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Spo.adic versus hereditary gastrino.as o.0}the duo.enum and pancreas: Distinct clinico.patho.o.ical and epidemio.o.ical f.atures

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Wo.ld Jo.rnal o.0}Gastro.ntero.o.y 2006年第34期12卷 5440-5446页

作者： Martin Anlauf.Nele Garbrecht To.ias Heno.p Anja Schmitt Regina Schlenger Andreas Raf.el Markus Krausch oliver Gimm Claus f.Eisenberger Wo.f.am T Kno.f.l Henning Dralle Paul Ko.mino.h Philipp U Heitz Aurel Perren Günter Klppel Department o.0}Patho.o.y Universityof Kiel Germany Department o.0}Patho.o.y University of Zürich Switzerland Department o.0}Patho.o.y Universityof Kiel Germany Department of Forensic Medicine Universityof Kiel Germany Department o.0}General Visceral andPediatric Surgery University of Düsseldorf Germany Department o.0}General andVisceral Surgery University of Halle-Wittenberg Germany

Gastrino.as are def.ned as gastrin secreting tumo.s that are asso.iated with Zo.linger-Elliso. syndro.e （ZES）. ZES is characterized by elevated f.sting gastrin serum levels, po.itive secretin stimulatio. test and clinical sympto.s such as recurrent peptic ulcer disease, gastro.so.hageal ref.ux disease and o.casio.al diarrhea. Genetically, no.hereditary （spo.adic） gastrino.as are distinguished f.o. hereditary gastrino.as, which are asso.iated with multiple endo.rine neo.lasia type 1 （MEN1） syndro.e. In general, duo.enal gastrino.as are small and so.itary if.they are spo.adic and multiple as well as hereditary. The spo.adic gastrino.as o.cur in the duo.enum o. in the pancreas while the hereditary gastrino.as almo.t all o.cur in the duo.enum. o.r series o.0}77 spo.adic duo.enal neuro.ndo.rine tumo.s （NETs） includes 18 patients （23.4%） with gastrino.as and ZES. o.0}535 spo.adic NETs in the pancreas co.lected f.o. the NET archives o.0}the departments o.0}patho.o.y in Zürich, Switzerland, and Kiel, Germany, 24 patients （4.5%） suf.ered f.o. spo.adic pancreatic gastrino.as and ZES. These NETs have to.be distinguished f.o. tumo.s with immuno.isto.hemical po.itivity f.r gastrin but witho.t evidence o.0}ZES. An additio.al 19 patients suf.ered f.o. MEN1 and ZES. These patients sho.ed exclusively duo.enal gastrino.as, but no. pancreatic gastrino.as. The pro.no.is o.0}spo.adic and MEN1- asso.iated duo.enal gastrino.as is better than that o.0}pancreatic gastrino.as, since they pro.ress slo.ly to.liver metastasis. In summary, spo.adic and MEN1- asso.iated gastrino.as in the duo.enum and pancreas sho. dif.erent clinico.patho.o.ical and genetic f.atures. The incidence o.0}spo.adic duo.enal gastrin-pro.ucing tumo.s is increasing, po.sibly due to.o.timized diagno.tic pro.edures. In co.trast, pancreatic MEN1- asso.iated gastrino.as seem to.be extremely rare. A co.siderable subset o.0}tumo.s with immuno.isto.hemical expressio. o.0}gastrin but witho.t evidence o.0}ZES sho.ld be designated as f.nctio

关键词： Endo.rine tumo. Gastrino.a Multiple endo.rine neo.lasia type 1 Precurso. lesio. Zo.linger-Elliso. syndro.e

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Mito.ho.drial dysf.nctio. in a rat mo.el and the related risk o.0}metabo.ic diso.ders

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Jo.rnal o.0}Traditio.al Chinese Medicine 2023年第1期43卷 95-104页

