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Potential synergistic implications for stromal-targeted radiopharmaceuticals in bone-metastatic prostate cancer

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Asian Journal of Andrology 2011年第3期13卷 366-368,510页

作者： oliver Sartor Departments of Medicine and Urology Tulane Medical School New Orleans LA 70115 USA

Genetic heterogeneity and chemotherapy-resistant ＇stem cells＇ represent two of the most pressing issues in devising new strategies for the treatment of advanced prostate cancer. Though curative strategies have long been present for men with localized disease, metastatic prostate cancer is currently incurable. Though substantial improvements in outcomes are now possible through the utilization of newly approved therapies, novel combinations are clearly needed. Herein we describe potentially synergistic interactions between bone stromal-targeted radiopharmaceuticals and other therapies for treatment of bone-metastatic prostate cancer. Radiation has long been known to synergize with cytotoxic chemotherapies and recent data also suggest the possibility of synergy when combining radiation and immune-based strategies. Combination therapies will be required to substantially improve survival for men with castrate-resistant metastatic prostate cancer and we hypothesize that bone-targeted radiopharmaceuticals will play an important role in this Drocess.

关键词： bone immunotherapy metastasis prostate cancer radiopharmaceuticals radium samarium stroma strontium XL-184

Denosumab in bone-metastatic prostate cancer： known effects on skeletal＇related events but unknown effects on quality of life

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Asian Journal of Andrology 2011年第4期13卷 612-613页

作者： oliver Sartor Departments of Medicine and Urology Tulane University School of Medicine New Orleans LA USA

The purpose of new pharmaceuticals is to improve how patients feel, function or survive. Exceptions exist when surrogates are developed and we know that those surrogates correlate well with one of the above. Hypercholesterolemia is a well-accepted example. We know that high cholesterol is a reasonable indicator that results in increased risk of strokes and heart attacks. Thus, we treat hypercholesterolemia in hopes that our patients＇ health will improve.

关键词： new pharmaceuticals skeletal-related

Exercise training improves long-term memory in obese mice

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Life Metabolism 2024年第1期3卷 37-50页

作者： oliver K.Fuller Casey L.Egan Tina L.Robinson Nimna Perera Heidy K.Latchman Lauren V.Terry Emma D.McLennan Carolina Chavez Emma L.Burrows John W.Scott Robyn M.Murphy Henriette van Praag Martin Whitham Mark A.Febbraio Monash Institute of Pharmaceutical Sciences Monash UniversityMelbourneVictoria3052Australia La Trobe Institute for Molecular Science La Trobe UniversityMelbourneVictoria3086Australia Florey Institute of Neuroscience and Mental Health University of MelbourneMelbourneVictoria3052Australia Department of Biomedical Sciences Charles E.Schmidt College of Medicineand Stiles-Nicholson Brain InstituteFlorida Atlantic UniversityJupiterFL 33458United States College of Life and Environmental Sciences University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom

Obesity has been linked to a range of pathologies,including *** contrast,regular physical activity is associated with the prevention or reduced progression of ***,physical activity can improve memory and spatial cognition,reduce age-related cognitive decline,and preserve brain volume,but the mechanisms are not fully ***,we investigated whether any detrimental effects of high-fat diet(HFD)-induced obesity on cognition,motor behavior,adult hippocampal neurogenesis,and brain-derived neurotrophic factor(BDNF)could be mitigated by voluntary exercise training in male C57Bl/6 ***-induced impairment of motor function was not reversed by ***,voluntary wheel running improved long-term memory and increased hippocampal neurogenesis,suggesting that regular physical activity may prevent cognitive decline in obesity.

