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Factors associated with trabecular bone score in postmenopausal women with type 2 diabetes and normal bone mineral density

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World Journal of Diabetes 2022年第7期13卷 553-565页

作者： olga N Fazullina Anton I Korbut vadim v Klimontov Laboratory of Endocrinology Research Institute of Clinical and Experimental Lymphology-Branch of the Institute of Cytology and GeneticsSiberian Branch of Russian Academy of SciencesNovosibirsk 630060Russia

BACKGROUND Osteoporosis and type 2 diabetes(T2D)have been recognized as a widespread comorbidity leading to excess mortality and an enormous healthcare *** T2D,bone mineral density(BMD)may underestimate the risk of low-energy fractures as bone quality is *** was hypothesized that a decrease in the trabecular bone score(TBS),a parameter assessing bone microarchitecture,may be an early marker of impaired bone health in women with *** To identify clinical and body composition parameters that affect TBS in postmenopausal women with T2D and normal *** A non-interventional cross-sectional comparative study was *** eligible subjects were screened at tertiary referral *** women with T2D,aged 50-75 years,with no established risk factors for secondary osteoporosis,were ***,TBS and body composition parameters were assessed by dual-energy X-ray *** women with normal BMD,a wide range of anthropometric,general and diabetes-related clinical and laboratory parameters were evaluated as risk factors for TBS decrease using univariate and multivariate regression analysis and analysis of receiver operating characteristic(ROC)*** Three hundred twelve women were initially screened,176 of them met the inclusion criteria and underwent dual X-ray *** with reduced BMD were subsequently excluded;96 women with normal BMD were included in final *** them,43 women(44.8%)showed decreased TBS values(≤1.31).Women with TBS≤1.31 were taller and had a lower body mass index(BMI)when compared to those with normal TBS(Р=0.008 and P=0.007 respectively).No significant differences in HbA1c,renal function,calcium,phosphorus,alkaline phosphatase,PTH and 25(ОН)D levels were *** a model of multivariate linear regression analysis,TBS was positively associated with gynoid fat mass,whereas the height and androgen fat mass were associated negatively(all P<0.001).In a multiple logistic regres

关键词： Diabetes Osteoporosis Bone mineral density Trabecular bone score Obesity Body composition

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Trapped on the Roof of the World:taxonomic diversity and evolutionary patterns of Tibetan Plateau endemic freshwater snails(Gastropoda:Lymnaeidae:Tibetoradix)

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Integrative Zoology 2022年第5期17卷 825-848页

作者： Maxim v.vINARSKI Parm viktor vON OHEIMB olga v.AKSENOvA Mikhail Yu.GOFAROv Alexander v.KONDAKOv Ivan O.NEKHAEv Ivan N.BOLOTOv Laboratory of Macroecology and Biogeography Saint-Petersburg State UniversitySaint-PetersburgRussia Museum für Naturkunde-Leibniz Institute for Evolution and Biodiversity Science BerlinGermany N.Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences ArkhangelskRussia Department of Applied Ecology Saint-Petersburg State UniversitySaint-PetersburgRussia Northern(Arctic)Federal University ArkhangelskRussia

The high-elevation Tibetan Plateau(western China)is inhabited by a unique,though not particularly species-rich,community of *** explored the species content and evolutionary history of the Tibetan Plateau endemic freshwater snail genus *** relationships within the genus were reconstructed based on available sequence *** used a single-rate Poisson Tree Processes approach for species delimitation and compared putative species-level clades with already described *** found that the genus consists of at least 6 species,of which we described 4 as new to *** and soft body morphology was examined and the radula in Tibetoradix was described for theﬁrst *** on ourﬁndings,the diversiﬁcation of the genus did not result in a prominent morphological differentiation and a number of species can be regarded as morphologically *** species found in different drainage areas indicate relatively good passive dispersal abilities of the *** allopatric distribution of the species could result from competitive exclusion between *** absence of Tibetoradix *** the Tibetan Plateau could be explained by a scenario of an“evolutionary trap”,where adaptations to high elevation conditions prevented the taxa from a successful colonization of lower elevations.

