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Blood coagulation factors and platelet response to drug-induced hepatitis and hepatosis in rats

Animal Models and Experimental Medicine 2023年第1期6卷 66-73页

作者： Daria Korolova Viktoriya Gryshchenko Tamara Chernyshenko Oleh Platonov olha hornytska Volodymyr Chernyshenko Pavlo Klymenko Yevdokiia Reshetnik Tetyana Platonova Department of Structure and function of proteins Palladin Institute of Biochemistry of NAS of UkraineKyivUkraine National University of Life and Environmental Sciences of Ukraine KyivUkraine SI“D.F.Chebotarev Institute of Gerontology of the National Academy of Medical Sciences of Ukraine ”KyivUkraine Taras Shevchenko National University of Kyiv KyivUkraine

Background:Knowing the variability of blood coagulation responses to liver damage of different origins can provide a key to curing liver tissues or to mitigating treatment side *** aim of the present work was to compare the changes in the main components of hemostasis under experimental drug-induced hepatosis and hepatitis in ***:We modeled diclofenac-induced hepatitis and tetracycline-induced *** response was gauged by measuring fibrinogen,factor X,protein C(PC),and prothrombin in *** decarboxylated form of prothrombin was de-tected by measuring prothrombin index and ecamulin *** reactivity was studied using ***:Both hepatitis and hepatosis decreased the synthesis of fibrinogen,factor X,and ***,protein carboxylation was not disrupted in hepatosis but was much impaired in *** decreased in both models as a consequence of its consumption possibly during inflammatory *** aggregation rate was lower in hepatosis but higher in ***:Our findings imply the need for a thorough monitoring of the hemostasis system in liver diseases to avoid possible thrombotic *** state indicates the disorder's rate and character.

关键词： hemostasis hepatitis hepatosis platelets prothrombin

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