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Olfactory dysfunction as a common biomarker for neurodegenerative and neuropsychiatric disorders

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Neural Regeneration Research 2023年第5期18卷 1029-1030页

作者： David Slabik olga garaschuk Department of Psychiatry and Psychotherapy Tübingen Center for Mental HealthEberhard Karls University of TübingenTübingenGermany Institute of Physiology Department NeurophysiologyEberhard Karls University of TübingenTübingenGermany

The sense of smell supports the identification and the safety of food,warns of danger/predators,and plays a key role in mating(Croy and Hummel,2017;Kondo et al.,2020;Tzeng et al.,2021).Via connection to the limbic system,it supports behavioral adaption and emotions and can detect fear,tears,and happiness in the body odor of others(Croy and Hummel,2017;Tzeng et al.,2021).

关键词： Kondo tears al.

Role of presynaptic calcium stores for neural network dysfunction in Alzheimer＇s disease

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Neural Regeneration Research 2018年第6期13卷 977-978页

作者： Chommanad Lerdkrai olga garaschuk Institute of Physiology Department Neurophysiology Eberhard KarlsUniversity of Tubingen Tubingen Germany Department of Physiology Faculty of Veterinary Medicine Kasetsart UniversityBangkok Thailand

Alzheimer’s disease（AD）is the most common form of dementia representing a major problem for public *** 2017 there were an estimated 50 million patients worldwide and this number is expected to almost double every 2... 详细信息

关键词： In Role of presynaptic calcium stores for neural network dysfunction in Alzheimer’s disease AD

Role of serotonin in modulating the development and function of adult-born neurons in the olfactory bulb

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Neural Regeneration Research 2022年第6期17卷 1253-1254页

作者： Natalie Fomin-Thunemann olga garaschuk Department of Biomedical Engineering Boston UniversityBostonMAUSA Institute of Physiology Department NeurophysiologyEberhard Karls University of TübingenTübingenGermany

The neuromodulatory transmitter serotonin(5-hydroxytryptamine,5-HT)is synthesized by neurons located in the brainstem,which project more or less densely to the entire central nervous system(Charnay and Leger,2010).Serotonin regulates a variety of physiological functions,including food intake,reward,reproduction,sleep-wake cycle,memory,cognition,emotion,and mood(Charnay and Leger,2010).

关键词： serotonin intake modulator

K^(+) channel-mediated retarded maturation of interneurons and its role in neurodevelopmental disorders

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Neural Regeneration Research 2024年第7期19卷 1403-1404页

作者： Kaizhen Li Daria Savitska olga garaschuk Laboratory of Systems Neuroscience Department of PhysiologyUniversity of BernBernSwitzerland Institute of Physiology Department of NeurophysiologyEberhard Karls University of TübingenTübingenGermany

De novo mutations in genes encoding K^(+)channels are implicated in many severe neurodevelopmental ***,mutations in KCNA2,encoding the Shaker-type voltage-gated K^(+)channel Kv1.2,and KCNJ2,encoding the inwardly rectifying K^(+)channel Kir2.1,associate with focal and generalized epilepsies,brain atrophy,autism,ataxia and hereditary spastic paraplegia(Syrbe et al.,2015;Masnada et al.,2017;Cheng et al.,2021).

关键词： disorders atrophy