关键词： biogeography High Asia molecular phylogenetics morphology species delimitation

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Promotion effects of alkali metals on iron molybdate catalysts for CO_(2)catalytic hydrogenation

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Journal of Energy Chemistry 2023年第10期85卷 291-300,I0009页

作者： Yong Zhou Aliou Sadia Traore Deizi v.Peron Alan J.Barrios Sergei A.Chernyak Massimo Corda olga v.Safonova Achim Iulian Dugulan Ovidiu Ersen Mirella virginie vitaly v.Ordomsky Andrei Y.Khodakov University of Lille CNRSCentrale LilleUniversity of ArtoisUMR 8181-UCCS-Unitéde Catalyse et Chimie du SolideLille F-59000France IPCMS UMR 7504 CNRSUniversitéde Strasbourg23 rue du LoessBP 43Cedex 267034 StrasbourgFrance PSI CH-5232 VilligenSwitzerland Fundamental Aspects of Materials and Energy Group Delft University of TechnologyMekelweg 15Delft 2629 JBNetherlands

CO_(2)hydrogenation is an attractive way to store and utilize carbon dioxide generated by industrial processes,as well as to produce valuable chemicals from renewable and abundant *** catalysts are commonly used for the hydrogenation of carbon oxides to ***-molybdenum catalysts have found numerous applications in catalysis,but have been never evaluated in the CO_(2)*** this work,the structural properties of iron-molybdenum catalysts without and with a promoting alkali metal(Li,Na,K,Rb,or Cs)were characterized using X-ray diffraction,hydrogen temperatureprogrammed reduction,CO_(2)temperature-programmed desorption,in-situ^(57)Fe Mossbauer spectroscopy and operando X-ray adsorption *** catalytic performance was evaluated in the CO_(2)*** the reaction conditions,the catalysts undergo the formation of an iron(Ⅱ)molybdate structure,accompanied by a partial reduction of molybdenum and carbidization of *** rate of CO_(2)conversion and product selectivity strongly depend on the promoting alkali metals,and electronegativity was identified as an important factor affecting the catalytic *** CO_(2)conversion rates were observed with the promoters having higher electronegativity,while low electronegativity of alkali metals favors higher light olefin selectivity.

关键词： CO_(2)utilization Iron molybdate catalysts Promotion Alkali metals Light olefins In-situ characterization

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Identification of genes involved in the formation of soluble dietary fiber in winter rye grain and their expression in cultivars with different viscosities of wholemeal water extract

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The Crop Journal 2022年第2期10卷 532-549页

作者： Liudmila v.Kozlova Alsu R.Nazipova Oleg v.Gorshkov Liliya F.Gilmullina olga v.Sautkina Natalia v.Petrova Oksana I.Trofimova Sergey N.Ponomarev Mira L Ponomareva Tatyana A.Gorshkova Kazan Institute of Biochemistry and Biophysics Federal Research CenterKazan Scientific Center of the Russian Academy of Sciences420111 KazanRussia Tatar Scientific Research Institute of Agriculture Federal Research CenterKazan Scientific Center of the Russian Academy of Sciences420059 KazanRussia

The grain of rye(Secale cereale L.) used for baking contains a large amount of non-starch polysaccharides,making it an excellent component of functional foods. But rye grain intended for alcohol production and forage use should have a reduced content of these polysaccharides. A comprehensive parameter that can predict the best field of application for winter rye grain is the viscosity of its wholemeal water ***, our understanding of the genetic background underlying this key trait and associated features of rye grain is poor. By analyzing six Russian winter rye cultivars, we identified the most contrasting forms and characterized the peculiarities of their water-soluble carbohydrates capable of influencing the viscosity of water extracts. Then, using phylogenetic and transcriptomic analyses, we identified in the rye genome many genes encoding putative glycosyltransferases and glycosylhydrolases responsible for the synthesis and degradation of arabinoxylans, mixed-linkage glucans, cellulose, and some other polysaccharides. We determined the dynamics of m RNA abundance for these genes at three stages of kernel development. Comparisons of gene expression levels in two contrasting cultivars revealed specific members of multigene families that may serve as promising targets for manipulating non-starch polysaccharide content in rye grain. High-viscosity cultivars were characterized by up-regulation of many glycosyltransferases involved in the biosynthesis of arabinoxylans and other cell-wall polysaccharides,whereas low-viscosity cultivars showed up-regulation of several genes encoding polysaccharidedegrading enzymes.