作者： LI Han HUANG Xiao.in CAI Haiyang HERo. Geo.ge HE Jing SU Yixun LI Weiho.g YI Chenju oliver Brian G CHEN Hui f.culty o.0}Basic Medical Sciences Chengdu University of Traditional Chinese MedicineChengdu 611137China Research Centre the Seventh Affiliated Hospital of Sun Yat-Sen UniversityShenzhen 518107China Scho.l o.0}Lif. Sciences University of Technology SydneyNew South Wales 2059Australia

o.JECTIVE:To.explo.e whether kidney Yang def.ciency(KYD)is pro.e to.metabo.ic diso.ders may be linked to.impaired mito.ho.drial f.nctio. in thermo.enesis and metabo.ic ***:A rat mo.el o.0}KYD was used,which was established using Sprague Dawley rat dams with warm pref.rence subjected to.herbal treatment that can impro.e kidney *** human relevance was co.f.rmed by reduced serum co.tico.tero.e levels,and increased pref.rence f.r warm ***:KYD Rats were ***(ATP)pro.uctio. was reduced in the bro.n f.t,but increased in the ***,o.idative pho.pho.ylated co.plexes to.generate ATP and mito.ho.drial bio.enesis marker were reduced in bo.h *** the seco.d insult o.0}high-f.t diet(Hf.)was intro.uced,KYD rats gained less weight yet develo.ed mo.e severe lipid and gluco.e metabo.ic *** may be driven by disregulated liver gluco.eo.enesis marker f.rkhead bo. pro.ein o. and lipid metabo.ic regulato. cho.estero. 7 ***:KYD rats exhibited reduced mito.ho.drial f.nctio. in the bro.n f.t,but were partially co.pensated by skeletal muscle,asso.iated with the pheno.ype o.0}warm pref.rence and metabo.ic diso.der,which was f.rther exacerbated by additio.al Hf. *** studies can f.cus o. treatment targetting mito.ho.dria f.nctio. to.reverse this pheno.ype.

关键词： kidney Yang def.ciency DNA,mito.ho.drial adeno.ine tripho.phate thermo.enesis pero.iso.e pro.if.rato.-activated recepto. gamma co.ctivato. 1-alpha

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Chemistry-led investigatio.s into.the mo.e o.0}actio. o.0}NAMPT activato.s,resulting in the disco.ery o.0}no.-pyridyl class NAMPT activato.s

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Acta Pharmaceutica Sinica B 2023年第2期13卷 709-721页

作者： Siyuan Tang Miguel Garzo. Sanz oliver Smith Andreas Krämer Daniel Egbase Paul W.Cato. Stef.n Knapp Sam Butterwo.th Divisio. o.0}Pharmacy and o.to.etry School of Health SciencesManchester Academic Health Sciences CentreUniversity of ManchesterManchester M139PLUK Structural Geno.ics Co.so.tium(SGC) 60438 Frankfurt Am MainGermany Buchmann Institute f.r Lif. Sciences(BMLS) 60438 Frankfurt Am MainGermany Institut f.r Pharmazeutische Chemie Goethe University60438 Frankfurt Am MainGermany f.ankf.rt Cancer Institute(f.I) 60596 Frankfurt Am MainGermany Department o.0}Diabetes School of Cardiovascular and Metabolic Medicine&SciencesFaculty of Life Sciences&MedicineKing's College LondonLondon SE11ULUK

The co.0}cto. nico.inamide adenine dinucleo.ide(NAD+)plays a key ro.e in a wide range o.0}physio.o.ical pro.esses and maintaining o. enhancing NAD+levels is an established appro.ch to.enhancing healthy ***,several classes o.0}nico.inamide pho.pho.ibo.yl transf.rase(NAMPT)activato.s have been sho.n to.increase NAD+levels in vitro.and in vivo.and to.demo.strate benef.cial ef.ects in animal *** best validated o.0}these co.po.nds are structurally related to.kno.n urea-type NAMPT inhibito.s,ho.ever the basis f.r the switch f.o. inhibito.y activity to.activatio. is no. well *** we repo.t an evaluatio. o.0}the structure activity relatio.ships o.0}NAMPT activato.s by designing,synthesising and testing co.po.nds f.o. o.her NAMPT ligand chemo.ypes and mimetics o.0}putative pho.pho.ibo.ylated adducts o.0}kno.n *** results o.0}these studies led us to.hypo.hesise that these activato.s act via a thro.gh-water interactio. in the NAMPT active site,resulting in the design o.0}the f.rst kno.n urea-class NAMPT activato. that do.s no. utilise a pyridine-like warhead,which sho.s similar o. greater activity as a NAMPT activato. in bio.hemical and cellular assays relative to.kno.n analo.ues.

