral response induced between N. meningitidis and N. gonorrhoeae, and proteoliposome (pL, also named outer membrane vesicles, OMV) vaccine has shown high impact on this response. Objective: To determine effect of VAMENGOC-BC? and its derivates (AFpL1 and AFCo1) at mucosal and systemic level and possible cross response against Neisseria gonhorroeae in Balb/c and C57Bl/6 mice. Methods: We evaluated cross response against N. gonorrhoeae in mouse serum IgG and saliva IgA after mucosal immunization with VA-MENGOC-BC or its derivatives (AF, Adjuvant Finlay pL1 or AFCo (cochleate) 1). Results: Immunizations with AFpL1 or AFCo1 induce anti N. gonorrhoeae at saliva IgA and serum IgG responses similar to VA-MENGOC-BC? vaccine. Conclusions: Such data confirms a new possible window of prime-boost vaccination strategy against gonorrhea and extends our knowledge regarding the effect of pL vaccines on cross responses.

关键词： N. meningitidis N. gonorrhoeae Vaccine Cross Reactivity

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Quality Characteristics of Dark Muscle from Yellowfin Tuna Thunnus albacares to Its potential Application in the Food Industry

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Food and Nutrition Sciences 2011年第1期2卷 22-30页

作者： Elena Sánchez-Zapata Mahassine Amensour Rosa oliver Evangélica Fuentes-Zaragoza Casilda Navarro Juana Fernández-López Esther Sendra Estrella Sayas José Angel p.rez-Alvarez 不详

Dark muscle from yellowfin tuna is an important edible fish by-product. However, it has a low commercial value, and it is underutilized. The present study was conducted to establish the characteristic of this by-product. Myoglobin concen- tration in tuna dark muscle is high (9650.12 mg/kg). Total iron in tuna muscle was 32.11 mg/kg, higher than other animal foods like veal or pork, and heme iron concentration was 23.56 mg/kg (73.38% of the total iron), indicating a high bioavailability of heme iron in dark muscle from yellowfin tuna, which is a nutritional advantage. As for the techno- logical properties, yellowfin tuna dark muscle had a water holding capacity of 8.37 g water/g and oil holding capacity of 8.11 g oil/g. This indicates that tuna dark muscle has possible applications to elaborate products, such as emulsion- ated foods or cooked products, so its industrialization is possible.

关键词： Dark Muscle Tuna Fish Haemopigments Myoglobin Heme Iron physicochemical properties

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饲喂全亚麻籽和瘤胃保护共轭亚油酸丰富的日粮对荷斯坦种公牛脂肪酸的组成

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饲料博览 2015年第10期25卷 43-43页

作者： Gómez I Mendizabal J A Sarriés M V Insausti K Albertí p Realini C p.rez-Juan M oliver M A purroy A Beriain M J

试验选取48头年轻荷斯坦公牛来评估日粮补充亚麻籽和共轭亚油酸(CLA)对肌内和皮下脂肪的脂肪酸组成的影响。试验分为4个处理,分别饲喂等能等蛋白日粮:对照组(亚麻籽0,CLA 0),亚麻籽组(亚麻籽10%,CLA 0),CLA组(亚麻籽0,CLA 2%),亚麻籽+C... 详细信息

试验选取48头年轻荷斯坦公牛来评估日粮补充亚麻籽和共轭亚油酸(CLA)对肌内和皮下脂肪的脂肪酸组成的影响。试验分为4个处理,分别饲喂等能等蛋白日粮:对照组(亚麻籽0,CLA 0),亚麻籽组(亚麻籽10%,CLA 0),CLA组(亚麻籽0,CLA 2%),亚麻籽+CLA(亚麻籽10%,CLA 2%)。日粮富含亚麻籽和CLA,增加CLAc-9,t-11,α亚麻酸(ALA)的水平,并减少在n-6/n-3脂肪酸比值。日粮富含亚麻籽和CLA时,肌内和皮下脂肪脂肪酸组成有相似的趋势,CLAc-9、t-11、α亚麻酸(ALA)水平均增加,n-6/n-3脂肪酸比值降低。与对照组相比,日粮补充亚麻籽通过增加n-3和共轭亚油酸的脂肪酸比率,降低n-6/n-3改善了脂肪酸组成。补充亚麻籽可以增加n-3和共轭亚油酸的脂肪酸的比例,降低n-6/n-3比率,与对照组相比改善了的脂肪酸组成。CLA水平的增加与补充亚麻籽取得了相似的组织CLA水平,但与对照组得到了相似的n-3比率。CLA能提高组织CLA水平,以亚麻籽补充的日粮,其含量受n-6/n-3的比例影响。亚麻籽与CLA的联合补充比单独添加能更有效地增加总多不饱和脂肪酸和共轭亚油酸含量。可以得出结论,补充亚麻籽和/或CLA能够增加对人类健康有益的一些脂肪酸的水平。

关键词： n-3 共轭亚油酸 α-亚麻酸牛肉肌内脂肪皮下脂肪

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