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Gallbladder carcinoma: prognostic factors and therapeutic options

World Journal of Gastroenterology 2015年第43期21卷 12211-12217页

作者： Thorsten oliver goetze Institut of Clinical Cancer Research UCT-University Cancer Center Frankfurt

The outcome of gallbladder carcinoma is poor,and the overall 5-year survival rate is less than 5%. In early-stage disease,a 5-year survival rate up to 75% can be achieved if stage-adjusted therapy is performed. There is wide geographic variability in the frequency of gallbladder carcinoma,which can only be explained by an interaction between genetic factors and their alteration. Gallstones and chronic cholecystitis are important risk factors in the formation of gallbladder malignancies. Factors such as chronic bacterial infection,primary sclerosing cholangitis,an anomalous junction of the pancreaticobiliary duct,and several types of gallbladder polyps are associated with a higher risk of gallbladder cancer. There is also an interesting correlation between risk factors and the histological type of cancer. However,despite theoretical risk factors,only a third of gallbladder carcinomas are recognized preoperatively. In most patients,the tumor is diagnosed by the pathologist after a routine cholecystectomy for a benign disease and is termed ‘‘incidental or occult gallbladder carcinoma''(IGBC). A cholecystectomy is performed frequently due to the minimal invasiveness of the laparoscopic technique. Therefore,the postoperative diagnosis of potentially curable early-stage disease is more frequent. A second radical re-resection to complete a radical cholecystectomy is required for several IGBCs. However,the literature and guidelines used in different countries differ regarding the radicality or T-stage criteria for performing a radical cholecystectomy. The NCCN guidelines and data from the German registry(GR),which records the largest number of incidental gallbladder carcinomas in Europe,indicate that carcinomas infiltrating the muscularis propria or beyond require radical surgery. According to GR data and current literature,a wedge resection with a combined dissection of the lymph nodes of the hepatoduodenal ligament is adequate for T1 b and T2 carcinomas. The reason for a

关键词： Gallbladder carcinoma Stage-adjusted therapy Radic

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Influence of high- and low-volume liver surgery in gallbladder carcinoma

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World Journal of Gastroenterology 2014年第48期20卷 18445-18451页

作者： Thorsten oliver goetze Vittorio Paolucci Department of Surgery Ketteler-Krankenhaus 63071 Offenbach Germany

AIM: To clarify whether the performance of liver resections (LR) for incidental gallbladder carcinoma (IGBC)’s depends more on the experience of the hospitals in liver surgery than on complying with the guidelines in... 详细信息

关键词： Gallbladder carcinoma Radical cholecystectomy High-volume center German-registry Volume cut-off Hepatobiliary surgery

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Unicentric Castleman's disease of the pancreas with massive central calcification

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World Journal of Gastroenterology 2005年第42期11卷 6725-6727页

作者： oliver goetze Matthias Banasch Klaus Junker Wolfgang E.Schmidt Christian Szymanski Department of Medicine St. Josef-Hospital Ruhr-University Bochum Germany Institute of Pathology Bergmannsheil University Hospital Ruhr-University Bochum Germany Christian Szymanski Department of Medicine St. Josef-Hospital Ruhr-University Bochum Germany

Unicentric Castleman＇s disease of the pancreas is extremely rare, with only six cases described in the worldwide literature. An asymptomatic case of unicentric, hyaline, vascular-type Castleman＇s disease （UCD） localized to the tail of bhe pancreas with central calcification imitating a primary neoplasm of the pancreas is presented. This is the first description of endosonographic and endoscopic retrograde pancreatographic findings of pancreatic UCD. Additionally, computed tomography, histological and serologic findings are reported.

关键词： Unicentric Castleman's disease Calcification Pancreas Endoscopic ultrasound

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