关键词： Rye(Secale cereale) Kernel development Arabinoxylan Mixed-linkage glucan viscosity

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Extended Corey-Chaykovsky reactions:transformation of 2-hydroxychalcones to benzannulated 2,8-dioxabicyclo[3.2.1]octanes and 2,3-dihydrobenzofurans

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Organic Chemistry Frontiers 2022年第3期9卷 737-744页

作者： Alexander A.Fadeev Anton S.Makarov olga A.Ivanova Maxim G.Uchuskin Igor v.Trushkov Department of Chemistry Perm State UniversityBukireva 15Perm 614990Russian Federation Department of Chemistry M.V.Lomonosov Moscow State UniversityLeninskie Gory 1-3Moscow 119991Russian Federation N.D.Zelinsky Institute of Organic Chemistry Leninsky pr.47Moscow 119334Russian Federation. D.Rogachev National Medical Research Center of Pediatric Hematology Oncology and ImmunologySamory Mashela 1Moscow 117997Russian Federation

We report the divergent synthesis of benzannulated 2,8-dioxabicyclo[3.2.1]octanes and 2,3-dihydrobenzofurans using the concept of extended Corey-Chaykovsky *** this concept,2-hydroxychalcones were treated with the Corey ylide providing highly reactive donor-acceptor cyclopropanes that were introduced in a one pot manner for further transformations.

关键词： octane donor

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Selective footprints and genes relevant to cold adaptation and other phenotypic traits are unscrambled in the genomes of divergently selected chicken breeds

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Journal of Animal Science and Biotechnology 2023年第3期14卷 887-907页

作者： Michael N.Romanov Alexandra S.Abdelmanova vladimir I.Fisinin Elena A.Gladyr Natalia A.volkova olga A.Koshkina Andrey N.Rodionov Anastasia N.vetokh Igor v.Gusev Dmitry v.Anshakov olga I.Stanishevskaya Arsen v.Dotsev Darren K.Griffin Natalia A.Zinovieva L.K.Ernst Federal Research Centre for Animal Husbandry DubrovitsyPodolskMoscow RegionRussia School of Biosciences University of KentCanterburyUK Federal State Budget Scientific Institution Federal Research Centre“All-Russian Poultry Research and Technological Institute”of the Russian Academy of Sciences Sergiev PosadMoscow RegionRussia Breeding and Genetic Centre“Zagorsk Experimental Breeding Farm”–Branch of the Federal Research Centre“All-Russian Poultry Research and Technological Institute”of the Russian Academy of Sciences Sergiev PosadMoscow RegionRussia Russian Research Institute of Farm Animal Genetics and Breeding–Branch of the L.K.Ernst Federal Research Centre for Animal Husbandry St.PetersburgRussia

Background The genomes of worldwide poultry breeds divergently selected for performance and other phenotypic traits may also be affected by,and formed due to,past and current admixture *** to diverse environments,including acclimation to harsh climatic conditions,has also left selection footprints in breed *** Using the Chicken 50K_CobbCons SNP chip,we genotyped four divergently selected breeds:two aboriginal,cold tolerant Ushanka and Orloff Mille Fleur,one egg-type Russian White subjected to artificial selection for cold tolerance,and one meat-type White *** of selective sweeps were determined in the studied breeds using three methods:(1)assessment of runs of homozygosity islands,(2)F_(ST) based population differential analysis,and(3)haplotype differentiation *** regions of true selection signatures were identified by two or more methods or in two or more *** these regions,we detected 540 prioritized candidate genes supplemented them with those that occurred in one breed using one statistic and were suggested in other *** them,SOX5,ME3,ZNF536,WWP1,RIPK2,OSGIN2,DECR1,TPO,PPARGC1A,BDNF,MSTN,and beta-keratin genes can be especially mentioned as candidates for cold *** factors may be involved in regulating some of these important genes(e.g.,TPO and BDNF).Conclusion Based on a genome-wide scan,our findings can help dissect the genetic architecture underlying various phenotypic traits in chicken *** include genes representing the sine qua non for adaptation to harsh *** tolerance in acclimated chicken breeds may be developed following one of few specific gene expression mechanisms or more than one overlapping response known in cold-exposed individuals,and this warrants further investigation.

