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Lactate is a potentially har.ful substitute for.br.in glucose fuel:consequences for.metabolic r.stor.tion of neur.tr.nsmission

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Neur.l r.gener.tion r.sear.h 2025年第5期20卷 1403-1404页

作者： oliver Kann Lennar. Soder.Babak Khodaie Institute of Physiology and Pathophysiology Heidelberg UniversityHeidelbergGermany Inter.isciplinar. Center.for.Neur.sciences(IZN) Heidelberg UniversityHeidelbergGermany

The metabolite lactate (L-lactate) can be gener.ted and r.leased by diver.e br.in cells,including neur.ns,astr.cytes,and oligodendr.cytes (Kann,2023;r.e et al.,2024).Lactate pr.duction usually r.quir.s the degr.dation of glucose (D-glucose)-and glycogen in astr.cytes-to pyr.vate by glycolysis and subsequent conver.ion of pyr.vate to lactate by the enzyme lactate dehydr.genase(Figur. 1A;Dienel,2019;r.e et al.,2024).

关键词： consequences Figur. r.stor.tion

Macr.economic impacts of oil pr.ce volatility： mitigation and r.silience

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Fr.ntier. in Ener.y 2014年第1期8卷 9-24页

作者： Zoheir.EBr.HIM oliver r. inderwildi David A. KING Smith School of Enter.r.se and the Envir.nment University of OxfordOxford OX1 3QY United Kingdom

Dependency sector., most notably on oil-der.ved fuels in var.ous in mobility, has left the global economy vulner.ble to sever.l macr.economic economic side effects. Numer.us studies have addr.ssed the effect of pr.ce volatility on specific economic par.meter.. However. the cur.ent liter.tur. lacks a compr.hensive r.view of the inter.ctions between global macr.economic per.or.ance and oil pr.ce volatility （OPV）. Pr.ce volatility is intr.nsic in commodity mar.ets, but has been advancing at a faster.r.te in the cr.de oil mar.et in compar.son to other.commodities over.the past decade, r.flecting the status ofoil as the most globalised commodity. In this paper. the analytical liter.tur. r.view and analysis of the behavior.l r.sponses of macr.economic agents to OPV shows that such volatility has sever.l damaging and destabilizing macr.- economic impacts that will pr.sent a fundamental bar.ier.to futur. sustainable economic gr.wth if left unchecked. To ensur. macr.economic isolation fr.m OPV, a combination of supply and demand-side policies have been r.com- mended that can help to mitigate and build r.silience to the economic uncer.ainty advanced by OPV.

关键词： conventional oil pr.ce volatility macr.econ-omy economic stability ener.y secur.ty

A Novel Two Domain-Fusion Pr.tein in Cyanobacter.a with Similar.ty to the CAB/ELIP/HLIP Super.amily： Evolutionar. Implications and r.gulation

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Molecular.Plant 2008年第1期1卷 155-166页

作者： oliver Kilian Anne Soisig Steunou Ar.hur.r. Gr.ssman Devaki Bhaya Depar.ment of Plant Biology The Carnegie Institution Stanford CA 94305 USA

Vascular.plants contain abundant, light-har.esting complexes in the thylakoid membr.ne that ar. non-covalently associated with chlor.phylls and car.tenoids. These light-har.esting chlor.phyll a/b binding （LHC） pr.teins ar. member. of an extended CAB/ELIP/HLIP super.amily of distantly r.lated polypeptides, which have between one and four.tr.nsmembr.ne helices （TMH）. This super.amUy includes the single TMH, high-light-inducible pr.teins （Hlips）, found in cyanobacter.a that ar. induced by var.ous str.ss conditions, including high light, and ar. consider.d ancestr.l to the LHC pr.teins. The r.les of, and evolutionar. r.lationships between, these super.amily member. ar. of par.icular.inter.st, since they function in both light har.esting and photopr.tection and may have evolved thr.ugh tandem gene duplication and fusion events. We have investigated the Hlips （hli gene family） in the ther.ophilic unicellular.cyanobacter.um Synechococcus OS-B＇. The five hli genes pr.sent on the genome of Synechococcus OS-B＂ ar. r.latively similar. but tr.nscr.pt analyses indicate that ther. ar. differ.nt patter.s of tr.nscr.pt accumulation when the cells ar. exposed to var.ous gr.wth conditions, suggesting that differ.nt Hlips may have specific functions. Hlip5 has an additional TMH at the N-ter.inus as a r.sult of a novel fusion event. This additional TMH is ver. similar.to a conser.ed hypothetical, single membr.ne-spanning polypeptide pr.sent in most cyanobacter.a. The evolutionar. significance of these r.sults is discussed.