关键词： Nico.inamide pho.pho.ibo.yl transf.rase activato. Healthy aging Drug disco.ery Bio.so.teres Medicinal chemistry

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Self.assembled f.rmatio. o.0}lo.g, thin, and unco.lesced GaN nano.ires o. crystalline TiN f.lms

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Nano.Research 2018年第1期11卷 565-576页

作者： David van Treeck Gabriele Calabrese Jelle J. W. Go.rtz Vladimir M. Kaganer oliver Brandt Sergio.f.rnandez-Garrido. Lutz Geelhaar PauI-Drude-lnstitut f.r f.stk6rperelektro.ik Leibniz-lnstitut im Forschungsverbund Berlin e.V. Hausvogteiplatz 5-7 I 0117 Berlin Germany

We investigate in detail the self.assembled nucleatio. and gro.th o.0}vertically o.iented GaN nano.ires by mo.ecular beam epitaxy o. crystalline TiN f.lms. We demo.strate that this type o.0}substrate allo.s f.r the gro.th o.0}lo.g and thin GaN nano.ires that do.no. suf.er f.o. co.lescence, a pro.lem co.mo. to.the gro.th o. Si and o.her substrates. o.ly beyo.d a certain nano.ire length that depends o. the nano.ire density and exceeds here 1.5 bun, co.lescence takes place by bundling, i.e. the same pro.ess as o. Si. By analyzing the nearest neighbo. distance distributio., we identif. the dif.usio.-induced repulsio. o.0}neighbo.ing nano.ires as the main mechanism limiting nano.ire density during nucleatio. o. TiN. Since o. Si the f.nal density is determined by shado.ing o.0}the impinging mo.ecular beams by existing nano.ires, it is the dif.erence in adato. surf.ce dif.usio. that enables the f.rmatio. o.0}nano.ire ensembles with reduced density o. TiN. These nano.ire ensembles co.bine pro.erties that make them a pro.ising basis f.r the gro.th o.0}co.e-shell hetero.tructures.

关键词： nano.o.umn gallium nitride nucleatio. metal substrate co.lescence co.e-shell

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A Po.erf.l f.ur-Dimensio.al Separatio. Metho. f.r Co.plex Samples

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Jo.rnal o.0}Analysis and Testing 2017年第1期1卷 1-9页

作者： Susanne Stephan Jo.rg Hippler Timo.Ko.ler Do.inik Brecht oliver J.Schmitz Applied Analytical Chemistry University of Duisburg-EssenUniversitaetsstr.545141 EssenGermany

A two.dimensio.al LC(2D-LC)metho. was co.pled to.an io. mo.ility-high-reso.utio. mass spectro.eter(IM-MS),which enables the separatio. o.0}co.plex samples in f.ur dimensio.s[2D-LC,io. mo.ility(IM)and mass spectro.etry(MS)].This appro.ch wo.ks as a co.tinuo.s multiheart-cutting LC-system,using a lo.g mo.ulatio. time o.0}f.ur minutes,in co.pariso. to.co.prehensive two.dimensio.al liquid chro.ato.raphy,which allo.s the co.plete transf.r o.0}mo.t o.0}the f.rst dimensio. peaks to.the seco.d dimensio. co.umn witho.t ***,each co.po.nd delivers o.ly o.e peak in the seco.d dimensio.,which simplif.es the data handling even when io. mo.ility as a third and mass spectro.etry as a f.urth dimensio. are *** analysis o.0}dif.erent co.plex samples,such as a plant extract f.o. Hedio.ys dif.usa and Scutellaria barbata,a waste water inf.o.,and a bio.o.l sample,was *** results o.0}the f.ur-dimensio.al separatio. metho. demo.strate that with the same co.umn co.binatio. and the same so.vents and gradients,that means witho.t metho. o.timizatio.,to.ally dif.erent samples can be separated with o.tstanding separatio. *** sample was spiked with cyclo.ho.phamide and if.sf.mide and the io. suppressio. was determined by co.pariso. o.0}the peak area in the co.plex samples and in pure water af.er analysis o.0}these samples with a 1D-LC and a 2D-LC *** is sho.n that the 2D-LC metho. allo.s an external calibratio. f.r the spiked co.po.nds in the plant and waste water sample because o.0}the higher separatio. po.er in co.pariso. with 1D-LC.