关键词： Acclimation Adaptation Chicken breeds Cold tolerance Divergent selection Genetic diversity Genomewide scan Phenotypic traits Selective sweeps

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The state of gold in phases of the Cu-Fe-S system:In situ X-ray absorption spectroscopy study

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Geoscience Frontiers 2023年第3期14卷 103-116页

作者： Boris R.Tagirov olga N.Filimonova Alexander L.Trigub Ilya v.vikentyev Elena v.Kovalchuk Maximilian S.Nickolsky Andrey A.Shiryaev vladimir L.Reukov Dmitry A.Chareev Institute of Geology of Ore Deposits(IGEM RAS) 35Staromonetnyi per119017 MoscowRussia National Research Centre‘Kurchatov Institute’ 1Akademika Kurchatova pl123182 MoscowRussia Institute of Physical Chemistry and Electrochemistry(IPCE RAS) 31Leninsky Prospect119071 MoscowRussia Institute of Experimental Mineralogy(IEM RAS) 142432 ChernogolovkaMoscow RegionRussia

Chalcopyrite and bornite are the main Au-bearing minerals at Cu porphyry deposits,volcanogenic massive sulfide(vMS)deposits,Cu-Ni deposits of the mafic magmatic complexes,and ores of submarine sulfide *** and intermediate solid solutions with wide compositional variations(bnss and iss–high-temperature chalcopyrite,correspondingly),which can scavenge economic concentrations of Au,appear in the Cu-Fe-S system at ore-forming ***,the state of Au in bnss and iss is yet *** solve this conundrum,we synthesized samples with net chemical composition of bnss and iss,studied them by in situ X–ray absorption spectroscopy(XAS),and used the experimental data to explain the Au distribution among natural ore-forming *** sulfide samples were obtained at 495–700℃ in Au-saturated system by means of salt flux *** bnss contained1.2–1.6 log units more Au than iss:up to 18 wt.%Au in bnss vs 0.4 wt.%Au in iss at 700*** increase of temperature resulted in the sharp increase of Au concentration in both phases,1 log unit per 100℃ at f(S2)close to S_((l)) *** of Au L_(3)-edge spectra recorded at 25–675℃ revealed that at 25℃ Au exists mainly in the metallic *** t>500℃ the spectral features of Audisappear,and “chemically bound”Au *** Au form of occurrence in the iss field is interpreted as Au-bearing clusters with a stromeyerite-like(CuAgS)*** Cu_(2–x)S and bnss contain Au in a mixture of stromeyeritelike and petrovskaite-like(Au_(0.8)Ag_(1.2)S)*** chemical composition of both forms is close to CuAuS,where the nearest Au neighbors are two S atoms at R_(Au-S)=2.34–2.36Å.Results of the present study allow to determine the state of Au and its concentration in the main Cu-bearing minerals of sulfide ores as a function of the T-f(S_(2))-compositional *** to the sharp increase of the CuAuS clusters stability with increasing temperature,in high-temperature ores formed at t>350℃ A

关键词： “Invisible”gold Bornite solid solution Intermediate solid solution Digenite Chalcopyrite X-ray absorption spectroscopy

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Evaluating chromosomal segregation in a family where both spouses carry an autosomal translocation

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Reproductive and Developmental Medicine 2023年第3期7卷 189-192页

作者： Irina L.Puppo Ziravard N.Tonyan Alsu F.Saifitdinova Julia A.Loginova Anna A.Kinunen Alisa N.Panina Julia R.Pastuhova olga A.Leonteva olga G.Chiryaeva olga v.Malysheva Oleg S.Glotov Irina v.Poliakova Andrey v.Tikhonove Tatyana v.vavilova Irina L.Menshikova Elvira v.Isakova Andrey S.Glotov Natalya K.Bichevaya International Centre for Reproductive Medicine Saint-Petersburg 197350Russia Department of Laboratory Medicine and Genetics Almazov National Medical Research CentreSaint-Petersburg197341Russia Department of Genomic Medicine D.O.Ott's Institute of ObstetricsGynecologyand ReproductologySaint-Petersburg 199034Russia Department of Biology.Herzen State Pedagogical University of Russia Saint-Petersburg 191186Russia DiaCarta Inc.2600 Hilltop DriveRichmondCA 94806 St.Petersburg Centre for Medical Genetics Saint Petersburg194044Russia Department of ExperimentalMedical virology MolecularGenetics and Biobankingof Pediatric Researchand Clinical Center for Infectious DiseasesSaint-Petersburg 197022Russia Medical institute of Surgut State University Surgut 628403 Russia CerbaLab Ltd. Saint-Petersburg 199106Russia