关键词： obesity exercise cognition

Interfacial synthesis of crystalline quasi-two-dimensional polyaniline thin films for high-performance flexible on-chip micro-supercapacitors

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Chinese Chemical Letters 2022年第8期33卷 3921-3924页

作者： Tao Zhang Panpan Zhang Zhongquan Liao Faxing wang Jinhui wang Mingchao wang Ehrenfried Zschech Xiaodong Zhuang oliver G.Schmidt Xinliang Feng Key Laboratory of Bio-based Polymeric Materials Technology and Application of Zhejiang Province Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo 315201China Faculty of Chemistry and Food Chemistry Technische Universität DresdenDresden 01062Germany Center for Advancing Electronics Dresden(cfaed) Technische Universität DresdenDresden 01062Germany Fraunhofer Institute for Ceramic Technologies and Systems(IKTS) Dresden 01109Germany Material Systems for Nanoelectronics Chemnitz University of TechnologyChemnitz 09107Germany Institute for Integrative Nanosciences IFW DresdenDresden 01069Germany School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Special Functional Materials of Ministry of Education Henan UniversityKaifeng 475004China

Quasi-two-dimensional(q2 D)conducting polymer thin film synergizes the advantageous features of longrange molecular ordering and high intrinsic conductivity,which are promising for flexible thin film-based micro-supercapacitors(MSCs).Herein,we present the high-performance flexible MSCs based on highly ordered quasi-two-dimensional polyaniline(q2 D-PANI)thin film using surfactant monolayer assisted interfacial synthesis(SMAIS).Owing to high electrical conductivity,rich redox chemistry,and thin-film morphology,the q2 D-PANI MSCs show high volumetric specific capacitance(ca.360 F/cm^(3))and energy density(17.9 m Wh/cm^(3)),which outperform the state-of-art PANI thin-film based MSCs and promise for future flexible electronics.

关键词： 2D polymers Conducting polymers Interfacial synthesis Flexible electronics Microsupercapacitor

ON THE EXISTENCE OF SOLUTIONS TO A BI-PLANAR MONGE-AMPèRE EQUATION

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Acta Mathematica Scientia 2020年第2期40卷 379-388页

作者： Ibrokhimbek AKRAMOV Marcel oliver Institut für Angewandte Analysis Universitat Ulm89069 UlmGermany School of Engineering and Science Jacobs University28759 BremenGermany

In this article,we consider a fully nonlinear partial differential equation which can be expressed as a sum of two Monge-Ampere operators acting in different two-dimensional coordinate *** equation is elliptic,for example,in the class of convex *** show that the notion of Monge-Ampere measures and Aleksandrov generalized solutions extends to this equation,subject to a weaker notion of convexity which we call bi-planar *** the equation is also elliptic in the class of bi-planar convex functions,the contrary is not necessarily *** is a substantial difference compared to the classical Monge-Ampere equation where ellipticity and convexity *** provide explicit counter-examples:classical solutions to the bi-planar equation that satisfy the ellipticity condition but are not generalized solutions in the sense *** conclude that the concept of generalized solutions based on convexity arguments is not a natural setting for the bi-planar equation.

关键词： Fully nonlinear elliptic equations generalized solution bi-planar convexity

Entangled-photons generation with quantum dots

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Chinese Physics B 2018年第2期27卷 140-153页

作者：李远丁飞 oliver G Schmidt Institute for Integrative Nanosciences IFW Dresden HelmholtzstraBe 20. 01069 Dresden. Germany Integrative for Solid State Physics. Leibniz University of Hunnover. AppelstBe 2.30 167 Hannovel Germany

Entanglement between particles is a crucial resource in quantum information processing, an important example of which is the exploitation of entangled photons in quantum communication protocols. Among the different available sources of entangled photons, semiconductor quantum dots （QDs） excel owing to their deterministic emission properties, potential for electrical injections, and direct compatibility with semiconductor manufacturing techniques. Despite the great promises, QD-based sources at＇e far from being ideal. In particular, such sources present several critical issues, which require the overcoming of challenges pertaining to spectral tunability, entanglement fidelity, photon indistinguishability and brightness. In this article, we will discuss the potential solutions to these problems and review the recent progress in the field.