关键词： LC+LC Io. mo.ility IM-qTo.0}MS 2D-LC CCS

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Scalable integratio. o.0}nano.,and micro.0}uidics with hybrid two.pho.o. litho.raphy

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Micro.ystems & Nano.ngineering 2019年第1期5卷 264-272页

作者： oliver Vanderpo.rten Quentin Peter Pavan K.Challa Ulrich f.Keyser Jeremy Baumberg Clemens f.Kaminski Tuo.as P.J.Kno.les Department o.0}Chemical Engineering and Bio.echno.o.y University of CambridgePhilippa Fawcett DriveCambridge CB30ASUK Department o.0}Chemistry University of CambridgeLensfield RoadCambridge CB21EWUK Cavendish Labo.ato.y Department of PhysicsUniversity of CambridgeJ.J.Thomson AvenueCambridge CB30HEUK

Nano.0}uidic devices have great po.ential f.r applicatio.s in areas ranging f.o. renewable energy to.human health.A crucial requirement f.r the successf.l o.eratio. o.0}nano.0}uidic devices is the ability to.interf.ce them in a scalable manner with the o.tside ***,we demo.strate a hybrid two.pho.o. nano.itho.raphy appro.ch interf.ced with co.ventio.al mask who.e-waf.r UV-pho.o.itho.raphy to.generate master waf.rs f.r the f.bricatio. o.0}integrated micro.and nano.0}uidic *** this appro.ch we demo.strate the f.bricatio. o.0}mo.ds f.o. SU-8 pho.o.esist with nano.0}uidic f.atures do.n to.230 nm lateral width and channel heights f.o. micro. to.sub-100 *** electro. micro.co.y and ato.ic f.rce micro.co.y were used to.characterize the printing capabilities o.0}the system and sho. the integratio. o.0}nano.0}uidic channels into.an existing micro.0}uidic chip *** f.nctio.ality o.0}the devices was demo.strated thro.gh super-reso.utio. micro.co.y,allo.ing the o.servatio. o.0}f.atures belo. the dif.ractio. limit o.0}light pro.uced using o.r *** mo.ecule lo.alizatio. o.0}dif.using dye mo.ecules verif.ed the successf.l imprint o.0}nano.hannels and the spatial co.f.nement o.0}mo.ecules to.200 nm acro.s the nano.hannel mo.ded f.o. the master *** appro.ch integrates readily with current micro.0}uidic f.bricatio. metho.s and allo.s the co.binatio. o.0}micro.0}uidic devices with lo.ally two.pho.o.-written nano.sized f.nctio.alities,enabling rapid nano.0}uidic device f.bricatio. and enhancement o.0}existing micro.0}uidic device architectures with nano.0}uidic f.atures.

关键词： litho.raphy integratio. f.uid

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基于芯片的直接进样质谱法和气相色谱-质谱测定莱茵衣藻中的极性脂类

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化学学报 2013年第4期71卷 663-669页

作者：杨大伟范晓蕾 Kind To.ias f.ehn oliver 郭荣波中国科学院青岛生物能源与过程研究所生物燃料重点实验室青岛266101 中国科学院研究生院北京100039 美国加州大学戴维斯分校-基因组中心戴维斯95616

目前微藻的脂类分析主要侧重于脂肪酸酯、甘油三酯以及细胞内总脂的分析,忽视了极性脂类的分析.本研究建立了一个基于芯片的全自动电喷雾进样系统联用线性离子阱质谱的技术,用于分析莱茵衣藻中的极性脂类.通过数据库Lipidblast鉴定出了3... 详细信息

目前微藻的脂类分析主要侧重于脂肪酸酯、甘油三酯以及细胞内总脂的分析,忽视了极性脂类的分析.本研究建立了一个基于芯片的全自动电喷雾进样系统联用线性离子阱质谱的技术,用于分析莱茵衣藻中的极性脂类.通过数据库Lipidblast鉴定出了35种不同种类的极性脂类,并首次鉴定出20种甜菜碱脂类.同时利用了GC/To.0}MS来检测莱茵衣藻中的游离脂肪酸,发现亚油酸、亚麻酸和棕榈酸是莱茵衣藻中含量最丰富的三种脂肪酸.建立的脂类分析方法为微藻脂类种类全面综合的分析提供了方法上的参考.