Autosomal reciprocal translocations represent exchanges of chromatin fragments between non-homologous *** are facilitated by the creation of quadrivalent structures during the first meiotic division,which are characterized by the length of the translocated and centric segments,asymmetry,and the presence of terminal breakpoints,all of which may impact segregation ***,we report a rare case of multiple reciprocal translocations within a single *** includes the evaluation of the translocations in each of the spouses and an analysis of their chromosome segregation patterns as determined by the constellation of universal characteristics in each of their *** obtained results will be of interest to fundamental biology,as they will expand the understanding of the factors affecting chromosome segregation during meiosis.

关键词： Embryo viability Genetic counseling Pre-implantation genetic testing Quadrivalent characteristics

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Polyphony of domestic dog whines and vocal cues to body size

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Current Zoology 2021年第2期67卷 165-176页

作者： olga v.SIBIRYAKOvA Ilya A.vOLODIN Elena v.vOLODINA Department of vertebrate Zoology Faculty of BiologyLomonosov Moscow State UniversityMoscow 119234Russia Department of Behaviour and Behavioural Ecology A.N.Severtsov Institute of Ecology and EvolutionRussian Academy of SciencesMoscow 119071Russia

In domestic dogs Canis familiaris,vocal traits have been investigated for barks and growls,and the relationship between individual body size and vocal traits investigated for growls,with less corre-sponding information for *** this study,we examined the frequency and temporal traits of whines of 20 adult companion dogs(9 males,11 females),ranging in body mass from 3.5 to 70.0 kg and belonging to 16 *** whines(26-71 per individual,824 in total)were recorded in condi-tioned begging contexts modeled by dog *** had 3 independent fundamental fre-quencies:the low,the high and the ultra-high that occurred singly as monophonic calls or simul-taneously as 2-voice biphonic or 3 voice polyphonic *** the smallest to largest dog,the upper frequency limit varied from 0.24 to 2.13 kHz for the low fundamental frequency,from 2.95 to 10.46 kHz for the high fundamental frequency and from 9.99 to 23.26 kHz for the ultra-high funda-mental *** individuals,the low fundamental frequency was lower in monophonic than in biphonic whines,whereas the high fundamental frequency did not differ between those whine *** frequency variables of the low,high,and ultra-high fundamental frequencies cor-related negatively with dog body *** duration,no correlation with body mass was *** discuss potential production mechanisms and sound sources for each fundamental frequency;point to the acoustic similarity between high-frequency dog whines and rodent ultrasonic calls and hypothesize that ultra-high fundamental frequencies function to allow private,"tete-a-tete"com-munication between members of social groups.

关键词： acoustic communication Canis familiaris companion dogs high-frequency calls nonlinear phenomena vocalization

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Empowering sonic hedgehog to rescue brain cells after ischemic stroke

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Neural Regeneration Research 2015年第3期10卷 360-362页

作者： olga v.Chechneva Wenbin Deng Department of Biochemistry and Molecular Medicine University of California Institute for Pediatric Regenerative Medicine Shriners Hospitals for Children

Ischemic stroke occurs when blood supply to the brain is interrupted. This can cause irreversible injury to the cen- tral nervous system （CNS） tissue. Each year in the United States almost 800,000 people experience a new or recur- rent stroke. 15% of stroke patients die shortly after insult and only 10% recover completely, leaving the majority of surviving stroke patients with disabilities. Tissue-type plasminogen activator （tPA） is the only available therapy for stroke but its clinical use is limited because of associ- ated danger of intracranial hemorrhage. Therefore, there is an emergent need for stroke therapeutics that are safe and effective when administered at a later time point after insult.

关键词： Shh Empowering sonic hedgehog to rescue brain cells after ischemic stroke PUR MCAO BBB

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