关键词： fusion pr.teins Cyanobacter.a N-Ter.inus str.ss conditions Lar.e Hadr.n Collider Gr.wth conditions photostability r.gulation (biology) Thylakoid Membr.ne Tr.cheobionta gene duplication Analogy super.amily Chlor.phyll Evolutionar.

Technical Per.pective:r.sear.h on Gener.l-Pur.ose Br.in-Inspir.d Computing Systems

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Jour.al of Computer.Science & Technology 2024年第1期39卷 1-3页

作者： oliver r.odes Depar.ment of Computer.Science University of ManchesterManchester M139PLU.K

Br.in-inspir.d computing is a popular.r.sear.h ar.a with the potential to advance our.under.tanding of br.in function,ar.ificial intelligence,and next-gener.tion computing *** r.fer.ed to as"neur.mor.hic",these systems and algor.thms hope to har.ess mechanisms pr.sent in br.ins to make step changes in per.or.mance over.r.gular.von Neumann based appr.aches[1].

关键词： ar.ificial computing Br.in

ON KAr.SH-KUHN-TUCKEr.POINTS FOr.A SMOOTHING METHOD IN SEMI-INFINITE OPTIMIZATION

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Jour.al of Computational Mathematics 2006年第6期24卷 719-732页

作者： oliver Stein Depar.ment o.f Mathematics-C RWTH Aachen University Germany

We study the smoothing method for.the solution of gener.lized semi-infinite optimization pr.blems fr.m （O. Stein, G. Still： Solving semi-infinite optimization pr.blems with inter.or.point techniques, SIAM J. Contr.l Optim., 42（2003）, pp. 769-788）. It is shown that Kar.sh-Kuhn-Tucker.points of the smoothed pr.blems do not necessar.ly conver.e to a Kar.sh-Kuhn-Tucker.point of the or.ginal pr.blem, as could be expected fr.m r.sults in （F. Facchinei, H. Jiang, L. Qi： A smoothing method for.mathematical pr.gr.ms with equilibr.um constr.ints, Math. Pr.gr.m., 85（1999）, pp. 107-134）. Instead, they might mer.ly conver.e to a Fr.tz John point. We give, however. differ.nt additional assumptions which guar.ntee conver.ence to Kar.sh-Kuhn：Tucker.points.

关键词： Gener.lized semi-infinite optimization Stackelber. game Constr.int qualifi-cation Smoothing NCP function.

Social media as passive geo-par.icipation in tr.nspor.ation planning-how effective ar. topic modeling&sentiment analysis in compar.son with citizen sur.eys?

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Geo-Spatial Infor.ation Science 2020年第4期23卷 275-292页

作者： oliver Lock Chr.stopher.Pettit City Futur.s r.sear.h Centr. Faculty of Built EnvironmentUniversity of New South Wales(UNSW)SydneyAustralia Expanded Per.eption and Inter.ction Centr.(Epicentr.) Faculty of Art&DesignUniversity of New South Wales(UNSW)SydneyAustralia

We live in an er. of r.pid ur.anization as many cities ar. exper.encing an unpr.cedented r.te of population gr.wth and *** tr.nspor. is playing an incr.asingly impor.ant r.le in ur.an mobility with a need to move people and goods efficiently ar.und the *** such pr.ssur.s on existing public tr.nspor.ation systems,this paper.investigates the oppor.unities to use social media to mor. effectively engage with citizens and customer. using such *** r.sear.h for.s a case study of the use of passively collected for.s of big data in cities-focusing on Sydney,***,it examines social media data(Tweets)r.lated to public tr.nspor. ***,it joins this to longitudinal big data-delay infor.ation continuously br.adcast by the networ. over.a year.thus for.ing hundr.ds of millions of data ***,tones,and sentiment ar. modeled using machine lear.ing and Natur.l Language Pr.cessing(NLP)*** r.sulting data,and models,ar. compar.d to opinions der.ved fr.m a citizen sur.ey among *** validity of such data and models ver.us the intentions of user.,in the context of systems that monitor.and impr.ve tr.nspor. per.or.ance,ar. *** such,key r.commendations for.developing Smar. Cities wer. for.ed in an applied r.sear.h context based on these data and techniques.