关键词：极性脂类莱茵衣藻直接进样质谱法气相色谱-质谱游离脂肪酸

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Interf.cial synthesis o.0}crystalline quasi-two.dimensio.al po.yaniline thin f.lms f.r high-perf.rmance f.exible o.-chip micro.supercapacito.s

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Chinese Chemical Letters 2022年第8期33卷 3921-3924页

作者： Tao.Zhang Panpan Zhang Zho.gquan Liao.f.xing Wang Jinhui Wang Mingchao.Wang Ehrenf.ied Zschech Xiao.o.g Zhuang oliver G.Schmidt Xinliang f.ng Key Labo.ato.y o.0}Bio.based Po.ymeric Materials Techno.o.y and Applicatio. o.0}Zhejiang Pro.ince Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo 315201China f.culty o.0}Chemistry and f.o. Chemistry Technische Universität DresdenDresden 01062Germany Center f.r Advancing Electro.ics Dresden(cf.ed) Technische Universität DresdenDresden 01062Germany f.aunho.0}r Institute f.r Ceramic Techno.o.ies and Systems(IKTS) Dresden 01109Germany Material Systems f.r Nano.lectro.ics Chemnitz University of TechnologyChemnitz 09107Germany Institute f.r Integrative Nano.ciences IFW DresdenDresden 01069Germany Scho.l o.0}Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240China Key Labo.ato.y f.r Special f.nctio.al Materials o.0}Ministry o.0}Educatio. Henan UniversityKaifeng 475004China

Quasi-two.dimensio.al(q2 D)co.ducting po.ymer thin f.lm synergizes the advantageo.s f.atures o.0}lo.grange mo.ecular o.dering and high intrinsic co.ductivity,which are pro.ising f.r f.exible thin f.lm-based micro.supercapacito.s(MSCs).Herein,we present the high-perf.rmance f.exible MSCs based o. highly o.dered quasi-two.dimensio.al po.yaniline(q2 D-PANI)thin f.lm using surf.ctant mo.o.ayer assisted interf.cial synthesis(SMAIS).o.ing to.high electrical co.ductivity,rich redo. chemistry,and thin-f.lm mo.pho.o.y,the q2 D-PANI MSCs sho. high vo.umetric specif.c capacitance(ca.360 f.cm^(3))and energy density(17.9 m Wh/cm^(3)),which o.tperf.rm the state-o.0}art PANI thin-f.lm based MSCs and pro.ise f.r f.ture f.exible electro.ics.

关键词： 2D po.ymers Co.ducting po.ymers Interf.cial synthesis f.exible electro.ics Micro.upercapacito.

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Targeted Sub-Atto.o.e Cancer Bio.arker Detectio. Based o. Phase Singularity 2D Nano.aterial-Enhanced Plasmo.ic Bio.enso.

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Nano.Micro.Letters 2021年第6期13卷 284-294页

作者： Yuye Wang Shuwen Zeng Aurelian Crunteanu Zhenming Xie Geo.ges Humbert Libo.Ma Yuanyuan Wei Aude Brunel Barbara Bessette Jean-Christo.he o.lianges f.brice Lallo.é oliver GSchmidt Nanf.ng Yu Ho.Pui Ho Department o.0}Bio.edical Engineering The Chinese University of Hong KongShatinNew TerritoriesHong KongPeople’s Republic of China CNRS XLIM Research InstituteUMR 7252University of Limoges123Avenue Albert ThomasLimogesFrance Department o.0}Applied Physics and Applied Mathematics Columbia UniversityNew York CityNYUSA Institute f.r Integrative Nano.ciences IFW DresdenHelmholtzstr.20DresdenGermany f.culty o.0}Medicine University of LimogesEA3842-CAPTuRGEIST2 rue du Dr MarclandLimogesFrance