关键词： quantum information entangled-photon source quantum dots

Stem cell injection for complex anal fistula in Crohn’s disease: A single-center experience

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World Journal of Gastroenterology 2021年第24期27卷 3643-3653页

作者： oliver Schwandner Department of Proctology Krankenhaus Barmherzige BruederRegensburg 93049Germany

BACKGROUND Despite tremendous progress in medical therapy and optimization of surgical strategies,considerable failure rates after surgery for complex anal fistula in Crohn’s disease have been ***,stem cell therapy for the treatment of complex perianal fistula can be an innovative option with potential long-term *** To evaluate the results of local administration of allogenic,adipose-derived mesenchymal stem cells(darvadstrocel)for complex anal Crohn’s *** All patients with complex anal fistulas associated with Crohn’s disease who were amenable for definite fistula closure within a defined observation period were potential candidates for stem cell injection(darvadstrocel)if at least one conventional or surgical attempt to close the fistula had *** was only indicated in patients without active Crohn’s disease and without presence of anorectal *** injection of darvadstrocel was performed as a standardized procedure under general anesthesia including single-shot antibiotic prophylaxis,removal of seton drainage,fistula curettage,closure of the internal openings and local stem cell *** collection focusing on healing rates,occurrence of abscess and follow-up was performed on a regular basis of quality control and patient *** were retrospectively *** Between July 2018 and January 2021,12 patients(6 females,6 males)with a mean age of 42.5(range:26-61)years underwent stem cell *** patients had a minimum of one complex fistula,including patients with two complex fistulas in 58.3%(7/12).Two of the 12 patients had horse-shoe fistula and 3 had one complex *** to Parks classification,the majority of fistulas were transsphincteric(76%)or suprasphincteric(14%).All patients underwent removal of seton,fistula curettage,transanal closure of internal opening by suture(11/12)or mucosal flap(1/12)and stem cell *** a mean follow-up of 14.3(range:3-30)mo,a healing rate

关键词： Complex anal fistula Crohn’s disease Stem cell therapy Mesenchymal stem cells Darvadstrocel Treatment Surgery Outcomes

Detection and Localization of Load Redistribution Attacks on Large-scale Systems

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Journal of Modern Power Systems and Clean Energy 2022年第2期10卷 361-370页

作者： Andrea Pinceti Lalitha Sankar oliver Kosut the School of Electrical Computer and Energy EngineeringArizona State UniversityTempeUSA

A nearest-neighbor-based detector against load redistribution attacks is *** detector is designed to scale from small-scale to very large-scale systems while guaranteeing consistent detection *** testing is performed on a realistic large-scale system to evaluate the perfor-mance of the proposed detector against a wide range of attacks,from simple random noise attacks to sophisticated load redistribution *** detection capability is analyzed against different attack parameters to evaluate its sensitivity.A statistical test that leverages the proposed detector is introduced to identify which loads are likely to have been maliciously modified,thus,localizing the attack *** test is based on ascribing to each load a risk measure(probability of being attacked)and then computing the best posterior likelihood that minimizes log-loss.

关键词： Attack detection cyber-security false data injection(FDI)attack load redistribution attack machine learning nearest neighbor

Treatment sequencing in metastatic castrate-resistant prostate cancer

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Asian Journal of Andrology 2014年第3期16卷 426-431页

作者： oliver Sartor Silke Gillessen Department of Medicine and Urology Tulane University School of Medicine New Orleans Louisiana USA Department of Medical Oncology Kantonsspital St. Gallen St. Gallen Switzerland.

Six different treatments have demonstrated improved survival in phase III trials targeted to patients with metastatic castration-resistant prostate cancer （mCRPC）. Front-line therapeutic options for mCRPC include docetaxel, sipuleuceI-T, abiraterone and radium-223. Post-docetaxel options include cabazitaxel, abiraterone, enzalutamide and radium-223. Despite much progress in recent years, much is yet unknown and debates occur over optimal treatment choices and sequences. None of the new agents have been compared to one another, thus physicians in practice today must make choices based on non-randomized comparisons, toxicity considerations and various assumptions. Abiraterone is now moving into the front line mCRPC space given recent regulatory approvals and enzalutamide will follow soon. Both of the hormonal agents have less toxicity when compared to chemotherapeutic options and both of these hormonal agents are expected to be used in a considerable number of mCRPC patients in the years ahead. Little data are available for the post-abiraterone or post-enzalutamide setting. In this review the currently available sequencing data are summarized and interpreted. It is now clear that cross resistance is a potential issue between various treatments, especially those agents that target the androgen axis. This review highlights the need for additional studies to optimize the current treatments for these patients.

关键词： abiraterone cabazitaxel castrate-resistant docetaxel enzalutamide~ radium-223 sipuleuceI-T