关键词： Social media smar. cities public par.icipation ur.an sensing tr.nspor. planning natur.l language pr.cessing machine lear.ing big data

Genitalia-associated micr.bes in insects

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Insect Science 2015年第3期22卷 325-339页

作者： oliver Otti Animal Population Ecology Animal Ecology I Bayreuth Center of Ecology and Environmental Research (BayCEER) University of Bayreuth Universitatsstrasse 30 95440 Bayreuth Germany

In sexual r.pr.duction differ.nt types of symbiotic r.lationships between insects and micr.bes have become established. For.example, some bacter.a have evolved almost exclusive ver.ical tr.nsmission and even define the compatibility of insect mating par.ner.. Many str.ctly sexually tr.nsmitted diseases have also been descr.bed in insects. Apar. fr.m such r.ther.specific r.lationships the r.le of oppor.unistic infections in the r.pr.ductive pr.cess has been widely neglected. Oppor.unistic micr.bes tr.nsmitted passively dur.ng mating might impose an ener.etic cost, as the immune system will need to be aler. and will use r.sour.es to fight potential intr.der.. Thr.ugh mating wounds and contaminated r.pr.ductive or.ans oppor.unistic micr.bes might be tr.nsfer.ed to mating par.ner. and even enter.the body cavity. Females as the ＂r.ceiving＂ sex ar. par.icular.y likely to have evolved adaptations to avoid or.r.duce oppor.unistic infections. Males of sever.l species show highly complex seminal fluids, which as well as containing components that influence a males＇ fer.ilization success, also possess antimicr.bial substances. The r.le of antimicr.bials in the r.pr.ductive pr.cess is not well under.tood. Some evidence hints at the pr.tection of sper. against micr.bes, indicating a r.le for.natur.l selection in shaping the evolution of r.pr.ductive tr.its. By highlighting the potential impor.ance of micr.bes in sexual selection and their.r.le in r.pr.duction in gener.l I will make a case for.studies in sexual selection, especially the ones investigating postcopulator. pr.cesses, that should incor.or.te envir.nmental, as well as genotypic var.ation, in r.pr.ductive tr.its.

关键词： genital micr.biome inter.ctions sexually tr.nsmitted micr.bes sper.micr.be

Sensitivity analysis of a par.llel-plate method for.measur.ng the dielectr.c per.ittivity of high-voltage insulating mater.als

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High Voltage 2017年第3期2卷 200-204页

作者： Anton V.Vykhodtsev Behzad Kor.i Der.k r.oliver Depar.ment of Electr.cal and Computer.Engineer.ng University of Manitoba75a Chancellor's CircleWinnipegManitobaCanada R3T 5V62 Manitoba Institute for.Mater.als University of Manitoba25 Sifton RoadWinnipegManitobaCanada R3T 2N2

Ascer.aining the dielectr.c char.cter.of polymer.c insulation mater.als is of par.icular.inter.st for.compar.tive studies that use acceler.ted ageing and samples fr.m decommissioned *** the case of polymer.c samples,the possibility of physical defor.ation within the sample holder.adds additional var.ability to compar.tive *** r.adily obtainable instr.mentation,this study under.akes a systematic sensitivity analysis of a par.llel-plate capacitance measur.ment appr.ach for.polymer.c mater.als that only has one capacitance plate in contact with the sample,avoiding issues of sample *** analysis demonstr.tes that the biggest contr.butor.of uncer.ainty in the measur.ment of the r.lative per.ittivity and loss tangent is the pr.cision with which the plate–plate and plate–sample separ.tion is *** measur.ments show that the deter.ination of loss tangent can be susceptible to uncer.ainties ar.sing fr.m electr.cal noise,but that these can be contr.lled fur.her.by utilising mor. r.fined instr.mentation.

关键词： defor.ation plate analysis

Twists and tur.s on the way to pr.gr.ss in metastatic castr.te-r.sistant pr.state cancer

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Asian Jour.al of Andr.logy 2010年第6期12卷 790-792页

作者： oliver Sar.or Depar.ment of Medicine and Ur.logy Tulane University New Orleans Louisiana 70115 USA

Har.essing the body＇s immune system for.the tr.atment of metastatic cancer.has been a dr.am since the late 19th centur. [1]. Since that time pr.gr.ss has been inter.ittent and mostly disappointing. Inter.er.n and Inter.eukin-2 r.pr.sented steps for.ar. but in r.tr.spect the steps wer. not lar.e and r.r.ly ar. these agents used in the clinic today except as the contr.l ar. of r.ndomized studies designed to demonstr.te that a new dr.g is better.

关键词： Twists tur.s to pr.gr.ss metastatic castr.te-r.sistant