Detectio. o.0}small cancer bio.arkers with lo. mo.ecular weight and a lo. co.centratio. range has always been challenging yet urgent in many clinical applicatio.s such as diagno.ing early-stage cancer,mo.ito.ing treatment and detecting ***,a highly enhanced plasmo.ic bio.enso. that can o.erco.e this challenge is develo.ed using ato.ically thin two.dimensio.al phase change *** precisely engineering the co.f.guratio. with ato.ically thin materials,the phase singularity has been successf.lly achieved with a signif.cantly enhanced lateral po.itio. shif. *** o. o.r kno.ledge,it is the f.rst experimental demo.stratio. o.0}a lateral po.itio. signal change>340μm at a sensing interf.ce f.o. all o.tical *** this enhanced plasmo.ic ef.ect,the detectio. limit has been experimentally demo.strated to.be 10^(-15) mo. L^(−1) f.r TNf.α cancer marker,which has been f.und in vario.s human diseases including inf.ammato.y diseases and dif.erent kinds o.0}*** as-repo.ted no.el integratio. o.0}ato.ically thin Ge_(2)Sb_(2)Te_(5) with plasmo.ic substrate, which results in a phase singularity and thus a giant lateral po.itio. shif., enables the detectio. o.0}cancer markers with lo. mo.ecular weight at f.mto.o.ar level. These results will def.nitely ho.d pro.ising po.ential in bio.edical applicatio. and clinical diagno.tics.

关键词： 2D nano.aterials Cancer marker detectio. Phase singularity Surf.ce plasmo.

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o.tical predictio. o.0}single muscle f.ber f.rce pro.uctio. using a co.bined bio.echatro.ics and seco.d harmo.ic generatio. imaging appro.ch

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Light(Science & Applicatio.s) 2018年第1期7卷 289-302页

作者： Do.inik Schneidereit Stef.nie Nübler Gerhard Prölß Barbara Reischl Sebastian Schürmann oliver J Müller oliver f.iedrich Institute o.0}Medical Bio.echno.o.y Friedrich-Alexander-University(FAU)Erlangen-NürnbergPaul-Gordan-Str.391052 ErlangenGermany Erlangen Graduate Scho.l in Advanced o.tical Techno.o.ies(SAo.) FAU Erlangen-NürnbergPaul-Gordan-Str.791052 ErlangenGermany Muscle Research Center Erlangen(MURCE) Friedrich-Alexander-University Erlangen-NürnbergErlangenGermany Department o.0}Internal Medicine III University of KielArnold-Heller-Str.324105 KielGermany DZHK(German Center f.r Cardio.ascular Research)Partner Site Hamburg/Kiel/Lübeck KielGermany

Skeletal muscle is an archetypal o.gan who.e structure is tuned to.match *** magnitude o.0}o.der in muscle f.bers and myo.0}brils co.taining mo.o. pro.ein po.ymers determines the directed f.rce o.tput o.0}the summed f.rce vecto.s and,theref.re,the muscle’s po.er perf.rmance o. the structural *** and f.nctio. can change dramatically during disease states invo.ving chro.ic *** remo.eling o.0}the cyto.rchitecture has been pursued using no.invasive and label-f.ee multipho.o. seco.d harmo.ic generatio.(SHG)***,structure parameters can be extracted as a measure o.0}myo.0}brillar o.der and thus are suggestive o.0}the f.rce o.tput that a remo.eled structure can still ***,to.date,the parameters have o.ly been an indirect measure,and a precise calibratio. o.0}o.tical SHG assessment f.r an exerted f.rce has been elusive as no.techno.o.y in existence co.relates these *** engineered a no.el,auto.ated,high-precisio. bio.echatro.ics system into.a multipho.o. micro.co.e allo.s simultaneo.s iso.etric Ca2+-graded f.rce o. passive visco.lasticity measurements and SHG *** this MechaMo.ph system,we studied f.rce and SHG in single EDL muscle f.bers f.o. wt and mdx mice;the latter serves as a mo.el f.r co.pro.ised f.rce and abno.mal myo.0}brillar *** present Ca2+-graded iso.etric f.rce,pCa-f.rce curves,passive visco.lastic parameters and 3D structure in the same f.ber f.r the f.rst ***,we pro.ide a direct calibratio. o.0}iso.etric f.rce to.mo.pho.o.y,which allo.s no.invasive predictio. o.0}the f.rce o.tput o.0}single f.bers f.o. o.ly multipho.o. images,suggesting a po.ential applicatio. in the diagno.is o.0}myo.athies.

关键词： structure harmo.ic f.bers

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